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Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114736_bib31","doi-asserted-by":"crossref","first-page":"10824","DOI":"10.1039\/b910133k","article-title":"Cytotoxicity of the traditional Chinese medicine (TCM) plumbagin in its copper chemistry","author":"Chen","year":"2009","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2022.114736_bib32a","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1039\/c3sc51530c","article-title":"Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study","volume":"4","author":"Renfrew","year":"2013","journal-title":"Chem. 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