{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T14:50:42Z","timestamp":1794322242896,"version":"4.9.0"},"reference-count":246,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670359"],"award-info":[{"award-number":["31670359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016022","name":"Data Center of Management Science National Natural Science Foundation of China Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016022","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC 1905019"],"award-info":[{"award-number":["XLYC 1905019"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ejmech.2022.114861","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T11:14:58Z","timestamp":1666437298000},"page":"114861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications"],"prefix":"10.1016","volume":"244","author":[{"given":"Linzhou","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunxi","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiren","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2022.114861_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.ejmech.2022.114861_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2022.114861_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2018.03.017","article-title":"Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress","volume":"33","author":"Tsoi","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib9","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1158\/0008-5472.CAN-16-1979","article-title":"HSPA5 regulates ferroptotic cell death in cancer cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib10","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3389\/fphar.2017.00992","article-title":"The role of ferroptosis in cancer development and treatment response","volume":"8","author":"Lu","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114861_bib11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.20892\/j.issn.2095-3941.2019.0158","article-title":"The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer?","volume":"16","author":"Zhou","year":"2019","journal-title":"Cancer Biol Med"},{"key":"10.1016\/j.ejmech.2022.114861_bib12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.redox.2016.12.010","article-title":"Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis","volume":"11","author":"Roh","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib14","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1111\/cas.14496","article-title":"Ferroptosis at the crossroads of infection, aging and cancer","volume":"111","author":"Toyokuni","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib15","article-title":"Ferroptosis in cancer treatment: another way to rome","volume":"10","author":"Wu","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2022.114861_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejmech.2022.114861_bib17","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/ijc.28159","article-title":"Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib","volume":"133","author":"Louandre","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmech.2022.114861_bib18","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1172\/JCI99032","article-title":"Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma","volume":"128","author":"Hassannia","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejmech.2022.114861_bib19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.ejmech.2022.114861_bib20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2022.114861_bib21","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2022.114861_bib22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib24","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41419-020-03194-2","article-title":"Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo","volume":"11","author":"Xia","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2022.114861_bib25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1158\/1055-9965.EPI-13-0733","article-title":"Iron and cancer risk--a systematic review and meta-analysis of the epidemiological evidence","volume":"23","author":"Fonseca-Nunes","year":"2014","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.ejmech.2022.114861_bib26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib28","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting ferroptosis to iron out cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41419-021-03790-w","article-title":"MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma","volume":"12","author":"Lu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2022.114861_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.390","article-title":"Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin","volume":"11","author":"Tang","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib32","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.cell.2012.05.009","article-title":"Ironing out cell death mechanisms","volume":"149","author":"Reed","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib33","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbrc.2016.08.034","article-title":"CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2022.114861_bib34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.canlet.2018.06.018","article-title":"CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer","volume":"432","author":"Kim","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib35","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ncb3053","article-title":"Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo","volume":"16","author":"Dowdle","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib36","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2022.114861_bib37","article-title":"Characteristics and biomarkers of ferroptosis","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib39","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1021\/acschembio.5b00245","article-title":"Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death","volume":"10","author":"Dixon","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib40","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/s41589-019-0408-1","article-title":"The chemical basis of ferroptosis","volume":"15","author":"Conrad","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib42","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2022.114861_bib43","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41589-020-0472-6","article-title":"Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis","volume":"16","author":"Zou","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib44","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s13238-021-00823-0","article-title":"Cytochrome