{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T23:54:39Z","timestamp":1794614079410,"version":"4.9.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR202103040702"],"award-info":[{"award-number":["ZR202103040702"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3072021CFT1004"],"award-info":[{"award-number":["3072021CFT1004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.ejmech.2021.113977","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T01:41:47Z","timestamp":1636335707000},"page":"113977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Synthesis and bioactivities of new N-terminal dipeptide mimetics with aromatic amide moiety: Broad-spectrum antibacterial activity and high antineoplastic activity"],"prefix":"10.1016","volume":"228","author":[{"given":"Huan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2181-747X","authenticated-orcid":false,"given":"Lijia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5449-9642","authenticated-orcid":false,"given":"Toshifumi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.113977_bib1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jinf.2012.10.028","article-title":"Predictors of mortality in patients with infections due to multi-drug resistant Gram negative bacteria: the study, the patient, the bug or the drug?","volume":"66","author":"Vardakas","year":"2013","journal-title":"J.\u00a0Infect."},{"key":"10.1016\/j.ejmech.2021.113977_bib2","doi-asserted-by":"crossref","first-page":"N82","DOI":"10.1097\/00003246-200104001-00005","article-title":"Impact of Gram-positive resistance on outcome of nosocomial pneumonia","volume":"29","author":"Bodi","year":"2001","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejmech.2021.113977_bib3","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1039\/c0cc05111j","article-title":"Molecular mechanisms of antibiotic resistance","volume":"47","author":"Wright","year":"2011","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113977_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3949\/ccjm.80a.12182","article-title":"Carbapenem-resistant Enterobacteriaceae: a menace to our most vulnerable patients","volume":"80","author":"Perez","year":"2013","journal-title":"Cleve. Clin. J. Med."},{"key":"10.1016\/j.ejmech.2021.113977_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cnsns.2020.105279","article-title":"Dynamics and control of multidrug-resistant bacterial infection in hospital with multiple delays","volume":"89","author":"Das","year":"2020","journal-title":"Commun. Nonlinear. Sci."},{"key":"10.1016\/j.ejmech.2021.113977_bib6","article-title":"Surface modification approaches for prevention of implant associated infections","volume":"193","author":"Ahmadabadi","year":"2020","journal-title":"Colloids Surf., A"},{"key":"10.1016\/j.ejmech.2021.113977_bib7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/viru.1.5.12983","article-title":"Antimicrobial peptides the ancient arm of the human immune system","volume":"1","author":"Wiesner","year":"2010","journal-title":"Virulence"},{"key":"10.1016\/j.ejmech.2021.113977_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bcp.2016.09.018","article-title":"Antimicrobial peptides (AMPs): ancient compounds that represent novel weapons in the fight against bacteria","volume":"133","author":"Ageitos","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113977_bib9","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41564-018-0164-0","article-title":"Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides","volume":"3","author":"Lazar","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2021.113977_bib10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2165\/00003495-200363040-00005","article-title":"Antimicrobial peptides - current status and therapeutic potential","volume":"63","author":"Koczulla","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2021.113977_bib11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.coph.2006.04.006","article-title":"Antibacterial peptides for therapeutic use: obstacles and realistic outlook","volume":"6","author":"Marr","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.113977_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12272-012-0302-9","article-title":"Antimicrobial peptides: their physicochemical properties and therapeutic application","volume":"35","author":"Kang","year":"2012","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejmech.2021.113977_bib13","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1021\/ar400066v","article-title":"Designing mimics of membrane active proteins","volume":"46","author":"Sgolastra","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2021.113977_bib14","doi-asserted-by":"crossref","first-page":"6412","DOI":"10.1002\/anie.202000505","article-title":"Poly(2-Oxazoline)-Based functional peptide mimics: eradicating MRSA infections and persisters while alleviating antimicrobial resistance","volume":"59","author":"Zhou","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2021.113977_bib15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/cbic.201900275","article-title":"Targeting PCNA with peptide mimetics for therapeutic purposes","volume":"21","author":"Horsfall","year":"2020","journal-title":"Chembiochem"},{"key":"10.1016\/j.ejmech.2021.113977_bib16","doi-asserted-by":"crossref","first-page":"8521","DOI":"10.1021\/acs.macromol.9b01450","article-title":"Recent advances and future perspectives of synthetic polypeptides from N-carboxyanhydrides","volume":"52","author":"Song","year":"2019","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejmech.2021.113977_bib17","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1021\/bm300342u","article-title":"Cationic spacer arm design strategy for control of antimicrobial activity and conformation of amphiphilic methacrylate random copolymers","volume":"13","author":"Palermo","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejmech.2021.113977_bib18","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1128\/AAC.00530-10","article-title":"Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold","volume":"54","author":"Findlay","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2021.113977_bib19","doi-asserted-by":"crossref","first-page":"12276","DOI":"10.3390\/molecules171012276","article-title":"Antimicrobial peptides for therapeutic applications: a