{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:03Z","timestamp":1792789623768,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007776","name":"Deanship of Academic Research, University of Jordan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejmech.2020.112513","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T11:15:34Z","timestamp":1593256534000},"page":"112513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives"],"prefix":"10.1016","volume":"202","author":[{"given":"Aya A.M.","family":"Mohammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadeer A.R.Y.","family":"Suaifan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayadah B.","family":"Shehadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick N.","family":"Okechukwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2020.112513_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/AAC.33.2.131","article-title":"Structure-activity relationships of the fluoroquinolones","volume":"33","author":"Chu","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2020.112513_bib2","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/j.tet.2006.11.079","article-title":"Thermochemical reaction of 7-azido-1-ethyl-6,8-difluoroquinolone-3-carboxylate with heterocyclic amines. An expeditious synthesis of novel fluoroquinolone derivatives","volume":"63","author":"Leyva","year":"2007","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2020.112513_bib3","first-page":"69","article-title":"Evolution of the quinolones","volume":"27","author":"Liu","year":"2006","journal-title":"World Notes Antibiot"},{"key":"10.1016\/j.ejmech.2020.112513_bib4","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1016\/j.bmcl.2012.07.040","article-title":"Synthesis, antimycobacterial and antibacterial activity of ciprofloxacin derivatives containing a N-substituted benzyl moiety","volume":"22","author":"Wang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2020.112513_bib5","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1016\/j.ejmech.2010.09.036","article-title":"Synthesis and in\u00a0vitro antimicrobial evaluation of novel fluoroquinolone derivatives","volume":"45","author":"Srinivasan","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112513_bib6","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.1016\/j.bmcl.2012.05.026","article-title":"Studies on the antimicrobial properties of N-acylated ciprofloxacins","volume":"22","author":"Cormier","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2020.112513_bib7","series-title":"An Introduction to Medicinal Chemistry","author":"Patrick","year":"2013"},{"key":"10.1016\/j.ejmech.2020.112513_bib8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/ddr.21508","article-title":"Design, synthesis, and biological evaluation of 1,8-naphthyridine glucosamine conjugates as antimicrobial agents","volume":"80","author":"Mohammed","year":"2019","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2020.112513_bib9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/cbdd.12503","article-title":"Novel glycoconjugate of 8-fluoro norfloxacin derivatives as gentamicin-resistant Staphylococcus aureus inhibitors: synthesis and molecular modeling studies","volume":"86","author":"Azad","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2020.112513_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.riam.2009.06.003","article-title":"Amphotericin B: side effects and toxicity","volume":"26","author":"Laniado-Labor\u00edn","year":"2009","journal-title":"Rev. Iberoam. De. Micol."},{"key":"10.1016\/j.ejmech.2020.112513_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.29.1.1","article-title":"Effects of norfloxacin on DNA metabolism in Pseudomonas aeruginosa","volume":"29","author":"Benbrook","year":"1986","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2020.112513_bib12","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1128\/AAC.47.7.2242-2248.2003","article-title":"Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China, Antimicrob","volume":"47","author":"Wang","year":"2003","journal-title":"Agents Chemother"},{"key":"10.1016\/j.ejmech.2020.112513_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ejmech.2004.11.008","article-title":"Benzenesulfonamide analogs of fluoroquinolones. Antibacterial activity and QSAR studies","volume":"40","author":"Nieto","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112513_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0223-5234(00)00125-2","article-title":"Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin Mannich bases","volume":"35","author":"Pandeya","year":"2000","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112513_bib15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/prot.20545","article-title":"Modeling protein recognition of carbohydrates","volume":"60","author":"Laederach","year":"2005","journal-title":"Proteins: Struct. Funct. Bioinf."