P450 reductase (POR) as a ferroptosis fuel","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib47","doi-asserted-by":"crossref","first-page":"R1292","DOI":"10.1016\/j.cub.2020.09.068","article-title":"Ferroptosis","volume":"30","author":"Tang","year":"2020","journal-title":"Curr Biol"},{"key":"10.1016\/j.ejmech.2022.114861_bib48","doi-asserted-by":"crossref","first-page":"37423","DOI":"10.1074\/jbc.M506439200","article-title":"Redox imbalance in cystine\/glutamate transporter-deficient mice","volume":"280","author":"Sato","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib49","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib50","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib51","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib52","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib53","doi-asserted-by":"crossref","first-page":"48389","DOI":"10.1074\/jbc.M409935200","article-title":"A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages","volume":"279","author":"Kumagai","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib54","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/jid.2013.52","article-title":"Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2","volume":"133","author":"Sengupta","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejmech.2022.114861_bib55","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/embor.2012.156","article-title":"Mammalian proapoptotic factor ChaC1 and its homologues function as \u03b3-glutamyl cyclotransferases acting specifically on glutathione","volume":"13","author":"Kumar","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ejmech.2022.114861_bib56","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.ejmech.2022.114861_bib57","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2019.09.023","article-title":"Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma","volume":"519","author":"Wang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2022.114861_bib58","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","article-title":"Identification of ACSL4 as a biomarker and contributor of ferroptosis","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2022.114861_bib59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2022.114861_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin receptor is a specific ferroptosis marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejmech.2022.114861_bib61","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114584","article-title":"Recent progress on targeting ferroptosis for cancer therapy","volume":"190","author":"Xu","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114861_bib63","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1073\/pnas.042707999","article-title":"Antigen-presenting cells control T cell proliferation by regulating amino acid availability","volume":"99","author":"Edinger","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2022.114861_bib64","doi-asserted-by":"crossref","first-page":"11455","DOI":"10.1074\/jbc.274.17.11455","article-title":"Cloning and expression of a plasma membrane cystine\/glutamate exchange transporter composed of two distinct proteins","volume":"274","author":"Sato","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib65","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1476-5381.2011.01480.x","article-title":"System xc\u207b cystine\/glutamate antiporter: an update on molecular pharmacology and roles within the CNS","volume":"165","author":"Bridges","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114861_bib66","first-page":"1650","article-title":"Insights into the novel function of system Xc- in regulated cell death","volume":"25","author":"Tu","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105450","article-title":"Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis","volume":"152","author":"Xu","year":"2020","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib68","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","article-title":"Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer","volume":"38","author":"Koppula","year":"2018","journal-title":"Cancer Commun."},{"key":"10.1016\/j.ejmech.2022.114861_bib69","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s00018-016-2194-1","article-title":"Mechanisms of ferroptosis","volume":"73","author":"Cao","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib70","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2022.114861_bib71","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X activity","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib73","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12935-021-02366-0","article-title":"Induction and application of ferroptosis in cancer therapy","volume":"22","author":"Nie","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ejmech.2022.114861_bib74","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1158\/1535-7163.MCT-08-0013","article-title":"Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling","volume":"7","author":"Wilhelm","year":"2008","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2022.114861_bib75","doi-asserted-by":"crossref","first-page":"377","DOI":"10.7326\/0003-4819-101-3-377","article-title":"Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development","volume":"101","author":"Peppercorn","year":"1984","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib76","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2165\/00003495-200565130-00008","article-title":"Sulfasalazine: a review of its use in the management of rheumatoid arthritis","volume":"65","author":"Plosker","year":"2005","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2022.114861_bib77","first-page":"381","article-title":"Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer","author":"Roh","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib78","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/pros.20508","article-title":"Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy","volume":"67","author":"Doxsee","year":"2007","journal-title":"Prostate"},{"key":"10.1016\/j.ejmech.2022.114861_bib79","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.canlet.2011.07.024","article-title":"Disruption of xCT inhibits cell growth via the ROS\/autophagy pathway in hepatocellular carcinoma","volume":"312","author":"Guo","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib80","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccr.2013.08.020","article-title":"Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target","volume":"24","author":"Timmerman","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib81","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00280-008-0894-4","article-title":"The