{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:58:52Z","timestamp":1790261932987,"version":"4.1.0"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2019\/35\/B\/NZ7\/01165"],"award-info":[{"award-number":["2019\/35\/B\/NZ7\/01165"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ejmech.2022.114934","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T09:18:03Z","timestamp":1668417483000},"page":"114934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Potential of glycyrrhizic and glycyrrhetinic acids against influenza type A and B viruses: A perspective to develop new anti-influenza compounds and drug delivery systems"],"prefix":"10.1016","volume":"246","author":[{"given":"Dominik","family":"Langer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-0752","authenticated-orcid":false,"given":"Dariusz T.","family":"Mlynarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Dlugaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Tykarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2022.114934_bib1","doi-asserted-by":"crossref","DOI":"10.5694\/j.1326-5377.2006.tb00705.x","article-title":"The influenza viruses","volume":"185","author":"Hampson","year":"2006","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.ejmech.2022.114934_bib2","series-title":"Encyclopedia of Virology","first-page":"95","article-title":"Influenza","author":"Lamb","year":"2008"},{"key":"10.1016\/j.ejmech.2022.114934_bib3","first-page":"138","article-title":"Orthomyxoviruses \u2013 influenza and other viruses","volume":"57","author":"Wici\u0144ski","year":"2018","journal-title":"Postpy Mikrobiologii - Adv. Microbiol."},{"key":"10.1016\/j.ejmech.2022.114934_bib4","series-title":"Global Influenza Strategy 2019-2030","year":"2019"},{"key":"10.1016\/j.ejmech.2022.114934_bib5","first-page":"107","article-title":"Grypa \u2013 etiologia, epidemiologia, prewencja i leczenie w 2020 roku","volume":"14","author":"Ka\u0142ucka","year":"2020","journal-title":"Geriatria"},{"key":"10.1016\/j.ejmech.2022.114934_bib6","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(14)62449-1","article-title":"Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials","volume":"385","author":"Dobson","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2022.114934_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/ane.12629","article-title":"The mechanisms of sudden-onset type adverse reactions to oseltamivir","volume":"135","author":"Hama","year":"2017","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.ejmech.2022.114934_bib8","article-title":"Assessment of adverse events related to anti-infuenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews","volume":"10","author":"Han","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2022.114934_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/IDR.S105473","article-title":"Drug resistance in influenza A virus: the epidemiology and management","volume":"10","author":"Hussain","year":"2017","journal-title":"Infect. Drug. Resist."},{"issue":"7","key":"10.1016\/j.ejmech.2022.114934_bib10","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s10096-020-03840-9","article-title":"Influenza and antiviral resistance: an overview","volume":"39","author":"Lampejo","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejmech.2022.114934_bib11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s10156-011-0217-2","article-title":"Comparison of the efficacies of amantadine treatment of swine-origin influenza virus A H1N1 and seasonal influenza H1N1 and H3N2 in Japan (2008\u20132009)","volume":"17","author":"Miyachi","year":"2011","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.ejmech.2022.114934_bib12","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1002\/ptr.7099","article-title":"Natural products: a lead for drug discovery and development","volume":"35","author":"Chopra","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib13","doi-asserted-by":"crossref","first-page":"6090","DOI":"10.3390\/molecules26206090","article-title":"Glycyrrhizic acid inhibits SARS-CoV-2 infection by blocking spike protein-mediated cell attachment","volume":"26","author":"Li","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114934_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcab.2020.101890","article-title":"Therapeutic potential of medicinal plants against COVID-19: the role of antiviral medicinal metabolites","volume":"31","author":"Khan","year":"2021","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"10.1016\/j.ejmech.2022.114934_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jep.2005.04.015","article-title":"A history of the therapeutic use of liquorice in Europe","volume":"99","author":"Fiore","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2022.114934_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ptr.2295","article-title":"Antiviral effects of Glycyrrhiza species","volume":"22","author":"Fiore","year":"2008","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.yrtph.2006.06.002","article-title":"Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin","volume":"46","author":"Isbrucker","year":"2006","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"12","key":"10.1016\/j.ejmech.2022.114934_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/plants10122751","article-title":"Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology","volume":"10","author":"Wahab","year":"2021","journal-title":"Plants"},{"key":"10.1016\/j.ejmech.2022.114934_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0308-8146(90)90159-2","article-title":"Glycyrrhiza glabra L.