{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:47:41Z","timestamp":1783414061111,"version":"3.54.6"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["T-942"],"award-info":[{"award-number":["T-942"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LT18065"],"award-info":[{"award-number":["LT18065"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CM16225"],"award-info":[{"award-number":["CM16225"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CZ.2.16\/3.1.00\/21519"],"award-info":[{"award-number":["CZ.2.16\/3.1.00\/21519"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.ejmech.2020.112620","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T22:31:02Z","timestamp":1594420262000},"page":"112620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Synthesis, inhibitory activity and in silico docking of dual COX\/5-LOX inhibitors with quinone and resorcinol core"],"prefix":"10.1016","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-2048","authenticated-orcid":false,"given":"Miroslav","family":"Sisa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Dvorakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Temml","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-4450","authenticated-orcid":false,"given":"Veronika","family":"Jarosova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Vanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premysl","family":"Landa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2020.112620_bib1","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0006-2952(01)00747-X","article-title":"Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy?","volume":"62","author":"Fiorucci","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2020.112620_bib2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejps.2018.06.003","article-title":"Safer anti-inflammatory therapy through dual COX-2\/5-LOX inhibitors: a structure-based approach","volume":"121","author":"P","year":"2018","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2020.112620_bib3","first-page":"247","article-title":"Anti-inflammatory and side effects of cyclooxygenase inhibitors","volume":"59","author":"S\u00fcleyman","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejmech.2020.112620_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2006.10.003","article-title":"Coxibs and heart disease - what we have learned and what else we need to know","volume":"49","author":"Zarraga","year":"2007","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.ejmech.2020.112620_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1517\/13543771003602012","article-title":"5-Lipoxygenase inhibitors: a review of recent developments and patents","volume":"20","author":"Pergola","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2020.112620_bib6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1055\/s-0031-1280430","article-title":"Redox and non-redox mechanism of in\u00a0vitro cyclooxygenase inhibition by natural quinones","volume":"78","author":"Landa","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2020.112620_bib7","first-page":"105","article-title":"Inhibition of in\u00a0vitro leukotriene B4 biosynthesis in human neutrophil granulocytes and docking studies of natural quinones","volume":"8","author":"Landa","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.ejmech.2020.112620_bib8","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1055\/s-0042-102460","article-title":"Miconidin acetate and primin as potent 5-lipoxygenase inhibitors from brazilian Eugenia hiemalis (Myrtaceae)","volume":"3","author":"Zatelli","year":"2016","journal-title":"Planta Med. Lett."},{"key":"10.1016\/j.ejmech.2020.112620_bib9","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bcp.2013.04.015","article-title":"Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E synthase-1 by the anti-carcinogenic and antiinflammatory agent embelin","volume":"86","author":"Schaible","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2020.112620_bib10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejmech.2013.06.039","article-title":"Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase","volume":"67","author":"Filosa","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112620_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejmech.2015.02.042","article-title":"Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes","volume":"94","author":"Filosa","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112620_bib12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.ejmech.2016.10.046","article-title":"Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase","volume":"127","author":"Peduto","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112620_bib13","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1016\/j.tet.2017.07.029","article-title":"Concise access to primin, miconidin and related natural resorcinols","volume":"73","author":"Sisa","year":"2017","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2020.112620_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1586\/ecp.10.120","article-title":"Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity","volume":"3","author":"Knights","year":"2010","journal-title":"Expet Rev. Clin. Pharmacol."},{"key":"10.1016\/j.ejmech.2020.112620_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/35011103","article-title":"Structural insights into the stereochemistry of the cyclooxygenase reaction","volume":"405","author":"Kiefer","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2020.112620_bib16","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.foodchem.2008.08.008","article-title":"DPPH antioxidant assay revisited","volume":"113","author":"Sharma","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.ejmech.2020.112620_bib17","first-page":"151","article-title":"2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor","volume":"62","author":"Gupta","year":"2006","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.ejmech.2020.112620_bib18","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1074\/jbc.M116.725713","article-title":"Substrate-selective inhibition of cyclooxygeanse-2 by fenamic acid derivatives is dependent on peroxide tone","volume":"291","author":"Orlando","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2020.112620_bib19","doi-asserted-by":"crossref","first-page":"12793","DOI":"10.1074\/jbc.M114.635987","article-title":"Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2","volume":"290","author":"Blobaum","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2020.112620_bib20","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/384644a0","article-title":"Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents","volume":"384","author":"Kurumbail","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2020.112620_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1197203","article-title":"The structure of human 5-Lipoxygenase","volume":"331","author":"Gilbert","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2020.112620_bib22","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1038\/s41467-018-06158-5","article-title":"Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase","volume":"9","author":"Pein","year":"2018","journal-title":"Nat. Commun."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420305924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420305924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:36:58Z","timestamp":1778510218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523420305924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":22,"alternative-id":["S0223523420305924"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112620","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, inhibitory activity and in silico docking of dual COX\/5-LOX inhibitors with quinone and resorcinol core","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112620"}}