xc- cystine\/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine","volume":"64","author":"Guan","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114861_bib82","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.canlet.2015.07.031","article-title":"Xc- inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism","volume":"368","author":"Ma","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib83","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/sj.leu.2402238","article-title":"Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug","volume":"15","author":"Gout","year":"2001","journal-title":"Leukemia"},{"key":"10.1016\/j.ejmech.2022.114861_bib84","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa8103","article-title":"SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma","volume":"7","author":"Robert","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib85","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153370","article-title":"Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2\/HO-1 axis in EGFR wild-type non-small-cell lung cancer","volume":"80","author":"Lou","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejmech.2022.114861_bib87","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3892\/or.2015.3712","article-title":"Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-\u03b3-lyase function","volume":"33","author":"Chen","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejmech.2022.114861_bib88","article-title":"The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents","volume":"2","author":"Yu","year":"2015","journal-title":"Mol Cell Oncol"},{"key":"10.1016\/j.ejmech.2022.114861_bib89","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1021\/ja301056a","article-title":"Halogen-enriched fragment libraries as leads for drug rescue of mutant p53","volume":"134","author":"Wilcken","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"7","key":"10.1016\/j.ejmech.2022.114861_bib90","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41422-022-00642-w","article-title":"The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis","volume":"32","author":"Yan","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.chembiol.2019.01.008","article-title":"Imidazole Ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.ejmech.2022.114861_bib92","doi-asserted-by":"crossref","first-page":"8773","DOI":"10.1073\/pnas.1105941108","article-title":"Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress","volume":"108","author":"Shaw","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2022.114861_bib93","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/13543776.2017.1338687","article-title":"Novel benzopyran derivatives and their therapeutic applications: a patent review (2009-2016)","volume":"27","author":"Xiu","year":"2017","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2022.114861_bib94","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6901472","article-title":"IMCA induces ferroptosis mediated by SLC7A11 through the AMPK\/mTOR pathway in colorectal cancer","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejmech.2022.114861_bib95","doi-asserted-by":"crossref","first-page":"74630","DOI":"10.18632\/oncotarget.11858","article-title":"Temozolomide toxicity operates in a xCT\/SLC7a11 dependent manner and is fostered by ferroptosis","volume":"7","author":"Sehm","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejmech.2022.114861_bib96","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3349\/ymj.2021.62.9.843","article-title":"Temozolomide drives ferroptosis via a DMT1-dependent pathway in glioblastoma cells","volume":"62","author":"Song","year":"2021","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.ejmech.2022.114861_bib97","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8 T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib98","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/JLB.3MA1220-815RRR","article-title":"IFN\u03b3-mediated repression of system xc drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells","volume":"110","author":"Kong","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib99","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201807","article-title":"Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation","volume":"40","author":"Guan","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ejmech.2022.114861_bib100","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1038\/s41598-019-42251-5","article-title":"Small-molecule ferroptotic agents with potential to selectively target cancer stem cells","volume":"9","author":"Taylor","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2022.114861_bib101","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1134\/S0006297914130082","article-title":"Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes","volume":"79","author":"Kalinina","year":"2014","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.ejmech.2022.114861_bib102","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/biof.1476","article-title":"Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways","volume":"45","author":"Scir\u00e8","year":"2019","journal-title":"Biofactors"},{"key":"10.1016\/j.ejmech.2022.114861_bib103","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1134\/S0006297920080052","article-title":"Glutathione synthesis in cancer cells","volume":"85","author":"Kalinina","year":"2020","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.ejmech.2022.114861_bib104","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/s41388-018-0315-z","article-title":"The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma","volume":"37","author":"Miess","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmech.2022.114861_bib105","first-page":"8735","article-title":"Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors","volume":"15","author":"Nishizawa","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib106","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/ptr.6829","article-title":"Oridonin induces ferroptosis by inhibiting gamma-glutamyl cycle in TE1 cells","volume":"35","author":"Zhang","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib107","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrd1691","article-title":"Cellular processing of platinum anticancer drugs","volume":"4","author":"Wang","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2022.114861_bib108","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phrs.2016.01.001","article-title":"Cisplatin resistance and opportunities for precision medicine","volume":"106","author":"Amable","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib109","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4143\/crt.2016.572","article-title":"Ferroptosis: a novel anti-tumor action for cisplatin","volume":"50","author":"Guo","year":"2018","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.ejmech.2022.114861_bib110","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.joen.2015.01.024","article-title":"Acetaminophen: old drug, new issues","volume":"41","author":"Aminoshariae","year":"2015","journal-title":"J. Endod."