\u2014Composition, uses and analysis","volume":"38","author":"Fenwick","year":"1990","journal-title":"Food Chem."},{"key":"10.1016\/j.ejmech.2022.114934_bib20","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s10600-005-0171-2","article-title":"High-Resolution 1H and 13C NMR of Glycyrrhizic Acid and Its Esters","volume":"41","author":"Baltina","year":"2005","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.ejmech.2022.114934_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF02218774","article-title":"Hydrolysis of \u03b2-glycyrrhizic acid","volume":"30","author":"Baltina","year":"1996","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.ejmech.2022.114934_bib22","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1021\/jf404939f","article-title":"Bioactivity and potential health benefits of licorice","volume":"62","author":"Kao","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2022.114934_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/jac\/dkh287","article-title":"In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites","volume":"54","author":"Krausse","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2022.114934_bib24","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/ptr.6178","article-title":"Liquorice (Glycyrrhiza glabra): a phytochemical and pharmacological review: liquorice (Glycyrrhiza glabra): a Review","volume":"32","author":"Pastorino","year":"2018","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib25","first-page":"121","article-title":"Hypertension induced by licorice","volume":"18","author":"Langer","year":"2014","journal-title":"Arter. Hypertens."},{"key":"10.1016\/j.ejmech.2022.114934_bib26","first-page":"34","article-title":"Research progress on structure modification and biological activity of 18\u03b2-glycyrrhetinic acid","volume":"1","author":"Kang","year":"2014","journal-title":"Curr Opin Complement Alternat Med"},{"key":"10.1016\/j.ejmech.2022.114934_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.680674","article-title":"Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice","volume":"12","author":"Huan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114934_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/1479-5876-9-112","article-title":"Glycyrrhizin as antiviral agent against Hepatitis C Virus","volume":"9","author":"Ashfaq","year":"2011","journal-title":"J. Transl. Med."},{"issue":"7","key":"10.1016\/j.ejmech.2022.114934_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068992","article-title":"Antiviral Activity of Glycyrrhizin against Hepatitis C Virus In Vitro","volume":"8","author":"Matsumoto","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejmech.2022.114934_bib30","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jep.2013.02.017","article-title":"Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease","volume":"147","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"5\u20136","key":"10.1016\/j.ejmech.2022.114934_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0166-3542(89)90035-1","article-title":"Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS","volume":"11","author":"Hattori","year":"1989","journal-title":"Antiviral Res."},{"issue":"2","key":"10.1016\/j.ejmech.2022.114934_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jep.2013.04.040","article-title":"Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines","volume":"148","author":"Yeh","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2022.114934_bib33","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/S0140-6736(03)13615-X","article-title":"Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus","volume":"361","author":"Cinatl","year":"2003","journal-title":"The Lancet"},{"issue":"20","key":"10.1016\/j.ejmech.2022.114934_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26206090","article-title":"Glycyrrhizic Acid Inhibits SARS-CoV-2 Infection by Blocking Spike Protein-Mediated Cell Attachment","volume":"26","author":"Li","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114934_bib35","article-title":"Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114934_bib36","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1128\/AAC.41.3.551","article-title":"Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus","volume":"41","author":"Utsunomiya","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2022.114934_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.antiviral.2009.04.012","article-title":"Glycyrrhizin inhibits influenza A virus uptake into the cell","volume":"83","author":"Wolkerstorfer","year":"2009","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019705","article-title":"Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression","volume":"6","author":"Michaelis","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2022.114934_bib39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10600-014-0941-9","article-title":"New amino-acid conjugates of glycyrrhizic