{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:13:05Z","timestamp":1790838785553,"version":"4.1.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.ejmech.2021.114099","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T17:08:35Z","timestamp":1641229715000},"page":"114099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial\/antibiofilm activity against MRSA in\u00a0vitro and in\u00a0vivo"],"prefix":"10.1016","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-9759","authenticated-orcid":false,"given":"Xiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoji","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-0374","authenticated-orcid":false,"given":"Weida","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-7807","authenticated-orcid":false,"given":"Haifeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-8606","authenticated-orcid":false,"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-5358","authenticated-orcid":false,"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-6055","authenticated-orcid":false,"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-2258","authenticated-orcid":false,"given":"Hongze","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2021.114099_bib1","doi-asserted-by":"crossref","first-page":"60 e61","DOI":"10.1016\/j.cmi.2015.08.022","article-title":"The population structure of Staphylococcus aureus in China and Europe assessed by multiple-locus variable number tandem repeat analysis; clues to geographical origins of emergence and dissemination","volume":"22","author":"Yan","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.ejmech.2021.114099_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ja.2012.7","article-title":"Activity of sitafloxacin against extracellular and intracellular Staphylococcus aureus in\u00a0vitro and in\u00a0vivo: comparison with levofloxacin and moxifloxacin","volume":"65","author":"Shi","year":"2012","journal-title":"J.\u00a0Antibiot. (Tokyo)"},{"key":"10.1016\/j.ejmech.2021.114099_bib3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s002530100703","article-title":"Factors influencing the internalization of Staphylococcus aureus and impacts on the course of infections in humans","volume":"56","author":"Alexander","year":"2001","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2021.114099_bib4","article-title":"A\u00a0review on antibiotic resistance: alarm bells are ringing","volume":"9","author":"Zaman","year":"2017","journal-title":"Cureus"},{"key":"10.1016\/j.ejmech.2021.114099_bib5","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1128\/AAC.00369-11","article-title":"Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus","volume":"55","author":"Fan","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2021.114099_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/s41240-019-0145-0","article-title":"Potential of Fascaplysin and Palauolide from Fascaplysinopsis cf reticulata to reduce the risk of bacterial infection in fish farming","volume":"22","author":"Mai","year":"2019","journal-title":"Fish. Aquat. Sci."},{"key":"10.1016\/j.ejmech.2021.114099_bib7","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2021.114099_bib8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejmech.2018.11.012","article-title":"Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections","volume":"162","author":"Zha","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jac\/44.1.43","article-title":"Antibiotic susceptibility assay for Staphylococcus aureus in biofilms developed in\u00a0vitro","volume":"44","author":"Amorena","year":"1999","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2021.114099_bib10","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1016\/j.tetlet.2009.05.099","article-title":"Synthesis and structure elucidation of a new isoquinolinium inner salt","volume":"50","author":"Girreser","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2021.114099_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/ppap.201900270","article-title":"In\u00a0vitro antimicrobial effects and mechanism of air plasma-activated water on Staphylococcus aureus biofilm","volume":"17","author":"Xu","year":"2020","journal-title":"Plasma Process. Polym."},{"key":"10.1016\/j.ejmech.2021.114099_bib12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1021\/acsmedchemlett.8b00612","article-title":"N-benzylanilines as fatty acid synthesis inhibitors against biofilm-related methicillin-resistant Staphylococcus aureus","volume":"10","author":"Zhang","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2021.114099_bib13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejmech.2018.05.021","article-title":"Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents","volume":"154","author":"Xu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.110900","article-title":"Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA)","volume":"190","author":"Li","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"Suppl 1","key":"10.1016\/j.ejmech.2021.114099_bib15","first-page":"S15","article-title":"A\u00a0clinical armamentarium of marine-derived anti-cancer compounds","volume":"13","author":"Jimeno","year":"2002","journal-title":"Anti Cancer Drugs"},{"key":"10.1016\/j.ejmech.2021.114099_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0168-1656(99)00053-X","article-title":"The bioprocess\u2013technological potential of the sea","volume":"70","author":"Pomponi","year":"1999","journal-title":"J.\u00a0Biotechnol."