{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:58:00Z","timestamp":1767085080319,"version":"3.40.5"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ejmech.2022.114452","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T01:51:24Z","timestamp":1652493084000},"page":"114452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Novel flavonoid hybrids as potent antiviral agents against hepatitis A: Design, synthesis and biological evaluation"],"prefix":"10.1016","volume":"238","author":[{"given":"Shaochun","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Hirai-Yuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-2467","authenticated-orcid":false,"given":"Shao-Jiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2022.114452_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature12029","article-title":"A pathogenic picornavirus acquires an envelope by hijacking cellular membranes","volume":"496","author":"Feng","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114452_bib2","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1080\/21645515.2020.1819742","article-title":"Hepatitis A vaccination and its immunological and epidemiological long-term effects-a review of the evidence","volume":"17","author":"Herzog","year":"2021","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.ejmech.2022.114452_bib3","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1038\/s41598-020-80089-4","article-title":"Hepatitis A virus knowledge and immunization attitudes and practices in the United Arab Emirates community","volume":"11","author":"Samara","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2022.114452_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031708","article-title":"Natural history, clinical manifestations, and pathogenesis of hepatitis A","volume":"8","author":"Shin","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.ejmech.2022.114452_bib5","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/febs.14707","article-title":"Toward development of generic inhibitors against the 3C proteases of picornaviruses","volume":"286","author":"Banerjee","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.ejmech.2022.114452_bib6","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.vaccine.2009.10.136","article-title":"Hepatitis A and E: update on prevention and epidemiology","volume":"28","author":"FitzSimons","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.ejmech.2022.114452_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4254\/wjh.v4.i3.68","article-title":"Hepatitis A: epidemiology and prevention in developing countries","volume":"4","author":"Franco","year":"2012","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.ejmech.2022.114452_bib8","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1002\/hep.21052","article-title":"Hepatitis A virus: from discovery to vaccines","volume":"43","author":"Martin","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2022.114452_bib9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ejmech.2015.02.063","article-title":"Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease","volume":"94","author":"Sang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejmech.2014.07.013","article-title":"Flavones: an important scaffold for medicinal chemistry","volume":"84","author":"Singh","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.virol.2012.08.029","article-title":"Divergent antiviral effects of bioflavonoids on the hepatitis C virus life cycle","volume":"433","author":"Khachatoorian","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.ejmech.2022.114452_bib12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jhep.2011.02.011","article-title":"Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism","volume":"55","author":"Goldwasser","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejmech.2022.114452_bib13","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1111\/j.1365-2893.2011.01507.x","article-title":"Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity","volume":"19","author":"Bachmetov","year":"2012","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.ejmech.2022.114452_bib14","doi-asserted-by":"crossref","first-page":"31777","DOI":"10.1038\/srep31777","article-title":"Effect of quercetin on hepatitis C virus life cycle: from viral to host targets","volume":"6","author":"Rojas","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2022.114452_bib15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.antiviral.2014.09.009","article-title":"(-)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes","volume":"111","author":"Huang","year":"2014","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2022.114452_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201900511","article-title":"Breaking down the barriers to a natural antiviral agent: antiviral activity and molecular docking of erythrina speciosa extract, fractions, and the major compound","volume":"17","author":"Fahmy","year":"2020","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.ejmech.2022.114452_bib17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ejmech.2019.02.048","article-title":"New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: design, synthesis, anti-HAV effect and molecular modeling","volume":"168","author":"Kassem","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.fitote.2009.04.009","article-title":"Effects of Pithecellobium clypearia Benth extract and its main components on inflammation and allergy","volume":"80","author":"Bao","year":"2009","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejmech.2022.114452_bib19","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.ejmech.2010.01.005","article-title":"QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors","volume":"45","author":"Mercader","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib20","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1016\/j.bmc.2016.05.034","article-title":"Identification, characterization, kinetics, and