acid","volume":"50","author":"Baltina","year":"2014","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.ejmech.2022.114934_bib40","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1134\/S1068162017040045","article-title":"Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters","volume":"43","author":"Fayrushina","year":"2017","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2022.114934_bib41","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.bmcl.2015.02.074","article-title":"Glycyrrhizic acid derivatives as influenza A\/H1N1 virus inhibitors","volume":"25","author":"Baltina","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2022.114934_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002745.pub4","article-title":"Amantadine and rimantadine for influenza A in children and the elderly","author":"Alves Galv\u00e3o","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejmech.2022.114934_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/1743-422X-9-96","article-title":"18\u03b2-glycyrrhetinic acid inhibits rotavirus replication in culture","volume":"9","author":"Hardy","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.ejmech.2022.114934_bib44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jare.2021.11.012","article-title":"Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection","volume":"36","author":"Yi","year":"2021","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ejps.2017.06.015","article-title":"Glycyrrhetic acid, but not glycyrrhizic acid, strengthened entecavir activity by promoting its subcellular distribution in the liver via efflux inhibition","volume":"106","author":"Chen","year":"2017","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2022.114934_bib46","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1166\/jbn.2020.2986","article-title":"A tenofovir-loaded glycyrrhetinic acid-modified cationic liposome for targeted therapy of hepatitis B virus","volume":"16","author":"Yao","year":"2020","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ejmech.2022.114934_bib47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/1043-6618(94)80057-X","article-title":"Antiviral activity of new triterpenic derivatives","volume":"29","author":"Serra","year":"1994","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3762\/bjoc.8.79","article-title":"Synthesis and antiviral activities of spacer-linked 1-thioglucuronide analogues of glycyrrhizin","volume":"8","author":"Stanetty","year":"2012","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.ejmech.2022.114934_bib49","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/cbic.201000618","article-title":"Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives","volume":"12","author":"Logashenko","year":"2011","journal-title":"Chembiochem"},{"key":"10.1016\/j.ejmech.2022.114934_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14029-0","article-title":"Soloxolone methyl inhibits influenza virus replication and reduces virus-induced lung inflammation","volume":"7","author":"Markov","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2022.114934_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bmc.2017.09.038","article-title":"Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates","volume":"26","author":"Tsuji","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114934_bib52","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bmcl.2006.10.075","article-title":"Anti-influenza virus activity of biflavonoids","volume":"17","author":"Miki","year":"2007","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2022.114934_bib53","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3987\/COM-07-11285","article-title":"Synthesis and evaluation of influenza virus sialidase inhibitory activity of hinokiflavone-sialic acid conjugates","volume":"75","author":"Miki","year":"2008","journal-title":"Heterocycles"},{"key":"10.1016\/j.ejmech.2022.114934_bib54","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1016\/j.bmcl.2012.03.081","article-title":"Synthesis, biological evaluation and structure\u2013activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents","volume":"22","author":"Wang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2022.114934_bib55","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1248\/cpb.c14-00088","article-title":"Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives","volume":"62","author":"Zhao","year":"2014","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2022.114934_bib56","doi-asserted-by":"crossref","first-page":"9611","DOI":"10.1016\/j.vaccine.2011.10.053","article-title":"Immunological adjuvant efficacy of glycyrrhetinic acid liposome against Newcastle disease vaccine","volume":"29","author":"Zhao","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.ejmech.2022.114934_bib57","article-title":"A comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives","volume":"7","author":"Wang","year":"2012","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.ejmech.2022.114934_bib58","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ejmech.2019.01.074","article-title":"Synthesis and structure-activity relationship studies of water-soluble \u03b2-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents","volume":"166","author":"Liang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2022.114934_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.836955","article-title":"Novel \u03b2-cyclodextrin-based heptavalent glycyrrhetinic acid conjugates: synthesis, characterization, and anti-influenza activity","volume":"10","author":"Liang","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejmech.2022.114934_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110219","article-title":"Predicting