{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:27:03Z","timestamp":1791923223783,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ejmech.2021.113739","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T11:25:56Z","timestamp":1628162756000},"page":"113739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Synthesis and biological evaluation of novel coumarin derivatives in rhabdoviral clearance"],"prefix":"10.1016","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1947-1649","authenticated-orcid":false,"given":"Yang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipeng","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113739_bib1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.vetimm.2006.07.010","article-title":"Evaluation of cytokines concentration and percentage of survival of rabies virus-infected mice submitted to anti-rabies vero-cell propagated vaccine and p. acnes","volume":"114","author":"Megid","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.ejmech.2021.113739_bib2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(04)16982-1","article-title":"A\u00a0large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus","volume":"364","author":"Rao","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2021.113739_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.meegid.2009.02.005","article-title":"The rhabdoviruses: biodiversity, phylogenetics, and evolution","volume":"9","author":"Kuzmin","year":"2009","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.ejmech.2021.113739_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004846","article-title":"Post-marketing surveillance of human rabies diploid cell vaccine (Imovax) in the vaccine adverse event reporting system (VAERS) in the United States, 1990\u20122015","volume":"10","author":"Moro","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ejmech.2021.113739_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/jfd.12227","article-title":"Inhibition of spring viraemia of carp virus replication in an E pithelioma papulosum cyprini cell line by RNA i","volume":"38","author":"Gotesman","year":"2015","journal-title":"J.\u00a0Fish. Dis."},{"key":"10.1016\/j.ejmech.2021.113739_bib6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrd1657","article-title":"The evolving role of natural products in drug discovery","volume":"4","author":"Koehn","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2021.113739_bib7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.antiviral.2011.07.003","article-title":"Efficacy and tolerance of a combination of tenofovir disoproxil fumarate plus emtricitabine in patients with chronic hepatitis B: a European multicenter study","volume":"92","author":"Si-Ahmed","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bioelechem.2016.01.001","article-title":"Moderate intensity static magnetic fields affect mitotic spindles and increase the antitumor efficacy of 5-FU and Taxol","volume":"109","author":"Luo","year":"2016","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.ejmech.2021.113739_bib9","first-page":"6927675","article-title":"Metal complexes of a novel Schiff base based on penicillin: characterization, molecular modeling, and antibacterial activity study","volume":"4","author":"Chaudhary","year":"2017","journal-title":"Bioinorgan. Chem. Appl."},{"key":"10.1016\/j.ejmech.2021.113739_bib10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.ejmech.2021.113739_bib11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3109\/03602539008991449","article-title":"The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds","volume":"22","author":"Egan","year":"1990","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.ejmech.2021.113739_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1164\/rccm.201202-0314OC","article-title":"A\u00a0placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis","volume":"186","author":"Noth","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejmech.2021.113739_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/thoraxjnl-2013-203740","article-title":"Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study","volume":"69","author":"Navaratnam","year":"2014","journal-title":"Thorax"},{"key":"10.1016\/j.ejmech.2021.113739_bib14","doi-asserted-by":"crossref","first-page":"111900","DOI":"10.1016\/j.ejmech.2019.111900","article-title":"Rational design and Structure-Activity relationship of coumarin derivatives effective on HIV-1 protease and partially on HIV-1 reverse transcriptase","volume":"186","author":"Zhu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113739_bib15","doi-asserted-by":"crossref","first-page":"112595","DOI":"10.1016\/j.ejmech.2020.112595","article-title":"Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein","volume":"204","author":"Gao","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113739_bib16","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1021\/jm801240d","article-title":"Structure-activity relationship of new anti-Hepatitis C virus agents: heterobicycle-coumarin conjugates","volume":"52","author":"Neyts","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113739_bib17","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1016\/j.bmcl.2017.06.023","article-title":"Synthesis and anthelmintic activity of arctigenin derivatives against Dactylogyrus intermedius in goldfish","volume":"27","author":"Hu","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2021.113739_bib18","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.ejmech.2017.11.100","article-title":"Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents","volume":"143","author":"Hu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113739_bib19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.24272\/j.issn.2095-8137.2020.037","article-title":"Hydroxycoumarin efficiently inhibits spring viraemia of carp virus infection in\u00a0vitro and in\u00a0vivo","volume":"41","author":"Liu","year":"2020","journal-title":"Zool. Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.virusres.2019.01.009","article-title":"An imidazole coumarin derivative enhances the antiviral response to spring viremia of carp virus infection in zebrafish","volume":"263","author":"Liu","year":"2019","journal-title":"Virus Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib21","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.bmcl.2019.05.019","article-title":"Synthesis and antiviral activity of coumarin derivatives against infectious hematopoietic necrosis virus","volume":"29","author":"Hu","year":"2019","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2021.113739_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-422X-7-10","article-title":"Molecular characterization of the virulent infectious hematopoietic necrosis virus (IHNV) strain 220-90","volume":"7","author":"Ammayappan","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.ejmech.2021.113739_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13567-016-0341-1","article-title":"Epidemiological characteristics of infectious hematopoietic necrosis virus (IHNV): a review","volume":"47","author":"Dixon","year":"2016","journal-title":"Vet. Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib24","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1128\/JVI.00597-11","article-title":"Nonvirion protein of novirhabdovirus suppresses apoptosis at the early stage of virus infection","volume":"85","author":"Ammayappan","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ejmech.2021.113739_bib25","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1016\/j.bmcl.2017.06.023","article-title":"Synthesis and anthelmintic activity of arctigenin derivatives against Dactylogyrus intermedius in goldfish","volume":"27","author":"Hu","year":"2017","journal-title":"Bioorg. Med.l chem. Lett."},{"key":"10.1016\/j.ejmech.2021.113739_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejmech.2018.11.064","article-title":"Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus","volume":"163","author":"Hu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113739_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejmech.2021.113739_bib28","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejmech.2021.113739_bib29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","article-title":"Cell death: the significance of apoptosis","volume":"68","author":"Wyllie","year":"1980","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.ejmech.2021.113739_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.vetmic.2012.01.017","article-title":"Transmissible gastroenteritis virus infection induces apoptosis through FasL-and mitochondria-mediated pathways","volume":"158","author":"Ding","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ejmech.2021.113739_bib31","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10495-007-0089-1","article-title":"Mitochondrion-mediated apoptosis induced by Rana grylio virus infection in fish cells","volume":"12","author":"Huang","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejmech.2021.113739_bib32","doi-asserted-by":"crossref","first-page":"104672","DOI":"10.1016\/j.antiviral.2019.104672","article-title":"Inhibition of a novel coumarin on an aquatic rhabdovirus by targeting the early stage of viral infection demonstrates potential application in aquaculture","volume":"174","author":"Liu","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib33","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.antiviral.2017.06.007","article-title":"Evaluation on antiviral activity of coumarin derivatives against spring viraemia of carp virus in epithelioma papulosum cyprini cells","volume":"144","author":"Liu","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib34","doi-asserted-by":"crossref","first-page":"735349","DOI":"10.1016\/j.aquaculture.2020.735349","article-title":"Therapeutic potential of phenylpropanoid-based small molecules as anti-SVCV agents in aquaculture","volume":"526","author":"Song","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.ejmech.2021.113739_bib35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tibs.2004.09.009","article-title":"Instant decisions: transcription-independent control of death-receptor-mediated apoptosis","volume":"29","author":"Tran","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejmech.2021.113739_bib36","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.fsi.2017.12.035","article-title":"Magnolol protects Ctenopharyngodon idella kidney cells from apoptosis induced by grass carp