},{"key":"10.1016\/j.ejmech.2021.114099_bib17","series-title":"Bioactive Compounds from the Sea","first-page":"641","author":"Ireland","year":"2000"},{"key":"10.1016\/j.ejmech.2021.114099_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.106005","article-title":"Targeting antimicrobial drug resistance with marine natural products","volume":"56","author":"Barbosa","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2021.114099_bib19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.bcab.2019.01.007","article-title":"Marine sponge alkaloid aaptamine enhances the anti-bacterial and anti-cancer activity against ESBL producing Gram negative bacteria and HepG 2 human liver carcinoma cells","volume":"17","author":"Rajivgandhi","year":"2019","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"10.1016\/j.ejmech.2021.114099_bib20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/md18010005","volume":"18","author":"Mayer","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejmech.2021.114099_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/md15090273","volume":"15","author":"Mayer","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejmech.2021.114099_bib22","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.3390\/md11072510","volume":"11","author":"Mayer","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejmech.2021.114099_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cbpc.2010.08.008","volume":"153","author":"Mayer","year":"2011","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.114099_bib24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbagen.2009.03.011","volume":"1790","author":"Mayer","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2021.114099_bib25","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cbpc.2007.01.015","volume":"145","author":"Mayer","year":"2007","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.114099_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cca.2005.04.004","volume":"140","author":"Mayer","year":"2005","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.114099_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10126-003-0007-7","volume":"6","author":"Mayer","year":"2004","journal-title":"Mar Biotechnol (NY)"},{"key":"10.1016\/j.ejmech.2021.114099_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1532-0456(02)00094-7","volume":"132","author":"Mayer","year":"2002","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.ejmech.2021.114099_bib29","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S1473-3099(03)00655-8","article-title":"Marine natural products and their potential applications as anti-infective agents","volume":"3","author":"Donia","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.114099_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112245","article-title":"Indole-based derivatives as potential antibacterial activity against methicillin-resistance Staphylococcus aureus (MRSA)","volume":"194","author":"Qin","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib31","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.lfs.2005.09.007","article-title":"Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases","volume":"78","author":"Gul","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2021.114099_bib32","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1016\/j.ejmech.2011.10.036","article-title":"Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives","volume":"46","author":"Zhang","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/md18010036","article-title":"Efficient total synthesis of lissodendrin B, 2-aminoimidazole marine alkaloids isolated from lissodendoryx (acanthodoryx) fibrosa","volume":"18","author":"Wei","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejmech.2021.114099_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104558","article-title":"Indole alkaloids: 2012 until now, highlighting the new chemical structures and biological activities","volume":"143","author":"Rosales","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejmech.2021.114099_bib35","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.3390\/md13074044","article-title":"Biological activity of recently discovered halogenated marine natural products","volume":"13","author":"Gribble","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejmech.2021.114099_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2015.10.049","article-title":"Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship","volume":"107","author":"Manda","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib37","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1021\/jo00249a025","article-title":"Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sp","volume":"53","author":"Roll","year":"1988","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib38","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/jcb.25053","article-title":"Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K\/AKT\/mTOR signaling cascade in human leukemia HL-60 cells","volume":"116","author":"Kumar","year":"2015","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.ejmech.2021.114099_bib39","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1021\/acschemneuro.9b00503","article-title":"Fascaplysin derivatives are potent multitarget agents against Alzheimer's disease: in\u00a0vitro and in\u00a0vivo evidence","volume":"10","author":"Pan","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejmech.2021.114099_bib40","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3390\/md17090496","article-title":"Total syntheses and preliminary biological evaluation of brominated fascaplysin and reticulatine alkaloids and their analogues","volume":"17","author":"Zhidkov","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejmech.2021.114099_bib41","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1021\/np990555b","article-title":"A\u00a0new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta","volume":"63","author":"Kirsch","year":"2000","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.ejmech.2021.114099_bib42","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/bs.irn.2020.03.010","article-title":"Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review","volume":"151","author":"Lyakhova","year":"2020","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.ejmech.2021.114099_bib43","doi-asserted-by":"crossref","first-page":"26258","DOI":"10.1039\/c4ra01387e","article-title":"Unexplored reactivity of 2-oxoaldehydes towards Pictet-Spengler conditions: concise approach to beta-carboline based marine natural products","volume":"4","author":"Battini","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2021.114099_bib44","doi-asserted-by":"crossref","first-page":"12363","DOI":"10.1002\/slct.201803007","article-title":"Aerobic