{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:45:50Z","timestamp":1792662350850,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007195","name":"Universit\u00e0 degli Studi di Napoli Federico II","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["316213987"],"award-info":[{"award-number":["316213987"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["C02"],"award-info":[{"award-number":["C02"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1278 PolyTarget"],"award-info":[{"award-number":["SFB 1278 PolyTarget"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Airc Italian Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["21397"],"award-info":[{"award-number":["21397"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 2018"],"award-info":[{"award-number":["IG 2018"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ejmech.2021.113693","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T11:37:00Z","timestamp":1626176220000},"page":"113693","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways"],"prefix":"10.1016","volume":"224","author":[{"given":"Marianna","family":"Potenza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Sciarretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3943-5883","authenticated-orcid":false,"given":"Maria Giovanna","family":"Chini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anella","family":"Saviano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-4299","authenticated-orcid":false,"given":"Francesco","family":"Maione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Valeria","family":"D'Auria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-5048","authenticated-orcid":false,"given":"Simona","family":"De Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8139-407X","authenticated-orcid":false,"given":"Assunta","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-9703","authenticated-orcid":false,"given":"Robert Klaus","family":"Hofstetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8879-4332","authenticated-orcid":false,"given":"Carmen","family":"Festa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Werz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-5170","authenticated-orcid":false,"given":"Giuseppe","family":"Bifulco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113693_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pharmthera.2017.12.008","volume":"185","author":"Martinez-Colon","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2021.113693_bib2","doi-asserted-by":"crossref","first-page":"32783","DOI":"10.1074\/jbc.M003505200","volume":"275","author":"Murakami","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib3","doi-asserted-by":"crossref","first-page":"106383","DOI":"10.1016\/j.prostaglandins.2019.106383","volume":"147","author":"Bergqvist","year":"2020","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.ejmech.2021.113693_bib4","first-page":"146","volume":"1","author":"Korotkova","year":"2010","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.biochi.2010.02.006","volume":"92","author":"Nakanishi","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.ejmech.2021.113693_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00281-012-0342-8","volume":"35","author":"Nakanishi","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ejmech.2021.113693_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12885-016-3018-2","volume":"17","author":"Nandi","year":"2017","journal-title":"BMC Canc."},{"key":"10.1016\/j.ejmech.2021.113693_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2015.06.022","volume":"98","author":"Koeberle","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/ar1748","volume":"7","author":"Sampey","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejmech.2021.113693_bib10","doi-asserted-by":"crossref","first-page":"12203","DOI":"10.1007\/s13277-016-5087-x","volume":"37","author":"Ke","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.ejmech.2021.113693_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1210\/jc.2002-021061","volume":"88","author":"Meadows","year":"2003","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejmech.2021.113693_bib12","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1110\/ps.8.3.689","volume":"8","author":"Jakobsson","year":"1999","journal-title":"Protein Sci."},{"key":"10.1016\/j.ejmech.2021.113693_bib13","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1016\/j.bmcl.2005.05.027","volume":"15","author":"Riendeau","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2021.113693_bib14","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.ejmech.2018.03.045","volume":"150","author":"G\u00fcr","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1021\/acsmedchemlett.9b00618","volume":"11","author":"Chini","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2021.113693_bib16","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.ejmech.2017.10.039","volume":"143","author":"Di Micco","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1039\/C4MD00319E","volume":"6","author":"Chini","year":"2015","journal-title":"MedChemComm"},{"key":"10.1016\/j.ejmech.2021.113693_bib18","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1039\/C8MD00497H","volume":"9","author":"Lauro","year":"2018","journal-title":"MedChemComm"},{"key":"10.1016\/j.ejmech.2021.113693_bib19","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1021\/acs.jnatprod.5b00700","volume":"78","author":"Iranshahi","year":"2015","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.ejmech.2021.113693_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/bcpt.12134","volume":"114","author":"Meirer","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejmech.2021.113693_bib21","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.biotechadv.2018.02.010","volume":"36","author":"Koeberle","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ejmech.2021.113693_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ejmech.2012.05.014","volume":"54","author":"Chini","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/cmdc.201900694","volume":"15","author":"Lauro","year":"2020","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2021.113693_bib24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4103\/0253-7613.140584","volume":"46","author":"Durgashivaprasad","year":"2014","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib25","doi-asserted-by":"crossref","first-page":"10192","DOI":"10.3390\/molecules170910192","volume":"17","author":"de Oliveira","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2021.113693_bib26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2174\/1389557518666181015152433","volume":"19","author":"Verma","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejmech.2015.04.051","volume":"97","author":"Bajaj","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib28","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1038\/s41598-019-38840-z","volume":"9","author":"Di Leva","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2021.113693_bib29","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1021\/acsmedchemlett.8b00534","volume":"10","author":"Festa","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2021.113693_bib30","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.2174\/1389557518666180524112050","volume":"18","author":"Chawla","year":"2018","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib31","doi-asserted-by":"crossref","first-page":"127373","DOI":"10.1016\/j.bmcl.2020.127373","volume":"30","author":"Zhang","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2021.113693_bib32","first-page":"10305","volume":"3","author":"Yatam","year":"2018","journal-title":"Chemistry"},{"key":"10.1016\/j.ejmech.2021.113693_bib33","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1134\/S1070363218040278","volume":"88","author":"Vijaya Bhargavi","year":"2018","journal-title":"Russ. J. Gen. