{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:23:51Z","timestamp":1793759031372,"version":"4.6.1"},"reference-count":158,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009590","name":"Gansu Education Department","doi-asserted-by":"publisher","award":["2021CXZX-149"],"award-info":[{"award-number":["2021CXZX-149"]}],"id":[{"id":"10.13039\/501100009590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019530","name":"Science Fund for Distinguished Young Scholars of Gansu Province","doi-asserted-by":"publisher","award":["20JR5RA304"],"award-info":[{"award-number":["20JR5RA304"]}],"id":[{"id":"10.13039\/501100019530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ejmech.2022.114695","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T21:13:46Z","timestamp":1661634826000},"page":"114695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy"],"prefix":"10.1016","volume":"242","author":[{"given":"Honghua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsheng","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-1779","authenticated-orcid":false,"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4103\/1673-5374.320970","article-title":"Pathological mechanisms and therapeutic strategies for Alzheimer's disease","volume":"17","author":"Ju","year":"2022","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.ejmech.2022.114695_bib2","series-title":"World-alzheimer-report-2021","author":"Gauthier","year":"2022"},{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41582-021-00597-3","article-title":"Psychosis in alzheimer disease-mechanisms, genetics and therapeutic opportunities","volume":"18","author":"Ismail","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejmech.2022.114695_bib4","series-title":"Multiple Ligands in Neurodegenerative Diseases, Methods and Principles in Medicinal Chemistry Drug Selectivity (An Evolving Concept in Medicinal Chemistry)","first-page":"477","author":"Lalut","year":"2018"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40169-017-0181-2","article-title":"A perspective on multi-target drug discovery and design for complex diseases","volume":"7","author":"Ramsay","year":"2018","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ejmech.2022.114695_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114606","article-title":"Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease","volume":"240","author":"Zhang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib7","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ejmech.2018.05.004","article-title":"A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease","volume":"152","author":"Jalili-Baleh","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2022.114695_bib8","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2174\/1567205018666211208140551","article-title":"Multi-target directed ligands (MTDLs): promising coumarin hybrids for Alzheimer's disease","volume":"18","author":"Bhatia","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejmech.2022.114695_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105844","article-title":"Carbamate-based n-substituted tryptamine derivatives as novel pleiotropic molecules for alzheimer's disease","volume":"125","author":"Zhang","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105993","article-title":"Discovery of carbamate-based n-salicyloyl tryptamine derivatives as novel pleiotropic agents for the treatment of Alzheimer's disease","volume":"127","author":"Wang","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.mcna.2018.10.009","article-title":"The Alzheimer's disease clinical spectrum diagnosis and management","volume":"103","author":"Atri","year":"2019","journal-title":"Med. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12929-019-0609-7","article-title":"Clinical trials of new drugs for alzheimer disease","volume":"27","author":"Huang","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejmech.2022.114695_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1179573520907397","article-title":"Current and future treatments in alzheimer disease: an update","volume":"12","author":"Yiannopoulou","year":"2020","journal-title":"J. Cent. Nerv. Syst. Dis."},{"key":"10.1016\/j.ejmech.2022.114695_bib14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/978-3-030-78787-5_52","article-title":"Photo-oxygenation: an innovative new therapeutic approach against amyloidoses","volume":"1339","author":"Ikeda","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejmech.2022.114695_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.trci.2019.05.008","article-title":"Alzheimer's disease drug development pipeline","volume":"5","author":"Cummings","year":"2019","journal-title":"Alzheimers Dement (N Y)"},{"issue":"25","key":"10.1016\/j.ejmech.2022.114695_bib16","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1523\/JNEUROSCI.0293-11.2011","article-title":"The second-generation active abeta immunotherapy cad106 reduces amyloid accumulation in app transgenic mice while minimizing potential side effects","volume":"31","author":"Wiessner","year":"2011","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/JAD-2011-110977","article-title":"Gantenerumab: a novel human anti-abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta","volume":"28","author":"Bohrmann","year":"2012","journal-title":"J. Alzheimers Dis."