{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:23:11Z","timestamp":1791638591709,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.ejmech.2021.113897","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T23:24:21Z","timestamp":1633476261000},"page":"113897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR"],"prefix":"10.1016","volume":"227","author":[{"given":"Jun","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingshu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113897_bib1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41580-018-0009-y","article-title":"Microtubule dynamics: an interplay of biochemistry and mechanics","volume":"19","author":"Brouhard","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2021.113897_bib2","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.1002\/jcp.27978","article-title":"Microtubules: from understanding their dynamics to using them as potential therapeutic targets","volume":"234","author":"Ilan","year":"2019","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.ejmech.2021.113897_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejmech.2019.03.025","article-title":"Anti-tubulin agents of natural origin: targeting taxol, vinca, and colchicine binding domains","volume":"171","author":"Naaz","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib4","doi-asserted-by":"crossref","first-page":"112110","DOI":"10.1016\/j.ejmech.2020.112110","article-title":"Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents","volume":"190","author":"Hamze","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib5","doi-asserted-by":"crossref","first-page":"112873","DOI":"10.1016\/j.ejmech.2020.112873","article-title":"Cyclic bridged analogs of isoCA-4: design, synthesis and biological evaluation","volume":"209","author":"Pecnard","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib6","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.1021\/acs.jmedchem.6b00463","article-title":"Blocking blood flow to solid tumors by destabilizing tubulin: an approach to targeting tumor growth","volume":"59","author":"P\u00e9rez-P\u00e9rez","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib7","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1016\/j.bmc.2009.09.044","article-title":"Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: structure-based discovery of alpha-aryl chalcones","volume":"17","author":"Ducki","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1573409915666181221114107","article-title":"Towards further understanding the structural requirements of combretastatin- like chalcones as inhibitors of microtubule polymerization","volume":"16","author":"Naveen","year":"2020","journal-title":"Curr. Comput. Aided Drug Des."},{"key":"10.1016\/j.ejmech.2021.113897_bib9","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1021\/acs.jnatprod.0c00699","article-title":"Natural and semisynthetic chalcones as dual FLT3 and microtubule polymerization inhibitors","volume":"83","author":"Malik","year":"2020","journal-title":"J.\u00a0Nat Prod."},{"key":"10.1016\/j.ejmech.2021.113897_bib10","doi-asserted-by":"crossref","first-page":"103565","DOI":"10.1016\/j.bioorg.2019.103565","article-title":"Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors","volume":"95","author":"Wang","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib11","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1021\/acs.molpharmaceut.8b00359","article-title":"An indole\u2013chalcone inhibits multidrug-resistant cancer cell growth by targeting microtubules","volume":"15","author":"Cong","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejmech.2021.113897_bib12","doi-asserted-by":"crossref","first-page":"41510","DOI":"10.1039\/C4RA07998A","article-title":"The convenient aqueous synthesis and biological evaluation of ortho-(3,4,5-trimethoxybenzoyl)-acetanilides as novel anti-cancer agents","volume":"4","author":"Sheng","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2021.113897_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bcp.2015.07.008","article-title":"A\u00a0novel synthetic compound exerts effective anti-tumour activity in\u00a0vivo via the inhibition of tubulin polymerisation in A549 cells","volume":"97","author":"Yan","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113897_bib14","doi-asserted-by":"crossref","first-page":"98527","DOI":"10.1039\/C5RA19270F","article-title":"Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents","volume":"5","author":"Yan","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2021.113897_bib15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ejmech.2016.09.056","article-title":"Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization","volume":"125","author":"Yan","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib16","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1039\/C5MD00139K","article-title":"Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents","volume":"6","author":"Hu","year":"2015","journal-title":"Med. Chem. Comm."},{"key":"10.1016\/j.ejmech.2021.113897_bib17","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1039\/C6OB02507B","article-title":"Synthesis, in\u00a0vitro and in\u00a0vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors","volume":"15","author":"An","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib18","doi-asserted-by":"crossref","first-page":"88453","DOI":"10.1039\/C6RA16948A","article-title":"The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors","volume":"6","author":"Zhang","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2021.113897_bib19","doi-asserted-by":"crossref","first-page":"173975","DOI":"10.1016\/j.ejphar.2021.173975","article-title":"MIL-1, a novel antitumor agent derived from natural product millepachine, acts as tubulin polymerization inhibitor for the treatment of hepatocellular carcinoma","volume":"898","author":"Yan","year":"2021","journal-title":"Eur. J. Pharmocol."},{"key":"10.1016\/j.ejmech.2021.113897_bib20","doi-asserted-by":"crossref","first-page":"68128","DOI":"10.1039\/C5RA14888J","article-title":"Synthesis, biological evaluation and mechanism study of chalcone analogues as novel anti-cancer agents","volume":"5","author":"Chen","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2021.113897_bib21","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1021\/acs.jmedchem.6b00021","article-title":"Synthesis, evaluation, and mechanism study of novel indole-chalcone derivatives exerting effective antitumor activity through microtubule destabilization in\u00a0vitro and in\u00a0vivo","volume":"59","author":"Yan","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib22","doi-asserted-by":"crossref","first-page":"7404","DOI":"10.1039\/C7OB01655G","article-title":"Synthesis and evaluation of selenium-containing indole chalcone and diarylketone derivatives as tubulin polymerization inhibition agents","volume":"15","author":"Zhang","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib23","doi-asserted-by":"crossref","first-page":"7300","DOI":"10.1021\/acs.jmedchem.7b00480","article-title":"Design, synthesis, and biological evaluation of novel selenium-containing isocombretastatins and phenstatins as antitumor agents","volume":"60","author":"Pang","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib24","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1021\/acs.jmedchem.8b00128","article-title":"Synthesis and biological evaluation of selenium-containing 4-anilinoquinazoline derivatives as novel antimitotic agents","volume":"61","author":"An","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib25","doi-asserted-by":"crossref","first-page":"111670","DOI":"10.1016\/j.ejmech.2019.111670","article-title":"Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in\u00a0vitro and in\u00a0vivo","volume":"182","author":"Pang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib26","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ejmech.2015.03.030","article-title":"Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents","volume":"95","author":"Yan","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2021.113897_bib28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.oraloncology.2011.05.006","article-title":"Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue","volume":"47","author":"Zhu","year":"2011","journal-title":"Oral Oncol."},{"key":"10.1016\/j.ejmech.2021.113897_bib29","doi-asserted-by":"crossref","first-page":"120054","DOI":"10.1016\/j.biomaterials.2020.120054","article-title":"Anti-recurrence\/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system","volume":"249","author":"Yang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2021.113897_bib30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/13543776.2017.1272576","article-title":"Thioredoxin reductase inhibitors: a patent review","volume":"27","author":"Zhang","year":"2017","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2021.113897_bib31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.freeradbiomed.2018.05.081","article-title":"Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic","volume":"127","author":"Ren","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2021.113897_bib32","doi-asserted-by":"crossref","first-page":"9461","DOI":"10.1074\/jbc.RA117.001658","article-title":"The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in \u03b2-tubulin","volume":"293","author":"Yang","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2021.113897_bib33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00280-019-03869-4","article-title":"The role of thioredoxin system in cancer: strategy for cancer therapy","volume":"84","author":"Jia","year":"2019","journal-title":"Cancer Chemother. Pharmacol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421007467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421007467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:31:16Z","timestamp":1759329076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421007467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":33,"alternative-id":["S0223523421007467"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113897","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113897","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113897"}}