{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:40:09Z","timestamp":1792813209714,"version":"4.5.0"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["E22107"],"award-info":[{"award-number":["E22107"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2019JJ50145"],"award-info":[{"award-number":["2019JJ50145"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21877034"],"award-info":[{"award-number":["21877034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003602"],"award-info":[{"award-number":["82003602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ejmech.2021.113837","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T12:54:18Z","timestamp":1631105658000},"page":"113837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":194,"special_numbering":"C","title":["Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation"],"prefix":"10.1016","volume":"226","author":[{"given":"Yichao","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113837_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejmech.2018.10.037","article-title":"Research advances on anticancer activities of matrine and its derivatives: an updated overview","volume":"161","author":"Rashid","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104163","article-title":"Recent advancements of coumarin-based anticancer agents: an up-to-date review","volume":"103","author":"Al-Warhi","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112356","article-title":"Resveratrol - a comprehensive review of recent advances in anticancer drug design and development","volume":"200","author":"Ahmadi","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111700","article-title":"1,2,3-Triazole-containing hybrids as potential anticancer agents: current developments, action mechanisms and structure-activity relationships","volume":"183","author":"Xu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112526","article-title":"Pluronic-based nanovehicles: recent advances in anticancer therapeutic applications","volume":"206","author":"Jarak","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112044","article-title":"Artemisinin-derived hybrids and their anticancer activity","volume":"188","author":"Gao","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2021.113837_bib7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2174\/1568026616666160530152546","article-title":"Benzothiazole derivatives as potential anti-infective agents","volume":"17","author":"Sharma","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejmech.2018.08.002","article-title":"Pyrrole: an insight into recent pharmacological advances with structure activity relationship","volume":"157","author":"Ahmad","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2021.113837_bib9","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1021\/jm4016284","article-title":"Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility","volume":"57","author":"Cao","year":"2014","journal-title":"J.\u00a0Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2021.113837_bib10","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3390\/molecules25030598","article-title":"A\u00a0promising anti-inflammatory scaffold: structure, activity, and drug likeness analysis","volume":"25","author":"Feng","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2021.113837_bib11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ejmech.2019.04.043","article-title":"Antibacterial activity study of 1,2,4-triazole derivatives","volume":"173","author":"Gao","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112714","article-title":"Discovery and optimization of benzenesulfonamides-based hepatitis B virus capsid modulators via contemporary medicinal chemistry strategies","volume":"206","author":"Ren","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejmech.2019.01.017","article-title":"Quinolone hybrids and their anti-cancer activities: an overview","volume":"165","author":"Gao","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112953","article-title":"2-Aminothiazole: a privileged scaffold for the discovery of anti-cancer agents","volume":"210","author":"Wan","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2021.113837_bib15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2174\/1871520617666171103140749","article-title":"Recent development of sulfonyl or sulfonamide hybrids as potential anticancer agents: a key review","volume":"18","author":"Rakesh","year":"2018","journal-title":"Anticanc. Agents Med Chem"},{"issue":"3","key":"10.1016\/j.ejmech.2021.113837_bib16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/cmdc.201200585","article-title":"3rd Carboxylic acid (bio)isosteres in drug design","volume":"8","author":"Ballatore","year":"2013","journal-title":"ChemMedChem"},{"issue":"6","key":"10.1016\/j.ejmech.2021.113837_bib17","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/cbdd.13043","article-title":"N-acylsulfonamides: synthetic routes and biological potential in medicinal chemistry","volume":"90","author":"Ammazzalorso","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"issue":"23","key":"10.1016\/j.ejmech.2021.113837_bib18","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1016\/j.bmcl.2012.10.003","article-title":"Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase\/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: optimization of physical properties leading to antibacterial aryl sulfonamides","volume":"22","author":"Stokes","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"7","key":"10.1016\/j.ejmech.2021.113837_bib19","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.bmcl.2015.01.026","article-title":"Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives","volume":"25","author":"Konda","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2021.113837_bib20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bioorg.2016.12.007","article-title":"Synthesis, characterization, in\u00a0vitro cytotoxicity and antimicrobial investigation and evaluation of physicochemical properties of novel 4-(2-methylacetamide)benzenesulfonamide derivatives","volume":"70","author":"Durgun","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.ejmech.2013.03.012","article-title":"Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides","volume":"64","author":"Lal","year":"2013","journal-title":"Eur. J. Med. Chem."