{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:20:23Z","timestamp":1785547223940,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009045","name":"Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005690","name":"Universit\u00e4t des Saarlandes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.ejmech.2020.112435","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:56:59Z","timestamp":1589561819000},"page":"112435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma"],"prefix":"10.1016","volume":"200","author":[{"given":"Wesam","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Spengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annam\u00e1ria","family":"Kincses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Nov\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Battistelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gniewomir","family":"Latacz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Starek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"D\u0105browska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Honkisz-Orzechowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Romanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Monica","family":"Rasile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Szyma\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Zwergel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"Handzlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2020.112435_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2174\/138945006777709593","article-title":"Pharmacological strategies for overcoming multidrug resistance","volume":"7","author":"Nobili","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejmech.2020.112435_bib2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1134\/S0006297908050118","article-title":"Transport proteins of the ABC family and multidrug resistance of tumor cells","volume":"73","author":"Stavrovskaya","year":"2008","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.ejmech.2020.112435_bib3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-827X(02)01229-6","article-title":"The medicinal chemistry of multidrug resistance (MDR) reversing drugs","volume":"57","author":"Teodori","year":"2002","journal-title":"Farmaco"},{"key":"10.1016\/j.ejmech.2020.112435_bib4","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1742-4658.2009.07485.x","article-title":"Multidrug efflux pumps: substrate selection in ATP-binding cassette multidrug efflux pumps--first come, first served?","volume":"277","author":"Ernst","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.ejmech.2020.112435_bib5","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tips.2009.07.003","article-title":"Is resistance useless? Multidrug resistance and collateral sensitivity","volume":"30","author":"Hall","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2020.112435_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-981-13-7647-4_2","article-title":"ABC family transporters","volume":"1141","author":"Liu","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejmech.2020.112435_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.drup.2017.10.003","article-title":"Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins","volume":"32","author":"Genovese","year":"2017","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.ejmech.2020.112435_bib8","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1073\/pnas.83.20.7785","article-title":"Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies","volume":"83","author":"Hamada","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2020.112435_bib9","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0022-3565(25)10423-0","article-title":"Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1)","volume":"263","author":"Tanigawara","year":"1992","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"issue":"2","key":"10.1016\/j.ejmech.2020.112435_bib10","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3390\/molecules24020336","article-title":"Organoselenium compounds as novel adjuvants of chemotherapy drugs-A promising approach to fight cancer drug resistance","volume":"24","author":"Spengler","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2020.112435_bib11","first-page":"119","article-title":"Regulations of P-glycoprotein\/ABCB1\/MDR1 in human cancer cells","author":"Katayama","year":"2014","journal-title":"N.\u00a0J. Sci."},{"key":"10.1016\/j.ejmech.2020.112435_bib12","first-page":"3285","article-title":"Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis","volume":"31","author":"Spengler","year":"2011","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2020.112435_bib13","first-page":"293","article-title":"Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump","volume":"26","author":"Martins","year":"2012","journal-title":"Vivo"},{"key":"10.1016\/j.ejmech.2020.112435_bib14","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.bmc.2016.04.055","article-title":"The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): synthesis, crystallographic and biological studies","volume":"24","author":"Zeslawska","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib15","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.bmcl.2016.04.064","article-title":"Identification of selenocompounds with promising properties to reverse cancer multidrug resistance","volume":"26","author":"Dominguez-Alvarez","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2020.112435_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejmech.2017.07.033","article-title":"Recent advances (2015-2016) in anticancer hybrids","volume":"142","author":"Kerru","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2020.112435_bib17","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3390\/molecules23071616","article-title":"Hybrid molecules composed of 2,4-Diamino-1,3,5-triazines and 2-imino-coumarins and coumarins. Synthesis and Cytotoxic Properties","volume":"23","author":"Makowska","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2020.112435_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejmech.2016.03.088","article-title":"Synthesis and in\u00a0vitro evaluation of novel triazine analogues as anticancer agents and their interaction studies with bovine serum albumin","volume":"117","author":"Singla","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib19","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bmcl.2017.01.033","article-title":"Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: a confirmation study in a colon cancer MDR cell line","volume":"27","author":"Gajdacs","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2020.112435_bib20","doi-asserted-by":"crossref","first-page":"2486783","DOI":"10.1155\/2019\/2486783","article-title":"Combination of sodium selenite and doxorubicin prodrug Ac-Phe-Lys-PABC-ADM affects gastric cancer cell apoptosis in xenografted mice","volume":"2019","author":"Wu","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2020.112435_bib21","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1016\/j.bmc.2012.02.009","article-title":"Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with alpha(1)-adrenoceptor affinities","volume":"20","author":"Handzlik","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib22","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1016\/j.ejmech.2011.09.032","article-title":"Amine-alkyl derivatives of hydantoin: new tool to combat resistant bacteria","volume":"46","author":"Handzlik","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib23","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ejmech.2019.06.022","article-title":"Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6","volume":"178","author":"Ali","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib24","doi-asserted-by":"crossref","first-page":"103172","DOI":"10.1039\/C5RA12837D","article-title":"Design, synthesis and biological evaluation of novel podophyllotoxin derivatives bearing 4\u03b2-disulfide\/trisulfide bond as cytotoxic agents","volume":"5","author":"Zhu","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2020.112435_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejmech.2017.04.033","article-title":"The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine","volume":"135","author":"Lazewska","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib26","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.bmc.2016.03.044","article-title":"Design, synthesis, and biological evaluation of arylpiperazine-benzylpiperidines with dual serotonin and norepinephrine reuptake inhibitory activities","volume":"24","author":"Paudel","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib27","series-title":"Preparation of substituted phenols as histamine H3 ligands","first-page":"126","author":"Bernardelli","year":"2005"},{"key":"10.1016\/j.ejmech.2020.112435_bib28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1246\/cl.1980.867","article-title":"A\u00a0direct phenylselenenylation of alkyl halides, alkenyl sulfonates, and epoxides by an electroreduction of diphenyl diselenide","volume":"9","author":"Torii","year":"1980","journal-title":"Chem. Lett."