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Rev."},{"key":"10.1016\/j.ejmech.2020.112665_bib202","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.actbio.2019.07.042","article-title":"Hydrogen Sulfide-releasing peptide hydrogel limits the development of intimal hyperplasia in human vein segments","volume":"97","author":"Longchamp","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejmech.2020.112665_bib203","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3109\/0886022X.2014.882218","article-title":"Hydrogen sulphide and tempol treatments improve the blood pressure and renal excretory responses in spontaneously hypertensive rats","volume":"36","author":"Ahmad","year":"2014","journal-title":"Ren. Fail."},{"key":"10.1016\/j.ejmech.2020.112665_bib204","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1517\/17460441.2016.1122590","article-title":"Using hydrogen sulfide to design and develop drugs","volume":"11","author":"Calderone","year":"2016","journal-title":"Expet Opin. 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Exp. Pharmacol. 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