},{"issue":"17","key":"10.1016\/j.ejmech.2021.113837_bib22","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1016\/j.bmc.2013.05.043","article-title":"Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury","volume":"21","author":"Ning","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.molstruc.2016.03.066","article-title":"Synthesis, antioxidant, enzyme inhibition and DNA binding studies of novel N-benzylated derivatives of sulphonamide","volume":"1117","author":"Abbas","year":"2016","journal-title":"J.\u00a0Mol. Struct."},{"issue":"15","key":"10.1016\/j.ejmech.2021.113837_bib24","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1016\/j.bmc.2013.05.029","article-title":"Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors","volume":"21","author":"Chandna","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"15","key":"10.1016\/j.ejmech.2021.113837_bib25","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1016\/j.bmcl.2016.06.037","article-title":"Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis","volume":"26","author":"Lu","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"12","key":"10.1016\/j.ejmech.2021.113837_bib26","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.1016\/j.ejmech.2011.08.015","article-title":"Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents","volume":"46","author":"Bano","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejmech.2013.12.042","article-title":"Synthesis of 2-{2-[(\u03b1\/\u03b2-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11\u03b2-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities","volume":"74","author":"Navarrete-V\u00e1zquez","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bioorg.2017.11.010","article-title":"Design, synthesis and molecular docking of thiazolidinedione based benzene sulphonamide derivatives containing pyrazole core as potential anti-diabetic agents","volume":"76","author":"Naim","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejmech.2016.08.060","article-title":"Biological evaluation of some new N-(2,6-dimethoxypyrimidinyl) thioureido benzenesulfonamide derivatives as potential antimicrobial and anticancer agents","volume":"124","author":"Ghorab","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2021.113837_bib30","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.bmcl.2017.03.018","article-title":"Synthesis and anti-cancer activities of new sulfonamides 4-substituted-triazolyl nucleosides","volume":"27","author":"Alaoui","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"21","key":"10.1016\/j.ejmech.2021.113837_bib31","doi-asserted-by":"crossref","first-page":"12460","DOI":"10.1021\/acs.jmedchem.0c00830","article-title":"Thirty years of HDAC inhibitors: 2020 insight and hindsight","volume":"63","author":"Ho","year":"2020","journal-title":"J.\u00a0Med. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2021.113837_bib32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd.2016.253","article-title":"From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors","volume":"16","author":"Ashkenazi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.ejmech.2021.113837_bib33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/acs.jmedchem.5b01888","article-title":"Expanding the cancer arsenal with targeted therapies: disarmament of the antiapoptotic Bcl-2 proteins by small molecules","volume":"60","author":"Yap","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2021.113837_bib34","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0145-2126(86)90331-0","article-title":"A\u00a0review","volume":"10","author":"Cassileth","year":"1986","journal-title":"Leuk. Res."},{"key":"10.1016\/j.ejmech.2021.113837_bib35","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejmech.2018.11.017","article-title":"Pharmaceutical and medicinal significance of sulfur (S(VI))-Containing motifs for drug discovery: a critical review","volume":"162","author":"Zhao","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib36","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejmech.2017.05.041","article-title":"Combating breast cancer with non-steroidal aromatase inhibitors (NSAIs): understanding the chemico-biological interactions through comparative SAR\/QSAR study","volume":"137","author":"Adhikari","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112845","article-title":"Effective anti-aromatase therapy to battle against estrogen-mediated breast cancer: comparative SAR\/QSAR assessment on steroidal aromatase inhibitors","volume":"208","author":"Adhikari","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ejmech.2015.08.010","article-title":"Shagufta Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer","volume":"102","author":"Ahmad","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2021.113837_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1530\/ERC-13-0099","article-title":"Aromatase inhibition 2013: clinical state of the art and questions that remain to be solved","volume":"20","author":"L\u00f8nning","year":"2013","journal-title":"Endocr. Relat. Canc."