},{"issue":"7618","key":"10.1016\/j.ejmech.2022.114695_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces abeta plaques in Alzheimer's disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ejmech.2022.114695_bib19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa1304839","article-title":"Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease","volume":"370","author":"Salloway","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.ejmech.2022.114695_bib20","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.14336\/AD.2021.0719","article-title":"Comparative analysis of aducanumab, zagotenemab and pioglitazone as targeted treatment strategies for Alzheimer's disease","volume":"12","author":"Abyadeh","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.ejmech.2022.114695_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112746","article-title":"\"Aducanumab\" making a comeback in Alzheimer's disease: an old wine in a new bottle","volume":"148","author":"Behl","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1517\/14728222.11.2.161","article-title":"Targeting acetylcholinesterase to treat neurodegeneration","volume":"11","author":"Holzgrabe","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejmech.2022.114695_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1017\/S1041610203008676","article-title":"Butyrylcholinesterase: an important new target in Alzheimer's disease therapy","volume":"14","author":"Greig","year":"2002","journal-title":"Int. Psychogeriatrics"},{"key":"10.1016\/j.ejmech.2022.114695_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114044","article-title":"Design, synthesis, and biological evaluation of carbamate derivatives of n-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease","volume":"229","author":"Liu","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.ejmech.2022.114695_bib25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2174\/1389557520666200103100521","article-title":"Potent acetylcholinesterase inhibitors: potential drugs for Alzheimer's disease","volume":"20","author":"Akincioglu","year":"2020","journal-title":"Mini Rev Med Chem"},{"issue":"21","key":"10.1016\/j.ejmech.2022.114695_bib26","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.2174\/1385272825666210716154531","article-title":"Recent advances in the synthesis of tacrine derivatives as multifunctional agents for Alzheimer's disease","volume":"25","author":"Ahmed","year":"2021","journal-title":"Curr. Org. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2022.114695_bib27","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1007\/s11033-021-06512-9","article-title":"Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease","volume":"48","author":"Athar","year":"2021","journal-title":"Mol Biol Rep"},{"issue":"5","key":"10.1016\/j.ejmech.2022.114695_bib28","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2174\/1389450121999200819144544","article-title":"Alzheimer's disease: related targets, synthesis of available drugs, bioactive compounds under development and promising results obtained from multi-target approaches","volume":"22","author":"Pirolla","year":"2021","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.ejmech.2022.114695_bib29","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejmech.2019.02.076","article-title":"Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease","volume":"169","author":"Wang","year":"2019","journal-title":"Eur J Med Chem"},{"issue":"6","key":"10.1016\/j.ejmech.2022.114695_bib30","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1111\/1541-4337.12821","article-title":"Current overview and perspectives in environmentally friendly microextractions of carbamates and dithiocarbamates","volume":"20","author":"Martins","year":"2021","journal-title":"Compr R Food Sci F"},{"issue":"4","key":"10.1016\/j.ejmech.2022.114695_bib31","first-page":"285","article-title":"Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents","volume":"71","author":"Matosevic","year":"2020","journal-title":"Arh Hig Rada Toksiko"},{"issue":"17","key":"10.1016\/j.ejmech.2022.114695_bib32","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.1021\/acs.jmedchem.0c00528","article-title":"Centrally active multitarget anti-alzheimer agents derived from the antioxidant lead cr6","volume":"63","author":"P\u00e9rez-Areales","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib33","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.6b01178","article-title":"The antioxidant additive approach for Alzheimer's disease therapy: new ferulic (lipoic) acid plus melatonin modified tacrines as cholinesterases inhibitors, direct antioxidants, and nuclear factor (erythroid-derived 2)-like 2 activators","author":"Benchekroun","year":"2016","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2022.114695_bib34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2174\/1385272823666191021124443","article-title":"Molecular hybridization as a tool in the design of multi-target directed drug candidates for neurodegenerative diseases","volume":"18","author":"Gontijo","year":"2020","journal-title":"Curr. Neuropharmacol"},{"key":"10.1016\/j.ejmech.2022.114695_bib35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jinorgbio.2017.11.015","article-title":"Hydroxypyridinone-benzofuran hybrids with potential protective roles for alzheimers disease therapy","volume":"179","author":"Hiremathad","year":"2018","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/14756366.2019.1689237","article-title":"Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's disease","volume":"35","author":"Fancellu","year":"2020","journal-title":"J Enzyme Inhib Med Chem"},{"issue":"13","key":"10.1016\/j.ejmech.2022.114695_bib37","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/cmdc.201800156","article-title":"Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease","volume":"13","author":"Goyal","year":"2018","journal-title":"ChemMedChem"},{"issue":"4","key":"10.1016\/j.ejmech.2022.114695_bib38","doi-asserted-by":"crossref","first-page":"785","DOI":"10.4155\/fmc-2020-0184","article-title":"Design and synthesis of novel tacrine\u2013indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease","volume":"13","author":"Hamulakova","year":"2021","journal-title":"Future Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128100","article-title":"Huprine