},{"key":"10.1016\/j.ejmech.2022.114861_bib111","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s12253-015-9946-3","article-title":"Ferroptosis is involved in acetaminophen induced cell death","volume":"21","author":"L\u0151rincz","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib112","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nm.4232","article-title":"Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth","volume":"23","author":"Cramer","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib113","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0005-2760(82)90150-3","article-title":"Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides","volume":"710","author":"Ursini","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2022.114861_bib114","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0304-4165(85)90182-5","article-title":"The selenoenzyme phospholipid hydroperoxide glutathione peroxidase","volume":"839","author":"Ursini","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2022.114861_bib115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2018.03.001","article-title":"Selenium and GPX4, a vital symbiosis","volume":"127","author":"Friedmann Angeli","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib117","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib118","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.bmcl.2011.09.047","article-title":"Development of small-molecule probes that selectively kill cells induced to express mutant RAS","volume":"22","author":"We\u00efwer","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2022.114861_bib119","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nchembio.2079","article-title":"Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis","volume":"12","author":"Shimada","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib120","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41589-020-0501-5","article-title":"Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles","volume":"16","author":"Eaton","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib121","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1021\/acs.jmedchem.1c00569","article-title":"Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer","volume":"64","author":"Xu","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib122","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/s41419-021-04306-2","article-title":"Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells","volume":"12","author":"Sun","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2022.114861_bib123","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.7150\/jca.58500","article-title":"FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma","volume":"12","author":"Zhang","year":"2021","journal-title":"J. Cancer"},{"key":"10.1016\/j.ejmech.2022.114861_bib124","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1021\/acschembio.5b00900","article-title":"Five-membered ring peroxide selectively initiates ferroptosis in cancer cells","volume":"11","author":"Abrams","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib125","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","article-title":"FINO initiates ferroptosis through GPX4 inactivation and iron oxidation","volume":"14","author":"Gaschler","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib126","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2165\/00003088-199528060-00002","article-title":"Clinical pharmacokinetics of altretamine","volume":"28","author":"Damia","year":"1995","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejmech.2022.114861_bib127","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cell.2015.05.056","article-title":"Elucidating compound mechanism of action by network perturbation analysis","volume":"162","author":"Woo","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2022.114861_bib128","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.canlet.2014.11.014","article-title":"The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells","volume":"356","author":"Louandre","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib129","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/tox.23388","article-title":"Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis","volume":"37","author":"Ni","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ejmech.2022.114861_bib130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13045-020-01016-8","article-title":"Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells","volume":"14","author":"Ding","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejmech.2022.114861_bib131","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1021\/acs.jmedchem.1c01775","article-title":"Discovery of a novel stilbene derivative as a microtubule targeting agent capable of inducing cell ferroptosis","volume":"65","author":"Zhou","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101413","article-title":"AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis","volume":"30","author":"Chen","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib133","first-page":"3039","article-title":"Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity","volume":"11","author":"Guo","year":"2021","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.ejmech.2022.114861_bib134","doi-asserted-by":"crossref","first-page":"517","DOI":"10.18632\/oncoscience.160","article-title":"Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells","volume":"2","author":"Eling","year":"2015","journal-title":"Oncoscience"},{"key":"10.1016\/j.ejmech.2022.114861_bib135","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.phymed.2015.08.002","article-title":"Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells","volume":"22","author":"Ooko","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejmech.2022.114861_bib136","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.2147\/DDDT.S199459","article-title":"Role of GRP78 inhibiting artesunate-induced ferroptosis in mutant pancreatic cancer cells","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejmech.2022.114861_bib137","first-page":"12","article-title":"Artesunate affects T antigen expression