},{"key":"10.1016\/j.ejmech.2020.112435_bib29","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1021\/jo302467w","article-title":"Minaruzzaman, Synthetic studies on CP-225,917 and CP-263,114: access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-Wittig rearrangement","volume":"78","author":"Malihi","year":"2013","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib30","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/S0021-9258(18)61633-3","article-title":"Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein","volume":"262","author":"Cornwell","year":"1987","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib31","first-page":"2173","article-title":"Demonstration of the activity of P-glycoprotein by a semi-automated fluorometric method","volume":"29","author":"Spengler","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2020.112435_bib32","first-page":"4867","article-title":"Biological activity of hydantoin derivatives on P-glycoprotein (ABCB1) of mouse lymphoma cells","volume":"30","author":"Spengler","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2020.112435_bib33","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/cbdd.13106","article-title":"The search for a lead structure among series of potent and selective hydantoin 5-HT7 R agents: the drug-likeness in\u00a0vitro study","volume":"90","author":"Latacz","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2020.112435_bib34","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bmcl.2018.02.003","article-title":"MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: in\u00a0vitro drug-likeness studies and in\u00a0vivo pharmacological evaluation","volume":"28","author":"Latacz","year":"2018","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2020.112435_bib35","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1039\/C8MD00313K","article-title":"Search for a 5-CT alternative. In\u00a0vitro and in\u00a0vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazole-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists","volume":"9","author":"Latacz","year":"2018","journal-title":"Medchemcomm"},{"key":"10.1016\/j.ejmech.2020.112435_bib36","doi-asserted-by":"crossref","first-page":"15043","DOI":"10.1038\/cddiscovery.2015.43","article-title":"Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines","volume":"1","author":"Mahbub","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2020.112435_bib37","doi-asserted-by":"crossref","first-page":"10550","DOI":"10.1038\/s41598-017-10338-6","article-title":"A\u00a0comprehensive characterization of the impact of mycophenolic acid on the metabolism of Jurkat T cells","volume":"7","author":"Fernandez-Ramos","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2020.112435_bib38","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1042\/CBI20120274","article-title":"Expression of cyclin A, B1 and D1 after induction of cell cycle arrest in the Jurkat cell line exposed to doxorubicin","volume":"36","author":"Zuryn","year":"2012","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejmech.2020.112435_bib39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.canlet.2011.10.014","article-title":"Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of beta-catenin survival axis","volume":"315","author":"Luo","year":"2012","journal-title":"Canc. Lett."},{"key":"10.1016\/j.ejmech.2020.112435_bib40","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jnutbio.2012.04.008","article-title":"Methylselenol, a selenium metabolite, modulates p53 pathway and inhibits the growth of colon cancer xenografts in Balb\/c mice","volume":"24","author":"Zeng","year":"2013","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.ejmech.2020.112435_bib41","first-page":"1173","article-title":"Topoisomerase II inhibitors in cancer treatment","volume":"3","author":"Thakur","year":"2011","journal-title":"Int J Pharm Sci Nanotechnol"},{"key":"10.1016\/j.ejmech.2020.112435_bib42","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/jphp.12144","article-title":"Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes?","volume":"65","author":"Tacar","year":"2013","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.ejmech.2020.112435_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2020.112435_bib44","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1021\/jo070664s","article-title":"Intramolecular conjugate displacement: a general route to hexahydroquinolizines, hexahydroindolizines, and related [m,n,0]-bicyclic structures with nitrogen at a bridgehead","volume":"72","author":"Clive","year":"2007","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib45","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0022-328X(83)85050-5","article-title":"Capto-dative substituent effects","volume":"250","author":"Janousek","year":"1983","journal-title":"J.\u00a0Organomet. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib46","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.ejmech.2018.11.050","article-title":"Development of alkyl glycerone phosphate synthase inhibitors: structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells","volume":"163","author":"Stazi","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112435_bib47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0021-9673(01)86422-0","article-title":"The relation between the composition of certain ternary two-phase solvent systems and RM values","volume":"7","author":"Soczewi\u0144ski","year":"1962","journal-title":"J.\u00a0Chromatogr. A"},{"issue":"24","key":"10.1016\/j.ejmech.2020.112435_bib48","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.3390\/molecules24244472","article-title":"Are the hydantoin-1,3,5-triazine 5-HT6R ligands a hope to a find new procognitive and anti-obesity drug? Considerations based on primary in\u00a0vivo assays and ADME-tox profile in\u00a0vitro","volume":"24","author":"Lubelska","year":"2019","journal-title":"Molecules"},{"issue":"14","key":"10.1016\/j.ejmech.2020.112435_bib49","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.3390\/ijms20143420","article-title":"The 1,3,5-triazine derivatives as innovative chemical family of 5-HT6 serotonin receptor agents with therapeutic perspectives for cognitive impairment","volume":"20","author":"Latacz","year":"2019","journal-title":"Int. J. Mol. Sci."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420304062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420304062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:15:30Z","timestamp":1759328130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523420304062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":49,"alternative-id":["S0223523420304062"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112435","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112435"}}