y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment","volume":"43","author":"Mezeiova","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib40","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3390\/molecules24030587","article-title":"New multitarget hybrids bearing tacrine and phenylbenzothiazole motifs as potential drug candidates for Alzheimer's disease","volume":"24","author":"Rajeshwari","year":"2019","journal-title":"Molecules"},{"issue":"15","key":"10.1016\/j.ejmech.2022.114695_bib41","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3390\/molecules24152757","article-title":"Novel benzothiazole-based ureas as 17\u03b2-hsd10 inhibitors, a potential Alzheimer's disease treatment","volume":"24","author":"Aitken","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114695_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104596","article-title":"Tacrine-benzothiazoles: novel class of potential multitarget anti-alzheimers drugs dealing with cholinergic, amyloid and mitochondrial systems","volume":"107","author":"Nepovimova","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"5669","key":"10.1016\/j.ejmech.2022.114695_bib43","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1091230","article-title":"Abad directly links abeta to mitochondrial toxicity in alzheimer's disease","volume":"304","author":"Lustbader","year":"2004","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202000083","article-title":"Multi-targeting tacrine conjugates with cholinesterase and amyloid-beta inhibitory activities: new anti-Alzheimer's agents","volume":"18","author":"Hiremathad","year":"2021","journal-title":"Chem Biodivers"},{"issue":"10","key":"10.1016\/j.ejmech.2022.114695_bib45","first-page":"1642","volume":"22","author":"Claudiu","year":"2017","journal-title":"Special issue: Sulfonamides, Molecules"},{"issue":"16","key":"10.1016\/j.ejmech.2022.114695_bib46","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.bmcl.2019.06.041","article-title":"Sulfonamide derivatives as multi-target agents for complex diseases","volume":"29","author":"Apaydn","year":"2019","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.18596\/jotcsa.516444","article-title":"Design, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors","volume":"6","author":"Akocak","year":"2019","journal-title":"J. Turk. Chem. Soc. Sect. Chem."},{"issue":"24","key":"10.1016\/j.ejmech.2022.114695_bib48","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.4155\/fmc-2019-0106","article-title":"Multifunctional hybrid sulfonamides as novel therapeutic agents for Alzheimer's disease","volume":"11","author":"Swetha","year":"2019","journal-title":"Future Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1134\/S1607672918060200","article-title":"Conjugates of tacrine and its cyclic homologues with p-toluenesulfonamide are novel acetylcholinesterase and butyrylcholinesterase inhibitors","volume":"483","author":"Makhayeva","year":"2018","journal-title":"Dokl. Biochem. Biophys."},{"issue":"17","key":"10.1016\/j.ejmech.2022.114695_bib50","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.3390\/molecules25173915","article-title":"New hybrids of 4-amino-2,3-polymethylene-quinoline and p-tolylsulfonamide as dual inhibitors of acetyl- and butyrylcholinesterase and potential multifunctional agents for Alzheimer's disease treatment","volume":"25","author":"Makhaeva","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114695_bib51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.saa.2014.11.062","article-title":"Spectroscopic study on the interaction of a\u03b242 with di(picolyl)amine derivatives and the toxicity to sh-s5y5 cells","volume":"138","author":"Kong","year":"2015","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"10.1016\/j.ejmech.2022.114695_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103721","article-title":"Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: design, synthesis, and biological evaluation","volume":"98","author":"Xu","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105387","article-title":"Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer's disease","volume":"116","author":"Zhang","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"20","key":"10.1016\/j.ejmech.2022.114695_bib54","doi-asserted-by":"crossref","first-page":"8576","DOI":"10.1021\/jm5010804","article-title":"Multitarget drug design strategy: quinone\u2013tacrine hybrids designed to block amyloid-\u03b2 aggregation and to exert anticholinesterase and antioxidant effects","volume":"57","author":"Nepovimova","year":"2014","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2022.114695_bib55","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1021\/acschemneuro.1c00184","article-title":"Phenothiazine-tacrine heterodimers: pursuing multitarget directed approach in Alzheimer's disease","volume":"12","author":"Gorecki","year":"2021","journal-title":"ACS Chem Neurosci"},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201800433","article-title":"Design and synthesis of selective acetylcholinesterase inhibitors: arylisoxazole-phenylpiperazine derivatives","volume":"16","author":"Saeedi","year":"2019","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.ejmech.2022.114695_bib57","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.2174\/1568026616666160506145700","article-title":"Medicinal chemistry perspective of fused isoxazole derivatives","volume":"16","author":"Barmade","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib58","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11030-021-10248-w","article-title":"Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer's disease","volume":"26","author":"Rastegari","year":"2022","journal-title":"Mol Divers"},{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib59","first-page":"303","article-title":"Donepezil in Alzheimer's disease: from conventional trials to