{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:48:04Z","timestamp":1779115684264,"version":"3.51.4"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008431","name":"Junta de Castilla y Leon Consejeria de Educacion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008051","name":"Centro de la Fundacio Caixa Castello","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n AECC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007801","name":"Fundacion Seneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ejmech.2021.113600","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T21:48:16Z","timestamp":1623275296000},"page":"113600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy\u2020"],"prefix":"10.1016","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-4806","authenticated-orcid":false,"given":"Enrique","family":"Ortega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"P\u00e9rez-Arnaiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venancio","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-9605","authenticated-orcid":false,"given":"Christoph","family":"Janiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-1209","authenticated-orcid":false,"given":"Natalia","family":"Busto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113600_bib1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1086\/518873","article-title":"Polymicrobial infection in patients with cancer: an underappreciated and underreported entity","volume":"45","author":"Rolston","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.113600_bib2","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.6004\/jnccn.2012.0146","article-title":"National comprehensive cancer network, prevention and treatment of cancer-related infections","volume":"10","author":"Baden","year":"2012","journal-title":"J.\u00a0Natl. Compr. Canc. Netw."},{"key":"10.1016\/j.ejmech.2021.113600_bib3","doi-asserted-by":"crossref","first-page":"111804","DOI":"10.1016\/j.ejmech.2019.111804","article-title":"Structure-activity relationships (SAR) of triazine derivatives: promising antimicrobial agents","volume":"185","author":"Liu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1086\/598620","article-title":"Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria","volume":"29","author":"Zinner","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.113600_bib5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s10096-013-1819-7","article-title":"Recent changes in bacteremia in patients with cancer: a systematic review of epidemiology and antibiotic resistance","volume":"32","author":"Montassier","year":"2013","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.113600_bib6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejmech.2018.11.017","article-title":"Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: a critical review","volume":"162","author":"Zhao","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bmc.2017.11.026","article-title":"Podophyllotoxin derivatives as an excellent anticancer aspirant for future chemotherapy: a key current imminent needs","volume":"26","author":"Zhang","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bioorg.2019.02.030","article-title":"The significance of N-methylpicolinamides in the development of anticancer therapeutics: synthesis and structure-activity relationship (SAR) studies","volume":"86","author":"Moku","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bioorg.2019.01.019","article-title":"Innovative nano-carriers in anticancer drug delivery-a comprehensive review","volume":"85","author":"Dong","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bioorg.2019.03.038","article-title":"Anticancer and DNA binding studies of potential amino acids based quinazolinone analogs: synthesis, SAR and molecular docking","volume":"87","author":"Rakesh","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib11","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1039\/C7RA13754K","article-title":"Arylnaphthalene lactone analogues: synthesis and development as excellent biological candidates for future drug discovery","volume":"8","author":"Zhao","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2021.113600_bib12","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1039\/C7MD00449D","article-title":"Benzisoxazole: a privileged scaffold for medicinal chemistry","volume":"8","author":"Rakesh","year":"2017","journal-title":"MedChemComm"},{"key":"10.1016\/j.ejmech.2021.113600_bib13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","article-title":"The resurgence of platinum-based cancer chemotherapy","volume":"7","author":"Kelland","year":"2007","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejmech.2021.113600_bib14","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","article-title":"The next generation of platinum drugs: targeted Pt(II) agents, nanoparticle delivery, and Pt(IV) prodrugs","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2021.113600_bib15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cbpa.2012.01.013","article-title":"The potential of organometallic complexes in medicinal chemistry","volume":"16","author":"Gasser","year":"2012","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejmech.2021.113600_bib16","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1016\/j.ccr.2013.03.024","article-title":"Anticancer cyclometalated complexes of platinum group metals and gold","volume":"257","author":"Cutillas","year":"2013","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2021.113600_bib17","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1021\/acs.molpharmaceut.8b00003","article-title":"Induction of the endoplasmic reticulum stress pathway by highly cytotoxic organoruthenium schiff-base complexes","volume":"15","author":"Chow","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejmech.2021.113600_bib18","doi-asserted-by":"crossref","DOI":"10.1039\/C8CC06427J","article-title":"A\u00a0new C,N-cyclometalated osmium(II) arene anticancer scaffold with a handle for functionalization and antioxidative