{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:38:47Z","timestamp":1789097927976,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21672091"],"award-info":[{"award-number":["21672091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177045"],"award-info":[{"award-number":["22177045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ejmech.2023.115191","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T12:32:15Z","timestamp":1675686735000},"page":"115191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition"],"prefix":"10.1016","volume":"250","author":[{"given":"Xuefeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuohu","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2023.115191_bib1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2023.115191_bib2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1089\/ars.2011.4367","article-title":"The tumor microenvironment: characterization, redox considerations, and novel approaches for reactive oxygen species-targeted gene therapy","volume":"19","author":"Policastro","year":"2013","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejmech.2023.115191_bib3","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1126\/science.aaa5004","article-title":"Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH","volume":"350","author":"Yun","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2023.115191_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2006.08.009","article-title":"Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate","volume":"10","author":"Trachootham","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ejmech.2023.115191_bib5","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1158\/1535-7163.1101.3.9","article-title":"Effect of curcumin on normal and tumor cells: role of glutathione and Bcl-2","volume":"3","author":"Syng-Ai","year":"2004","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2023.115191_bib6","doi-asserted-by":"crossref","first-page":"15115","DOI":"10.1073\/pnas.1212802109","article-title":"Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs","volume":"109","author":"Adams","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2023.115191_bib7","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1182\/blood-2007-05-090621","article-title":"An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells","volume":"110","author":"Guzman","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ejmech.2023.115191_bib8","doi-asserted-by":"crossref","first-page":"18203","DOI":"10.1074\/jbc.M117.813923","article-title":"The NQO1 bioactivatable drug, \u03b2-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism","volume":"292","author":"Silvers","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib9","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1073\/pnas.77.4.1763","article-title":"Spontaneous cancer and its possible relationship to oxygen metabolism","volume":"77","author":"Totter","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2023.115191_bib10","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41416-018-0278-4","article-title":"Phase 1 study of ARQ 761, \u03b1 \u03b2-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis","volume":"119","author":"Gerber","year":"2018","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejmech.2023.115191_bib11","article-title":"Phase I trial of ARQ 501, an activated checkpoint therapy (ACT) agent, in patients with advanced solid tumors","volume":"23","author":"Shapiro","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2023.115191_bib12","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1089\/ars.2012.4650","article-title":"Thioredoxin system in cell death progression","volume":"17","author":"Lu","year":"2012","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejmech.2023.115191_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nchembio.1695","article-title":"Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling","volume":"11","author":"Sobotta","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2023.115191_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/mnfr.200700492","article-title":"Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy","volume":"53","author":"Tonissen","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejmech.2023.115191_bib16","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tips.2017.06.001","article-title":"Targeting the thioredoxin system for cancer therapy","volume":"38","author":"Zhang","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2023.115191_bib17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.freeradbiomed.2011.10.447","article-title":"Small molecule inhibitors of mammalian thioredoxin reductase","volume":"52","author":"Cai","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib18","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.1021\/acs.jmedchem.8b01595","article-title":"Targeting the thioredoxin system as a strategy for cancer therapy","volume":"62","author":"Bian","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib19","doi-asserted-by":"crossref","first-page":"25284","DOI":"10.1074\/jbc.M414645200","article-title":"Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity","volume":"280","author":"Fang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.freeradbiomed.2015.04.017","article-title":"Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: the case of diarylpentanoids","volume":"85","author":"Dai","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib21","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1021\/acs.jmedchem.5b01203","article-title":"Discovery of new monocarbonyl ligustrazine-curcumin hybrids for intervention of drug-sensitive and drug-resistant lung cancer","volume":"59","author":"Ai","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib22","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1021\/jm200353f","article-title":"Synthesis of N-substituted 3,5-bis(arylidene)-4-piperidones with high antitumor and antioxidant activity","volume":"54","author":"K\u00e1lai","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejmech.2018.01.088","article-title":"Novel dissymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo","volume":"147","author":"Li","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ejmech.2017.11.077","article-title":"Synthesis and anti-tumor activity of EF24 analogues as IKK\u03b2 inhibitors","volume":"144","author":"Jin","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.freeradbiomed.2016.05.021","article-title":"Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: