{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:03:51Z","timestamp":1787868231219,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005186","name":"Corporation for National and Community Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018987","name":"Romanian Government Ministry of Research Innovation and Digitization","doi-asserted-by":"publisher","award":["PN\u2013III\u2013P4-ID-PCCF-2016-0050"],"award-info":[{"award-number":["PN\u2013III\u2013P4-ID-PCCF-2016-0050"]}],"id":[{"id":"10.13039\/100018987","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018987","name":"Romanian Government Ministry of Research Innovation and Digitization","doi-asserted-by":"publisher","award":["PN\u2013III\u2013P4-ID-PCE-2020-1523"],"award-info":[{"award-number":["PN\u2013III\u2013P4-ID-PCE-2020-1523"]}],"id":[{"id":"10.13039\/100018987","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ejmech.2022.114811","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T02:29:49Z","timestamp":1664764189000},"page":"114811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Carbonic Anhydrase inhibitors bearing organotelluride moieties as novel agents for antitumor therapy"],"prefix":"10.1016","volume":"244","author":[{"given":"Andrea","family":"Petreni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Iacobescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Simionescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca-Roxana","family":"Petrovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Fifere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Pinteala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2022.114811_bib1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114811_bib2","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1126\/science.1232751","article-title":"Cell death from antibiotics without the involvement of reactive oxygen species","volume":"339","author":"Liu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2022.114811_bib3","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1126\/science.1232688","article-title":"Killing by bactericidal antibiotics does not depend on reactive oxygen species","volume":"339","author":"Keren","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2022.114811_bib4","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1089\/ars.2013.5728","article-title":"Redox-sensitive materials for drug delivery: targeting the correct intracellular environment, tuning release rates, and appropriate predictive systems","volume":"21","author":"Phillips","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejmech.2022.114811_bib5","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1021\/acs.chemrev.7b00698","article-title":"Redox signaling by reactive electrophiles and oxidants","volume":"118","author":"Parvez","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2022.114811_bib6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev-biochem-060815-014431","article-title":"Multiple functions and regulation of mammalian peroxiredoxins","volume":"86","author":"Rhee","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejmech.2022.114811_bib7","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/ars.2019.7905","article-title":"Regulatory phenomena in the glutathione peroxidase superfamily","volume":"33","author":"Brigelius-Floh\u00e9","year":"2020","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejmech.2022.114811_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101284","article-title":"Biochemical basis and metabolic interplay of redox regulation","volume":"26","author":"Zhang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejmech.2022.114811_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nchembio.1695","article-title":"Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling","volume":"11","author":"Sobotta","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114811_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/936486","article-title":"Reactive oxygen species in health and disease","volume":"2012","author":"Alfadda","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.ejmech.2022.114811_bib11","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2012.13659","article-title":"Reactive oxygen species: from health to disease","volume":"142","author":"Brieger","year":"2012","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.ejmech.2022.114811_bib12","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.freeradbiomed.2011.05.004","article-title":"Reactive oxygen species in cardiovascular disease","volume":"51","author":"Sugamura","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2022.114811_bib13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/antiox10060985","article-title":"The implication of reactive oxygen species and antioxidants in knee osteoarthritis","volume":"10","author":"Tudorachi","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejmech.2022.114811_bib14","series-title":"New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications","first-page":"295","author":"Fifere","year":"2021"},{"key":"10.1016\/j.ejmech.2022.114811_bib15","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","article-title":"Interfering with pH regulation in tumours as a therapeutic strategy","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2022.114811_bib16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18632\/oncotarget.422","article-title":"Recent developments in targeting carbonic anhydrase IX for cancer therapeutics","volume":"3","author":"McDonald","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejmech.2022.114811_bib17","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/med.21497","article-title":"Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: three for the price of one","volume":"38","author":"Supuran","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2022.114811_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/metabo10100412","article-title":"Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment","volume":"10","author":"Angeli","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.ejmech.2022.114811_bib19","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/adsc.201901536","article-title":"Rongalite-promoted on water synthesis of functionalised tellurides and ditellurides","volume":"362","author":"Tanini","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.ejmech.2022.114811_bib20","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1002\/adsc.202101147","article-title":"Capperucci A synthesis and applications of organic selenols","volume":"363","author":"Tanini","year":"2021","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.ejmech.2022.114811_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10534-013-9701-8","article-title":"Tellurite reduction by Escherichia coli NDH-II dehydrogenase results in superoxide production in membranes of toxicant-exposed cells","volume":"27","author":"D\u00edaz-V\u00e1squez","year":"2014","journal-title":"Biometals"},{"key":"10.1016\/j.ejmech.2022.114811_bib22","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1080\/10715762.2018.1536824","article-title":"Toxicity