review","volume":"17","author":"Seo","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2021.113977_bib20","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1002\/smll.201303921","article-title":"Overcoming multidrug resistance in microbials using nanostructures self-assembled from cationic bent-core oligomers","volume":"10","author":"Liu","year":"2014","journal-title":"Small"},{"key":"10.1016\/j.ejmech.2021.113977_bib21","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1021\/acs.jmedchem.7b00847","article-title":"Membrane-active hydantoin derivatives as antibiotic agents","volume":"60","author":"Su","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113977_bib22","doi-asserted-by":"crossref","first-page":"11948","DOI":"10.1039\/C7CC07285F","article-title":"Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential","volume":"53","author":"Teng","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2021.113977_bib23","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ejmech.2016.07.068","article-title":"Amphiphilic xanthones as a potent chemical entity of anti-mycobacterial agents with membrane-targeting properties","volume":"123","author":"Koh","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113977_bib24","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1021\/acs.jmedchem.6b01403","article-title":"Symmetrically substituted xanthone amphiphiles combat gram-positive bacterial resistance with enhanced membrane selectivity","volume":"60","author":"Lin","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113977_bib25","first-page":"24","article-title":"Chiral derivatives of xanthones with antimicrobial activity","author":"Araujo","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2021.113977_bib26","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1021\/jm0105070","article-title":"Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics","volume":"45","author":"Ding","year":"2002","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2021.113977_bib27","first-page":"18","article-title":"The microbiome modulating activity of bile acids","author":"Tian","year":"2020","journal-title":"Gut Microb."},{"key":"10.1016\/j.ejmech.2021.113977_bib28","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbagen.2019.05.003","article-title":"Phyto-inspired cyclic peptides derived from plant Pin-II type protease inhibitor reactive center loops for crop protection from insect pests","volume":"1863","author":"Sailthedkar","year":"2019","journal-title":"BBA-Gen Subjects"},{"key":"10.1016\/j.ejmech.2021.113977_bib29","first-page":"10","article-title":"Natural indole-containing alkaloids and their antibacterial activities","author":"Liu","year":"2020","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ejmech.2021.113977_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/jhet.4020","article-title":"Synthesis, biological evaluation, and docking study of a series of 1,4-disubstituted 1,2,3-triazole derivatives with an indole-triazole-peptide conjugate","author":"Suryapeta","year":"2020","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2021.113977_bib31","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00239-007-9045-5","article-title":"Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation","volume":"65","author":"Tennessen","year":"2007","journal-title":"J.\u00a0Mol. Evol."},{"key":"10.1016\/j.ejmech.2021.113977_bib32","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.bbamem.2006.07.001","article-title":"Detergent-like actions of linear amphipathic cationic antimicrobial peptides, Biochim. Biophys","volume":"1758","author":"Bechinger","year":"2006","journal-title":"Acta-Biomembr."},{"key":"10.1016\/j.ejmech.2021.113977_bib33","doi-asserted-by":"crossref","DOI":"10.4161\/onci.29181","article-title":"LTX-315 (Oncopore (TM)) A short synthetic anticancer peptide and novel immunotherapeutic agent","volume":"3","author":"Camilio","year":"2014","journal-title":"OncoImmunology"},{"key":"10.1016\/j.ejmech.2021.113977_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.eururo.2005.12.043","article-title":"Antitumor activity of the antimicrobial peptide Magainin II against bladder cancer cell lines","volume":"50","author":"Lehmann","year":"2006","journal-title":"Eur. Urol."},{"key":"10.1016\/j.ejmech.2021.113977_bib35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/acsinfecdis.5b00056","article-title":"Lysine-based small molecules that disrupt biofilms and kill both actively growing planktonic and nondividing stationary phase bacteria","volume":"1","author":"Konai","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.113977_bib36","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1128\/AAC.43.4.782","article-title":"In\u00a0vitro antibacterial properties of pexiganan, an analog of magainin","volume":"43","author":"Ge","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2021.113977_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800354","article-title":"From antimicrobial peptides to antimicrobial poly(alpha-amino acid)s","volume":"7","author":"Shen","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.ejmech.2021.113977_bib38","doi-asserted-by":"crossref","first-page":"11784","DOI":"10.1002\/chem.200900049","article-title":"Synthetic mimics of antimicrobial peptides-A versatile ring-opening metathesis polymerization based platform for the synthesis of selective antibacterial and cell-penetrating polymers","volume":"15","author":"Lienkamp","year":"2009","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2021.113977_bib39","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0956-7135(02)00026-9","article-title":"Anti-Listeria monocytogenes activity of essential oils components of conifers","volume":"13","author":"Mourey","year":"2002","journal-title":"Food Control"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421008266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523421008266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:35:53Z","timestamp":1759329353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523421008266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":39,"alternative-id":["S0223523421008266"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113977","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and bioactivities of new N-terminal dipeptide mimetics with aromatic amide moiety: Broad-spectrum antibacterial activity and high antineoplastic activity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.113977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113977"}}