properties","author":"Ortega","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113600_bib19","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1002\/chem.201705267","article-title":"Benzothiazole-based cycloplatinated chromophores: synthetic, optical, and biological studies","volume":"24","author":"Lalinde","year":"2018","journal-title":"Chemistry"},{"key":"10.1016\/j.ejmech.2021.113600_bib20","doi-asserted-by":"crossref","first-page":"10119","DOI":"10.1002\/anie.201405384","article-title":"Luminescent cyclometalated platinum(II) complex forms emissive intercalating adducts with double-stranded DNA and RNA: differential emissions and anticancer activities","volume":"53","author":"Zou","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2021.113600_bib21","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.1002\/chem.201700717","article-title":"Exploring the influence of the aromaticity on the anticancer and antivascular activities of organoplatinum(II) complexes","volume":"23","author":"Zamora","year":"2017","journal-title":"Chemistry"},{"key":"10.1016\/j.ejmech.2021.113600_bib22","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1021\/jm501662b","article-title":"Dual antitumor and antiangiogenic activity of organoplatinum(II) complexes","volume":"58","author":"Zamora","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib23","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1021\/acs.inorgchem.0c02648","article-title":"Organoplatinum(II) complexes self-assemble and recognize AT-rich duplex DNA sequences","volume":"60","author":"Zamora","year":"2021","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib24","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.7150\/thno.30886","article-title":"NF-\u03baB hijacking theranostic Pt(ll) complex in cancer therapy","volume":"9","author":"Zhu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2021.113600_bib25","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1021\/acs.inorgchem.7b03210","article-title":"Rollover cyclometalated bipyridine platinum complexes as potent anticancer agents: impact of the ancillary ligands on the mode of action","volume":"57","author":"Babak","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib26","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1021\/acs.organomet.5b00751","article-title":"Catalytically generated ferrocene-containing guanidines as efficient precursors for new redox-active heterometallic platinum(II) complexes with anticancer activity","volume":"34","author":"Nieto","year":"2015","journal-title":"Organometallics"},{"key":"10.1016\/j.ejmech.2021.113600_bib27","doi-asserted-by":"crossref","first-page":"14938","DOI":"10.1002\/chem.202002517","article-title":"Influence of ligand and nuclearity on the cytotoxicity of cyclometallated C^N^C platinum(II) complexes","volume":"26","author":"Kergreis","year":"2020","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2021.113600_bib28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ejmech.2019.07.059","article-title":"Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships","volume":"180","author":"Xu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib29","doi-asserted-by":"crossref","first-page":"7310","DOI":"10.1021\/acs.jmedchem.5b01194","article-title":"Novel C,N-cyclometalated benzimidazole ruthenium(II) and iridium(III) complexes as antitumor and antiangiogenic agents: a structure\u2013activity relationship study","volume":"58","author":"Yellol","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib30","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1021\/ic502119b","article-title":"Synthesis of 2-Pyridyl-benzimidazole iridium(III), ruthenium(II), and platinum(II) complexes. Study of the activity as inhibitors of amyloid-\u03b2 aggregation and neurotoxicity evaluation","volume":"54","author":"Yellol","year":"2015","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib31","doi-asserted-by":"crossref","first-page":"1800247","DOI":"10.1002\/ardp.201800247","article-title":"Synthesis, CYP 450 evaluation, and docking simulation of novel 4-aminopyridine and coumarin derivatives","volume":"352","author":"Ghalehshahi","year":"2019","journal-title":"Archiv Der Pharmazie"},{"key":"10.1016\/j.ejmech.2021.113600_bib32","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/cmdc.201800282","article-title":"Towards novel angiogenesis inhibitors based on the conjugation of organometallic platinum(II) complexes to RGD peptides","volume":"13","author":"Marchan","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2021.113600_bib33","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1039\/C9SC06460E","article-title":"Metal complexes as a promising source for new antibiotics","volume":"11","author":"Frei","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejmech.2021.113600_bib34","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1021\/acs.chemrev.8b00209","article-title":"Stimuli-responsive therapeutic metallodrugs","volume":"119","author":"Wang","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2021.113600_bib35","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1021\/jacs.7b09476","article-title":"Photoswitching of DNA hybridization using a molecular motor","volume":"140","author":"Lubbe","year":"2018","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2021.113600_bib36","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1039\/C6DT04405K","article-title":"Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage","volume":"46","author":"Zamora","year":"2017","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2021.113600_bib37","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1039\/C8DT01585F","article-title":"Why develop photoactivated chemotherapy?","volume":"47","author":"Bonnet","year":"2018","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2021.113600_bib38","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1021\/acs.accounts.8b00066","article-title":"Ru(II) polypyridyl complexes derived from tetradentate ancillary ligands for effective