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molstruc.2018.01.060","volume":"1159","author":"Yatam","year":"2018","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.ejmech.2021.113693_bib35","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1021\/jm501719e","volume":"58","author":"Mukherjee","year":"2014","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0003-2697(88)90256-4","volume":"169","author":"Wixtrom","year":"1988","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2021.113693_bib37","author":"CombiGlide","year":"2017","journal-title":"New York, NY"},{"key":"10.1016\/j.ejmech.2021.113693_bib38","author":"LigPrep","year":"2017","journal-title":"LLC, New York, NY"},{"key":"10.1016\/j.ejmech.2021.113693_bib39","author":"QikProp","year":"2017","journal-title":"LLC, New York, NY"},{"key":"10.1016\/j.ejmech.2021.113693_bib40","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.bmcl.2016.11.011","volume":"27","author":"Partridge","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2021.113693_bib41","author":"Glide","year":"2017","journal-title":"LLC, New York, NY"},{"key":"10.1016\/j.ejmech.2021.113693_bib42","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1021\/acs.jmedchem.5b00330","volume":"58","author":"Luz","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib43","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1073\/pnas.1218504110","volume":"110","author":"Sjogren","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2021.113693_bib44","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1021\/acs.jmedchem.5b01249","volume":"59","author":"Schiffler","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib45","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1016\/j.bmcl.2016.08.023","volume":"26","author":"Kuklish","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2021.113693_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nmeth.3211","volume":"12","author":"Weinert","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejmech.2021.113693_bib47","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2021.113693_bib48","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1124\/jpet.108.139444","volume":"326","author":"Koeberle","year":"2008","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejmech.2021.113693_bib49","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1096\/fj.15-278010","volume":"30","author":"Gerstmeier","year":"2015","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejmech.2021.113693_bib50","first-page":"11","author":"Pannunzio","year":"2018","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2021.113693_bib51","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1021\/acs.jmedchem.7b01788","volume":"61","author":"Meanwell","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113693_bib52","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00024382-199705000-00007","volume":"7","author":"Cuzzocrea","year":"1997","journal-title":"Shock"},{"key":"10.1016\/j.ejmech.2021.113693_bib53","doi-asserted-by":"crossref","first-page":"109788","DOI":"10.1016\/j.biopha.2019.109788","volume":"123","author":"Bellavita","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2021.113693_bib54","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1189\/jlb.0405206","volume":"78","author":"Chatterjee","year":"2005","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.ejmech.2021.113693_bib55","author":"Raucci","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib56","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bcp.2009.09.015","volume":"79","author":"D'Acquisto","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib57","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/SHK.0000000000000502","volume":"45","author":"Liu","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.ejmech.2021.113693_bib58","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejmech.2021.113693_bib59","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature05877","volume":"447","author":"Schwab","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2021.113693_bib60","first-page":"379","article-title":"Chapter 17 zymosan-induced peritonitis as a simple experimental system for the study of inflammation","author":"Cash","year":"2009"},{"key":"10.1016\/j.ejmech.2021.113693_bib61","first-page":"77","volume":"97","author":"Boyum","year":"1968","journal-title":"Scand. J. Clin. Lab. Invest. Suppl."},{"key":"10.1016\/j.ejmech.2021.113693_bib62","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/sj.bjp.0707416","volume":"152","author":"Fischer","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib63","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1124\/jpet.108.139444","volume":"326","author":"Koeberle","year":"2008","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejmech.2021.113693_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.02-0815fje","volume":"17","author":"Fischer","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.ejmech.2021.113693_bib65","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0006-2952(02)01387-4","volume":"64","author":"Albert","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib66","doi-asserted-by":"crossref","first-page":"9398","DOI":"10.1038\/s41598-017-09795-w","volume":"7","author":"Garscha","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2021.113693_bib67","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1021\/acs.jcim.5b00592","volume":"56","author":"Waltenberger","year":"2016","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2021.113693_bib68","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib69","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1111\/bph.12856","volume":"172","author":"Curtis","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib70","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.3389\/fimmu.2018.02752","volume":"9","author":"Maione","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2021.113693_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24010139","volume":"24","author":"Baradaran Rahimi","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2021.113693_bib72","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/bph.14112","volume":"175","author":"Alexander","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113693_bib73","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1111\/bph.13925","volume":"174","author":"George","year":"2017","journal-title":"Br. J. Pharmacol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421005420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421005420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:33:44Z","timestamp":1759329224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421005420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":73,"alternative-id":["S0223523421005420"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113693","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113693","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113693"}}