{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T21:05:35Z","timestamp":1785618335864,"version":"3.56.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"am","delay-in-days":645,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ejmech.2022.114716","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T11:16:58Z","timestamp":1661599018000},"page":"114716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain"],"prefix":"10.1016","volume":"243","author":[{"given":"Yoshihito","family":"Kasanami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoka","family":"Chonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Toyooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Iba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyako","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kawase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-7711","authenticated-orcid":false,"given":"Takuya","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsufumi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2022.114716_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.biocel.2019.01.008","article-title":"T-type calcium channels: from molecule to therapeutic opportunities","volume":"108","author":"Weiss","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114716_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189737","article-title":"Selected molecular targets for antiepileptogenesis","volume":"22","author":"Pawlik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2022.114716_bib3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/bcp.12205","article-title":"Low threshold T-type calcium channels as targets for novel epilepsy treatments","volume":"77","author":"Powell","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00424-020-02429-7","article-title":"Neuronal Cav3 channelopathies: recent progress and perspectives","volume":"472","author":"Lory","year":"2020","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.ejmech.2022.114716_bib5","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tips.2016.05.002","article-title":"Voltage-gated ion channels in the PNS: novel therapies for neuropathic pain?","volume":"37","author":"Tibbs","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2022.114716_bib6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1254\/jphs.13R05CP","article-title":"T-type calcium channels: functional regulation and implication in pain signaling","volume":"122","author":"Sekiguchi","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2022.114716_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.trsl.2021.01.002","article-title":"Targeting T-type\/CaV3.2 channels for chronic pain","volume":"234","author":"Cai","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.ejmech.2022.114716_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173587","article-title":"Cav3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: an emerging signaling pathway for neuropathic pain","volume":"888","author":"Tomita","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173576","article-title":"Essential role of Cav3.2 T-type calcium channels in butyrate-induced colonic pain and nociceptor hypersensitivity in mice","volume":"887","author":"Tsubota","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cells9081748","article-title":"Cystitis-related bladder pain involves ATP-dependent HMGB1 release from macrophages and its downstream H2S\/Cav3.2 signaling in mice","volume":"9","author":"Hiramoto","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ejmech.2022.114716_bib11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tox.2018.12.003","article-title":"Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice","volume":"413","author":"Tomita","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.ejmech.2022.114716_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuropharm.2018.01.037","article-title":"Involvement of the cystathionine-gamma-lyase\/Cav3.2 pathway in substance P-induced bladder pain in the mouse, a model for nonulcerative bladder pain syndrome","volume":"133","author":"Tsubota","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejmech.2022.114716_bib13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jphs.2019.07.010","article-title":"Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL\/6 mice","volume":"140","author":"Matsui","year":"2019","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2022.114716_bib14","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/bph.14608","article-title":"Inhibition of Cav 3.2 calcium channels: a new target for colonic hypersensitivity associated with low-grade inflammation","volume":"176","author":"Picard","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib15","doi-asserted-by":"crossref","first-page":"11268","DOI":"10.1073\/pnas.1100869108","article-title":"T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome","volume":"108","author":"Marger","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2022.114716_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113838","article-title":"Painful diabetic neuropathy leads to functional CaV3.2 expression and spontaneous activity in skin nociceptors of mice","volume":"346","author":"Hoffmann","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejmech.2022.114716_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao4425","article-title":"Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain","volume":"11","author":"Joksimovic","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ejmech.2022.114716_bib18","series-title":"Cav3.2 Calcium Channels Contribute to Trigeminal Neuralgia","author":"Gambeta","year":"2022"},{"key":"10.1016\/j.ejmech.2022.114716_bib19","article-title":"Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2022.114716_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13041-020-00663-9","article-title":"Cav3.2 T-type calcium channels control acute itch in mice","volume":"13","author":"Gadotti","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejmech.2022.114716_bib21","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1080\/13543776.2018.1541982","article-title":"T-type calcium channel blockers: a patent review (2012-2018)","volume":"28","author":"Nam","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2022.114716_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000085329","article-title":"Voltage-dependent and frequency-independent inhibition of recombinant Cav3.2 T-type Ca2+ channel by bepridil","volume":"74","author":"Uchino","year":"2005","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejmech.2022.114716_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2165\/00003495-200969010-00002","article-title":"Development of newer calcium channel antagonists: therapeutic potential of efonidipine in preventing electrical remodelling during atrial fibrillation","volume":"69","author":"Ohashi","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2022.114716_bib24","doi-asserted-by":"crossref","first-page":"121ra119","DOI":"10.1126\/scitranslmed.3003120","article-title":"T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures","volume":"4","author":"Tringham","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejmech.2022.114716_bib25","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1111\/bph.15498","article-title":"The T-type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity","volume":"178","author":"Harding","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib26","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bcp.2014.03.015","article-title":"A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats","volume":"89","author":"Jarvis","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib27","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1172\/JCI36954","article-title":"Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice","volume":"119","author":"Uebele","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejmech.2022.114716_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pain.2012.10.023","article-title":"State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects","volume":"154","author":"Francois","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.ejmech.2022.114716_bib29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1124\/jpet.110.171058","article-title":"In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice","volume":"335","author":"Kraus","year":"2010","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejmech.2022.114716_bib30","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/j.pain.0000000000000565","article-title":"Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain","volume":"157","author":"Sekiguchi","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.ejmech.2022.114716_bib31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/jpet.103.060814","article-title":"NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2, 