},{"key":"10.1016\/j.ejmech.2021.113837_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsbmb.2016.03.019","article-title":"Unravelling exemestane: from biology to clinical prospects","volume":"163","author":"Sobral","year":"2016","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"issue":"5","key":"10.1016\/j.ejmech.2021.113837_bib41","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1200\/JCO.2006.08.8617","article-title":"Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98","volume":"25","author":"Coates","year":"2007","journal-title":"J.\u00a0Clin. Oncol."},{"issue":"17","key":"10.1016\/j.ejmech.2021.113837_bib42","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/jnci\/djr242","article-title":"Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: a systematic review and meta-analysis","volume":"103","author":"Amir","year":"2011","journal-title":"J.\u00a0Natl. Cancer Inst."},{"issue":"13","key":"10.1016\/j.ejmech.2021.113837_bib43","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1016\/j.bmc.2015.04.036","article-title":"Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors","volume":"23","author":"Pingaew","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103327","article-title":"Novel triazole-tetrahydroisoquinoline hybrids as human aromatase inhibitors","volume":"93","author":"Chamduang","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2021.113837_bib45","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jinorgbio.2009.10.011","article-title":"Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors","volume":"104","author":"Rahman","year":"2010","journal-title":"J.\u00a0Inorg. Biochem."},{"issue":"13","key":"10.1016\/j.ejmech.2021.113837_bib46","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1016\/j.bmcl.2016.04.078","article-title":"Synthesis and biological characterization of 3-(imidazole-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors","volume":"26","author":"Di Matteo","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"2","key":"10.1016\/j.ejmech.2021.113837_bib47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/abio.2000.4729","article-title":"A\u00a0high-throughput screen to identify inhibitors of aromatase (CYP19)","volume":"284","author":"Stresser","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2021.113837_bib48","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ejmech.2016.10.020","article-title":"Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers","volume":"124","author":"Ghorab","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib49","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ejmech.2017.04.028","article-title":"Aromatase inhibitors and apoptotic inducers: design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules","volume":"134","author":"Ghorab","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib50","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.ejmech.2017.10.057","article-title":"Synthesis, molecular docking, and QSAR study of sulfonamide-based indoles as aromatase inhibitors","volume":"143","author":"Pingaew","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"19","key":"10.1016\/j.ejmech.2021.113837_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.08.001","article-title":"Synthesis, molecular docking, and QSAR study of bis-sulfonamide derivatives as potential aromatase inhibitors","volume":"27","author":"Leechaisit","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111691","article-title":"A\u00a0privileged scaffold for the design of anti-cancer agents","volume":"183","author":"Wan","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111815","article-title":"Synthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors","volume":"185","author":"Fantacuzzi","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2021.113837_bib54","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.canlet.2013.01.042","article-title":"Microenvironment and tumor cell plasticity: an easy way out","volume":"341","author":"Taddei","year":"2013","journal-title":"Canc. Lett."},{"issue":"12","key":"10.1016\/j.ejmech.2021.113837_bib55","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00109-007-0281-3","article-title":"Hypoxia and cancer","volume":"85","author":"Brahimi-Horn","year":"2007","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"issue":"2","key":"10.1016\/j.ejmech.2021.113837_bib56","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"issue":"10","key":"10.1016\/j.ejmech.2021.113837_bib57","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","article-title":"Interfering with pH regulation in tumours as a therapeutic strategy","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.ejmech.2021.113837_bib58","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","article-title":"Structure-based drug discovery of carbonic anhydrase inhibitors","volume":"27","author":"Supuran","year":"2012","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib59","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejmech.2016.01.030","article-title":"Amido\/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar\/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII","volume":"110","author":"Eldehna","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib60","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejmech.2017.07.073","article-title":"Novel 4\/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies","volume":"139","author":"Eldehna","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib61","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bioorg.2018.09.007","article-title":"Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in\u00a0vitro antitumor activity towards colon cancer","volume":"81","author":"Eldehna","year":"2018","journal-title":"Bioorg. Chem."