{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:39:27Z","timestamp":1781062767557,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ejmech.2021.113608","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T11:17:27Z","timestamp":1622891847000},"page":"113608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Development of photocontrolled BRD4 PROTACs for tongue squamous cell carcinoma (TSCC)"],"prefix":"10.1016","volume":"222","author":[{"given":"Zhenzhen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaopan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lupei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-4921","authenticated-orcid":false,"given":"Minyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113608_bib1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/nature06526","article-title":"Reaching for high-hanging fruit in drug discovery at protein-protein interfaces","volume":"450","author":"Wells","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2021.113608_bib2","doi-asserted-by":"crossref","first-page":"14629","DOI":"10.1021\/ja508343a","article-title":"Privileged structures: efficient chemical \"navigators\" toward unexplored biologically relevant chemical spaces","volume":"136","author":"Kim","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2021.113608_bib3","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1021\/acschembio.6b01068","article-title":"Proteolysis-targeting chimeras: induced protein degradation as a therapeutic strategy","volume":"12","author":"Ottis","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2021.113608_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrd.2016.211","article-title":"Induced protein degradation: an emerging drug discovery paradigm","volume":"16","author":"Lai","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2021.113608_bib5","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/anie.201507978","article-title":"Small-molecule PROTACS: new approaches to protein degradation","volume":"55","author":"Toure","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2021.113608_bib6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pharmthera.2017.02.027","article-title":"Targeted protein degradation by PROTACs","volume":"174","author":"Neklesa","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2021.113608_bib7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1021\/acs.jmedchem.7b01272","article-title":"Protac-induced protein degradation in drug discovery: breaking the rules or just making new ones?","volume":"61","author":"Churcher","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113608_bib8","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1080\/17460441.2019.1659242","article-title":"PROTACs- a game-changing technology","volume":"14","author":"Konstantinidou","year":"2019","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.ejmech.2021.113608_bib9","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1111\/bph.15014","article-title":"Proteolysis-targeting chimeras in drug development: a safety perspective","volume":"177","author":"Moreau","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113608_bib10","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1021\/acscentsci.9b00713","article-title":"Reversible spatiotemporal control of induced protein degradation by bistable PhotoPROTACs","volume":"5","author":"Pfaff","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2021.113608_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.639176","article-title":"Photopharmacology of proteolysis-targeting chimeras: a new frontier for drug discovery","volume":"9","author":"Zeng","year":"2021","journal-title":"Frontiers in Chemistry"},{"key":"10.1016\/j.ejmech.2021.113608_bib12","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1039\/D0MD00107D","article-title":"Photocontrolled activation of small molecule cancer therapeutics","volume":"11","author":"Dcona","year":"2020","journal-title":"Rsc Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2021.113608_bib13","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nn.4091","article-title":"Optogenetics: 10 years of microbial opsins in neuroscience","volume":"18","author":"Deisseroth","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejmech.2021.113608_bib14","doi-asserted-by":"crossref","first-page":"9460","DOI":"10.1021\/jacs.0c02949","article-title":"Optical control of CRAC channels using photoswitchable azopyrazoles","volume":"142","author":"Yang","year":"2020","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2021.113608_bib15","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/nn.4094","article-title":"Optogenetics and the future of neuroscience","volume":"18","author":"Boyden","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejmech.2021.113608_bib16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nphoton.2014.90","article-title":"Photodynamic therapy by in situ nonlinear photon conversion","volume":"8","author":"Kachynski","year":"2014","journal-title":"Nat. Photonics"},{"key":"10.1016\/j.ejmech.2021.113608_bib17","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1021\/jacs.9b12718","article-title":"Optical control of small molecule-induced protein degradation","volume":"142","author":"Naro","year":"2020","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2021.113608_bib18","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1039\/D0CC00523A","article-title":"A\u00a0caged E3 ligase ligand for PROTAC-mediated protein degradation with light","volume":"56","author":"Kounde","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113608_bib19","article-title":"Light-induced control of protein destruction by opto-PROTAC","volume":"6","author":"Liu","year":"2020","journal-title":"Science Advances"},{"key":"10.1016\/j.ejmech.2021.113608_bib20","first-page":"425","article-title":"Cancer statistics for hispanics\/latinos, 2018","volume":"68","author":"Miller","year":"2018","journal-title":"Ca-a Cancer Journal for