{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:35:05Z","timestamp":1791527705605,"version":"4.3.4"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"am","delay-in-days":360,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1AI116917"],"award-info":[{"award-number":["RO1AI116917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ejmech.2022.114203","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T20:58:38Z","timestamp":1645217918000},"page":"114203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Development of small molecules that work cooperatively with ciprofloxacin to clear salmonella biofilms in a chronic gallbladder carriage model"],"prefix":"10.1016","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6493-5417","authenticated-orcid":false,"given":"Katherine J.","family":"Woolard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-377X","authenticated-orcid":false,"given":"Jenna L.","family":"Sandala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta J.","family":"Melander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-8346","authenticated-orcid":false,"given":"John S.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-4696","authenticated-orcid":false,"given":"Christian","family":"Melander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2022.114203_bib1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1086\/650733","article-title":"The global burden of nontyphoidal Salmonella gastroenteritis","volume":"50","author":"Majowicz","year":"2010","journal-title":"Clin. Infect. Dis."},{"issue":"11","key":"10.1016\/j.ejmech.2022.114203_bib2","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.tim.2014.06.007","article-title":"Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence","volume":"22","author":"Gunn","year":"2014","journal-title":"Trends Microbiol."},{"issue":"4","key":"10.1016\/j.ejmech.2022.114203_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1473-3099(18)30685-6","article-title":"The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017","volume":"19","author":"GTaP","year":"2019","journal-title":"Lancet Infect. Dis."},{"issue":"9","key":"10.1016\/j.ejmech.2022.114203_bib4","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1073\/pnas.1000862107","article-title":"Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage","volume":"107","author":"Crawford","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.ejmech.2022.114203_bib5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The biofilm matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2022.114203_bib6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrmicro.2016.94","article-title":"Biofilms: an emergent form of bacterial life","volume":"14","author":"Flemming","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2022.114203_bib7","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1039\/C8MD00298C","article-title":"2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium","volume":"9","author":"Huggins","year":"2018","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.ejmech.2022.114203_bib8","doi-asserted-by":"crossref","first-page":"b1865","DOI":"10.1136\/bmj.b1865","article-title":"A\u00a0comparison of fluoroquinolones versus other antibiotics for treating enteric fever: meta-analysis","volume":"338","author":"Thaver","year":"2009","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.ejmech.2022.114203_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2174\/09298673113206660294","article-title":"Small molecules modulating AHL-based quorum sensing to attenuate bacteria virulence and biofilms as promising antimicrobial drugs","volume":"21","author":"Wang","year":"2014","journal-title":"Curr. Med. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2022.114203_bib10","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.tim.2013.08.005","article-title":"Small molecules are natural triggers for the disassembly of biofilms","volume":"21","author":"Oppenheimer-Shaanan","year":"2013","journal-title":"Trends Microbiol."},{"issue":"5","key":"10.1016\/j.ejmech.2022.114203_bib11","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/jam.12940","article-title":"A\u00a0new small molecule inhibits Streptococcus mutans biofilms in\u00a0vitro and in\u00a0vivo","volume":"119","author":"Pan","year":"2015","journal-title":"J.\u00a0Appl. Microbiol."},{"key":"10.1016\/j.ejmech.2022.114203_bib12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1039\/D0MD00238K","article-title":"A\u00a0scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors","volume":"12","author":"Weig","year":"2021","journal-title":"RSC Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2022.114203_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009192","article-title":"A\u00a0dual-therapy approach for the treatment of biofilm-mediated Salmonella gallbladder carriage","volume":"16","author":"Sandala","year":"2020","journal-title":"PLoS Pathog."},{"issue":"12","key":"10.1016\/j.ejmech.2022.114203_bib14","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1016\/j.bmcl.2010.04.042","article-title":"Identification of aryl 2-aminoimidazoles as biofilm inhibitors in gram-negative bacteria","volume":"20","author":"Bunders","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114203_bib15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41598-017-18516-2","article-title":"biofilm formation protects Salmonella from the antibiotic ciprofloxacin in\u00a0vitro and in\u00a0vivo in the mouse model of chronic carriage","volume":"8","author":"Gonzalez","year":"2018","journal-title":"Sci. Rep."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422001052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422001052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:42:28Z","timestamp":1759329748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422001052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":15,"alternative-id":["S0223523422001052"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114203","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of small molecules that work cooperatively with ciprofloxacin to clear salmonella biofilms in a chronic gallbladder carriage model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114203"}}