},{"issue":"14","key":"10.1016\/j.ejmech.2021.113837_bib62","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1016\/j.bmc.2017.05.029","article-title":"Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases","volume":"25","author":"Karal\u0131","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib63","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.bioorg.2018.01.021","article-title":"New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors","volume":"77","author":"Gul","year":"2018","journal-title":"Bioorg. Chem."},{"issue":"46","key":"10.1016\/j.ejmech.2021.113837_bib64","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.1002\/anie.201004437","article-title":"Combining independent drug classes into superior, synergistically acting hybrid molecules","volume":"49","author":"M\u00fcller-Schiffmann","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2021.113837_bib65","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejmech.2018.05.034","article-title":"Synthesis, characterization and biological evaluation of tertiary sulfonamide derivatives of pyridyl-indole based heteroaryl chalcone as potential carbonic anhydrase IX inhibitors and anticancer agents","volume":"155","author":"Peerzada","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"23","key":"10.1016\/j.ejmech.2021.113837_bib66","doi-asserted-by":"crossref","first-page":"10860","DOI":"10.1021\/acs.jmedchem.8b01504","article-title":"4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced antiproliferative profiles","volume":"61","author":"Nocentini","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib67","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bioorg.2017.10.005","article-title":"Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic hCA II and membrane-bound hCA IX isoforms","volume":"76","author":"Krasavin","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib68","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejmech.2018.12.049","article-title":"Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment","volume":"164","author":"Krasavin","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2021.113837_bib69","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1021\/acs.jmedchem.6b00443","article-title":"An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition, and protein X-ray structures of psammaplin C","volume":"59","author":"Mujumdar","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"issue":"8","key":"10.1016\/j.ejmech.2021.113837_bib70","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1021\/acs.jmedchem.9b00282","article-title":"Carbonic anhydrase XII inhibitors overcome Temozolomide resistance in glioblastoma","volume":"62","author":"Mujumdar","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111702","article-title":"Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies","volume":"183","author":"Zengin Kurt","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2021.113837_bib72","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1021\/acs.jmedchem.9b01669","article-title":"A\u00a0sweet combination\": developing Saccharin and Acesulfame K structures for selectively targeting the tumor-associated carbonic anhydrases IX and XII","volume":"63","author":"Bua","year":"2020","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.112021","article-title":"Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases","volume":"188","author":"Khalil","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.112019","article-title":"Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: design, synthesis, and in\u00a0vitro biological evaluation","volume":"189","author":"Said","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103754","article-title":"Synthesis and SAR studies of novel 1,2,4-oxadiazole-sulfonamide based compounds as potential anticancer agents for colorectal cancer therapy","volume":"98","author":"Shamsi","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104237","article-title":"Design, synthesis and biological evaluation of novel carbohydrate-based sulfonamide derivatives as antitumor agents","volume":"104","author":"Hao","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113283","article-title":"Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors","volume":"216","author":"Shaldam","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113360","article-title":"Identification of N-phenyl-2-(phenylsulfonyl)acetamides\/propanamides as new SLC-0111 analogues: synthesis and evaluation of the carbonic anhydrase inhibitory activities","volume":"218","author":"Elbadawi","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113038","article-title":"Development of Mcl-1 inhibitors for cancer therapy","volume":"210","author":"Negi","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2021.113837_bib80","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/cdd.2015.50","article-title":"The BCL-2 protein family, BH3-mimetics and cancer therapy","volume":"22","author":"Delbridge","year":"2015","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.ejmech.2021.113837_bib81","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","article-title":"ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor","volume":"68","author":"Tse","year":"2008","journal-title":"Canc. Res"},{"issue":"2","key":"10.1016\/j.ejmech.2021.113837_bib82","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nm.3048","article-title":"ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets","volume":"19","author":"Souers","year":"2013","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.ejmech.2021.113837_bib83","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1158\/1535-7163.MCT-12-0767","article-title":"A\u00a0novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in\u00a0vitro and in\u00a0vivo","volume":"13","author":"Abulwerdi","year":"2014","journal-title":"Mol. Canc. Therapeut."