photocaging","volume":"51","author":"Li","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2021.113600_bib39","doi-asserted-by":"crossref","first-page":"14322","DOI":"10.1021\/acs.inorgchem.8b02299","article-title":"Strong influence of ancillary ligands containing benzothiazole or benzimidazole rings on cytotoxicity and photoactivation of Ru(II) arene complexes","volume":"57","author":"Lari","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib40","doi-asserted-by":"crossref","first-page":"13845","DOI":"10.1039\/C8CC06496B","article-title":"Photoactivatable platinum anticancer complex can generate tryptophan radicals","volume":"54","author":"Vallotto","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113600_bib41","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1039\/C8CC05928D","article-title":"Mechanisms of action of Ru(II) polypyridyl complexes in living cells upon light irradiation","volume":"54","author":"Jakubaszek","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113600_bib42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejmech.2017.09.058","article-title":"Synthesis and biological evaluation of a Platinum(II)-c(RGDyK) conjugate for integrin-targeted photodynamic therapy","volume":"141","author":"Chatzisideri","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep22668","article-title":"Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand","volume":"6","author":"Doherty","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2021.113600_bib44","doi-asserted-by":"crossref","first-page":"17523","DOI":"10.1002\/chem.201803784","article-title":"Strong influence of the ancillary ligand over the photodynamic anticancer properties of neutral biscyclometalated IrIII complexes bearing 2-benzoazole-phenolates","volume":"24","author":"Mart\u00ednez-Alonso","year":"2018","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2021.113600_bib45","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ccr.2018.01.010","article-title":"Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy","volume":"360","author":"Zamora","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2021.113600_bib46","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/acs.chemrev.8b00211","article-title":"Transition metal complexes and photodynamic therapy from a tumor-centered approach: challenges, opportunities, and highlights from the development of TLD1433","volume":"119","author":"Monro","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2021.113600_bib47","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1021\/jacs.0c01369","article-title":"The self-assembly of a cyclometalated palladium photosensitizer into protein-stabilized nanorods triggers drug uptake in\u00a0vitro and in\u00a0vivo","volume":"142","author":"Zhou","year":"2020","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2021.113600_bib48","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1039\/C8CC10134E","article-title":"The two isomers of a cyclometallated palladium sensitizer show different photodynamic properties in cancer cells","volume":"55","author":"Zhou","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113600_bib49","first-page":"786","article-title":"Randomized trial of partial gland ablation with vascular targeted phototherapy versus active surveillance for low risk prostate cancer: extended followup and analyses of effectiveness","volume":"200","author":"Gill","year":"2018","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.ejmech.2021.113600_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202100568","article-title":"A\u00a0cyclometalated IrIII complex conjugated to a coumarin derivative is a potent photodynamic agent against prostate differentiated and tumorigenic cancer stem cells","author":"Novohradsky","year":"2021","journal-title":"Chemistry"},{"key":"10.1016\/j.ejmech.2021.113600_bib51","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4161\/viru.2.6.17889","article-title":"All you need is light: antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease","volume":"2","author":"St Denis","year":"2011","journal-title":"Virulence"},{"key":"10.1016\/j.ejmech.2021.113600_bib52","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1039\/C6SC03028A","article-title":"Photoactivatable ruthenium(II)-isoniazid complex exhibits rapid selective antimycobacterial activity","volume":"8","author":"Smith","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejmech.2021.113600_bib53","doi-asserted-by":"crossref","first-page":"11129","DOI":"10.1021\/acs.inorgchem.7b01459","article-title":"Characterization of the fleeting hydroxoiron(III) complex of the pentadentate TMC-py ligand","volume":"56","author":"Ching","year":"2017","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib54","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jinorgbio.2010.12.005","article-title":"N-chelate platinum(II) antitumor complexes bearing a lipophilic ethisterone pendant","volume":"105","author":"Ruiz","year":"2011","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2021.113600_bib55","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1107\/S090744490804362X","article-title":"Structure validation in chemical crystallography","volume":"65","author":"Spek","year":"2009","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.ejmech.2021.113600_bib56","doi-asserted-by":"crossref","first-page":"13873","DOI":"10.1039\/c1cp20404a","article-title":"The CH\/\u03c0 hydrogen bond in chemistry. Conformation, supramolecules, optical resolution and interactions involving carbohydrates","volume":"13","author":"Nishio","year":"2011","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.ejmech.2021.113600_bib57","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1039\/b313104a","article-title":"CH\/\u03c0 hydrogen bonds in crystals","volume":"6","author":"Nishio","year":"2004","journal-title":"CrystEngComm"},{"key":"10.1016\/j.ejmech.2021.113600_bib58","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1039\/b902318f","article-title":"CH\/\u03c0 hydrogen bonds in organic and organometallic chemistry","volume":"11","author":"Nishio","year":"2009","journal-title":"CrystEngComm"},{"key":"10.1016\/j.ejmech.2021.113600_bib59","series-title":"The CH\/\u03c0 Interaction: Evidence, Nature, and Consequences","author":"Nishio","year":"1998"},{"key":"10.1016\/j.ejmech.2021.113600_bib60","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1016\/S0040-4020(99)00539-6","article-title":"CH\u03c0 interaction in the conformation of organic compounds","volume":"55","author":"Umezawa","year":"1999","journal-title":"A\u00a0database study, Tetrahedron."