{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:34:23Z","timestamp":1786988063978,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ejmech.2021.113319","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T19:35:09Z","timestamp":1615232109000},"page":"113319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Design and synthesis of N-(3-sulfamoylphenyl)amides as Trypanosoma brucei leucyl-tRNA synthetase inhibitors"],"prefix":"10.1016","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4132-6491","authenticated-orcid":false,"given":"Zezhong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiang","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huchen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113319_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0140-6736(09)60829-1","article-title":"Human african trypanosomiasis","volume":"375","author":"Brun","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2021.113319_bib2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMra064142","article-title":"Control of neglected tropical diseases","volume":"357","author":"Hotez","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ejmech.2021.113319_bib3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0140-6736(16)30171-4","article-title":"Neglected tropical diseases: progress towards addressing the chronic pandemic","volume":"389","author":"Molyneux","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2021.113319_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrmicro.2016.193","article-title":"Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need","volume":"15","author":"Field","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2021.113319_bib5","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.pt.2018.08.006","article-title":"The Long wait for a new drug for human African trypanosomiasis","volume":"34","author":"Baker","year":"2018","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ejmech.2021.113319_bib6","article-title":"Drug resistance in eukaryotic microorganisms","volume":"1","author":"Fairlamb","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2021.113319_bib7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1473-3099(13)70191-9","article-title":"Do we need new drugs against human African trypanosomiasis?","volume":"13","author":"Stich","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.113319_bib8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.biochem.69.1.617","article-title":"Aminoacyl-tRNA synthesis","volume":"69","author":"Ibba","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejmech.2021.113319_bib9","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1016\/j.ejmech.2011.08.049","article-title":"Aminoacyl-tRNA synthetase inhibitors as potential antibiotics","volume":"46","author":"Vondenhoff","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113319_bib10","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1128\/AAC.49.12.4821-4833.2005","article-title":"Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents","volume":"49","author":"Hurdle","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2021.113319_bib11","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1039\/C6MD00274A","article-title":"Natural products and their derivatives as tRNA synthetase inhibitors and antimicrobial agents","volume":"7","author":"Cochrane","year":"2016","journal-title":"MedChemComm"},{"key":"10.1016\/j.ejmech.2021.113319_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpddr.2013.10.001","article-title":"Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites","volume":"4","author":"Pham","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ejmech.2021.113319_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2174\/1389203717999160226173754","article-title":"Enzymatic targets in Trypanosoma brucei","volume":"17","author":"Luciana","year":"2016","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.ejmech.2021.113319_bib14","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1021\/jm101225g","article-title":"Design, synthesis, and structure\u2212activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents","volume":"54","author":"Ding","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113319_bib15","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1039\/c3ob40236c","article-title":"Discovery of N-(4-sulfamoylphenyl) thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors","volume":"11","author":"Zhang","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2021.113319_bib16","doi-asserted-by":"crossref","first-page":"12290","DOI":"10.1021\/acs.jmedchem.0c00530","article-title":"Amide bond bioisosteres: strategies, synthesis, and successes","volume":"63","author":"Kumari","year":"2020","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113319_bib17","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1021\/jm101225g","article-title":"Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents","volume":"54","author":"Ding","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113319_bib18","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2307\/3282883","article-title":"Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers","volume":"75","author":"Hirumi","year":"1989","journal-title":"J.\u00a0Parasitol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421001689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421001689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:25:14Z","timestamp":1759328714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421001689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":18,"alternative-id":["S0223523421001689"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113319","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of N-(3-sulfamoylphenyl)amides as Trypanosoma brucei leucyl-tRNA synthetase inhibitors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113319","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113319"}}