},{"issue":"11","key":"10.1016\/j.ejmech.2021.113837_bib84","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1158\/0008-5472.CAN-07-6590","article-title":"276, an antagonist against Bcl-2 proteins, overcomes drug resistance and suppresses prostate tumor growth","volume":"68","author":"Wang","year":"2008","journal-title":"Canc. Res"},{"issue":"24","key":"10.1016\/j.ejmech.2021.113837_bib85","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.1016\/j.bmc.2015.11.014","article-title":"Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors","volume":"23","author":"Wan","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2021.113837_bib86","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bmc.2016.10.020","article-title":"Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains","volume":"25","author":"Wan","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.ejmech.2021.113837_bib87","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.bmc.2017.02.014","article-title":"Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2\/Mcl-1 dual inhibitors","volume":"25","author":"Liu","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"20","key":"10.1016\/j.ejmech.2021.113837_bib88","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1016\/j.bmc.2017.08.024","article-title":"1-Phenyl-1H-indole derivatives as a new class of Bcl-2\/Mcl-1 dual inhibitors: design, synthesis, and preliminary biological evaluation","volume":"25","author":"Xu","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"13","key":"10.1016\/j.ejmech.2021.113837_bib89","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1016\/j.bmc.2019.05.003","article-title":"Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2\/Mcl-1 dual inhibitors","volume":"27","author":"Chen","year":"2019","journal-title":"Bioorg. Med. Chem."},{"issue":"17","key":"10.1016\/j.ejmech.2021.113837_bib90","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1016\/j.bmc.2018.08.030","article-title":"Discovery and development of substituted tyrosine derivatives as Bcl-2\/Mcl-1 inhibitors","volume":"26","author":"Liu","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112142","article-title":"Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors","volume":"191","author":"Liu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.102938","article-title":"Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2\/Mcl-1 inhibitors","volume":"88","author":"Liu","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104217","article-title":"Discovery of novel indazole-acylsulfonamide hybrids as selective Mcl-1 inhibitors","volume":"104","author":"Wan","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2021.113837_bib94","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1021\/jm501258m","article-title":"Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity","volume":"58","author":"Bruncko","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2021.113837_bib95","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1021\/acs.jmedchem.9b00455","article-title":"From inhibition to degradation: targeting the antiapoptotic protein myeloid cell leukemia 1 (MCL1)","volume":"62","author":"Papatzimas","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2021.113837_bib96","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1021\/acs.jmedchem.5b01660","article-title":"Discovery of 2-Indole-acylsulfonamide myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods","volume":"59","author":"Pelz","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"issue":"24","key":"10.1016\/j.ejmech.2021.113837_bib97","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1039\/C5OB02063H","article-title":"Structure-based design of 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines as inhibitors of myeloid cell leukemia-1 (Mcl-1)","volume":"14","author":"Chen","year":"2016","journal-title":"Org. Biomol. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2021.113837_bib98","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1021\/jm301448p","article-title":"Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design","volume":"56","author":"Friberg","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2021.113837_bib99","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201600251","article-title":"Fragment-based design, synthesis, and biological evaluation of 1-Substituted-indole-2-carboxylic acids as selective mcl-1 inhibitors","volume":"350","author":"Wang","year":"2017","journal-title":"Arch. Pharm. (Weinheim)"},{"issue":"12","key":"10.1016\/j.ejmech.2021.113837_bib100","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1158\/2159-8290.CD-18-0387","article-title":"AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies","volume":"8","author":"Caenepeel","year":"2018","journal-title":"Canc. Discov."},{"issue":"2","key":"10.1016\/j.ejmech.2021.113837_bib101","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bmc.2017.12.001","article-title":"Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors","volume":"26","author":"Liu","year":"2018","journal-title":"Bioorg. Med. Chem."