{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:12:51Z","timestamp":1787501571948,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007059","name":"Univerzita Palack\u00e9ho v Olomouci","doi-asserted-by":"publisher","award":["JG_2019_002"],"award-info":[{"award-number":["JG_2019_002"]}],"id":[{"id":"10.13039\/501100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministry of Education Youth and Sports of the Czech Republic","doi-asserted-by":"publisher","award":["LM2018131"],"award-info":[{"award-number":["LM2018131"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G066619N"],"award-info":[{"award-number":["G066619N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006475","name":"Bergens Forskningsstiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006475","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ejmech.2022.114831","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T01:54:47Z","timestamp":1664934887000},"page":"114831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Novel heterocyclic hydroxamates as inhibitors of the mycobacterial zinc metalloprotease Zmp1 to probe its mechanism of function"],"prefix":"10.1016","volume":"244","author":[{"given":"Milan","family":"Dak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"\u0160lachtov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"\u0160ebela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e1clav","family":"Bazgier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Berka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Smiejkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Oorts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davie","family":"Cappoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8380-073X","authenticated-orcid":false,"given":"Lucie","family":"Brul\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ejmech.2022.114831_bib2","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.3390\/ijms20122868","article-title":"Opportunities for overcoming Mycobacterium tuberculosis drug resistance: emerging mycobacterial targets and host-directed therapy","volume":"20","author":"Torfs","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.ejmech.2022.114831_bib3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.chom.2008.03.003","article-title":"Mycobacterium tuberculosis prevents inflammasome activation","volume":"3","author":"Master","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.ejmech.2022.114831_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.chom.2008.03.006","article-title":"Linking inflammasome activation and phagosome maturation","volume":"3","author":"Lazarevic","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"37","key":"10.1016\/j.ejmech.2022.114831_bib5","doi-asserted-by":"crossref","first-page":"32475","DOI":"10.1074\/jbc.M111.271809","article-title":"Crystal structure of Mycobacterium tuberculosis zinc-dependent metalloprotease-1 (Zmp1), a metalloprotease involved in pathogenicity","volume":"286","author":"Ferraris","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2022.114831_bib6","series-title":"Encyclopedia of Inorganic and Bioinorganic Chemistry","first-page":"1","article-title":"Zinc-dependent metalloprotease-1 (Zmp1)","author":"Ferraris","year":"2013"},{"issue":"7","key":"10.1016\/j.ejmech.2022.114831_bib7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1515\/hsz-2012-0106","article-title":"Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates","volume":"393","author":"Petrera","year":"2012","journal-title":"Biol. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2022.114831_bib8","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.bmcl.2014.04.004","article-title":"Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor","volume":"24","author":"Mori","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"9","key":"10.1016\/j.ejmech.2022.114831_bib9","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.bmcl.2016.03.045","article-title":"Novel tetrazoloquinoline-rhodanine conjugates: highly efficient synthesis and biological evaluation","volume":"26","author":"Subhedar","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2022.114831_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ejmech.2016.09.059","article-title":"Quinolidene-rhodanine conjugates: facile synthesis and biological evaluation","volume":"125","author":"Subhedar","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2022.114831_bib11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bmcl.2018.01.031","article-title":"Design, synthesis, SAR and biological investigation of 3-(Carboxymethyl)Rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1","volume":"28","author":"Mori","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.ejmech.2022.114831_bib12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/cmdc.201700759","article-title":"Development of potent inhibitors of the Mycobacterium tuberculosis virulence factor Zmp1 and evaluation of their effect on mycobacterial survival inside macrophages","volume":"13","author":"Paolino","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2022.114831_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111812","article-title":"Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1","volume":"185","author":"\u0160lachtov\u00e1","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2022.114831_bib14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1021\/acs.jmedchem.5b00361","article-title":"Pan assay interference compounds (PAINS) and other promiscuous compounds in antifungal research: miniperspective","volume":"59","author":"Pouliot","year":"2016","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2022.114831_bib15","doi-asserted-by":"crossref","first-page":"978","DOI":"10.2174\/1385272823666190424142821","article-title":"Methods for hydroxamic acid synthesis","volume":"23","author":"Alam","year":"2019","journal-title":"Curr. Org. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2022.114831_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4103\/ijmy.ijmy_33_18","article-title":"Mycobacterium tuberculosis strains H37ra and H37rv have equivalent minimum inhibitory concentrations to most antituberculosis drugs","volume":"7","author":"Heinrichs","year":"2018","journal-title":"Int. J. Mycobacteriol."},{"issue":"1","key":"10.1016\/j.ejmech.2022.114831_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17460441.2017.1255604","article-title":"Current challenges in drug discovery for tuberculosis","volume":"12","author":"Kumar","year":"2017","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.ejmech.2022.114831_bib18","first-page":"181","article-title":"The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]Phenanthridine-7,12-diones against Mycobacterium tuberculosis","author":"Cappoen","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114831_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ejmech.2017.06.061","article-title":"Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-Ones","volume":"138","author":"de Macedo","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2022.114831_bib20","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1021\/jm401735w","article-title":"de. 1,2,3,4,8,9,10,11-Octahydrobenzo[ j ]Phenanthridine-7,12-Diones as New Leads against Mycobacterium Tuberculosis","volume":"57","author":"Cappoen","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114831_bib21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejmech.2011.12.035","article-title":"1,4-Diarylpiperazines and analogs as anti-tubercular agents: synthesis and biological evaluation","volume":"49","author":"Forge","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114831_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejmech.2014.02.065","article-title":"Anti-mycobacterial activity of 1,3-diaryltriazenes","volume":"77","author":"Cappoen","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"16","key":"10.1016\/j.ejmech.2022.114831_bib23","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock and AutoDockTools: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2022.114831_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422007334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422007334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:48:46Z","timestamp":1759330126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422007334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":23,"alternative-id":["S0223523422007334"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114831","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel heterocyclic hydroxamates as inhibitors of the mycobacterial zinc metalloprotease Zmp1 to probe its mechanism of function","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114831"}}