pharmacogenetics","volume":"3","author":"Cacabelos","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.ejmech.2022.114695_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103649","article-title":"Novel small molecule therapeutic agents for alzheimer disease: focusing on bace1 and multi-target directed ligands","volume":"97","author":"Iraji","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2022.114695_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201900746","article-title":"Design and synthesis of novel arylisoxazole\u2010chromenone carboxamides: investigation of biological activities associated with Alzheimer's disease","volume":"17","author":"Saeedi","year":"2020","journal-title":"Chem Biodivers"},{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202000258","article-title":"Novel n-benzylpiperidine derivatives of 5-arylisoxazole-3-carboxamides as anti-Alzheimer's agents","volume":"354","author":"Saeedi","year":"2021","journal-title":"Arch Pharm (Weinheim)"},{"issue":"6","key":"10.1016\/j.ejmech.2022.114695_bib63","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.3390\/molecules26061658","article-title":"Novel donepezil-arylsulfonamide hybrids as multitarget-directed ligands for potential treatment of Alzheimer's disease","volume":"26","author":"Queda","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114695_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114305","article-title":"Novel inhibitors of ache and abeta aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease","volume":"235","author":"Liu","year":"2022","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104922","article-title":"Design, synthesis, and evaluation of n-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease","volume":"111","author":"Choubey","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"8","key":"10.1016\/j.ejmech.2022.114695_bib66","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1021\/acschemneuro.0c00803","article-title":"(+\/-)-bigi-3h: pentatarget-directed ligand combining cholinesterase, monoamine oxidase, and glycogen synthase kinase 3beta inhibition with calcium channel antagonism and antiaggregating properties for Alzheimer's disease","volume":"12","author":"Ismaili","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.ejmech.2022.114695_bib67","article-title":"Redox ticklers and beyond: naphthoquinone repository in the spotlight against inflammation and associated maladies","volume":"174","author":"Nk","year":"2021","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib68","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cmdc.202000484","article-title":"Turning donepezil into a multi-target-directed ligand through a merging strategy","volume":"16","author":"Perone","year":"2021","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2022.114695_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111707","article-title":"Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease","volume":"183","author":"Tripathi","year":"2019","journal-title":"Eur J Med Chem"},{"issue":"10","key":"10.1016\/j.ejmech.2022.114695_bib70","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1021\/acschemneuro.9b00430","article-title":"Novel molecular hybrids of n -benzylpiperidine and 1,3,4-oxadiazole as multitargeted therapeutics to treat Alzheimer's disease","volume":"10","author":"Sharma","year":"2019","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.ejmech.2022.114695_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111916","article-title":"1-benzylpyrrolidine-3-amine-based buche inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease","volume":"187","author":"Wichur","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103025","article-title":"Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions","volume":"89","author":"Mishra","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2022.114695_bib73","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1021\/acs.jmedchem.5b01416","article-title":"Synthesis and biological evaluation of novel sigma-1 receptor ligands for treating neuropathic pain: 6-hydroxypyridazinones","volume":"59","author":"Cao","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114098","article-title":"Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2h)-one derivatives as balanced multifunctional agents against Alzheimer's disease","volume":"230","author":"Shi","year":"2022","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.lfs.2018.10.066","article-title":"Pharmacokinetic, pharmacodynamic and formulations aspects of naringenin: an update","volume":"215","author":"Joshi","year":"2018","journal-title":"Life Sci"},{"issue":"12","key":"10.1016\/j.ejmech.2022.114695_bib76","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1080\/14786419.2017.1346637","article-title":"In vitro antioxidant\/prooxidant effects of combined use of flavonoids","volume":"32","author":"Eren-Guzelgun","year":"2017","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.ejmech.2022.114695_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112180","article-title":"The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease","volume":"192","author":"Sang","year":"2020","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib78","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1080\/14756366.2022.2041627","article-title":"Development of naringenin-o-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer's disease","volume":"37","author":"Yang","year":"2022","journal-title":"J Enzyme Inhib Med Chem"},{"issue":"12","key":"10.1016\/j.ejmech.2022.114695_bib79","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1021\/acs.chemrev.7b00020","article-title":"Chalcone: a privileged structure in medicinal chemistry","volume":"117","author":"Zhuang","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2022.114695_bib80","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bioorg.2018.06.009","article-title":"Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: current view and upcoming advice","volume":"80","author":"Xu","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111737","article-title":"Development of chalcone-o-alkylamine derivatives as multifunctional agents against Alzheimer's disease","volume":"183","author":"Bai","year":"2019","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib82","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/14756366.2021.1993845","article-title":"Design, synthesis, and evaluation of chalcone-vitamin e-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease","volume":"37","author":"Sang","year":"2022","journal-title":"J Enzyme Inhib Med Chem"},{"issue":"9","key":"10.1016\/j.ejmech.2022.114695_bib83","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.3390\/molecules23092182","article-title":"Natural scaffolds with multi-target activity for the potential treatment of Alzheimer's disease","volume":"23","author":"Luca","year":"2018","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib84","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/biom11010111","article-title":"Derivatives of tenuazonic acid as potential new multi-target anti-Alzheimer's disease agents","volume":"11","author":"Poliseno","year":"2021","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.ejmech.2022.114695_bib85","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.bmc.2013.01.064","article-title":"Phenylimino-2h-chromen-3-carboxamide derivatives as novel small molecule inhibitors of \u03b2-secretase (bace1)","volume":"21","author":"Edraki","year":"2013","journal-title":"Biorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib86","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202100599","article-title":"Imino-2h-chromene based derivatives as potential anti-Alzheimer's agents: design, synthesis, biological evaluation and in silico study","volume":"19","author":"Attarroshan","year":"2022","journal-title":"Chem Biodivers"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib87","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1080\/14756366.2020.1835882","article-title":"Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease","volume":"35","author":"Szaaj","year":"2020","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113792","article-title":"Development and crystallography-aided sar studies of multifunctional buche inhibitors and 5-ht6r antagonists with beta-amyloid anti-aggregation properties","volume":"225","author":"Wichur","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib89","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbrc.2018.02.024","article-title":"Butylphthalide ameliorates experimental autoimmune encephalomyelitis by suppressing pgam5-induced necroptosis and inflammation in microglia","volume":"497","author":"Wang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ejmech.2022.114695_bib90","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2009.07.020","article-title":"Dl-3-n-butylphthalide protects endothelial cells against oxidative\/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose deprivation in vitro","volume":"1290","author":"Ling","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.ejmech.2022.114695_bib91","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/slct.201904615","article-title":"Temperature-dependent green synthesis of new series of mannich bases from 4\u2010hydroxy-pyridine\u20102\u2010one and their antioxidant activity evaluation","volume":"5","author":"Kamali","year":"2020","journal-title":"ChemistrySelect"},{"issue":"6","key":"10.1016\/j.ejmech.2022.114695_bib92","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bmc.2019.01.040","article-title":"Discovery of 4\u2032-oh-flurbiprofen mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities","volume":"27","author":"Liu","year":"2019","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116074","article-title":"Novel 3-benzylidene\/benzylphthalide mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease","volume":"35","author":"Cao","year":"2021","journal-title":"Bioorg. Med. Chem."},{"issue":"7\u201312","key":"10.1016\/j.ejmech.2022.114695_bib94","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1080\/13543776.2017.1360284","article-title":"Coumarin derivatives: an updated patent review (2015-2016)","volume":"27","author":"Detsi","year":"2017","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.ejmech.2022.114695_bib95","first-page":"303","article-title":"Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer's compounds: in vitro and in vivo biological evaluation and docking study","volume":"83","author":"Zahra","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib96","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejmech.2018.01.055","article-title":"Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease","volume":"146","author":"Jiang","year":"2018","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib97","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0254-6272(15)30016-9","article-title":"Medicinal properties of peganum harmala l. In traditional iranian medicine and modern phytotherapy: a review","volume":"35","author":"Niroumand","year":"2015","journal-title":"J Tradit Chin Med"},{"key":"10.1016\/j.ejmech.2022.114695_bib98","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bioorg.2016.11.011","article-title":"Synthesis of novel chromenones linked to 1,2,3-triazole ring system: investigation of biological activities against Alzheimer's disease","volume":"70","author":"Saeedi","year":"2017","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib99","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13065-020-00715-0","article-title":"Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease","volume":"14","author":"Karimi