molecular docking of flavonoid constituents from Archidendron clypearia (Jack.) Nielsen leaves and twigs","volume":"24","author":"Thao","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib21","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1021\/acs.jafc.6b02683","article-title":"Design, synthesis, and biological activities of spirooxindoles containing acylhydrazone fragment derivatives based on the biosynthesis of alkaloids derived from tryptophan","volume":"64","author":"Chen","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib22","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1016\/j.ejmech.2009.04.001","article-title":"Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation","volume":"44","author":"el-Sabbagh","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib23","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.ejmech.2006.12.032","article-title":"Conversion of some 2(3H)-furanones bearing a pyrazolyl group into other heterocyclic systems with a study of their antiviral activity","volume":"42","author":"Hashem","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib24","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1021\/jo0109016","article-title":"Serine and threonine beta-lactones: a new class of hepatitis a virus 3C cysteine proteinase inhibitors","volume":"67","author":"Lall","year":"2002","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib25","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1016\/j.bmcl.2017.07.038","article-title":"Synthesis, antiviral activity, and molecular docking study of trans-ferulic acid derivatives containing acylhydrazone moiety","volume":"27","author":"Wang","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2022.114452_bib26","doi-asserted-by":"crossref","first-page":"103917","DOI":"10.1016\/j.bioorg.2020.103917","article-title":"Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease","volume":"100","author":"Shi","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejmech.2017.12.096","article-title":"Picolyl amides of betulinic acid as antitumor agents causing tumor cell apoptosis","volume":"145","author":"Bildziukevich","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib28","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ejmech.2018.05.004","article-title":"A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease","volume":"152","author":"Jalili-Baleh","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib29","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1021\/acs.jmedchem.0c00053","article-title":"In vitro and in vivo evaluation of membrane-active flavone amphiphiles: semisynthetic kaempferol-derived antimicrobials against drug-resistant gram-positive bacteria","volume":"63","author":"Lin","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ejmech.2019.02.057","article-title":"Hederagenin amide derivatives as potential antiproliferative agents","volume":"168","author":"Rodriguez-Hernandez","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib31","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1016\/j.bmcl.2016.09.036","article-title":"Synthesis of 3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)benzopyran-4-one derivatives as anticancer agents","volume":"26","author":"Singh","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2022.114452_bib32","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1021\/acs.orglett.7b03841","article-title":"Tetramethyl orthosilicate (TMOS) as a reagent for direct amidation of carboxylic acids","volume":"20","author":"Braddock","year":"2018","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2022.114452_bib33","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3109\/14756366.2012.723206","article-title":"Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors","volume":"28","author":"Sun","year":"2013","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib34","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1021\/acsinfecdis.8b00325","article-title":"Derivatives of natural product agrimophol as disruptors of intrabacterial pH homeostasis in mycobacterium tuberculosis","volume":"5","author":"Wu","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2022.114452_bib35","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cclet.2013.07.007","article-title":"First total synthesis of (\u00b1)-malaysianone A and (\u00b1)-tanariflavanones B","volume":"24","author":"Yang","year":"2013","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2022.114452_bib36","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1039\/C7OB01004D","article-title":"Total synthesis of agalloside, isolated from Aquilaria agallocha, by the 5-O-glycosylation of flavan","volume":"15","author":"Arai","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejmech.2016.05.017","article-title":"Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells","volume":"121","author":"Kulabas","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib38","article-title":"Synthesis and in vitro anticancer activity of novel dehydroabietic acid-based acylhydrazones","volume":"22","author":"Li","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114452_bib39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejmech.2015.04.063","article-title":"Novel myricetin derivatives: design, synthesis and anticancer activity","volume":"97","author":"Xue","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib40","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41564-019-0425-6","article-title":"Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses","volume":"4","author":"Yamane","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.ejmech.2022.114452_bib41","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s007050050343","article-title":"Membrane association and RNA binding of recombinant hepatitis A virus protein 2C","volume":"143","author":"Kusov","year":"1998","journal-title":"Arch. Virol."