{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:35:39Z","timestamp":1759336539363,"version":"build-2065373602"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Gyeonggi provincial government"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.ejmech.2020.112280","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T11:10:26Z","timestamp":1586171426000},"page":"112280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Synthesis and evaluation of butein derivatives for in\u00a0vitro and in\u00a0vivo inflammatory response suppression in lymphedema"],"prefix":"10.1016","volume":"197","author":[{"given":"Kangsan","family":"Roh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngju","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukchan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Mo","family":"Ku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2020.112280_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/1358836X9800300209","article-title":"Lymphedema: classification, diagnosis and therapy","volume":"3","author":"Szuba","year":"1998","journal-title":"Vasc. Med."},{"key":"10.1016\/j.ejmech.2020.112280_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0002-9343(00)00727-0","article-title":"Lymphedema","volume":"110","author":"Rockson","year":"2001","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejmech.2020.112280_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1186\/s40064-016-2300-8","article-title":"Worse and worse off: the impact of lymphedema on work and career after breast cancer","volume":"5","author":"Boyages","year":"2016","journal-title":"SpringerPlus"},{"key":"10.1016\/j.ejmech.2020.112280_bib4","first-page":"95","article-title":"Lymphedema reduction by noninvasive complex lymphedema therapy","volume":"8","author":"Boris","year":"1994","journal-title":"Oncology"},{"key":"10.1016\/j.ejmech.2020.112280_bib5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/PRS.0b013e3182450b2d","article-title":"Regulation of adipogenesis by lymphatic fluid stasis part I: adipogenesis, fibrosis, and inflammation","volume":"129","author":"Zampell","year":"2012","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.ejmech.2020.112280_bib6","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/NNR.0b013e31818c3de2","article-title":"Predictors of lymphedema in patients with breast cancer undergoing axillary lymph node dissection in Hong Kong","volume":"57","author":"Mak","year":"2008","journal-title":"Nurs. Res."},{"key":"10.1016\/j.ejmech.2020.112280_bib7","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1371\/journal.pmed.0030254","article-title":"Inflammatory manifestations of experimental lymphatic insufficiency","volume":"3","author":"Tabibiazar","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.ejmech.2020.112280_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052021","article-title":"Prospective transcriptomic pathway analysis of human lymphatic vascular insufficiency: identification and validation of a circulating biomarker panel","volume":"7","author":"Lin","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.ejmech.2020.112280_bib9","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8 effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejmech.2020.112280_bib10","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A\u00a0paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha","volume":"25","author":"Suganami","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejmech.2020.112280_bib11","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/ajpheart.00598.2014","article-title":"Regulation of inflammation and fibrosis by macrophages in lymphedema","volume":"308","author":"Swapna","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejmech.2020.112280_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/lrb.2013.0024","article-title":"Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery","volume":"12","author":"Leung","year":"2014","journal-title":"Lymphatic Res. Biol."},{"key":"10.1016\/j.ejmech.2020.112280_bib13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0091-6749(91)90185-Q","article-title":"Improved in\u00a0vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen)","volume":"88","author":"Ambus","year":"1991","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.ejmech.2020.112280_bib14","doi-asserted-by":"crossref","first-page":"14345","DOI":"10.1038\/ncomms14345","article-title":"Topical tacrolimus for the treatment of secondary lymphedema","volume":"8","author":"Gardenier","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2020.112280_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.phrs.2017.05.003","article-title":"Sulfuretin has therapeutic activity against acquired lymphedema by reducing adipogenesis","volume":"121","author":"Roh","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejmech.2020.112280_bib16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jep.2006.10.013","article-title":"Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages","volume":"110","author":"Jung","year":"2007","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2020.112280_bib17","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1194\/jlr.M035576","article-title":"Butein is a novel anti-adipogenic compound","volume":"54","author":"Song","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ejmech.2020.112280_bib18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1055\/s-2003-45143","article-title":"The chalcone butein from Rhus verniciflua shows antifibrogenic activity","volume":"69","author":"Lee","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2020.112280_bib19","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112280_bib20","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ejmech.2017.07.044","article-title":"Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties","volume":"139","author":"Subbaiah","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112280_bib21","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1021\/acs.jmedchem.6b00220","article-title":"Design, synthesis, and biological evaluation of potential prodrugs related to the experimental anticancer agent indotecan (LMP400)","volume":"59","author":"Lv","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112280_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejmech.2012.08.039","article-title":"Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity","volume":"57","author":"Abonia","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112280_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ejmech.2017.01.027","article-title":"Synthesis and antitrypanosomal activities of novel pyridylchalcones","volume":"128","author":"Bhamabra","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112280_bib24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejmech.2019.05.013","article-title":"New chalcone-sulfonamide hybrids exhibiting anticancer and antituberculosis activity","volume":"176","author":"Castano","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112280_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ejmech.2017.11.010","article-title":"Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors","volume":"143","author":"Ramya","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112280_bib26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejmech.2016.08.042","article-title":"Sulfonamide chalcones: synthesis and in\u00a0vitro exploration for therapeutic potential against Brugia malayi","volume":"124","author":"Bahekar","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112280_bib27","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2174\/1385272821666161216102008","article-title":"Cu(II) mediated chalcone synthesis via \u03b1-bromocarbonyl intermediate: a one step synthesis of echinatin","volume":"21","author":"Lee","year":"2017","journal-title":"Curr. Org. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342030249X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342030249X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:10:46Z","timestamp":1759327846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342030249X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":27,"alternative-id":["S022352342030249X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112280","relation":{},"ISSN":["0223-5234"],"issn-type":[{"type":"print","value":"0223-5234"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and evaluation of butein derivatives for in\u00a0vitro and in\u00a0vivo inflammatory response suppression in lymphedema","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112280"}}