oxidation of methyl-substituted beta-carbolines catalyzed by N-hydroxyphthalimide and metal catalyst","volume":"3","author":"Qiu","year":"2018","journal-title":"Chemistryselect"},{"key":"10.1016\/j.ejmech.2021.114099_bib45","doi-asserted-by":"crossref","first-page":"12978","DOI":"10.1002\/slct.201903444","article-title":"Efficient and chemoselective amidation of \u03b2-carboline carboxylic acids","volume":"4","author":"Lin","year":"2019","journal-title":"Chemistryselect"},{"key":"10.1016\/j.ejmech.2021.114099_bib46","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jhet.5570310442","article-title":"Oxidative halogenation of substituted pyrroles with Cu(II). PartIV.Bromination of 2-(2\u2032-hydroxybenzoyl)pyrrole. A new synthesis of bioactive analogs of monodeoxypyoluteorin","volume":"31","author":"Petruso","year":"1994","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib47","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.ejmech.2006.07.009","article-title":"Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin","volume":"41","author":"Raimondi","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib48","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.medmal.2016.01.010","article-title":"d.I.-d.-F. Groupe des referents en infectiologie, Preparing and administering injectable antibiotics: how to avoid playing God","volume":"46","author":"Longuet","year":"2016","journal-title":"Med. Maladies Infect."},{"key":"10.1016\/j.ejmech.2021.114099_bib49","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.4315\/0362-028X.JFP-19-168","article-title":"Antibiofilm efficacy of peptide 1018 against Listeria monocytogenes and Shiga toxigenic Escherichia coli on equipment surfaces","volume":"82","author":"Yin","year":"2019","journal-title":"J.\u00a0Food Protect."},{"key":"10.1016\/j.ejmech.2021.114099_bib50","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1136\/ejhpharm-2019-002076","article-title":"Evaluation of the stability of vancomycin solutions at concentrations used in clinical services","volume":"27","author":"Masse","year":"2020","journal-title":"Eur. J. Hosp. Pharm."},{"key":"10.1016\/j.ejmech.2021.114099_bib51","article-title":"Antimicrobial ionic liquid-based materials for biomedical applications","author":"Nikfarjam","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ejmech.2021.114099_bib52","doi-asserted-by":"crossref","first-page":"12225","DOI":"10.1021\/la302303d","article-title":"Cleavable cationic antibacterial amphiphiles: synthesis, mechanism of action, and cytotoxicities","volume":"28","author":"Hoque","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.ejmech.2021.114099_bib53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jhazmat.2015.12.028","article-title":"Antimicrobial activity and cytotoxicity of piperazinium- and guanidinium-based ionic liquids","volume":"307","author":"Yu","year":"2016","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.ejmech.2021.114099_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042612","article-title":"Fascaplysin as a specific inhibitor for CDK4: insights from molecular modelling","volume":"7","author":"Shafiq","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2021.114099_bib55","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/anie.200702287","article-title":"Antibacterial and hemolytic activities of pyridinium polymers as a function of the spatial relationship between the positive charge and the pendant alkyl tail","volume":"47","author":"Sambhy","year":"2008","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejmech.2021.114099_bib56","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1038\/s41467-018-04247-z","article-title":"Supramolecular Kandinsky circles with high antibacterial activity","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2021.114099_bib57","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1021\/bi972927q","article-title":"The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells","volume":"37","author":"Bonjean","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2021.114099_bib58","first-page":"71","article-title":"Intercalative binding of ellipticine to DNA","volume":"35","author":"Kohn","year":"1975","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2021.114099_bib59","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0968-0896(00)00313-8","article-title":"DNA binding properties of the marine sponge pigment fascaplysin","volume":"9","author":"Hormann","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib60","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ejmech.2019.02.046","article-title":"Challenges and current status of computational methods for docking small molecules to nucleic acids","volume":"168","author":"Luo","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib61","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(00)03572-8","article-title":"Effect of vancomycin and rifampicin on meticillin-resistant Staphylococcus aureus biofilms","volume":"357","author":"Jones","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2021.114099_bib62","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrd1008","article-title":"Understanding biofilm resistance to antibacterial agents","volume":"2","author":"Davies","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2021.114099_bib63","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1574-6968.2007.00688.x","article-title":"Ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus","volume":"270","author":"O'Gara","year":"2007","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ejmech.2021.114099_bib64","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1128\/IAI.01143-06","article-title":"Isolation and characterization of biofilm formation-defective mutants of Staphylococcus aureus","volume":"75","author":"Tu