3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels","volume":"309","author":"Huang","year":"2004","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejmech.2022.114716_bib32","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/j.1476-5381.2012.01886.x","article-title":"Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice","volume":"166","author":"Okubo","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jphs.2019.02.002","article-title":"NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice","volume":"140","author":"Matsuda","year":"2019","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2022.114716_bib34","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1111\/bph.13906","article-title":"Recent advances in the development of T-type calcium channel blockers for pain intervention","volume":"175","author":"Snutch","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13041-022-00923-w","article-title":"Central and peripheral contributions of T-type calcium channels in pain","volume":"15","author":"Harding","year":"2022","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejmech.2022.114716_bib36","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuropharm.2018.06.020","article-title":"Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice","volume":"138","author":"Sekiguchi","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejmech.2022.114716_bib37","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1016\/j.bmc.2018.07.023","article-title":"Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers","volume":"26","author":"Du Nguyen","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114716_bib38","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1523\/JNEUROSCI.22-02-00396.2002","article-title":"Differential inhibition of T-type calcium channels by neuroleptics","volume":"22","author":"Santi","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejmech.2022.114716_bib39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1248\/bpb.b20-00742","article-title":"Effects of bepridil and pimozide, existing medicines capable of blocking T-type Ca2+ channels, on visceral pain in mice","volume":"44","author":"Tsubota","year":"2021","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2022.114716_bib40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bbrc.2014.01.185","article-title":"Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells","volume":"445","author":"Sekiguchi","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2022.114716_bib41","doi-asserted-by":"crossref","first-page":"8895","DOI":"10.1021\/acs.jmedchem.8b01136","article-title":"Optimization of a series of Mu Opioid receptor (MOR) agonists with high G protein signaling Bias","volume":"61","author":"Kennedy","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114716_bib42","unstructured":"X. Fu; C. Lu; X. Liu; C. Lufei; Y. Zhou, Heterocyclic compounds as STAT5 inhibitors and their preparation, pharmaceutical compositions and use in the treatment of rheumatoid arthritis, PCT Int. Appl. WO2020216378."},{"key":"10.1016\/j.ejmech.2022.114716_bib43","unstructured":"C.S. Lee; J.T. Oh; H. Yun; H. Song; H.M. Kim, Preparation of 1,3,4-oxadiazole Derivatives as Histone Deacetylase 6 Inhibitors, PCT Int Appl WO2020240492."},{"key":"10.1016\/j.ejmech.2022.114716_bib44","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1073\/pnas.1600418113","article-title":"Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain","volume":"113","author":"Choi","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2022.114716_bib45","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S1016-8478(23)17576-5","article-title":"Attenuated neuropathic pain in Cav3.1 null mice","volume":"25","author":"Na","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejmech.2022.114716_bib46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0014-2999(94)90238-0","article-title":"Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan","volume":"256","author":"Ybema","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib47","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0022-3565(25)24342-7","article-title":"Effect of nitrendipine, diltiazem, trifluoperazine and pimozide on serotonin2 (5-HT2) receptor activation in the rat uterus and jugular vein","volume":"238","author":"Cohen","year":"1986","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejmech.2022.114716_bib48","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1124\/jpet.109.163014","article-title":"Serotonin receptors in rat jugular vein: presence and involvement in the contraction","volume":"334","author":"Linder","year":"2010","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejmech.2022.114716_bib49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-2999(00)00123-0","article-title":"High affinity blockade of the HERG cardiac K+ channel by the neuroleptic pimozide","volume":"392","author":"Kang","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib50","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/gut.2007.144543","article-title":"Luminal hydrogen sulfide plays a pronociceptive role in mouse colon","volume":"58","author":"Matsunami","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.ejmech.2022.114716_bib51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pain.2010.04.022","article-title":"Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain","volume":"150","author":"Takahashi","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.ejmech.2022.114716_bib52","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2011.05.004","article-title":"Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats","volume":"188","author":"Okubo","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejmech.2022.114716_bib53","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/gut.2008.151910","article-title":"Hydrogen sulfide as a novel mediator for pancreatic pain in rodents","volume":"58","author":"Nishimura","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.ejmech.2022.114716_bib54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-3-319-18144-8_11","article-title":"H2S and pain: a novel aspect for processing of somatic, visceral and neuropathic pain signals","volume":"230","author":"Terada","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib55","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1476-5381.2012.02060.x","article-title":"Involvement of the endogenous hydrogen sulfide\/Cav 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice","volume":"167","author":"Matsunami","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114716_bib56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s007020050152","article-title":"The duration of the effects of a single administration of dopamine antagonists on ambulatory activity and motor coordination","volume":"106","author":"Agmo","year":"1999","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.ejmech.2022.114716_bib57","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pain.2007.01.026","article-title":"Hydrogen sulfide as a novel nociceptive messenger","volume":"132","author":"Kawabata","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.ejmech.2022.114716_bib58","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00232-007-0043-8","article-title":"Inhibition of the activity of human lymphocyte Kv1.3 potassium channels by resveratrol","volume":"214","author":"Teisseyre","year":"2006","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.ejmech.2022.114716_bib59","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejmech.2022.114716_bib60","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1254\/jphs.12086SC","article-title":"Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Cav3.2 and TRPA1 channels in mice","volume":"119","author":"Tsubota-Matsunami","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2022.114716_bib61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12974-019-1581-6","article-title":"Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin\/thrombomodulin system in rodents: negative impact of anticoagulants","volume":"16","author":"Tsubota","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejmech.2022.114716_bib62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(99)00916-4","article-title":"Haloperidol-induced catalepsy is absent in dopamine D2, but maintained in dopamine D3 receptor knock-out mice","volume":"391","author":"Boulay","year":"2000","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422006183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422006183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:44:23Z","timestamp":1759329863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422006183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":62,"alternative-id":["S0223523422006183"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114716","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114716","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114716"}}