Askarani","year":"2020","journal-title":"BMC Chem"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40199-020-00378-1","article-title":"Chromone-lipoic acid conjugate: neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities","volume":"29","author":"Jalili-Baleh","year":"2021","journal-title":"Daru"},{"issue":"5","key":"10.1016\/j.ejmech.2022.114695_bib101","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201900746","article-title":"Design and synthesis of novel arylisoxazole-chromenone carboxamides: investigation of biological activities associated with Alzheimer's disease","volume":"17","author":"Saeedi","year":"2020","journal-title":"Chem Biodivers"},{"issue":"20","key":"10.1016\/j.ejmech.2022.114695_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127477","article-title":"New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation","volume":"30","author":"Singh","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"11","key":"10.1016\/j.ejmech.2022.114695_bib103","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/ardp.201300242","article-title":"Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors","volume":"346","author":"Modh","year":"2013","journal-title":"Arch. Pharm."},{"issue":"12","key":"10.1016\/j.ejmech.2022.114695_bib104","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s13205-020-02481-1","article-title":"Synthesis of novel 4-methylthiocoumarin and comparison with conventional coumarin derivative as a multi-target-directed ligand in Alzheimer's disease","volume":"10","author":"Kumar","year":"2020","journal-title":"3 Biotech"},{"issue":"5","key":"10.1016\/j.ejmech.2022.114695_bib105","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1021\/acschemneuro.8b00699","article-title":"Novel deoxyvasicinone-donepezil hybrids as potential multitarget drug candidates for Alzheimer's disease","volume":"10","author":"Du","year":"2019","journal-title":"ACS Chem Neurosci"},{"issue":"19","key":"10.1016\/j.ejmech.2022.114695_bib106","doi-asserted-by":"crossref","first-page":"5884","DOI":"10.1016\/j.bmc.2012.07.045","article-title":"O-hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-\u03b2 aggregation","volume":"20","author":"Fei","year":"2012","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116311","article-title":"Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease","volume":"45","author":"Bowroju","year":"2021","journal-title":"Bioorg. Med. Chem."},{"issue":"24","key":"10.1016\/j.ejmech.2022.114695_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127659","article-title":"Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation","volume":"30","author":"Du","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"4","key":"10.1016\/j.ejmech.2022.114695_bib109","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1021\/jf0259361","article-title":"Wedge, Dewayne, Harries, Natural fungicides from ruta graveolens l. Leaves, including a new quinolone alkaloid","volume":"51","author":"Anna","year":"2003","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115190","article-title":"Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-alzheimer agents","volume":"28","author":"Luo","year":"2020","journal-title":"Bioorg. Med. Chem."},{"issue":"17","key":"10.1016\/j.ejmech.2022.114695_bib111","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.2174\/1389557517666170321103139","article-title":"Berberine derivatives with different pharmacological activities via structural modifications","volume":"18","author":"Xiao","year":"2017","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112593","article-title":"Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile","volume":"203","author":"Sobolova","year":"2020","journal-title":"Eur J Med Chem"},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib113","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/ddr.21631","article-title":"Dual targeting of cholinesterase and amyloid beta with pyridinium\/isoquinolium derivatives","volume":"81","author":"Chakravarty","year":"2020","journal-title":"Drug Dev. Res."},{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib114","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1039\/C7QO00836H","article-title":"Pyridinium salts: from synthesis to reactivity and applications","volume":"5","author":"Sowmiah","year":"2018","journal-title":"Org Chem Front"},{"key":"10.1016\/j.ejmech.2022.114695_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103192","article-title":"Novel n-benzylpyridinium moiety linked to arylisoxazole derivatives as selective butyrylcholinesterase inhibitors: synthesis, biological evaluation, and docking study","volume":"92","author":"Vafadarnejad","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib116","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/ddr.21631","article-title":"Dual targeting of cholinesterase and amyloid beta with pyridinium\/isoquinolium derivatives","volume":"81","author":"Chakravarty","year":"2019","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2022.114695_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105390","article-title":"Interest of novel n-alkylpyridinium-indolizine hybrids in the field of Alzheimer's disease: synthesis, characterization and evaluation of antioxidant activity, cholinesterase inhibition, and amyloid fibrillation interference","volume":"116","author":"Baussanne","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104186","article-title":"Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and beta-amyloid aggregation for Alzheimer's disease","volume":"103","author":"Ghotbi","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib119","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bmc.2017.12.042","article-title":"A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease","volume":"26","author":"Zhang","year":"2017","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib120","article-title":"Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease","volume":"94","author":"Lan","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib121","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejmech.2017.02.039","article-title":"Design, synthesis