the environmental emissions arising from conventional and nanotechnology-related pharmaceutical drug products","volume":"192","author":"Jung","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejmech.2022.114934_bib62","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s11051-009-9607-0","article-title":"How interdisciplinary is nanotechnology?","volume":"11","author":"Porter","year":"2009","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib63","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.2217\/nnm.12.87","article-title":"Nanotechnology in therapeutics: a focus on nanoparticles as a drug delivery system","volume":"7","author":"Bamrungsap","year":"2012","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejmech.2022.114934_bib64","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.2147\/IJN.S315705","article-title":"Antiviral drug delivery system for enhanced bioactivity, better metabolism and pharmacokinetic characteristics","volume":"16","author":"Chen","year":"2021","journal-title":"IJN"},{"key":"10.1016\/j.ejmech.2022.114934_bib65","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1208\/s12249-020-01908-5","article-title":"Recent advancement in nanotechnology-based drug delivery system Against viral infections","volume":"22","author":"Pradhan","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejmech.2022.114934_bib66","first-page":"385","article-title":"Safe nanoparticles: are we there yet?","volume":"22","author":"Najahi-Missaoui","year":"2020","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.ejmech.2022.114934_bib67","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1515\/zpch-2016-0845","article-title":"Self-association of glycyrrhizic acid. NMR study","volume":"231","author":"Petrova","year":"2017","journal-title":"Z. Phys. Chem."},{"key":"10.1016\/j.ejmech.2022.114934_bib68","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.colsurfa.2016.04.032","article-title":"Aggregate formation of glycyrrhizic acid","volume":"500","author":"Matsuoka","year":"2016","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.ejmech.2022.114934_bib69","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ijpharm.2019.01.047","article-title":"Glycyrrhizic acid as a multifunctional drug carrier \u2013 from physicochemical properties to biomedical applications: a modern insight on the ancient drug","volume":"559","author":"Oyu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2022.114934_bib70","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2174\/2210289201102010064","article-title":"Glycyrrhizic acid as a novel drug delivery vector: synergy of drug transport and efficacy","volume":"2","author":"Polyakov","year":"2011","journal-title":"TOPROCJ"},{"key":"10.1016\/j.ejmech.2022.114934_bib71","first-page":"695","article-title":"Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics","volume":"9","author":"Cheng","year":"2014","journal-title":"IJN"},{"key":"10.1016\/j.ejmech.2022.114934_bib72","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejps.2016.09.036","article-title":"Synthesis, characterization and liver targeting evaluation of self-assembled hyaluronic acid nanoparticles functionalized with glycyrrhetinic acid","volume":"96","author":"Wang","year":"2017","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2022.114934_bib73","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1021\/mp500394v","article-title":"Doxorubicin-loaded glycyrrhetinic acid modified recombinant human serum albumin nanoparticles for targeting liver tumor chemotherapy","volume":"12","author":"Qi","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejmech.2022.114934_bib74","first-page":"373","article-title":"Preparation and antibacterial activity evaluation of 18-\u03b2-glycyrrhetinic acid loaded PLGA nanoparticles","volume":"14","author":"Darvishi","year":"2015","journal-title":"Iran. J. Pharm. Res. (IJPR)"},{"key":"10.1016\/j.ejmech.2022.114934_bib75","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1055\/s-0034-1390487","article-title":"Enhanced cellular cytotoxicity and antibacterial activity of 18-\u03b2-Glycyrrhetinic acid by albumin-conjugated PLGA nanoparticles","volume":"65","author":"Darvishi","year":"2015","journal-title":"Drug Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib76","first-page":"129","article-title":"Nanoparticles in modern medicine: state of the art and future challenges","volume":"2","author":"Murthy","year":"2007","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejmech.2022.114934_bib77","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/sj.bjp.0707130","article-title":"Nanoparticles: pharmacological and toxicological significance","volume":"150","author":"Medina","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114934_bib78","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.2174\/1389450115666140804124808","article-title":"Safety of nanoparticles in medicine","volume":"16","author":"Wolfram","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejmech.2022.114934_bib79","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.abb.2014.12.010","article-title":"Solubilization and stabilization of macular carotenoids by water soluble oligosaccharides and polysaccharides","volume":"572","author":"Apanasenko","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejmech.2022.114934_bib80","first-page":"1377","article-title":"Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid","volume":"8","author":"Wang","year":"2013","journal-title":"IJN"},{"key":"10.1016\/j.ejmech.2022.114934_bib81","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s13204-018-0758-0","article-title":"Effect of two glycyrrhizinic acid nanoparticle carriers on MARC-145 cells actin filaments","volume":"8","author":"Jardon","year":"2018","journal-title":"Appl. Nanosci."