},{"issue":"16","key":"10.1016\/j.ejmech.2021.113837_bib102","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.bmcl.2019.06.008","article-title":"Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors","volume":"29","author":"Follows","year":"2019","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2021.113837_bib103","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejmech.2019.03.034","article-title":"A\u00a0comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade","volume":"171","author":"Liang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2021.113837_bib104","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1080\/14756366.2020.1821676","article-title":"DNA topoisomerases as molecular targets for anticancer drugs","volume":"35","author":"Buzun","year":"2020","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103725","article-title":"Synthesis, anticancer evaluation and molecular docking studies of new heterocycles linked to sulfonamide moiety as novel human topoisomerase types I and II poisons","volume":"98","author":"Halawa","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"14","key":"10.1016\/j.ejmech.2021.113837_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127246","article-title":"Synthesis and evaluation of novel sulfonamide analogues of 6\/7-aminoflavones as anticancer agents via topoisomerase II inhibition","volume":"30","author":"Shelke","year":"2020","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2021.113837_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111718","article-title":"Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer","volume":"183","author":"Elmenier","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113729","article-title":"PI3K\/AKT\/mTOR signaling as a molecular target in head and neck cancer","volume":"172","author":"Marquard","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113837_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103737","article-title":"Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors","volume":"98","author":"Jin","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"20","key":"10.1016\/j.ejmech.2021.113837_bib110","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1016\/j.bmc.2017.09.025","article-title":"Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474","volume":"25","author":"Gamage","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.ejmech.2021.113837_bib111","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1021\/acs.jmedchem.9b01736","article-title":"Design, synthesis, and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3K\/mTOR dual inhibitors","volume":"63","author":"Yu","year":"2020","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib112","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ejmech.2017.07.020","article-title":"Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation","volume":"138","author":"Huang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib113","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejmech.2017.04.037","article-title":"Design and synthesis of sulfonamide-substituted diphenylpyrimidines (SFA-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B-cell lymphoblastic leukemia","volume":"135","author":"Liu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2021.113837_bib114","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1021\/acs.jmedchem.7b01474","article-title":"Quinazolinone-based anticancer agents: synthesis, antiproliferative SAR, antitubulin activity, and tubulin Co-crystal structure","volume":"61","author":"Dohle","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib115","article-title":"Novel tertiary sulfonamide derivatives containing benzimidazole moiety as potent anti-gastric cancer agents: design, synthesis and SAR studies","volume":"183","author":"Jian","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2021.113837_bib116","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/acs.jmedchem.9b01659","article-title":"Discovery and optimization of small molecules targeting the protein-protein interaction of heat shock protein 90 (Hsp90) and cell division cycle 37 as orally active inhibitors for the treatment of colorectal cancer","volume":"63","author":"Wang","year":"2020","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103766","article-title":"Design, synthesis, and evaluations of the antiproliferative activity and aqueous solubility of novel carbazole sulfonamide derivatives as antitumor agents","volume":"99","author":"Sun","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112181","article-title":"Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents","volume":"191","author":"Liu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103808","article-title":"New tranylcypromine derivatives containing sulfonamide motif as potent LSD1 inhibitors to target acute myeloid leukemia: design, synthesis and biological evaluation","volume":"99","author":"Liang","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"13","key":"10.1016\/j.ejmech.2021.113837_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115525","article-title":"Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA\/B) inhibitors: synthesis, biological evaluation and in silico insights","volume":"28","author":"Al-Sanea","year":"2020","journal-title":"Bioorg. Med. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2021.113837_bib121","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1021\/acs.jmedchem.0c00932","article-title":"Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c] quinoline-8-sulfonamide as a potent dual MDM2\/XIAP inhibitor","volume":"64","author":"Wu","year":"2021","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113837_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113362","article-title":"Discovery of N-substituted sulfamoylbenzamide derivatives as novel inhibitors of STAT3 signaling pathway based on Niclosamide","volume":"218","author":"Wang","year":"2021","journal-title":"Eur. J. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421006863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421006863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:30:25Z","timestamp":1759329025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421006863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":122,"alternative-id":["S0223523421006863"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113837","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113837","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113837"}}