{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:40:04Z","timestamp":1790732404072,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001645","name":"Boehringer Ingelheim Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["EFOP 3.6.3-VEKOP-16-406 2017\u201300009"],"award-info":[{"award-number":["EFOP 3.6.3-VEKOP-16-406 2017\u201300009"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["GINOP-2.3.2\u201315\u20132016\u201300014"],"award-info":[{"award-number":["GINOP-2.3.2\u201315\u20132016\u201300014"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["GINOP-2.3.2\u201315\u20132016\u201300020"],"award-info":[{"award-number":["GINOP-2.3.2\u201315\u20132016\u201300020"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["GINOP-2.3.3\u201315\u20132016\u201300001"],"award-info":[{"award-number":["GINOP-2.3.3\u201315\u20132016\u201300001"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["KKP 126506"],"award-info":[{"award-number":["KKP 126506"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["LP-2017\u201310\/2017"],"award-info":[{"award-number":["LP-2017\u201310\/2017"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["BI-HU\/19-20-008"],"award-info":[{"award-number":["BI-HU\/19-20-008"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["J1-9192"],"award-info":[{"award-number":["J1-9192"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P1-0208"],"award-info":[{"award-number":["P1-0208"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015498","name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["H2020-ERC-2014-CoG 648364"],"award-info":[{"award-number":["H2020-ERC-2014-CoG 648364"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.ejmech.2021.113200","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T06:10:07Z","timestamp":1611295807000},"page":"113200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens"],"prefix":"10.1016","volume":"213","author":[{"given":"Martina","family":"Durcik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Nyerges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u017diga","family":"Skok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darja Gramec","family":"Skledar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurij","family":"Trontelj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nace","family":"Zidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janez","family":"Ila\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamarija","family":"Zega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina D.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Tammela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Welin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yengo R.","family":"Kimbung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-7335","authenticated-orcid":false,"given":"Dorota","family":"Focht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-1933","authenticated-orcid":false,"given":"Ond\u0159ej","family":"Benek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"R\u00e9v\u00e9sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Draskovits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-4260","authenticated-orcid":false,"given":"Petra \u00c9va","family":"Szili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejla","family":"Daruka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"P\u00e1l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-7604","authenticated-orcid":false,"given":"Danijel","family":"Kikelj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucija Peterlin","family":"Ma\u0161i\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-209X","authenticated-orcid":false,"given":"Tihomir","family":"Toma\u0161i\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113200_bib1","doi-asserted-by":"crossref","first-page":"fnw084","DOI":"10.1093\/femsle\/fnw084","article-title":"Keeping it simple: lessons from the golden era of antibiotic discovery","volume":"363","author":"Lyddiard","year":"2016","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ejmech.2021.113200_bib2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1086\/533452","article-title":"Federal funding for the study of antimicrobial resistance in nosocomial pathogens: No ESKAPE","volume":"197","author":"Rice","year":"2008","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.113200_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw1944","article-title":"Global trends in antimicrobial resistance in animals in low- and middle-income countries","volume":"365","author":"Van Boeckel","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2021.113200_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad Bugs, No drugs: No ESKAPE! An update from the infectious diseases society of America","volume":"48","author":"Boucher","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.113200_bib5","series-title":"Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics. World Health Organization","year":"2017"},{"key":"10.1016\/j.ejmech.2021.113200_bib6","series-title":"Tackling a Crisis for the Health and Wealth of Nations","author":"O\u2019Neill","year":"2014"},{"key":"10.1016\/j.ejmech.2021.113200_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1586\/eri.13.12","article-title":"Clinical relevance of the ESKAPE pathogens","volume":"11","author":"Pendleton","year":"2013","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.ejmech.2021.113200_bib8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nbt.4193","article-title":"A\u00a0reward for antibiotic development","volume":"36","author":"Wanted","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejmech.2021.113200_bib9","series-title":"Targeting Innovation in Antibiotic Drug Discovery and Development: the Need for a One Health - One Europe - One World Framework, World Health Organization","author":"Renwick","year":"2016"},{"key":"10.1016\/j.ejmech.2021.113200_bib10","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/ja.2017.124","article-title":"Incentivising innovation in antibiotic drug discovery and development: progress, challenges and next steps","volume":"70","author":"Simpkin","year":"2017","journal-title":"J.