reovirus","volume":"74","author":"Chen","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.ejmech.2021.113739_bib37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3390\/molecules21020249","article-title":"Synthesis and characterization of some new coumarins with in\u00a0vitro antitumor and antioxidant activity and high protective effects against DNA damage","volume":"21","author":"Salem","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2021.113739_bib38","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1080\/14786419.2016.1149705","article-title":"New coumarin derivatives from Ferula pseudalliacea with antibacterial activity","volume":"30","author":"Dastan","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib39","doi-asserted-by":"crossref","first-page":"1700199","DOI":"10.1002\/ardp.201700199","article-title":"Synthesis, antitumor activity evaluation, and DNA-binding study of coumarin-based agents","volume":"351","author":"Amin","year":"2018","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ejmech.2021.113739_bib40","doi-asserted-by":"crossref","first-page":"734558","DOI":"10.1016\/j.aquaculture.2019.734558","article-title":"Potential prospect of a therapeutic agent against spring viraemia of carp virus in aquaculture","volume":"515","author":"Qiu","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.ejmech.2021.113739_bib41","doi-asserted-by":"crossref","first-page":"735412","DOI":"10.1016\/j.aquaculture.2020.735412","article-title":"Rhabdoviral clearance effect of a phenylpropanoid medicine against spring viremia of carp virus infection in\u00a0vitro and in\u00a0vivo","volume":"526","author":"Song","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.ejmech.2021.113739_bib42","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.fsi.2018.09.054","article-title":"Antiviral effect of 7-(4-benzimidazole-butoxy)-coumarin on rhabdoviral clearance via nrf-2 activation regulated by pkc\u03b1\/\u03b2 phosphorylation","volume":"83","author":"Liu","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.ejmech.2021.113739_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.virusres.2019.01.008","article-title":"Evaluation on the antiviral activity of ribavirin against infectious hematopoietic necrosis virus in epithelioma papulosum cyprini cells","volume":"263","author":"Hu","year":"2019","journal-title":"Virus Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib44","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1631\/jzus.B1900027","article-title":"Isolation and characterization of a novel strain (YH01) of Micropterus salmoides rhabdovirus and expression of its glycoprotein by the baculovirus expression system","volume":"20","author":"Lyu","year":"2019","journal-title":"J.\u00a0Zhejiang. Uni. Sci. B."},{"key":"10.1016\/j.ejmech.2021.113739_bib45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.24272\/j.issn.2095-8137.2021.056","article-title":"Potential aquatic environmental risks of trifloxystrobin: enhancement of virus susceptibility in zebrafish through initiation of autophagy","volume":"42","author":"Wang","year":"2021","journal-title":"Zool. Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib46","doi-asserted-by":"crossref","first-page":"198019","DOI":"10.1016\/j.virusres.2020.198019","article-title":"Evaluation on antiviral activity of a novel arctigenin derivative against multiple rhabdoviruses in aquaculture","volume":"285","author":"Shen","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib47","doi-asserted-by":"crossref","first-page":"736694","DOI":"10.1016\/j.aquaculture.2021.736694","article-title":"Immune responses and protective efficacy on 4-(2-methoxyphenyl)-3,4-dihydro-2h-chromeno[4,3-d] pyrimidine-2,5 (1h)-dione against spring viremia of carp virus in\u00a0vivo","volume":"540","author":"Song","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.ejmech.2021.113739_bib48","doi-asserted-by":"crossref","first-page":"197741","DOI":"10.1016\/j.virusres.2019.197741","article-title":"Ursolic acid from prunella vulgaris l. efficiently inhibits IHNV infection in\u00a0vitro and in\u00a0vivo","volume":"273","author":"Li","year":"2019","journal-title":"Virus Res."},{"key":"10.1016\/j.ejmech.2021.113739_bib49","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.3390\/ijms17081315","article-title":"De novo transcriptome analysis of differential functional gene expression in largemouth bass (micropterus salmoides) after challenge with nocardia seriolae","volume":"17","author":"Omkar","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2021.113739_bib50","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using realtime quantitative PCR and the 2- \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421005882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421005882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:34:25Z","timestamp":1759329265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421005882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":50,"alternative-id":["S0223523421005882"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113739","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of novel coumarin derivatives in rhabdoviral clearance","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113739","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113739"}}