},{"key":"10.1016\/j.ejmech.2022.114452_bib42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1574-6968.2001.tb10897.x","article-title":"A fluorescence quenching test for the detection of flavonoid transformation","volume":"204","author":"Schoefer","year":"2001","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ejmech.2022.114452_bib43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1128\/jcm.20.1.28-33.1984","article-title":"Primary isolation and serial passage of hepatitis A virus strains in primate cell cultures","volume":"20","author":"Binn","year":"1984","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ejmech.2022.114452_bib44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jviromet.2008.06.014","article-title":"Evaluation of genomic regions of hepatitis A virus for phylogenetic analysis: suitability of the 2C region for genotyping","volume":"153","author":"Joshi","year":"2008","journal-title":"J Virol Methods"},{"key":"10.1016\/j.ejmech.2022.114452_bib45","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1128\/JVI.76.3.1171-1180.2002","article-title":"Replication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cells","volume":"76","author":"Yi","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2022.114452_bib46","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1743-422X-7-212","article-title":"Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha","volume":"7","author":"Yang","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.ejmech.2022.114452_bib47","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.vetmic.2012.06.019","article-title":"Antiviral activity of zinc salts against transmissible gastroenteritis virus in vitro","volume":"160","author":"Wei","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ejmech.2022.114452_bib48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.7883\/yoken.JJID.2018.279","article-title":"A cluster of hepatitis A infections presumed to be related to asari clams and investigation of the spread of viral contamination from Asari Clams","volume":"72","author":"Tsukada","year":"2019","journal-title":"Jpn. J. Infect. Dis."},{"issue":"Pt 6","key":"10.1016\/j.ejmech.2022.114452_bib49","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1099\/0022-1317-73-6-1365","article-title":"Genetic relatedness of hepatitis A virus strains recovered from different geographical regions","volume":"73","author":"Robertson","year":"1992","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ejmech.2022.114452_bib50","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jviromet.2007.05.023","article-title":"Rapid and real-time detection of hepatitis A virus by reverse transcription loop-mediated isothermal amplification assay","volume":"145","author":"Yoneyama","year":"2007","journal-title":"J Virol Methods"},{"key":"10.1016\/j.ejmech.2022.114452_bib51","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejmech.2018.07.001","article-title":"Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity","volume":"156","author":"Baldisserotto","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib52","doi-asserted-by":"crossref","first-page":"11683","DOI":"10.3390\/molecules181011683","article-title":"Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives","volume":"18","author":"Lopes","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114452_bib53","doi-asserted-by":"crossref","first-page":"104365","DOI":"10.1016\/j.bioorg.2020.104365","article-title":"4-Oxycoumarinyl linked acetohydrazide Schiff bases as potent urease inhibitors","volume":"105","author":"Naz","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ejmech.2018.10.002","article-title":"Synthesis and biological evaluation of novel Ani 9 derivatives as potent and selective ANO1 inhibitors","volume":"160","author":"Seo","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejmech.2019.04.021","article-title":"A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1","volume":"174","author":"van der Vlag","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114452_bib56","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1073\/pnas.0503596102","article-title":"Robust hepatitis C virus infection in vitro","volume":"102","author":"Zhong","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2022.114452_bib57","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1128\/JVI.03144-14","article-title":"Mechanism of angiopoietin-1 upregulation in Kaposi's sarcoma-associated herpesvirus-infected PEL cell lines","volume":"89","author":"Zheng","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2022.114452_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2021.06.022","article-title":"Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus","volume":"567","author":"Zheng","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2022.114452_bib59","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1128\/JCM.43.11.5679-5684.2005","article-title":"Detection of anti-hepatitis C virus effects of interferon and ribavirin by a sensitive replicon system","volume":"43","author":"Kato","year":"2005","journal-title":"J. Clin. Microbiol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422003543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422003543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T14:10:59Z","timestamp":1728396659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422003543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":59,"alternative-id":["S0223523422003543"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114452","relation":{},"ISSN":["0223-5234"],"issn-type":[{"type":"print","value":"0223-5234"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel flavonoid hybrids as potent antiviral agents against hepatitis A: Design, synthesis and biological evaluation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114452","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114452"}}