{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:34:25Z","timestamp":1786988065427,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ejmech.2020.112907","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T11:15:59Z","timestamp":1601982959000},"page":"112907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Investigating the antibacterial activity of salen\/salophene metal complexes: Induction of ferroptosis as part of the mode of action"],"prefix":"10.1016","volume":"209","author":[{"given":"Daniel","family":"Baecker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zcan","family":"Sesli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Knabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7021-1845","authenticated-orcid":false,"given":"Silke","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Orth-H\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Gust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2020.112907_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41579-019-0288-0","article-title":"The global preclinical antibacterial pipeline","volume":"18","author":"Theuretzbacher","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2020.112907_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/antibiotics9020090","article-title":"Metal complexes, an untapped source of antibiotic potential?","volume":"9","author":"Frei","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2020.112907_bib3","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/slct.201803073","article-title":"Anticancer and antimicrobial activity of transition metal complexes","volume":"4","author":"Nandanwar","year":"2019","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.ejmech.2020.112907_bib4","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/chem.201604512","article-title":"Gold(I) NHC complexes: antiproliferative activity, cellular uptake, inhibition of mammalian and bacterial thioredoxin reductases, and gram-positive directed antibacterial effects","volume":"23","author":"Schmidt","year":"2017","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2020.112907_bib5","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1089\/ars.2013.5447","article-title":"Are reactive oxygen species always detrimental to pathogens?","volume":"20","author":"Paiva","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ejmech.2020.112907_bib6","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1101\/gad.314674.118","article-title":"Regulation of lipid peroxidation and ferroptosis in diverse species","volume":"32","author":"Conrad","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejmech.2020.112907_bib7","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1172\/JCI99490","article-title":"Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium","volume":"128","author":"Dar","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ejmech.2020.112907_bib8","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1084\/jem.20181776","article-title":"A\u00a0major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis","volume":"216","author":"Amaral","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ejmech.2020.112907_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.micres.2017.11.016","article-title":"For the greater good: programmed cell death in bacterial communities","volume":"207","author":"Peeters","year":"2018","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.ejmech.2020.112907_bib10","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1080\/00958970902741244","article-title":"Transition metal complexes of a Schiff base: synthesis, characterization, and antibacterial studies","volume":"62","author":"Badwaik","year":"2009","journal-title":"J.\u00a0Coord. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.saa.2014.03.085","article-title":"Some new nano-structure zinc(II) coordination compounds of an imidazolidine Schiff base: spectral, thermal, antimicrobial properties and DNA interaction","volume":"129","author":"Montazerozohori","year":"2014","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.ejmech.2020.112907_bib12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.saa.2014.07.091","article-title":"Synthesis, characterization and antibacterial activity of a tridentate Schiff base derived from cephalothin and sulfadiazine, and its transition metal complexes","volume":"137","author":"Anacona","year":"2015","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.ejmech.2020.112907_bib13","doi-asserted-by":"crossref","first-page":"e4374","DOI":"10.1002\/aoc.4374","article-title":"Antibacterial activity of transition metal complexes with a tridentate NNO amoxicillin derived Schiff base. Synthesis and characterization","volume":"32","author":"Anacona","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1039\/B307853C","article-title":"Metal-salen Schiff base complexes in catalysis: practical aspects","volume":"33","author":"Cozzi","year":"2004","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2020.112907_bib15","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.ccr.2007.09.005","article-title":"Catalytic activities of Schiff base transition metal complexes","volume":"252","author":"Gupta","year":"2008","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2020.112907_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jorganchem.2015.05.041","article-title":"Catalytic activity of Schiff-base transition metal complexes supported on crosslinked polyacrylamides for hydrogen peroxide decomposition","volume":"794","author":"Tamami","year":"2015","journal-title":"J.\u00a0Organomet. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib17","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/cbin.10308","article-title":"Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells","volume":"38","author":"Pradhan","year":"2014","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejmech.2020.112907_bib18","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.msec.2015.05.061","article-title":"Antimicrobial activity, DNA cleavage, thermal analysis data and crystal structure of some new CdLX2 complexes: a supramolecular network","volume":"55","author":"Montazerozohori","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ejmech.2020.112907_bib19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/00958972.2016.1250153","article-title":"Antimicrobial, antioxidant and SOD activities of copper(II) complexes derived from 2-aminobenzothiazole derivatives","volume":"70","author":"Joseph","year":"2017","journal-title":"J.\u00a0Coord. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ica.2017.06.060","article-title":"Transition metal salen complexes in bioinorganic and medicinal chemistry","volume":"472","author":"Erxleben","year":"2018","journal-title":"Inorg. Chim. Acta."},{"key":"10.1016\/j.ejmech.2020.112907_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/ardp.200900048","article-title":"Relationship between anticancer activity and stereochemistry of saldach ligands and their iron(III) complexes","volume":"342","author":"Hille","year":"2009","journal-title":"Arch. Pharm. Chem. Life Sci."},{"key":"10.1016\/j.ejmech.2020.112907_bib22","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1016\/j.ejmech.2010.08.037","article-title":"Influence of methoxy groups on the antiproliferative effects of [FeIII(salopheneOMe)Cl] complexes","volume":"45","author":"Hille","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00775-009-0485-9","article-title":"[N,N\u2019-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties","volume":"14","author":"Hille","year":"2009","journal-title":"J.\u00a0Biol. Inorg. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib24","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1021\/jm100459k","article-title":"[NiII(3-OMe-salophene)]: a potent agent with antitumor activity","volume":"53","author":"Lee","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib25","first-page":"387","article-title":"[FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells, Leuk","volume":"35","author":"Lee","year":"2011","journal-title":"Res."},{"key":"10.1016\/j.ejmech.2020.112907_bib26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ardp.201000237","article-title":"Effects of metal salophene and saldach complexes on lymphoma and leukemia cells","volume":"344","author":"Hille","year":"2011","journal-title":"Arch. Pharm. Chem. Life Sci."},{"key":"10.1016\/j.ejmech.2020.112907_bib27","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1021\/jm040763n","article-title":"Development of cobalt(3,4-diarylsalen) complexes as tumor therapeutics","volume":"47","author":"Gust","year":"2004","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib28","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.1021\/acs.jmedchem.9b00814","article-title":"A\u00a0new approach in cancer treatment: discovery of chlorido[N,N\u2019-disalicylidene-1,2-phenylenediamine]iron(III) complexes as ferroptosis inducers","volume":"62","author":"Sagasser","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib29","series-title":"Synthese, pharmakologische Testung und wirkmechanistische Untersuchungen zytotoxischer Eisen(salophen)-Komplexe","author":"Hille","year":"2009"},{"key":"10.1016\/j.ejmech.2020.112907_bib30","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1021\/acsinfecdis.0c00138","article-title":"Gallium(III)-salophen as a dual inhibitor of Pseudomonas aeruginosa heme sensing and iron acquisition","volume":"6","author":"Centola","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2020.112907_bib31","first-page":"153","article-title":"Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus pseudintermedius isolated from various animals","volume":"52","author":"Rubin","year":"2011","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.ejmech.2020.112907_bib32","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/jcc.25823","article-title":"The gram-negative outer membrane modeler: automated building of lipopolysaccharide-rich bacterial outer membranes in four force fields","volume":"40","author":"Baltoumas","year":"2019","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib33","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.actbio.2017.05.001","article-title":"Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery","volume":"58","author":"Zheng","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejmech.2020.112907_bib34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0223-5234(93)90003-W","article-title":"Synthesis and evaluation of the anti-mammary tumor activity and of the estrogenic side effects of [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes","volume":"28","author":"Gust","year":"1993","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib35","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1021\/jm00012a006","volume":"38","author":"Gust","year":"1995","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1521-4184(19998)332:8<261::AID-ARDP261>3.0.CO;2-0","article-title":"Structure activity studies on leaving group derivatives of [meso-1,2-bis-(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]platinum(II)","volume":"332","author":"Gust","year":"1999","journal-title":"Arch. Pharm. Chem. Life Sci."