{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:34:23Z","timestamp":1786988063918,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013806","name":"Shenyang Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.ejmech.2020.112360","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T21:05:00Z","timestamp":1588539900000},"page":"112360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents"],"prefix":"10.1016","volume":"198","author":[{"given":"Hang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-bi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-hua","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2020.112360_bib1","first-page":"11","article-title":"Emerging Threats in antifungal-resistant fungal pathogens","volume":"3","author":"Dominique","year":"2016","journal-title":"Front. Med."},{"key":"10.1016\/j.ejmech.2020.112360_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1126\/science.1222236","article-title":"Tackling human fungal infections","volume":"336","author":"Brown","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2020.112360_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2147\/IDR.S124918","article-title":"Antifungal resistance: current trends and future strategies to combat","volume":"10","author":"Wiederhold","year":"2017","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.ejmech.2020.112360_bib4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/14787210.2017.1328279","article-title":"Drug development challenges and strategies to address emerging and resistant fungal pathogens","volume":"15","author":"Mccarthy","year":"2017","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.ejmech.2020.112360_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejim.2016.06.029","article-title":"Candidemia and invasive candidiasis in adults: a narrative review","volume":"34","author":"Antinori","year":"2016","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.ejmech.2020.112360_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s40588-015-0015-1","article-title":"Update on antifungal drug resistance","volume":"2","author":"Perlin","year":"2015","journal-title":"Curr. Clin. Micro. Rpt."},{"key":"10.1016\/j.ejmech.2020.112360_bib7","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1016\/j.bmc.2012.04.045","article-title":"The biology and chemistry of antifungal agents: a review","volume":"20","author":"Kathiravan","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112360_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182018000562","article-title":"CYP51 as drug targets for fungi and protozoan parasites: past, present and future","volume":"145","author":"Lepesheva","year":"2018","journal-title":"Parasitology"},{"key":"10.1016\/j.ejmech.2020.112360_bib9","doi-asserted-by":"crossref","first-page":"140206","DOI":"10.1016\/j.bbapap.2019.02.008","article-title":"Fungal Lanosterol 14\u03b1-demethylase: a target for next-generation antifungal design","volume":"1868","author":"Monk","year":"2020","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2020.112360_bib10","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1021\/acs.jmedchem.7b01413","article-title":"Emerging new targets for the treatment of resistant fungal infections","volume":"61","author":"Liu","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112360_bib11","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1021\/acs.jmedchem.8b01698","article-title":"Development of isoselenocyanate compounds\u2019 syntheses and biological applications","volume":"62","author":"Frieben","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112360_bib12","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1016\/j.ccr.2011.07.009","article-title":"Biologically significant selenium-containing heterocycles","volume":"255","author":"Ninomiya","year":"2011","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2020.112360_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/iub.1466","article-title":"Biological activity of selenium: revisited","volume":"68","author":"Wrobel","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ejmech.2020.112360_bib14","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.3390\/molecules22122124","article-title":"Celebrating two centuries of research in selenium chemistry: state of the art and new prospective","volume":"22","author":"Santi","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2020.112360_bib15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/acschembio.6b00031","article-title":"Why nature chose selenium","volume":"11","author":"Reich","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2020.112360_bib16","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1007\/s11696-017-0239-z","article-title":"Design, synthesis and antifungal activity of novel selenochroman-4-one derivatives","volume":"71","author":"Xu","year":"2017","journal-title":"Chem. Pap."},{"key":"10.1016\/j.ejmech.2020.112360_bib17","doi-asserted-by":"crossref","first-page":"126726","DOI":"10.1016\/j.bmcl.2019.126726","article-title":"Design, synthesis and biological evaluation of novel semicarbazone selenochroman-4-ones hybrids as potent antifungal agents","volume":"29","author":"Xu","year":"2019","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2020.112360_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2165\/00003495-198019010-00002","article-title":"Miconazole: a preliminary review of its therapeutic efficacy in systemic fungal infections","volume":"19","author":"Heel","year":"1980","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2020.112360_bib19","first-page":"1","article-title":"New insights on the antibacterial efficacy of miconazole in\u00a0vitro","author":"Nenoff","year":"2017","journal-title":"Mycoses"},{"key":"10.1016\/j.ejmech.2020.112360_bib20","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1039\/C8OB00897C","article-title":"Anti-staphylococcal biofilm activity of miconazoctylium bromide","volume":"16","author":"Tessier","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2020.112360_bib21","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1039\/C7MD00112F","article-title":"Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration","volume":"8","author":"Zhang","year":"2017","journal-title":"Medchemcomm"},{"key":"10.1016\/j.ejmech.2020.112360_bib22","first-page":"659","article-title":"Sulconazole. a review of its antimicrobial activity and therapeutic use in superficial dermatomycoses","volume":"42","author":"Benfiel","year":"1991","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2020.112360_bib23","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1002\/anie.201802416","article-title":"A\u00a0structural view on medicinal chemistry strategies against drug resistance","volume":"58","author":"Agnello","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2020.112360_bib25","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ejmech.2019.05.047","article-title":"Design, synthesis, and structure-activity relationship studies of L-amino alcohol derivatives as broad-spectrum antifungal agents","volume":"177","author":"Zhao","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112360_bib26","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1021\/acs.jmedchem.6b01203","article-title":"Tackling fungal resistance by biofilm inhibitors","volume":"60","author":"Wu","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112360_bib27","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/jb\/mvi073","article-title":"Effects of Y132H and F145L substitutions on the activity, azole resistance and spectral properties of Candida albicans sterol 14-demethylase P450 (CYP51): a live example showing the selection of altered P450 through interaction with environmental compounds","volume":"137","author":"Kudo","year":"2005","journal-title":"J.\u00a0Biochem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420303305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420303305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:10:50Z","timestamp":1759327850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523420303305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":26,"alternative-id":["S0223523420303305"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112360","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112360","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112360"}}