{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:09:25Z","timestamp":1785722965541,"version":"3.56.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council\u00a0of\u00a0Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.ejmech.2020.112276","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T20:33:21Z","timestamp":1585946001000},"page":"112276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex\u00a0vivo infection model and their mechanistic studies"],"prefix":"10.1016","volume":"195","author":[{"family":"Gagandeep","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prince","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamseer Kulangara","family":"Kandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasturi","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diwan S.","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2020.112276_bib1","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1016\/S1473-3099(18)30296-2","article-title":"Quantifying drivers of antibiotic resistance in humans: a systematic review","volume":"18","author":"Chatterjee","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2020.112276_bib2","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2020.112276_bib3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2020.112276_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(05)70295-4","article-title":"The role of nasal carriage in Staphylococcus aureus infections","volume":"5","author":"Wertheim","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2020.112276_bib5","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1001\/jama.293.24.3012","article-title":"Staphylococcus aureus endocarditis: a consequence of medical progress","volume":"293","author":"Fowler","year":"2005","journal-title":"Jama"},{"key":"10.1016\/j.ejmech.2020.112276_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijmm.2009.10.003","article-title":"Interaction of staphylococci with bone","volume":"300","author":"Wright","year":"2010","journal-title":"Int. J. Med. Microbiol. : IJMM"},{"key":"10.1016\/j.ejmech.2020.112276_bib7","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1097\/INF.0b013e318133a85e","article-title":"Pediatric bone and joint infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus","volume":"26","author":"Dohin","year":"2007","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ejmech.2020.112276_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0140-6736(02)07877-7","article-title":"Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients","volume":"359","author":"Gillet","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2020.112276_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1086\/498518","article-title":"Isolation of Staphylococcus aureus from the urinary tract: association of isolation with symptomatic urinary tract infection and subsequent staphylococcal bacteremia","volume":"42","author":"Muder","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2020.112276_bib10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jiac.2014.08.001","article-title":"Multi-drug-resistant Staphylococcus aureus and future chemotherapy","volume":"20","author":"Hiramatsu","year":"2014","journal-title":"J.\u00a0Infect. Chemother."},{"key":"10.1016\/j.ejmech.2020.112276_bib11","first-page":"729","article-title":"The central role of lipids in daptomycin action","volume":"14","author":"Hofer","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2020.112276_bib12","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1039\/C7NP00019G","article-title":"Opportunities for natural products in 21(st) century antibiotic discovery","volume":"34","author":"Wright","year":"2017","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2020.112276_bib13","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.2307\/3869817","article-title":"Two classes of plant antibiotics: phytoalexins versus \"phytoanticipins","volume":"6","author":"VanEtten","year":"1994","journal-title":"Plant Cell"},{"key":"10.1016\/j.ejmech.2020.112276_bib14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10295-015-1723-5","article-title":"Natural product discovery: past, present, and future","volume":"43","author":"Katz","year":"2016","journal-title":"J.\u00a0Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2020.112276_bib15","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/mnfr.201100741","article-title":"Multitargeting by turmeric, the golden spice: from kitchen to clinic","volume":"57","author":"Gupta","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejmech.2020.112276_bib16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/138945011794815356","article-title":"The targets of curcumin","volume":"12","author":"Zhou","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejmech.2020.112276_bib17","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.ejca.2005.05.009","article-title":"Curcumin: the story so far","volume":"41","author":"Sharma","year":"2005","journal-title":"Eur. J. Canc."},{"key":"10.1016\/j.ejmech.2020.112276_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0304-3835(95)03827-J","article-title":"Anti-tumour and antioxidant activity of natural curcuminoids","volume":"94","author":"Ruby","year":"1995","journal-title":"Cancer let"},{"key":"10.1016\/j.ejmech.2020.112276_bib19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejmech.2020.112276_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-0-387-46401-5_3","article-title":"Antioxidant and anti-inflammatory properties of curcumin","volume":"595","author":"Menon","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejmech.2020.112276_bib21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.dyepig.2004.05.008","article-title":"Antimicrobial activity of wool fabric treated with curcumin","volume":"64","author":"Han","year":"2005","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.ejmech.2020.112276_bib22","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1128\/AAC.01242-08","article-title":"Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice","volume":"53","author":"De","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2020.112276_bib23","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/ptr.4639","article-title":"A\u00a0randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis","volume":"26","author":"Chandran","year":"2012","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2020.112276_bib24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/biof.1063","article-title":"Curcumin and neurodegenerative diseases","volume":"39","author":"Monroy","year":"2013","journal-title":"Biofactors"},{"key":"10.1016\/j.ejmech.2020.112276_bib25","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bcp.2007.08.016","article-title":"Curcumin as \"Curecumin\": from kitchen to clinic","volume":"75","author":"Goel","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2020.112276_bib26","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112276_bib27","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/S0731-7085(96)02024-9","article-title":"Stability of curcumin in buffer solutions and characterization of its degradation products","volume":"15","author":"Wang","year":"1997","journal-title":"J.