},{"key":"10.1016\/j.ejmech.2022.114934_bib82","first-page":"236","article-title":"Coumarin: chemical and pharmacological profile","author":"Jain","year":"2012","journal-title":"J. Appl. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2022.114934_bib83","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jfda.2017.12.006","article-title":"Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection","volume":"26","author":"Richart","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.ejmech.2022.114934_bib84","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.intimp.2017.11.009","article-title":"Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2\/4, p38\/JNK MAPK and NF-\u03baB pathways","volume":"54","author":"Dai","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejmech.2022.114934_bib85","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3390\/ph14090880","article-title":"Elucidating the effects of curcumin against influenza using in silico and in vitro approaches","volume":"14","author":"Kim","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2022.114934_bib86","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/10717544.2019.1704944","article-title":"Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability","volume":"27","author":"Wu","year":"2020","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejmech.2022.114934_bib87","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/837042","article-title":"Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans","author":"Gambini","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejmech.2022.114934_bib88","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1086\/429694","article-title":"Inhibition of influenza A virus replication by resveratrol","volume":"191","author":"Palamara","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ejmech.2022.114934_bib89","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.antiviral.2010.08.016","article-title":"Inhibition of influenza virus replication by plant-derived isoquercetin","volume":"88","author":"Kim","year":"2010","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib90","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12951-020-00611-8","article-title":"Porous gold nanoparticles for attenuating infectivity of influenza A virus","volume":"18","author":"Kim","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejmech.2022.114934_bib91","doi-asserted-by":"crossref","first-page":"23851","DOI":"10.1039\/D1RA02678J","article-title":"Green synthesis and characterization of gold nanoparticles and their application for the rapid detection of glycyrrhizin with immunochromatographic strips","volume":"11","author":"Feng","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2022.114934_bib92","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.3390\/molecules27061775","article-title":"Recent advances in glycyrrhetinic acid-functionalized biomaterials for liver cancer-targeting therapy","volume":"27","author":"Speciale","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114934_bib93","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/acs.molpharmaceut.5b00677","article-title":"Glycyrrhetinic acid mediated drug delivery carriers for hepatocellular carcinoma therapy","volume":"13","author":"Cai","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejmech.2022.114934_bib94","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/v8010006","article-title":"Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry","volume":"8","author":"Wu","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2022.114934_bib95","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.3390\/pr9091627","article-title":"Uncovering quercetin's effects against influenza A virus using network pharmacology and molecular docking","volume":"9","author":"Kim","year":"2021","journal-title":"Processes"},{"key":"10.1016\/j.ejmech.2022.114934_bib96","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/biom11010010","article-title":"Quercetin as a natural therapeutic candidate for the treatment of influenza virus","volume":"11","author":"Mehrbod","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejmech.2022.114934_bib97","doi-asserted-by":"crossref","first-page":"13305","DOI":"10.3390\/molecules190913305","article-title":"Self-Assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin","volume":"19","author":"Yuan","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114934_bib98","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jcis.2015.08.049","article-title":"The role of glycyrrhetinic acid modification on preparation and evaluation of quercetin-loaded chitosan-based self-aggregates","volume":"460","author":"Du","year":"2015","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejmech.2022.114934_bib99","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.3390\/molecules26134049","article-title":"Forward precision