},{"key":"10.1016\/j.ejmech.2020.112513_bib16","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.tetlet.2008.01.081","article-title":"Synthesis of novel multidentate carbohydrate-triazole ligands","volume":"49","author":"Ziegler","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2020.112513_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0008-6215(02)00407-X","article-title":"Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-\u03b2-D-glucopyranoside hydrochloride and its derivatives","volume":"338","author":"Myszka","year":"2003","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.ejmech.2020.112513_bib18","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1039\/c3ra46007j","article-title":"Synthesis and characterization of N-acyl-tetra-O-acyl glucosamine derivatives","volume":"4","author":"Dang","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2020.112513_bib19","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ejmech.2016.08.031","article-title":"Design, synthesis and biological evaluation of ciprofloxacin tethered bis-1,2,3-triazole conjugates as potent antibacterial agents","volume":"124","author":"Kant","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112513_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3329\/bjp.v6i1.7720","article-title":"Synthesis of some NH-derivatives of ciprofloxacin as antibacterial and antifungal agents","volume":"6","author":"Rabbani","year":"2011","journal-title":"Bangladesh J. Pharmacol."},{"key":"10.1016\/j.ejmech.2020.112513_bib21","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.bmcl.2016.01.012","article-title":"Anionic fluoroquinolones as antibacterials against biofilm-producing Pseudomonas aeruginosa, Bioorg","volume":"26","author":"Long","year":"2016","journal-title":"Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2020.112513_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.ejmech.2020.112513_bib23","series-title":"Preparation of Amides","author":"Applewhite","year":"1966"},{"key":"10.1016\/j.ejmech.2020.112513_bib24","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1021\/jo00205a004","article-title":"A\u00a0simple and mild esterification method for carboxylic acids using mixed carboxylic-carbonic anhydrides","volume":"50","author":"Kim","year":"1985","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2020.112513_bib25","doi-asserted-by":"crossref","first-page":"9790","DOI":"10.3390\/molecules17089790","article-title":"Synthesis of disaccharides containing 6-deoxy-\u03b1-L-talose as potential heparan sulfate mimetics","volume":"17","author":"Fairweather","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2020.112513_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1046\/j.1460-9592.2000.00452.x","article-title":"Acute pulmonary haemorrhage in an infant during induction of general anaesthesia","volume":"10","author":"Tripi","year":"2000","journal-title":"Paediatr. Anaesth."},{"issue":"4","key":"10.1016\/j.ejmech.2020.112513_bib27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00604-019-3313-0","article-title":"Portable paper-based colorimetric nanoprobe for the detection of Stachybotrys chartarum using peptide labeled magnetic nanoparticles","volume":"186","author":"Suaifan","year":"2019","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.ejmech.2020.112513_bib28","series-title":"Antibacterial Chemotherapeutic Agents","first-page":"298","article-title":"Quinolone antibacterials","author":"Dax","year":"1997"},{"key":"10.1016\/j.ejmech.2020.112513_bib29","article-title":"Antibacterial derivatives of ciprofloxacin to inhibit growth of necrotizing fasciitis associated penicillin-resistant Escherichia coli","volume":"2013","author":"Bartzatt","year":"2013","journal-title":"J.\u00a0Pharm."},{"key":"10.1016\/j.ejmech.2020.112513_bib30","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.bmc.2019.05.038","article-title":"Fluoroquinolones structural and medicinal developments (2013-2018): where are we now?","volume":"27","author":"Suaifan","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112513_bib31","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3389\/fmicb.2018.01367","article-title":"Challenging the drug-likeness dogma for new drug discovery in tuberculosis","volume":"9","author":"Machado","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2020.112513_bib32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S1473-3099(03)00671-6","article-title":"Fluoroquinolones, tuberculosis, and resistance","volume":"3","author":"Ginsburg","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2020.112513_bib33","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.bmcl.2005.02.037","article-title":"Novel fluoroquinolones: design, synthesis, and in\u00a0vivo activity in mice against Mycobacterium tuberculosis H37Rv","volume":"15","author":"Shindikar","year":"2005","journal-title":"Bioorg. Med. Chem. Lett"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420304852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420304852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:10:36Z","timestamp":1759327836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523420304852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":33,"alternative-id":["S0223523420304852"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112513","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112513","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112513"}}