and survival of virus-positive merkel cell carcinoma","author":"Sarma","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ejmech.2022.114861_bib138","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","article-title":"Regulators of iron homeostasis: new players in metabolism, cell death, and disease","volume":"41","author":"Bogdan","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib139","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.biopha.2018.11.030","article-title":"Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway","volume":"109","author":"Kong","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2022.114861_bib140","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.canlet.2016.07.033","article-title":"Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells","volume":"381","author":"Lin","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib141","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","article-title":"Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis","volume":"27","author":"Chen","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2022.114861_bib142","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.133","article-title":"Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells","volume":"8","author":"Basit","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2022.114861_bib143","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41557-019-0261-6","article-title":"Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis","volume":"11","author":"Llabani","year":"2019","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib144","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.90777","article-title":"Inhibition of neuronal ferroptosis protects hemorrhagic brain","volume":"2","author":"Li","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejmech.2022.114861_bib145","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/j.bbadis.2019.05.009","article-title":"Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: protection by Melatonin","volume":"1865","author":"NaveenKumar","year":"2019","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.ejmech.2022.114861_bib146","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.transci.2018.05.028","article-title":"Haemin-induced cell death in human monocytic cells is consistent with ferroptosis","volume":"57","author":"Imoto","year":"2018","journal-title":"Transfus. Apher. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib147","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bbrc.2018.06.019","article-title":"Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors","volume":"503","author":"Fang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2022.114861_bib148","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/hep.29117","article-title":"Characterization of ferroptosis in murine models of hemochromatosis","volume":"66","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2022.114861_bib149","doi-asserted-by":"crossref","first-page":"H659","DOI":"10.1152\/ajpheart.00452.2017","article-title":"Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes","volume":"314","author":"Baba","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejmech.2022.114861_bib150","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.208","article-title":"Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells","volume":"7","author":"Ma","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2022.114861_bib151","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182921","article-title":"Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells","volume":"12","author":"Ma","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2022.114861_bib152","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13058-019-1177-1","article-title":"Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2 breast cancer metastasis","volume":"21","author":"Nagpal","year":"2019","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib153","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib154","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13046-018-0733-3","article-title":"Iron-dependent cell death as executioner of cancer stem cells","volume":"37","author":"Zhao","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib155","first-page":"516","article-title":"Ruscogenin induces ferroptosis in pancreatic cancer cells","volume":"43","author":"Song","year":"2020","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejmech.2022.114861_bib156","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2017.12.025","article-title":"Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis","volume":"416","author":"Chang","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib157","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3469840","article-title":"Transcriptome investigation and in vitro verification of curcumin-induced HO-1 as a feature of ferroptosis in breast cancer cells","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejmech.2022.114861_bib158","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/1759-7714.13904","article-title":"Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy","volume":"12","author":"Tang","year":"2021","journal-title":"Thorac Cancer"},{"key":"10.1016\/j.ejmech.2022.114861_bib159","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12951-021-01058-1","article-title":"Simvastatin induced ferroptosis for triple-negative breast cancer therapy","volume":"19","author":"Yao","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejmech.2022.114861_bib160","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2018.10.426","article-title":"Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer","volume":"129","author":"Shin","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101702","article-title":"NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway","volume":"37","author":"Liu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib162","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.7150\/thno.44705","article-title":"Combinative treatment of \u03b2-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2022.114861_bib163","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41392-020-0149-3","article-title":"Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium\/calmodulin-dependent ferroptosis","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejmech.2022.114861_bib164","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ejmech.2018.08.036","article-title":"Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway","volume":"157","author":"Wei","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib165","doi-asserted-by":"crossref","first-page":"9838","DOI":"10.1021\/acs.jmedchem.0c01016","article-title":"A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen species","volume":"63","author":"Hu","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118077","article-title":"FTY720 induces ferroptosis and autophagy via PP2A\/AMPK pathway in multiple myeloma cells","volume":"260","author":"Zhong","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib167","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3892\/ol.2022.13224","article-title":"Ophiopogonin B induces gastric cancer cell death by blocking the GPX4\/xCT-dependent ferroptosis pathway","volume":"23","author":"Zhang","year":"2022","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib168","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20215310","article-title":"Potential in integrative oncology","volume":"20","author":"Dutta","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib169","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.tcb.2020.03.002","article-title":"The complex interplay between antioxidants and ROS in cancer","volume":"30","author":"Harris","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ejmech.2022.114861_bib171","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1080\/15548627.2020.1739447","article-title":"Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death","volume":"17","author":"Li","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2022.114861_bib172","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1158\/1541-7786.MCR-19-0691","article-title":"A TAZ-ANGPTL4-NOX2 Axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer","volume":"18","author":"Yang","year":"2020","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib173","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2019.06.015","article-title":"Role of TLR4\/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure","volume":"516","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2022.114861_bib174","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: role of lipid peroxidation, iron and ferritinophagy","volume":"1861","author":"Latunde-Dada","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ejmech.2022.114861_bib175","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ebiom.2014.11.010","article-title":"A randomised, double blind, placebo-controlled pilot study of oral artesunate therapy for colorectal cancer","volume":"2","author":"Krishna","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ejmech.2022.114861_bib176","first-page":"21","article-title":"Artemisinin and its derivatives as a repurposing anticancer agent: what else do we need to do?","author":"Li","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114861_bib177","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/247597","article-title":"Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug","volume":"2012","author":"Crespo-Ortiz","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.ejmech.2022.114861_bib178","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbagen.2011.10.013","article-title":"Regulation of iron transport and the role of transferrin","volume":"1820","author":"Gkouvatsos","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2022.114861_bib179","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2020.02.015","article-title":"Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs","volume":"483","author":"Su","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib180","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","article-title":"Systemic iron homeostasis","volume":"93","author":"Ganz","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejmech.2022.114861_bib181","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.bbamcr.2015.01.021","article-title":"Cellular iron uptake, trafficking and metabolism: key molecules and mechanisms and their roles in disease","volume":"1853","author":"Lane","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2022.114861_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101670","article-title":"Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis","volume":"36","author":"Fuhrmann","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib183","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2022.114861_bib184","doi-asserted-by":"crossref","DOI":"10.3390\/biology10020083","article-title":"Metabolic regulation of ferroptosis in cancer","volume":"10","author":"Kim","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.ejmech.2022.114861_bib185","first-page":"266","volume":"2","author":"Heading","year":"2001","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"10.1016\/j.ejmech.2022.114861_bib186","first-page":"85","article-title":"The effects of the novel, reversible epidermal growth factor receptor\/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo","volume":"1","author":"Rusnak","year":"2001","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2022.114861_bib187","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.2174\/15672050113109990199","article-title":"Salinomycin: a novel anti-cancer agent with known anti-coccidial activities","volume":"20","author":"Zhou","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib188","doi-asserted-by":"crossref","first-page":"814","DOI":"10.7164\/antibiotics.27.814","article-title":"Salinomycin, a new polyether antibiotic","volume":"27","author":"Miyazaki","year":"1974","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.ejmech.2022.114861_bib189","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1080\/15548627.2017.1327104","article-title":"An iron hand over cancer stem cells","volume":"13","author":"Hama\u00ef","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2022.114861_bib190","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib191","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.ejmech.2022.114861_bib192","doi-asserted-by":"crossref","first-page":"24393","DOI":"10.18632\/oncotarget.5162","article-title":"Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death","volume":"6","author":"Kwon","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejmech.2022.114861_bib193","doi-asserted-by":"crossref","first-page":"21096","DOI":"10.1074\/jbc.272.34.21096","article-title":"Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo","volume":"272","author":"Pierce","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib194","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.exphem.2007.07.006","article-title":"Cytotoxicity of NF-kappaB inhibitors Bay 11-7085 and caffeic acid phenethyl ester to Ramos and other human B-lymphoma cell lines","volume":"35","author":"Berger","year":"2007","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.ejmech.2022.114861_bib195","doi-asserted-by":"crossref","first-page":"11668","DOI":"10.1158\/0008-5472.CAN-07-0632","article-title":"Targeting the nuclear factor-kappaB rescue pathway has promising future in human renal cell carcinoma therapy","volume":"67","author":"Sourbier","year":"2007","journal-title":"Cancer Res."