medicine: micelles for active targeting driven by peptides","volume":"26","author":"Prencipe","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114934_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153724","article-title":"Effect of paeoniflorin on acute lung injury induced by influenza A virus in mice. Evidences of its mechanism of action","volume":"92","author":"Yu","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejmech.2022.114934_bib101","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3390\/molecules21091133","article-title":"Anti-influenza virus activity and constituents characterization of paeonia delavayi extracts","volume":"21","author":"Li","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2022.114934_bib102","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3109\/00498254.2016.1149633","article-title":"Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6\u2019O-benzene sulfonate in rats via different routes of administration","volume":"46","author":"Wang","year":"2016","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ejmech.2022.114934_bib103","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/03639045.2020.1862178","article-title":"Glycyrrhizic acid-based self-assembled micelles for improving oral bioavailability of paeoniflorin","volume":"47","author":"Shen","year":"2021","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejmech.2022.114934_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120546","article-title":"Preparation, optimization, characterization and in vitro release of baicalein-solubilizing glycyrrhizic acid nano-micelles","volume":"601","author":"You","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2022.114934_bib105","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s11434-016-1136-5","article-title":"Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants","volume":"61","author":"Zhao","year":"2016","journal-title":"Sci. Bull."},{"key":"10.1016\/j.ejmech.2022.114934_bib106","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/263630","article-title":"Role of baicalin in anti-influenza virus A as a potent inducer of IFN-gamma","author":"Chu","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2022.114934_bib107","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1007\/s00705-014-2192-2","article-title":"Antiviral activity of baicalin against influenza A (H1N1\/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase","volume":"159","author":"Ding","year":"2014","journal-title":"Arch. Virol."},{"key":"10.1016\/j.ejmech.2022.114934_bib108","first-page":"5041","article-title":"Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR-146a","volume":"20","author":"Li","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejmech.2022.114934_bib109","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.antiviral.2014.11.003","article-title":"Baicalin inhibits autophagy induced by influenza A virus H3N2","volume":"113","author":"Zhu","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2022.114934_bib110","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s12272-018-1022-6","article-title":"The inhibitory effect of sodium baicalin on oseltamivir-resistant influenza A virus via reduction of neuraminidase activity","volume":"41","author":"Jin","year":"2018","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejmech.2022.114934_bib111","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s13318-018-0509-3","article-title":"Pharmacokinetics and bioavailability enhancement of baicalin: a review","volume":"44","author":"Huang","year":"2019","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.ejmech.2022.114934_bib112","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.fitote.2018.06.018","article-title":"A strategy to improve the oral availability of baicalein: the baicalein-theophylline cocrystal","volume":"129","author":"Li","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejmech.2022.114934_bib113","first-page":"1140","article-title":"The optimized delivery of triterpenes by liposomal nanoformulations: overcoming the challenges","volume":"23","author":"Milan","year":"2022","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.ejmech.2022.114934_bib114","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1556-276X-8-102","article-title":"Liposome: classification, preparation, and applications","volume":"8","author":"Akbarzadeh","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.ejmech.2022.114934_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2013.00143","article-title":"The use of lipid-based nanocarriers for targeted pain therapies","volume":"4","author":"Hua","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114934_bib116","article-title":"Preparation, characterization and uptake by primary cultured rat hepatocytes of liposomes surface-modified with glycyrrhetinic acid","volume":"614\u20139","author":"Mao","year":"2007","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejmech.2022.114934_bib117","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s11671-018-2737-5","article-title":"Preparation of glycyrrhetinic acid liposomes using lyophilization monophase solution method: preformulation, optimization, and in vitro evaluation","volume":"13","author":"Liu","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.ejmech.2022.114934_bib118","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.3390\/pharmaceutics13111792","article-title":"Glycyrrhizic