a mechanistic investigation","volume":"97","author":"Yan","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ejmech.2018.09.075","article-title":"Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals","volume":"159","author":"Dai","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.freeradbiomed.2018.11.018","article-title":"A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent","volume":"130","author":"Dai","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.freeradbiomed.2019.01.033","article-title":"Developing glutathione-activated catechol-type diphenylpolyenes as small molecule-based and mitochondria-targeted prooxidative anticancer theranostic prodrugs","volume":"134","author":"Bao","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib29","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1021\/acs.jafc.1c07690","article-title":"Redox-based strategy for selectively inducing energy crisis inside cancer cells: an example of modifying dietary curcumin to target mitochondria","volume":"70","author":"Zheng","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib30","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2023.115191_bib31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2023.115191_bib32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2023.115191_bib33","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/S0731-7085(96)02024-9","article-title":"Stability of curcumin in buffer solutions and characterization of its degradation products","volume":"15","author":"Wang","year":"1997","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejmech.2023.115191_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118429","article-title":"Rational design of an ESIPT-based fluorescent probe for selectively monitoring glutathione in live cells and zebrafish","volume":"238","author":"Zheng","year":"2020","journal-title":"Spectrochim. Acta, Part A: Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ejmech.2023.115191_bib35","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1021\/ja408792k","article-title":"Highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells","volume":"136","author":"Zhang","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2023.115191_bib36","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1073\/pnas.93.3.1006","article-title":"A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity","volume":"93","author":"Tamura","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2023.115191_bib37","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0891-5849(01)00724-9","article-title":"Reactive oxygen species, antioxidants, and the mammalian thioredoxin system","volume":"31","author":"Nordberg","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib38","article-title":"Biogenic selenium and its hepatoprotective activity","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2023.115191_bib39","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/med.21734","article-title":"Small molecules regulating reactive oxygen species homeostasis for cancer therapy","volume":"41","author":"Zhang","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2023.115191_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2021.10.013","article-title":"Natural diterpenoid eriocalyxin b covalently modifies glutathione and selectively inhibits thioredoxin reductase inducing potent oxidative stress-mediated apoptosis in colorectal carcinoma RKO cells","volume":"177","author":"Duan","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib41","doi-asserted-by":"crossref","first-page":"16132","DOI":"10.1021\/acs.jmedchem.1c01441","article-title":"Structural modification of aminophenylarsenoxides generates candidates for leukemia treatment via thioredoxin reductase inhibition","volume":"64","author":"Song","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1006\/bbrc.1993.2438","article-title":"A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1)","volume":"197","author":"Cossarizza","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2023.115191_bib43","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1158\/0008-5472.CAN-20-2017","article-title":"Iron and cancer: 2020 vision","volume":"80","author":"Torti","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2023.115191_bib44","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2023.115191_bib45","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2023.115191_bib46","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejmech.2023.115191_bib47","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1021\/acs.nanolett.6b04060","article-title":"Switching apoptosis to ferroptosis: metal-organic network for high-efficiency anticancer therapy","volume":"17","author":"Zheng","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.ejmech.2023.115191_bib48","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/anie.201106488","article-title":"Catalytic asymmetric synthesis of aromatic spiroketals by spinphox\/iridium(I)-catalyzed hydrogenation and spiroketalization of \u03b1,\u03b1\u2032-bis(2-hydroxyarylidene) ketones","volume":"51","author":"Wang","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2023.115191_bib49","doi-asserted-by":"crossref","first-page":"10029","DOI":"10.1021\/acs.jafc.0c04399","article-title":"Inhibiting NF-\u03baB-mediated inflammation by catechol-type diphenylbutadiene via an intracellular copper- and iron-dependent pro-oxidative role","volume":"68","author":"Dai","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2023.115191_bib50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.freeradbiomed.2015.04.017","article-title":"Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: the case of diarylpentanoids","volume":"85","author":"Dai","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2023.115191_bib51","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1074\/jbc.M807068200","article-title":"Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1","volume":"284","author":"Cheng","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342300106X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342300106X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:47:28Z","timestamp":1759330048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342300106X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":51,"alternative-id":["S022352342300106X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115191","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115191"}}