\u00a0Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.ejmech.2020.112276_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0378-5173(02)00323-X","article-title":"Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability","volume":"244","author":"Tonnesen","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2020.112276_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1021\/np060263s","article-title":"NMR study of the solution structure of curcumin","volume":"70","author":"Payton","year":"2007","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.ejmech.2020.112276_bib30","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: from extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2020.112276_bib31","first-page":"402","article-title":"Studies on curcumin and curcuminoids","volume":"180","author":"Tonnesen","year":"1985","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.ejmech.2020.112276_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111631","article-title":"Curcumin analogues and their hybrid molecules as multifunctional drugs","volume":"182","author":"Noureddin","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112276_bib33","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1021\/bi400734e","article-title":"Stable and potent analogues derived from the modification of the dicarbonyl moiety of curcumin","volume":"52","author":"Chakraborti","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2020.112276_bib34","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.bmcl.2007.12.068","volume":"18","author":"Liang","year":"2008","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2020.112276_bib35","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1021\/acs.jmedchem.5b01203","article-title":"Discovery of new monocarbonyl ligustrazine-curcumin hybrids for intervention of drug-sensitive and drug-resistant lung cancer","volume":"59","author":"Ai","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112276_bib36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bmcl.2012.11.004","article-title":"Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin","volume":"23","author":"Manohar","year":"2013","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2020.112276_bib37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2174\/15701808113109990061","article-title":"Synthesis of unsymmetrical C5-curcuminoids as potential anticancer agents","volume":"11","author":"Manohar","year":"2014","journal-title":"Letts. Drug Discov."},{"key":"10.1016\/j.ejmech.2020.112276_bib38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1039\/C4NJ00936C","article-title":"C\u00a05-curcuminoid-4-aminoquinoline based molecular hybrids: design, synthesis and mechanistic investigation of anticancer activity","volume":"39","author":"Kandi","year":"2015","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2020.112276_bib39","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1021\/acsomega.8b02625","article-title":"Monocarbonyl curcuminoids with improved stability as antibacterial agents against Staphylococcus aureus and their mechanistic studies","volume":"4","author":"Kumar","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2020.112276_bib40","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/14760584.2018.1488590","article-title":"Escherichia coli and Staphylococcus aureus: leading bacterial pathogens of healthcare associated infections and bacteremia in older-age populations","volume":"17","author":"Poolman","year":"2018","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.ejmech.2020.112276_bib41","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.bbapap.2008.11.005","article-title":"Outer membrane permeability and antibiotic resistance","volume":"1794","author":"Delcour","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2020.112276_bib42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5371\/hp.2014.26.4.235","article-title":"Clinical characteristics of methicillin-resistant Staphylococcus aureus infection for chronic periprosthetic hip and knee infection","volume":"26","author":"Ryu","year":"2014","journal-title":"Hip Pelvis"},{"key":"10.1016\/j.ejmech.2020.112276_bib43","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.peptides.2009.06.020","article-title":"In\u00a0vitro antimicrobial activity of alpha-melanocyte stimulating hormone against major human pathogen Staphylococcus aureus","volume":"30","author":"Madhuri","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.ejmech.2020.112276_bib44","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1128\/IAI.71.5.2716-2723.2003","article-title":"Strain-specific association of cytotoxic activity and virulence of clinical Staphylococcus aureus isolates","volume":"71","author":"Krut","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejmech.2020.112276_bib45","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1128\/IAI.71.2.1016-1019.2003","article-title":"Influence of extracellular bactericidal agents on bacteria within macrophages","volume":"71","author":"Hamrick","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejmech.2020.112276_bib46","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/j.bmc.2007.01.024","article-title":"New 1,3-dioxolane and 1,3-dioxane derivatives as effective modulators to overcome multidrug resistance","volume":"15","author":"Schmidt","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112276_bib47","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1021\/jm0607193","article-title":"Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging","volume":"49","author":"Ryu","year":"2006","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112276_bib48","series-title":"Methods for Dilution Antimicrobial Susceptibility Test for Bacteria that Grow Aerobically, Approved Standard M7-A8","author":"Wikler","year":"2009"},{"key":"10.1016\/j.ejmech.2020.112276_bib49","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41598-017-17234-z","article-title":"Novel miniature membrane active lipopeptidomimetics against planktonic and biofilm embedded methicillin-resistant Staphylococcus aureus","volume":"8","author":"Joshi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2020.112276_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/srep31492","article-title":"Enhanced cationic charge is a key factor in promoting staphylocidal activity of alpha-melanocyte stimulating hormone via selective lipid affinity","volume":"6","author":"Singh","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2020.112276_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121313","article-title":"Bactericidal activity of curcumin I is associated with damaging of bacterial membrane","volume":"10","author":"Tyagi","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.ejmech.2020.112276_bib52","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-1-60761-594-1_12","article-title":"Comparing bacterial membrane interactions of antimicrobial peptides and their mimics","volume":"618","author":"Chongsiriwatana","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejmech.2020.112276_bib53","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1128\/AAC.00957-10","article-title":"C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus","volume":"55","author":"Singh","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2020.112276_bib54","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature16057","article-title":"Novel antibody-antibiotic conjugate eliminates intracellular S.\u00a0aureus","volume":"527","author":"Lehar","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2020.112276_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/srep29707","article-title":"Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus","volume":"6","author":"Mohamed","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2020.112276_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2017.00505","article-title":"Impact of gentamicin concentration and exposure time on intracellular Yersinia pestis","volume":"7","author":"VanCleave","year":"2017","journal-title":"Front. Cell Infect. Microbiol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420302452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420302452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:08:13Z","timestamp":1759327693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523420302452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":56,"alternative-id":["S0223523420302452"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112276","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex\u00a0vivo infection model and their mechanistic studies","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112276"}}