},{"key":"10.1016\/j.ejmech.2021.113600_bib61","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/(SICI)1099-0682(200006)2000:6<1229::AID-EJIC1229>3.3.CO;2-G","article-title":"Binary [Hydrotris(indazol-1-yl)borato]metal complexes, M(Tp4Bo)2[1] with M\u00a0= Fe, Co, Ni, Cu, and Zn: electronic properties and solvent-dependent framework structures through C\u2212H\u00b7\u00b7\u00b7\u03c0 interactions","author":"Janiak","year":"2000","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib62","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1039\/B414999H","article-title":"From model compounds to protein binding: syntheses, characterizations and fluorescence studies of [Ru II (bipy)(terpy)L] 2+ complexes (bipy\u00a0= 2,2\u2032-bipyridine; terpy\u00a0= 2,2\u2032:6\u2032,2\u2033-terpyridine; L\u00a0= imidazole, pyrazole and derivatives, cytochrome c )","author":"Yang","year":"2005","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2021.113600_bib63","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.poly.2013.05.047","article-title":"Benzazolate complexes of pentacoordinate nickel(II). Synthesis, spectroscopic study and luminescent response towards metal cations","volume":"61","author":"Dolores Santana","year":"2013","journal-title":"Polyhedron"},{"key":"10.1016\/j.ejmech.2021.113600_bib64","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1021\/acs.inorgchem.7b00059","article-title":"Structure, spectra, and DFT simulation of nickel benzazolate complexes with tris(2-aminoethyl)amine ligand","volume":"56","author":"Cerezo","year":"2017","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib65","series-title":"Advances in Organometallic Chemistry","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/bs.adomc.2018.03.001","article-title":"Organometallic fluorophores of d8 metals (Pd, Pt, Au)","author":"Bischoff","year":"2018"},{"key":"10.1016\/j.ejmech.2021.113600_bib66","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/php.13177","article-title":"Synthesis and characterization of Ru(II) complexes with \u03c0-expansive imidazophen ligands for the photokilling of human melanoma cells","volume":"96","author":"Ghosh","year":"2020","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ejmech.2021.113600_bib67","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2021.113600_bib68","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/1087057112468765","article-title":"Rapid and specific measurements of superoxide using fluorescence spectroscopy","volume":"18","author":"Nazarewicz","year":"2013","journal-title":"J.\u00a0Biomol. Screen"},{"key":"10.1016\/j.ejmech.2021.113600_bib69","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4236\/ijoc.2013.34035","article-title":"Synthesis of multifunctionalised 2-substituted benzimidazoles using copper (II) hydroxide as efficient solid catalyst","volume":"4","author":"Chari","year":"2013","journal-title":"Int. J. Org Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib70","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.ejmech.2021.113600_bib71","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1107\/S0021889811043202","volume":"44","author":"H\u00fcbschle","year":"2011","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.ejmech.2021.113600_bib72","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S1600576714022985","volume":"48","author":"Krause","year":"2015","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.ejmech.2021.113600_bib73","unstructured":"K. Brandenburg, \u201cDIAMOND Version 4.6.2. Copyright 1997-2019 Crystal Impact Gbr, Bonn, Germany,\u201d can be found under https:\/\/www.crystalimpact.com\/diamond\/, n.d."},{"key":"10.1016\/j.ejmech.2021.113600_bib74","series-title":"The Nucleus","first-page":"35","article-title":"A\u00a0new rapid method for isolating nucleoli","author":"Li","year":"2015"},{"key":"10.1016\/j.ejmech.2021.113600_bib75","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s41557-019-0328-4","article-title":"Targeted photoredox catalysis in cancer cells","volume":"11","author":"Huang","year":"2019","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2021.113600_bib76","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1039\/C8CC09211G","article-title":"New half-sandwich ruthenium(II) complexes as proteosynthesis inhibitors in cancer cells","author":"Ballester","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113600_bib77","doi-asserted-by":"crossref","first-page":"10301","DOI":"10.1039\/D0CC02417A","article-title":"Ru(II) photosensitizers competent for hypoxic cancers via green light activation","volume":"56","author":"Ballester","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113600_bib78","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1039\/C9QI01704F","article-title":"Novel organo-osmium(II) proteosynthesis inhibitors active against human ovarian cancer cells reduce gonad tumor growth in Caenorhabditis elegans","volume":"8","author":"Ortega","year":"2021","journal-title":"Inorg. Chem. Front."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421004499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421004499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:31:51Z","timestamp":1759329111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421004499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":78,"alternative-id":["S0223523421004499"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113600","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy\u2020","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113600","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113600"}}