{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T02:36:33Z","timestamp":1794105393403,"version":"4.8.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ejmech.2022.114412","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T15:23:00Z","timestamp":1651072980000},"page":"114412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail\/dual-tail approaches as novel carbonic anhydrase inhibitors"],"prefix":"10.1016","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-4176","authenticated-orcid":false,"given":"Mostafa M.","family":"Elbadawi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-4017","authenticated-orcid":false,"given":"Wagdy M.","family":"Eldehna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-702X","authenticated-orcid":false,"given":"Alessio","family":"Nocentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warda R.","family":"Somaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara T.","family":"Al-Rashood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-8035","authenticated-orcid":false,"given":"Eslam B.","family":"Elkaeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"El Hassab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem A.","family":"Abdel-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Fares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2022.114412_bib1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev.ph.58.030196.002515","article-title":"Multiple roles of carbonic anhydrase in cellular transport and metabolism","volume":"58","author":"Henry","year":"1996","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejmech.2022.114412_bib2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/cr050262p","article-title":"Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein\u2212 ligand binding","volume":"108","author":"Krishnamurthy","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2022.114412_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/metabo8010022","article-title":"An update on the metabolic roles of carbonic anhydrases in the model alga Chlamydomonas reinhardtii","volume":"8","author":"Aspatwar","year":"2018","journal-title":"Metabolites"},{"key":"10.1016\/j.ejmech.2022.114412_bib4","doi-asserted-by":"crossref","first-page":"9828","DOI":"10.1073\/pnas.1603112113","article-title":"Thylakoid luminal \u03b8-carbonic anhydrase critical for growth and photosynthesis in the marine diatom Phaeodactylum tricornutum","volume":"113","author":"Kikutani","year":"2016","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.ejmech.2022.114412_bib5","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1152\/physrev.2000.80.2.681","article-title":"Carbon dioxide transport and carbonic anhydrase in blood and muscle","volume":"80","author":"Geers","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejmech.2022.114412_bib6","article-title":"Overview of carbonic anhydrase families\/isoforms","volume":"7","author":"Capasso","year":"2014","journal-title":"Targeting Carbonic Anhydrases"},{"key":"10.1016\/j.ejmech.2022.114412_bib7","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1021\/acs.jmedchem.9b02090","article-title":"Discovery of potent dual-tailed benzenesulfonamide inhibitors of human carbonic anhydrases implicated in glaucoma and in vivo profiling of their intraocular pressure-lowering action","volume":"63","author":"Fares","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejmech.2016.01.030","article-title":"Amido\/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar\/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII","volume":"110","author":"Eldehna","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib9","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/156802607780636726","article-title":"Carbonic anhydrase inhibitors as anticonvulsant agents","volume":"7","author":"Thiry","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"issue":"35","key":"10.1016\/j.ejmech.2022.114412_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj0364","article-title":"Genome-wide synthetic lethal screen unveils novel CAIX-NFS1\/xCT axis as a targetable vulnerability in hypoxic solid tumors","volume":"7","author":"Chafe","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2022.114412_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.04.016","article-title":"Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: selective inhibitors for the tumor-associated hCA IX isoform","volume":"152","author":"Ibrahim","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib12","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.bmc.2017.02.037","article-title":"Synthesis of bulky-tailed sulfonamides incorporating pyrido [2,3-d][1,2,4] triazolo [4,3-a] pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects","volume":"25","author":"Fares","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib13","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1021\/jm501798g","article-title":"Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site","volume":"58","author":"Tanpure","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bioorg.2018.11.014","article-title":"SLC-0111 enaminone analogs, 3\/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX","volume":"83","author":"Eldehna","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib15","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/COC.0000000000000691","article-title":"A phase 1 study of SLC-0111, a novel inhibitor of carbonic anhydrase IX, in patients with advanced solid tumors","volume":"43","author":"McDonald","year":"2020","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2022.114412_bib16","doi-asserted-by":"crossref","first-page":"113283","DOI":"10.1016\/j.ejmech.2021.113283","article-title":"Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors","volume":"216","author":"Shaldam","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib17","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.1021\/acs.jmedchem.5b01343","article-title":"Efficient expression and crystallization system of cancer-associated carbonic anhydrase isoform IX","volume":"58","author":"Leitans","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bpc.2015.05.009","article-title":"Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry","volume":"205","author":"Zubriene","year":"2015","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib19","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1002\/chem.200802451","article-title":"Design of tRNALys3 ligands: fragment evolution and linker selection guided by NMR spectroscopy","volume":"15","author":"Chung","year":"2009","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2022.114412_bib20","doi-asserted-by":"crossref","first-page":"113360","DOI":"10.1016\/j.ejmech.2021.113360","article-title":"Identification of N-phenyl-2-(phenylsulfonyl)acetamides\/propanamides as new SLC-0111 analogues: synthesis and evaluation of the carbonic anhydrase inhibitory activities","volume":"218","author":"Elbadawi","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib21","doi-asserted-by":"crossref","first-page":"112019","DOI":"10.1016\/j.ejmech.2019.112019","article-title":"Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: design, synthesis, and in vitro biological evaluation","volume":"189","author":"Said","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/14756366.2020.1862101","article-title":"Novel oxindole\/benzofuran hybrids as potential dual CDK2\/GSK-3\u03b2 inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies","volume":"36","author":"Eldehna","year":"2021","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib23","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1080\/14756366.2020.1806259","article-title":"Discovery of 3, 6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights","volume":"35","author":"Sabt","year":"2020","journal-title":"\u200f, J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114412_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40659-019-0221-z","article-title":"CoCl2 simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis","volume":"52","author":"Rana","year":"2019","journal-title":"Biol. Res."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422003142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422003142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T14:09:32Z","timestamp":1728396572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422003142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":24,"alternative-id":["S0223523422003142"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114412","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail\/dual-tail approaches as novel carbonic anhydrase inhibitors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114412","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114412"}}