Quoc","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejmech.2021.114099_bib65","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1128\/JCM.43.4.1973-1976.2005","article-title":"Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates","volume":"43","author":"Fitzpatrick","year":"2005","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.ejmech.2021.114099_bib66","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1128\/JCM.02280-06","article-title":"Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections","volume":"45","author":"O'Neill","year":"2007","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.ejmech.2021.114099_bib67","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1128\/IAI.01036-08","article-title":"Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation","volume":"77","author":"Lauderdale","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejmech.2021.114099_bib68","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3389\/fmicb.2020.01479","article-title":"Advanced glycation end products enhance biofilm formation by promoting extracellular DNA release through sigB upregulation in Staphylococcus aureus","volume":"11","author":"Xie","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2021.114099_bib69","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4155\/fmc-2017-0159","article-title":"Antimicrobial activity of 1,3,4-oxadiazole derivatives against planktonic cells and biofilm of Staphylococcus aureus","volume":"10","author":"Zheng","year":"2018","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2021.114099_bib70","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1016\/j.bmcl.2004.06.012","article-title":"Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors","volume":"14","author":"Wang","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2021.114099_bib71","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/acsinfecdis.9b00204","article-title":"(p)ppGpp and the stringent response: an emerging threat to antibiotic therapy","volume":"5","author":"Hobbs","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2021.114099_bib72","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejps.2011.04.018","article-title":"Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model","volume":"43","author":"Yan","year":"2011","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2021.114099_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/md17020121","article-title":"9-Methylfascaplysin is a more potent abeta aggregation inhibitor than the marine-derived alkaloid, fascaplysin, and produces nanomolar neuroprotective effects in SH-SY5Y cells","volume":"17","author":"Sun","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejmech.2021.114099_bib75","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejmech.2021.114099_bib76","doi-asserted-by":"crossref","first-page":"8495","DOI":"10.1073\/pnas.1201263109","article-title":"Dermatophytic defensin with antiinfective potential","volume":"109","author":"Zhu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2021.114099_bib77","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1038\/s41598-017-03664-2","article-title":"Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2021.114099_bib78","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12253-018-0486-5","article-title":"The long noncoding RNA HOST2 promotes gemcitabine resistance in human pancreatic cancer cells","volume":"26","author":"An","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.ejmech.2021.114099_bib79","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1007\/s00253-019-09785-0","article-title":"A\u00a0recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms","volume":"103","author":"Yang","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2021.114099_bib80","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1128\/AAC.01056-16","article-title":"Combined systems approaches reveal a multistage mode of action of a marine antimicrobial peptide against pathogenic Escherichia coli and its protective effect against bacterial peritonitis and endotoxemia","volume":"61","author":"Wang","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2021.114099_bib81","first-page":"124","article-title":"Conformational features of the Staphylococcus aureus AgrA-promoter interactions rationalize quorum-sensing triggered gene expression","volume":"6","author":"Rajasree","year":"2016","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.ejmech.2021.114099_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.12.003","article-title":"Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145","volume":"222","author":"de Breij","year":"2016","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.ejmech.2021.114099_bib83","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1126\/scitranslmed.aan4044","article-title":"The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms","volume":"10","author":"de Breij","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejmech.2021.114099_bib84","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/08927014.2013.788692","article-title":"Anti-biofilm activities of quercetin and tannic acid against Staphylococcus aureus","volume":"29","author":"Lee","year":"2013","journal-title":"Biofouling"},{"key":"10.1016\/j.ejmech.2021.114099_bib85","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/AAC.01998-15","article-title":"Antimicrobial peptide CMA3 derived from the CA-MA hybrid peptide: antibacterial and anti-inflammatory activities with low cytotoxicity and mechanism of action in Escherichia coli","volume":"60","author":"Lee","year":"2016","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342100948X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342100948X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:34:31Z","timestamp":1759329271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342100948X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":84,"alternative-id":["S022352342100948X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.114099","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial\/antibiofilm activity against MRSA in\u00a0vitro and in\u00a0vivo","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2021.114099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114099"}}