Clinicians"},{"key":"10.1016\/j.ejmech.2021.113608_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10147-014-0689-z","article-title":"Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma","volume":"19","author":"Omura","year":"2014","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2021.113608_bib22","first-page":"E2197","article-title":"Resection margins in oral cancer surgery: room for improvement","volume":"38","author":"Smits","year":"2016","journal-title":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck"},{"key":"10.1016\/j.ejmech.2021.113608_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.14639\/0392-100X-2336","article-title":"Long-term disease-free survival in surgically-resected oral tongue cancer: a 10-year retrospective study","volume":"39","author":"Marra","year":"2019","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"10.1016\/j.ejmech.2021.113608_bib24","first-page":"51","article-title":"The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012","volume":"67","author":"Shield","year":"2017","journal-title":"Ca-a Cancer Journal for Clinicians"},{"key":"10.1016\/j.ejmech.2021.113608_bib25","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/jcb.29420","article-title":"Expression and clinical value of PD-L1 which is regulated by BRD4 in tongue squamous cell carcinoma","volume":"121","author":"Zhao","year":"2020","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.ejmech.2021.113608_bib26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cellsig.2017.10.010","article-title":"Bromodomain protein BRD4 promotes cell proliferation in skin squamous cell carcinoma","volume":"42","author":"Xiang","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejmech.2021.113608_bib27","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41416-020-0907-6","article-title":"BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene","volume":"123","author":"Yamamoto","year":"2020","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.ejmech.2021.113608_bib28","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.1039\/C6CS00616G","article-title":"Overcoming the Achilles' heel of photodynamic therapy","volume":"45","author":"Fan","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2021.113608_bib29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2021.113608_bib30","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1039\/C5CS00118H","article-title":"Wavelength-selective cleavage of photoprotecting groups: strategies and applications in dynamic systems","volume":"44","author":"Hansen","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2021.113608_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/cr300177k","article-title":"Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy","volume":"113","author":"Klan","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2021.113608_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature13527","article-title":"Structure of the DDBI-CRBN E3 ubiquitin ligase in complex with thalidomide","volume":"512","author":"Fischer","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2021.113608_bib33","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.chembiol.2015.05.009","article-title":"Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4","volume":"22","author":"Lu","year":"2015","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejmech.2021.113608_bib34","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.aab1433","article-title":"Phthalimide conjugation as a strategy for in\u00a0vivo target protein degradation","volume":"348","author":"Winter","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2021.113608_bib35","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1021\/acs.jmedchem.7b01655","article-title":"Chemically induced degradation of anaplastic lymphoma kinase (ALK)","volume":"61","author":"Powell","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113608_bib36","doi-asserted-by":"crossref","first-page":"9642","DOI":"10.1021\/acs.jmedchem.9b01035","article-title":"Development and characterization of a fluorescent probe for GLS1 and the application for high-throughput screening of allosteric inhibitors","volume":"62","author":"Xu","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113608_bib37","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nrc3589","article-title":"Zebrafish cancer: the state of the art and the path forward","volume":"13","author":"White","year":"2013","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejmech.2021.113608_bib38","doi-asserted-by":"crossref","first-page":"18370","DOI":"10.1021\/jacs.9b06422","article-title":"Light-induced protein degradation with photocaged PROTACs","volume":"141","author":"Xue","year":"2019","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2021.113608_bib39","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1242\/dmm.015784","article-title":"Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era","volume":"7","author":"Veinotte","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ejmech.2021.113608_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17081375","article-title":"Development of a patient-derived xenograft (PDX) of breast cancer bone metastasis in a zebrafish model","volume":"17","author":"Mercatali","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2021.113608_bib41","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1021\/jm400159c","article-title":"The development of highly potent inhibitors for porcupine","volume":"56","author":"Wang","year":"2013","journal-title":"J.\u00a0Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421004578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421004578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:28:58Z","timestamp":1759328938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421004578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":41,"alternative-id":["S0223523421004578"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113608","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of photocontrolled BRD4 PROTACs for tongue squamous cell carcinoma (TSCC)","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113608"}}