},{"issue":"Pt 1","key":"10.1016\/j.ejmech.2022.114861_bib196","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bj3440153","article-title":"Haem oxygenase shows pro-oxidant activity in microsomal and cellular systems: implications for the release of low-molecular-mass iron","volume":"344","author":"Lamb","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejmech.2022.114861_bib197","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/978-1-60761-322-0_19","article-title":"Mammalian fatty acid elongases","volume":"579","author":"Jump","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib198","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0959-440X(01)00276-7","article-title":"Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures","volume":"11","author":"Istvan","year":"2001","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib199","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/bst0050611","article-title":"The function of thioredoxin and glutathione in deoxyribonucleic acid synthesis","volume":"5","author":"Holmgren","year":"1977","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejmech.2022.114861_bib200","doi-asserted-by":"crossref","first-page":"20815","DOI":"10.1074\/jbc.M115.641498","article-title":"Apoptosis-inducing factor (AIF) and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (NDH-2)","volume":"290","author":"Elguindy","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib201","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ejmech.2022.114861_bib202","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejmech.2022.114861_bib203","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tcm.2004.08.003","article-title":"Selenoproteins, cholesterol-lowering drugs, and the consequences: revisiting of the mevalonate pathway","volume":"14","author":"Moosmann","year":"2004","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib204","doi-asserted-by":"crossref","first-page":"44765","DOI":"10.1074\/jbc.M208704200","article-title":"Electrophile response element-mediated induction of the cystine\/glutamate exchange transporter gene expression","volume":"277","author":"Sasaki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0167-4781(00)00238-4","article-title":"Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein","volume":"1517","author":"Chan","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2022.114861_bib206","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.toxlet.2012.12.026","article-title":"Identification of aldo-keto reductases as NRF2-target marker genes in human cells","volume":"218","author":"Jung","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejmech.2022.114861_bib207","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.abb.2011.02.001","article-title":"Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages","volume":"508","author":"Harada","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejmech.2022.114861_bib208","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib209","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","article-title":"Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib210","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2019.03.027","article-title":"Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits bladder cancer cell growth via the mitochondrial apoptosis and JNK pathways","volume":"371","author":"Zhu","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114861_bib211","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biopha.2018.12.081","article-title":"Erianin induces cell apoptosis through ERK pathway in human nasopharyngeal carcinoma","volume":"111","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2022.114861_bib212","doi-asserted-by":"crossref","first-page":"e2247","DOI":"10.1038\/cddis.2016.138","article-title":"Erianin induces G2\/M-phase arrest, apoptosis, and autophagy via the ROS\/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2022.114861_bib213","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ymthe.2020.09.024","article-title":"A nuclear long non-coding RNA LINC00618 accelerates ferroptosis in a manner dependent upon apoptosis","volume":"29","author":"Wang","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejmech.2022.114861_bib214","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.tips.2019.06.004","article-title":"Advancing drug discovery via artificial intelligence","volume":"40","author":"Chan","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib215","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib216","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/d41586-022-00997-5","article-title":"What's next for AlphaFold and the AI protein-folding revolution","volume":"604","author":"Callaway","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib217","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jphs.2021.09.008","article-title":"Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism","volume":"148","author":"Cui","year":"2022","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib218","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41401-020-0478-3","article-title":"Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma","volume":"42","author":"Li","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejmech.2022.114861_bib219","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1021\/acs.jmedchem.1c01572","article-title":"Targeting regulated cell death with pharmacological small molecules: an update on autophagy-dependent cell death, ferroptosis, and necroptosis in cancer","volume":"65","author":"Wu","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114861_bib220","article-title":"Nanomaterials for cancer precision medicine","volume":"30","author":"Wang","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejmech.2022.114861_bib221","doi-asserted-by":"crossref","first-page":"17858","DOI":"10.1039\/C8NR05150J","article-title":"Development of a novel FePt-based multifunctional ferroptosis agent for high-efficiency anticancer therapy","volume":"10","author":"Yue","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.ejmech.2022.114861_bib222","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1002\/ctm2.364","article-title":"Clinical and functional significance of a novel ferroptosis-related prognosis signature in lung adenocarcinoma","volume":"11","author":"Wang","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ejmech.2022.114861_bib223","article-title":"Identification