acid and its hydrolyzed metabolite 18\u03b2-glycyrrhetinic acid as specific ligands for targeting nanosystems in the treatment of liver cancer","volume":"13","author":"Stecanella","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejmech.2022.114934_bib119","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijbiomac.2012.05.005","article-title":"Optimization on condition of glycyrrhetinic acid liposome by RSM and the research of its immunological activity","volume":"51","author":"Zhao","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2022.114934_bib120","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jconrel.2019.04.025","article-title":"Liposomes used as a vaccine adjuvant-delivery system: from basics to clinical immunization","volume":"303","author":"Wang","year":"2019","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejmech.2022.114934_bib121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1134\/S1990747822020076","article-title":"Liposomes as adjuvants and vaccine delivery systems","volume":"16","author":"Tretiakova","year":"2022","journal-title":"Biochem Moscow Suppl Ser A"},{"key":"10.1016\/j.ejmech.2022.114934_bib122","series-title":"Frontiers in Nanobiomedical Research","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1142\/9789814520652_0005","article-title":"Drug nanocrystals and nanosuspensions in medicine","author":"Peltonen","year":"2014"},{"key":"10.1016\/j.ejmech.2022.114934_bib123","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1166\/jnn.2017.13108","article-title":"Nanocrystals technology for improving bioavailability of poorly soluble drugs: a mini-review","volume":"17","author":"Zhou","year":"2017","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.ejmech.2022.114934_bib124","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/0929867033368538","article-title":"Chemical Modification of Glycyrrhizic Acid as a Route to New Bioactive Compounds for Medicine","volume":"10","author":"Baltina","year":"2003","journal-title":"CMC"},{"key":"10.1016\/j.ejmech.2022.114934_bib125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.etap.2017.03.011","article-title":"18\u03b2-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model","volume":"52","author":"Kim","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ejmech.2022.114934_bib126","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1038\/s41598-022-06455-6","article-title":"18\u03b2-Glycyrrhetinic acid suppresses allergic airway inflammation through NF-\u03baB and Nrf2\/HO-1 signaling pathways in asthma mice","volume":"12","author":"Liu","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2022.114934_bib127","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s13346-016-0300-4","article-title":"Enhanced oral bioavailability of glycyrrhetinic acid via nanocrystal formulation","volume":"6","author":"Lei","year":"2016","journal-title":"Drug Deliv and Transl Res"},{"key":"10.1016\/j.ejmech.2022.114934_bib128","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1039\/C9QM00658C","article-title":"Carbon dots: a booming material for biomedical applications","volume":"4","author":"Su","year":"2020","journal-title":"Mater. Chem. Front."},{"key":"10.1016\/j.ejmech.2022.114934_bib129","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1166\/jbn.2016.2225","article-title":"Nanobiotechnology of carbon dots: a review","volume":"12","author":"Dur\u00e1n","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ejmech.2022.114934_bib130","doi-asserted-by":"crossref","first-page":"671","DOI":"10.7150\/thno.39863","article-title":"Carbon dots as potent antimicrobial agents","volume":"10","author":"Dong","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2022.114934_bib131","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40580-022-00307-9","article-title":"Recent advances in carbon quantum dots for virus detection, as well as inhibition and treatment of viral infection","volume":"9","author":"Xue","year":"2022","journal-title":"Nano Convergence"},{"key":"10.1016\/j.ejmech.2022.114934_bib132","article-title":"Glycyrrhizic-acid-based carbon dots with high antiviral activity by multisite inhibition mechanisms","volume":"16","author":"Tong","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.ejmech.2022.114934_bib133","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s00604-020-04433-1","article-title":"Fluoroimmunoassay of influenza virus using sulfur-doped graphitic carbon nitride quantum dots coupled with Ag2S nanocrystals","volume":"187","author":"Achadu","year":"2020","journal-title":"Microchim. Acta"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422008364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523422008364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:44:49Z","timestamp":1759329889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523422008364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":133,"alternative-id":["S0223523422008364"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114934","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential of glycyrrhizic and glycyrrhetinic acids against influenza type A and B viruses: A perspective to develop new anti-influenza compounds and drug delivery systems","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2022.114934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114934"}}