and evaluation of novel ferulic acid-o-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease","volume":"130","author":"Sang","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104879","article-title":"Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer's disease","volume":"112","author":"Wang","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"8","key":"10.1016\/j.ejmech.2022.114695_bib123","first-page":"388","article-title":"Diverse molecular targets for chalcones with varied bioactivities","volume":"5","author":"Zhou","year":"2015","journal-title":"Med Chem"},{"issue":"12","key":"10.1016\/j.ejmech.2022.114695_bib124","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1021\/acs.chemrev.7b00020","article-title":"Chalcone: a privileged structure in medicinal chemistry","volume":"117","author":"Zhuang","year":"2017","journal-title":"Chem. Rev."},{"issue":"5","key":"10.1016\/j.ejmech.2022.114695_bib125","first-page":"1","article-title":"Licochalcone b, a chalcone derivative from glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease","volume":"34","author":"Cao","year":"2018","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.ejmech.2022.114695_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103477","article-title":"Flurbiprofen-chalcone hybrid mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: design, synthesis and biological evaluation","volume":"94","author":"Tian","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib127","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202100372","article-title":"Design and synthesis of novel chalcone derivatives and evaluation of their inhibitory activities against acetylcholinesterase","volume":"355","author":"Ceyhun","year":"2022","journal-title":"Arch Pharm (Weinheim)"},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib128","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s40199-020-00346-9","article-title":"Design, synthesis, and evaluation of novel cinnamic acid-tryptamine hybrid for inhibition of acetylcholinesterase and butyrylcholinesterase","volume":"28","author":"Ghafary","year":"2020","journal-title":"Daru"},{"key":"10.1016\/j.ejmech.2022.114695_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112257","article-title":"Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease","volume":"198","author":"Singh","year":"2020","journal-title":"Eur J Med Chem"},{"issue":"21","key":"10.1016\/j.ejmech.2022.114695_bib130","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1021\/acschemneuro.0c00448","article-title":"Further studies on triazinoindoles as potential novel multitarget-directed anti-Alzheimer's agents","volume":"11","author":"Patel","year":"2020","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.ejmech.2022.114695_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112368","article-title":"Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual ache and sert ligands for Alzheimer's disease","volume":"198","author":"Rodriguez-Lavado","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104617","article-title":"Biological evaluation and molecular docking of novel 1,3,4-thiadiazole-resorcinol conjugates as multifunctional cholinesterases inhibitors","volume":"107","author":"Skrzypek","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114695_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113973","article-title":"Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease","volume":"227","author":"Liu","year":"2022","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113224","article-title":"Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: design, synthesis, crystal structure and in-vitro biological evaluation","volume":"215","author":"Manzoor","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib135","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1248\/cpb.c19-00927","article-title":"Discovery and biological evaluation of new selective acetylcholinesterase inhibitors with anti-abeta aggregation activity through molecular docking-based virtual screening","volume":"68","author":"Liu","year":"2020","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"3","key":"10.1016\/j.ejmech.2022.114695_bib136","first-page":"612","article-title":"Pharmacognostical profiling on the root of rauwolfia serpentina","volume":"6","author":"Rungsung","year":"2014","journal-title":"Int. J. Pharmacogn. Phytochem. Res."},{"issue":"7","key":"10.1016\/j.ejmech.2022.114695_bib137","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.3390\/molecules25071609","article-title":"Ajmalicine and reserpine: indole alkaloids as multi-target directed ligands towards factors implicated in Alzheimer's disease","volume":"25","author":"Kashyap","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114695_bib138","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/bjc.1996.421","article-title":"Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by p-glycoprotein","volume":"74","author":"Quesada","year":"1996","journal-title":"Br. J. Cancer"},{"issue":"20","key":"10.1016\/j.ejmech.2022.114695_bib139","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.4155\/fmc-2019-0136","article-title":"Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: advances in synthesis and medicinal chemistry","volume":"11","author":"Matveeva","year":"2019","journal-title":"Future Med. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2022.114695_bib140","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/molecules26020359","article-title":"Homobivalent lamellarin-like schiff bases: in vitro evaluation of their cancer cell cytotoxicity and multitargeting anti-Alzheimer's disease potential","volume":"26","author":"Nevskaya","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114695_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113397","article-title":"Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters","volume":"218","author":"Pasieka","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"13","key":"10.1016\/j.ejmech.2022.114695_bib142","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc9750","article-title":"Catalytic photooxygenation degrades brain a beta in vivo","volume":"7","author":"Nagashima","year":"2021","journal-title":"Sci. Adv."},{"issue":"46","key":"10.1016\/j.ejmech.2022.114695_bib143","doi-asserted-by":"crossref","first-page":"10017","DOI":"10.1039\/D1OB01677F","article-title":"Chemical catalyst-promoted photooxygenation of amyloid proteins","volume":"19","author":"Sohma","year":"2021","journal-title":"Org. Biomol. Chem."},{"issue":"6","key":"10.1016\/j.ejmech.2022.114695_bib144","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1093\/brain\/awab058","article-title":"Photo-oxygenation by a biocompatible catalyst reduces amyloid-beta levels in Alzheimer's disease mice","volume":"144","author":"Ozawa","year":"2021","journal-title":"Brain"},{"issue":"44","key":"10.1016\/j.ejmech.2022.114695_bib145","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1039\/C9CC01728C","article-title":"Photo-oxygenation inhibits tau amyloid formation","volume":"55","author":"Suzuki","year":"2019","journal-title":"Chem Commun (Camb)"},{"issue":"4","key":"10.1016\/j.ejmech.2022.114695_bib146","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.chempr.2018.02.008","article-title":"Near-infrared photoactivatable oxygenation catalysts of amyloid peptide","volume":"4","author":"Ni","year":"2018","journal-title":"Chem"},{"issue":"10","key":"10.1016\/j.ejmech.2022.114695_bib147","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/nchem.2550","article-title":"Switchable photooxygenation catalysts that sense higher-order amyloid structures","volume":"8","author":"Taniguchi","year":"2016","journal-title":"Nat Chem"},{"issue":"5","key":"10.1016\/j.ejmech.2022.114695_bib148","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/anie.201308001","article-title":"Attenuation of the aggregation and neurotoxicity of amyloid-beta peptides by catalytic photooxygenation","volume":"53","author":"Taniguchi","year":"2014","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"5","key":"10.1016\/j.ejmech.2022.114695_bib149","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1021\/acschemneuro.1c00810","article-title":"Strategic design of amyloid-beta species fluorescent probes for Alzheimer's disease","volume":"13","author":"Su","year":"2022","journal-title":"ACS Chem Neurosci"},{"issue":"14","key":"10.1016\/j.ejmech.2022.114695_bib150","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1039\/D1TB01942B","article-title":"Fundamentals and exploration of aggregation-induced emission molecules for amyloid protein aggregation","volume":"10","author":"Tang","year":"2022","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.ejmech.2022.114695_bib151","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/bs.acc.2020.08.008","article-title":"Advances in fluorescent probes for detection and imaging of amyloid-beta peptides in Alzheimer's disease","volume":"103","author":"Zhang","year":"2021","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.ejmech.2022.114695_bib152","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cbpa.2021.04.011","article-title":"New strategies for fluorescently labeling proteins in the study of amyloids","volume":"64","author":"Shimogawa","year":"2021","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"4","key":"10.1016\/j.ejmech.2022.114695_bib153","first-page":"419","article-title":"An insight into the in vivo imaging potential of curcumin analogues as fluorescence probes","volume":"16","author":"Liu","year":"2021","journal-title":"Asian J Pharm Sci"},{"key":"10.1016\/j.ejmech.2022.114695_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111982","article-title":"Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer's disease","volume":"187","author":"Gyasi","year":"2020","journal-title":"Eur J Med Chem"},{"issue":"51","key":"10.1016\/j.ejmech.2022.114695_bib155","article-title":"Fluorescent diagnostic probes in neurodegenerative diseases","volume":"32","author":"Zhou","year":"2020","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114695_bib156","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acs.bioconjchem.9b00695","article-title":"Development of near-infrared fluorescent probes for use in alzheimers disease diagnosis","volume":"31","author":"Yang","year":"2020","journal-title":"Bioconjugate Chem"},{"issue":"23","key":"10.1016\/j.ejmech.2022.114695_bib157","doi-asserted-by":"crossref","first-page":"11819","DOI":"10.1021\/acs.chemrev.9b00404","article-title":"Interrogating amyloid aggregates using fluorescent probes","volume":"119","author":"Aliyan","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2022.114695_bib158","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bios.2017.06.030","article-title":"Abeta plaque-selective nir fluorescence probe to differentiate Alzheimer's disease from tauopathies","volume":"98","author":"Rajasekhar","year":"2017","journal-title":"Biosens. Bioelectron."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422005979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422005979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:45:40Z","timestamp":1759329940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422005979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":158,"alternative-id":["S0223523422005979"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114695","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114695"}}