{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:47:09Z","timestamp":1768481229032,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["82003600"],"award-info":[{"award-number":["82003600"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["82104007"],"award-info":[{"award-number":["82104007"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ejmech.2022.114647","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T17:17:48Z","timestamp":1659979068000},"page":"114647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin"],"prefix":"10.1016","volume":"241","author":[{"given":"Lianqi","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibo","family":"Kou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Along","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2022.114647_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13054-017-1801-3","article-title":"Incidence, prevalence, and management of mrsa bacteremia across patient populations-a review of recent developments in mrsa management and treatment","volume":"21","author":"Hassoun","year":"2017","journal-title":"Crit. Care"},{"key":"10.1016\/j.ejmech.2022.114647_bib2","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.2174\/0929867320666131119122520","article-title":"Mrsa infections: from classical treatment to suicide drugs","volume":"21","author":"Drebes","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114647_bib3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2146\/ajhp080434","article-title":"Therapeutic monitoring of vancomycin in adult patients: a consensus review of the american society of health-system pharmacists, the infectious diseases society of America, and the society of infectious diseases pharmacists","volume":"66","author":"Rybak","year":"2009","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.ejmech.2022.114647_bib4","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1093\/jac\/dks255","article-title":"Reduced vancomycin susceptibility and staphylococcal cassette chromosome mec (sccmec) type distribution in methicillin-resistant staphylococcus aureus bacteraemia","volume":"67","author":"Han","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2022.114647_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/cid\/cir764","article-title":"Daptomycin versus vancomycin for bloodstream infections due to methicillin-resistant staphylococcus aureus with a high vancomycin minimum inhibitory concentration: a case-control study","volume":"54","author":"Moore","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2022.114647_bib6","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1128\/AAC.02192-12","article-title":"Multicenter evaluation of the clinical outcomes of daptomycin with and without concomitant beta-lactams in patients with staphylococcus aureus bacteremia and mild to moderate renal impairment","volume":"57","author":"Moise","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2022.114647_bib7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0959-440X(95)80008-O","article-title":"Aminoacyl-trna synthetases","volume":"5","author":"Delarue","year":"1995","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ejmech.2022.114647_bib8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev.bi.62.070193.003435","article-title":"Cognition, mechanism, and evolutionary relationships in aminoacyl-trna synthetases","volume":"62","author":"Carter","year":"1993","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejmech.2022.114647_bib9","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1128\/AAC.49.12.4821-4833.2005","article-title":"Prospects for aminoacyl-trna synthetase inhibitors as new antimicrobial agents","volume":"49","author":"Hurdle","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2022.114647_bib10","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1126\/science.1142189","article-title":"An antifungal agent inhibits an aminoacyl-tRNAsynthetase by trapping trna in the editing site","volume":"316","author":"Rock","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2022.114647_bib11","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1016\/S0960-894X(02)00604-2","article-title":"The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase","volume":"12","author":"Brown","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2022.114647_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1976.tb10758.x","article-title":"Indolmycin inhibits prokaryotic tryptophanyl-trna ligase","volume":"68","author":"Werner","year":"1976","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejmech.2022.114647_bib13","first-page":"316","article-title":"Pa 155 a, b, and x antibiotics produced by a strain of Streptomyces albus","volume":"10","author":"Marsh","year":"1960","journal-title":"Antibiot. Chemother."},{"key":"10.1016\/j.ejmech.2022.114647_bib14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/jac\/dkh352","article-title":"Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections","volume":"54","author":"Hurdle","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2022.114647_bib15","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1128\/AAC.45.9.2455-2459.2001","article-title":"In vitro and in vivo antibacterial activities of tak-083, an agent for treatment of helicobacter pylori infection","volume":"45","author":"Kanamaru","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2022.114647_bib16","series-title":"Antibacterial 2-Amino-Oxazolinones and Process Therefor","author":"Dirlam","year":"1985"},{"key":"10.1016\/j.ejmech.2022.114647_bib17","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/0960-894X(96)00237-5","article-title":"Structure-activity dependency of new bacterial tryptophanyl trna synthetase inhibitors","volume":"6","author":"Witty","year":"1996","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2022.114647_bib18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature22308","article-title":"Predictive compound accumulation rules yield a broad-spectrum antibiotic","volume":"545","author":"Richter","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114647_bib19","series-title":"Ceramide Galactosyltransferase Inhibitors for the Treatment of Disease","author":"Wang","year":"2017"},{"key":"10.1016\/j.ejmech.2022.114647_bib20","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1248\/cpb.49.1604","article-title":"Development of a stereoselective practical synthetic route to indolmycin, a candidate anti-H. Pylori agent","volume":"49","author":"Hasuoka","year":"2001","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.ejmech.2022.114647_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1246\/cl.1980.163","article-title":"Asymmetric total synthesis of indolmycin","volume":"9","author":"Takeshi","year":"1980","journal-title":"Chem. Lett."},{"key":"10.1016\/j.ejmech.2022.114647_bib22","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.4155\/fmc-2019-0209","article-title":"Synthesis, resolution, derivatization and antibacterial activity of chuangxinmycin","volume":"11","author":"Sun","year":"2019","journal-title":"Future Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422005499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422005499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:45:30Z","timestamp":1759329930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422005499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":22,"alternative-id":["S0223523422005499"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114647","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114647"}}