of organochalcogens in human leukocytes is associated, but not directly related with reactive species production, apoptosis and changes in antioxidant gene expression","volume":"52","author":"Bueno","year":"2018","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ejmech.2022.114811_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111586","article-title":"Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity","volume":"181","author":"Tanini","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib24","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1021\/jm9900523","article-title":"Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic\/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105920","article-title":"A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors","volume":"126","author":"Kumar","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib26","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1021\/acs.jmedchem.0c00211","article-title":"Tellurides bearing sulfonamides as novel inhibitors of leishmanial carbonic anhydrase with potent antileishmanial activity","volume":"63","author":"Angeli","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128147","article-title":"Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity","volume":"45","author":"Angeli","year":"2021","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2022.114811_bib28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.bioorg.2017.12.010","article-title":"First evaluation of organotellurium derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors","volume":"76","author":"Angeli","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib29","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","article-title":"The carbon dioxide hydration activity of carbonic anhydrase. I. Stop flow kinetic studies on the native human isoenzymes B and C","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2018306","article-title":"Protective role of carbonic anhydrases III and VII in cellular defense mechanisms upon redox unbalance","volume":"2018","author":"Di Fiore","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejmech.2022.114811_bib31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.arabjc.2010.09.016","article-title":"Antioxidant activity of clove oil - a powerful antioxidant source","volume":"5","author":"G\u00fcl\u00e7in","year":"2012","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib32","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1039\/c0ob00086h","article-title":"Tellurium: an element with great biological potency and potential","volume":"8","author":"Ba","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib33","doi-asserted-by":"crossref","first-page":"7616","DOI":"10.1016\/j.tet.2009.06.109","article-title":"Formation of DMSO and DMF radicals with minute amounts of base","volume":"65","author":"\u00d8pstad","year":"2009","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2022.114811_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.vascn.2010.10.004","article-title":"Antioxidant properties of dimethyl sulfoxide and its viability as a solvent in the evaluation of neuroprotective antioxidants","volume":"63","author":"Sanmart\u00edn-Su\u00e1rez","year":"2011","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ejmech.2022.114811_bib35","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1016\/j.watres.2004.02.028","article-title":"Kinetics and mechanisms of DMSO (dimethylsulfoxide) degradation by UV\/H(2)O(2) process","volume":"38","author":"Lee","year":"2004","journal-title":"Water Res."},{"key":"10.1016\/j.ejmech.2022.114811_bib36","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/adsc.201901536","article-title":"Rongalite-promoted on water synthesis of functionalised tellurides and ditellurides","volume":"362","author":"Tanini","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.ejmech.2022.114811_bib37","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1039\/C8NJ00700D","article-title":"Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity","volume":"42","author":"Tanini","year":"2018","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules21081013","article-title":"Cytotoxicity, post-treatment recovery, and selectivity analysis of naturally occurring podophyllotoxins from Bursera fagaroides var. fagaroides on breast cancer cell lines","volume":"21","author":"Pe\u00f1a-Mor\u00e1n","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114811_bib39","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2022.114811_bib40","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.bioorg.2019.03.062","article-title":"Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators","volume":"87","author":"Tanini","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114811_bib41","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1021\/acsmedchemlett.8b00170","article-title":"Targeting tumor associated carbonic anhydrases IX and XII: highly isozyme selective coumarin and psoralen inhibitors","volume":"9","author":"Melis","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2022.114811_bib42","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/acsmedchemlett.8b00362","article-title":"Heterocoumarins are selective carbonic anhydrase IX and XII inhibitors with cytotoxic effects against cancer cells lines","volume":"9","author":"Angeli","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2022.114811_bib43","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3390\/antiox10050738","article-title":"New insights on hemp oil enriched in cannabidiol: decarboxylation, antioxidant properties and in vitro anticancer effect","volume":"10","author":"Petrovici","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejmech.2022.114811_bib44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1439-0507.2007.01391.x","article-title":"Antioxidant properties of the essential oil of Eugenia caryophyllata and its antifungal activity against a large number of clinical Candida species","volume":"50","author":"Chaieb","year":"2007","journal-title":"Mycoses"},{"key":"10.1016\/j.ejmech.2022.114811_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11010-016-2724-z","article-title":"Glycated LDL increase VCAM-1 expression and secretion in endothelial cells and promote monocyte adhesion through mechanisms involving endoplasmic reticulum stress","volume":"417","author":"Toma","year":"2016","journal-title":"Mol. Cell. Biochem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422007139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422007139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:44:05Z","timestamp":1759329845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422007139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":45,"alternative-id":["S0223523422007139"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114811","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic Anhydrase inhibitors bearing organotelluride moieties as novel agents for antitumor therapy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114811","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114811"}}