\u00a0Antibiot. (Tokyo)"},{"key":"10.1016\/j.ejmech.2021.113200_bib11","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1021\/cr4003984","article-title":"Non-quinolone inhibitors of bacterial type iia topoisomerases: a feat of bioisosterism","volume":"114","author":"Mayer","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2021.113200_bib12","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/1568026613666131113153251","article-title":"Prospects for developing new antibacterials targeting bacterial type IIA topoisomerases","volume":"14","author":"Toma\u0161i\u0107","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113200_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tim.2014.04.007","article-title":"Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success","volume":"22","author":"Redgrave","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2021.113200_bib15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1021\/id500013t","article-title":"A\u00a0new-class Antibacterial\u2014almost. Lessons in drug discovery and development: a critical analysis of more than 50 Years of effort toward ATPase inhibitors of DNA gyrase and topoisomerase IV","volume":"1","author":"Bisacchi","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.113200_bib16","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1021\/acs.jmedchem.5b00489","article-title":"Discovery of 4,5,6,7-tetrahydrobenzo[1,2- d ]thiazoles as novel DNA gyrase inhibitors targeting the ATP-binding site","volume":"58","author":"Toma\u0161i\u010d","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113200_bib17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bmc.2016.10.038","article-title":"Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-Carboxamide derivatives as novel DNA gyrase inhibitors","volume":"25","author":"Toma\u0161i\u010d","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113200_bib18","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1021\/acs.jmedchem.6b00864","article-title":"Discovery of benzothiazole scaffold-based DNA gyrase B inhibitors","volume":"59","author":"Gjorgjieva","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113200_bib19","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1021\/acs.jmedchem.5b00775","article-title":"N-Phenyl-4,5-dibromopyrrolamides and N-phenylindolamides as ATP competitive DNA gyrase B inhibitors: design, synthesis, and evaluation","volume":"58","author":"Zidar","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113200_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejmech.2018.05.011","article-title":"New N-phenylpyrrolamide DNA gyrase B inhibitors: optimization of efficacy and antibacterial activity","volume":"154","author":"Durcik","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113200_bib21","doi-asserted-by":"crossref","first-page":"1700333","DOI":"10.1002\/ardp.201700333","article-title":"Design, synthesis, and biological evaluation of 1-Ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors","volume":"351","author":"Toma\u0161i\u010d","year":"2018","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.ejmech.2021.113200_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejmech.2019.02.004","article-title":"An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors","volume":"167","author":"Benedetto Tiz","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113200_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000819","article-title":"Rational design of balanced multi-targeting antibiotics with limited resistance","volume":"18","author":"Nyerges","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejmech.2021.113200_bib24","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1128\/AAC.47.3.1037-1046.2003","article-title":"Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance","volume":"47","author":"Gross","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2021.113200_bib25","doi-asserted-by":"crossref","first-page":"8305","DOI":"10.1021\/acsomega.0c00768","article-title":"Efficient synthesis of hydroxy-substituted 2-Aminobenzo[d]thiazole-6-carboxylic acid derivatives as new building blocks in drug discovery","volume":"5","author":"Durcik","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2021.113200_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/nyas.13598","article-title":"The challenge of converting gram-positive-only compounds into broad-spectrum antibiotics: challenges in developing broad-spectrum antibiotics","volume":"1435","author":"Richter","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejmech.2021.113200_bib27","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/acs.jmedchem.9b00726","article-title":"Dual inhibitors of human DNA topoisomerase II and other cancer-related targets","volume":"63","author":"Skok","year":"2020","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113200_bib28","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1021\/acs.oprd.9b00233","article-title":"Data-rich experimentation enables palladium-catalyzed couplings of piperidines and five-membered (Hetero)aromatic electrophiles","volume":"23","author":"Sather","year":"2019","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.ejmech.2021.113200_bib29","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/adsc.201801272","article-title":"Synthesis of 4-alkenyl benzoxazoles via Pd-catalyzed ortho C\u2212H functionalization of 2-amidophenols","volume":"361","author":"Panda","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.ejmech.2021.113200_bib30","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1055\/s-0030-1258546","article-title":"2-Aminophenols containing electron-withdrawing groups from N-aryl hydroxylamines","volume":"2010","author":"Porzelle","year":"2010","journal-title":"Synlett"},{"key":"10.1016\/j.ejmech.2021.113200_bib31","series-title":"Bisarylsulfonamides Useful in the Treatment of Inflammation and Cancer. WO 2013\/093095 A1","author":"Martinsson","year":"2013"},{"key":"10.1016\/j.ejmech.2021.113200_bib32","series-title":"Quinoline Derivatives Inhibiting the Effect of Growth Factors Such as VEGF. US6809097B1","author":"Thomas","year":"2004"},{"key":"10.1016\/j.ejmech.2021.113200_bib33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/cmdc.201700549","article-title":"Synthesis and evaluation of N-phenylpyrrolamides as DNA gyrase B inhibitors","volume":"13","author":"Durcik","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2021.113200_bib34","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1073\/pnas.1520040113","article-title":"A\u00a0highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species","volume":"113","author":"Nyerges","year":"2016","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.ejmech.2021.113200_bib35","doi-asserted-by":"crossref","first-page":"e00207","DOI":"10.1128\/AAC.00207-19","article-title":"Rapid evolution of reduced susceptibility against a balanced dual-targeting antibiotic through stepping-stone mutations","volume":"63","author":"Szili","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2021.113200_bib36","series-title":"Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria. (Clinical and Laboratory Standards Inst","year":"2012"},{"key":"10.1016\/j.ejmech.2021.113200_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2007.02.006","article-title":"Evaluation of an automated in\u00a0vitro micronucleus assay in CHO-K1 cells","volume":"630","author":"Diaz","year":"2007","journal-title":"Mutat. Res. Toxicol. Environ. Mutagen."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421000490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421000490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:24:38Z","timestamp":1759328678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421000490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":36,"alternative-id":["S0223523421000490"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113200","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113200"}}