and validation of a four-gene ferroptosis signature for predicting overall survival of lung squamous cell carcinoma","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2022.114861_bib224","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7007933","article-title":"Comprehensive analysis of ferroptosis-related markers for the clinical and biological value in gastric cancer","volume":"2021","author":"Shao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejmech.2022.114861_bib225","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.7150\/ijbs.45050","article-title":"A novel ferroptosis-related gene signature for overall survival prediction in patients with hepatocellular carcinoma","volume":"16","author":"Liang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib226","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.890215","article-title":"Development and validation of a novel ferroptosis-related gene signature for prognosis and immunotherapy in hepatocellular carcinoma","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejmech.2022.114861_bib227","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1186\/s12885-021-08341-2","article-title":"Identification of the prognostic value of ferroptosis-related gene signature in breast cancer patients","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejmech.2022.114861_bib228","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.670184","article-title":"A novel ferroptosis-related gene signature for overall survival prediction in patients with breast cancer","volume":"9","author":"Zhu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib229","article-title":"Identification and validation of ferroptosis-related LncRNA signatures as a novel prognostic model for colon cancer","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2022.114861_bib230","article-title":"Identification of ferroptosis-related genes signature predicting the efficiency of invasion and metastasis ability in colon adenocarcinoma","volume":"9","author":"Shi","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib231","doi-asserted-by":"crossref","first-page":"942","DOI":"10.7150\/ijbs.57164","article-title":"Ferroptosis-related genes for overall survival prediction in patients with colorectal cancer can be inhibited by gallic acid","volume":"17","author":"Hong","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib232","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1186\/s12885-021-08559-0","article-title":"A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma","volume":"21","author":"Hong","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejmech.2022.114861_bib233","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1186\/s12935-021-02284-1","article-title":"Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma","volume":"21","author":"Xing","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ejmech.2022.114861_bib234","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12935-022-02700-0","article-title":"Construction and validation of a ferroptosis-related long noncoding RNA signature in clear cell renal cell carcinoma","volume":"22","author":"Zhu","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ejmech.2022.114861_bib235","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107789","article-title":"Development and validation of a novel ferroptosis-related gene signature for predicting prognosis and immune microenvironment in head and neck squamous cell carcinoma","volume":"98","author":"He","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejmech.2022.114861_bib236","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.785839","article-title":"Ferroptosis-related long non-coding RNA signature contributes to the prediction of prognosis outcomes in head and neck squamous cell carcinomas","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.ejmech.2022.114861_bib237","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1080\/21655979.2021.1925003","article-title":"A novel ferroptosis-related gene signature for predicting outcomes in cervical cancer","volume":"12","author":"Qi","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.ejmech.2022.114861_bib238","doi-asserted-by":"crossref","first-page":"17655","DOI":"10.18632\/aging.203257","article-title":"Characterization of ferroptosis signature to evaluate the predict prognosis and immunotherapy in glioblastoma","volume":"13","author":"Zhu","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ejmech.2022.114861_bib239","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1111\/cas.15131","article-title":"Ferroptosis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma","volume":"112","author":"Lei","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2022.114861_bib240","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1186\/s12885-021-08478-0","article-title":"Ferroptosis-related gene signature predicts the prognosis in Oral squamous cell carcinoma patients","volume":"21","author":"Li","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejmech.2022.114861_bib241","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib242","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/s41556-018-0178-0","article-title":"BAP1 links metabolic regulation of ferroptosis to tumour suppression","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejmech.2022.114861_bib243","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrd4253","article-title":"Tackling the cancer stem cells - what challenges do they pose?","volume":"13","author":"Pattabiraman","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2022.114861_bib244","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41586-020-2732-8","article-title":"Plasticity of ether lipids promotes ferroptosis susceptibility and evasion","volume":"585","author":"Zou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2022.114861_bib245","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.ymthe.2021.03.022","article-title":"Emerging mechanisms and targeted therapy of ferroptosis in cancer","volume":"29","author":"Wang","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejmech.2022.114861_bib246","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422007632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422007632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:55:37Z","timestamp":1759330537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422007632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":246,"alternative-id":["S0223523422007632"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114861","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114861"}}