},{"key":"10.1016\/j.ejmech.2020.112907_bib37","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.1021\/jm050186i","article-title":"[N-Ethyl- and [N,N\u2019-diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II):\u2009 structure and cytotoxic\/estrogenic activity in breast cancer cells","volume":"48","author":"Gust","year":"2005","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib38","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1089\/ars.2010.3663","article-title":"Anticancer activity of metal complexes: involvement of redox processes","volume":"15","author":"Jungwirth","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ejmech.2020.112907_bib39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1248\/cpb.55.26","article-title":"Synthesis, characterization and antioxidant activity of naringenin Schiff base and its Cu(II), Ni(II), Zn(II) complexes","volume":"55","author":"Li","year":"2007","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2020.112907_bib40","doi-asserted-by":"crossref","first-page":"213339","DOI":"10.1016\/j.ccr.2020.213339","article-title":"Recent advances in the chemistry of iron-based chemotherapeutic agents","volume":"417","author":"Basu","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2020.112907_bib41","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1039\/D0DT00168F","article-title":"Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(III) as necroptosis and ferroptosis inducers","volume":"49","author":"Baecker","year":"2020","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2020.112907_bib42","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1365-2958.2008.06204.x","article-title":"Borrelia burgdorferi membranes are the primary targets of reactive oxygen species","volume":"68","author":"Boylan","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ejmech.2020.112907_bib43","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1021\/acschembio.7b00237","article-title":"Membrane oxidation in cell delivery and cell killing applications","volume":"12","author":"Wang","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2020.112907_bib44","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1128\/JB.06421-11","article-title":"Identification of the bacteriochlorophylls, carotenoids, quinones, lipids, and hopanoids of \u201cCandidatus chloracidobacterium thermophilum\u201d","volume":"194","author":"Garcia Costas","year":"2012","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.ejmech.2020.112907_bib45","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1021\/acsmedchemlett.9b00489","article-title":"LogD contributions of substituents commonly used in medicinal chemistry","volume":"11","author":"Landry","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2020.112907_bib46","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/acscentsci.7b00028","article-title":"On the mechanism of cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death","volume":"3","author":"Zilka","year":"2017","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2020.112907_bib47","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ja.2011.5","article-title":"Bacteriostatic versus bactericidal activity of ciprofloxacin in Escherichia coli assessed by flow cytometry using a novel far-red dye","volume":"64","author":"Silva","year":"2011","journal-title":"J.\u00a0Antibiot."},{"key":"10.1016\/j.ejmech.2020.112907_bib48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijantimicag.2010.09.006","article-title":"In\u00a0vitro activity of N-chlorotaurine (NCT) in combination with NH4Cl against Trichomonas vaginalis","volume":"37","author":"F\u00fcrnkranz","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2020.112907_bib49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ica.2018.12.002","article-title":"Studies on the stability of the anticancer-active [N,N\u2019-bis(salicylidene)-1,2-phenylenediamine]chloridoiron(III) complex under pharmacological-like conditions","volume":"487","author":"El Deeb","year":"2019","journal-title":"Inorg. Chim. Acta."},{"key":"10.1016\/j.ejmech.2020.112907_bib50","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1128\/AAC.00427-08","article-title":"Effect of protein binding on the pharmacological activity of highly bound antibiotics","volume":"52","author":"Schmidt","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2020.112907_bib51","article-title":"EUCAST evaluation of 21 brands of Mueller-Hinton dehydrated media for disc diffusion testing","volume":"10","author":"Ahman","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.ejmech.2020.112907_bib52","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/jm500986h","article-title":"Fluorinated Fe(III) salophene complexes: optimization of tumor cell specific activity and utilization of fluorine labeling for in\u00a0vitro analysis","volume":"58","author":"W\u00fcrtenberger","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112907_bib53","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02527-16","article-title":"Bactericidal and fungicidal activity of N-chlorotaurine is enhanced in cystic fibrosis sputum medium","volume":"61","author":"Gruber","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2020.112907_bib54","doi-asserted-by":"crossref","first-page":"15856","DOI":"10.1039\/C9DT03330K","article-title":"Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes","volume":"48","author":"Baecker","year":"2019","journal-title":"Dalton Trans."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420308795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420308795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:19:33Z","timestamp":1759328373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523420308795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":54,"alternative-id":["S0223523420308795"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112907","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the antibacterial activity of salen\/salophene metal complexes: Induction of ferroptosis as part of the mode of action","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112907"}}