{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:50:01Z","timestamp":1759366201887,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009045","name":"Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"publisher","award":["N42\/DBS\/000093","N42\/DBS\/000165"],"award-info":[{"award-number":["N42\/DBS\/000093","N42\/DBS\/000165"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007088","name":"Uniwersytet Jagiello\u0144ski w Krakowie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.ejmech.2023.115224","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T02:01:35Z","timestamp":1678068095000},"page":"115224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Design and synthesis of novel arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive bacteria"],"prefix":"10.1016","volume":"251","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7940-9500","authenticated-orcid":false,"given":"Vittorio","family":"Canale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Czekajewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Klesiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Papie\u017c","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Kuziak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Witek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Piska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmara","family":"Niemiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patryk","family":"Kasza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"P\u0119kala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Empel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Tomczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Karczewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Zajdel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2023.115224_bib1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s12668-019-00658-4","article-title":"World Health Organization Report: current crisis of antibiotic resistance","volume":"9","author":"Abadi","year":"2019","journal-title":"BioNanoScience"},{"key":"10.1016\/j.ejmech.2023.115224_bib2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cmi.2016.03.012","article-title":"Do we need new antibiotics?","volume":"22","author":"Rolain","year":"2016","journal-title":"Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejmech.2023.115224_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5001\/omj.2019.37","article-title":"WHO global priority pathogens list: a bibliometric analysis of medline-PubMed for knowledge mobilization to infection prevention and control practices in Bahrain","volume":"34","author":"Asokan","year":"2019","journal-title":"Oman Med. J."},{"key":"10.1016\/j.ejmech.2023.115224_bib5","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3390\/pathogens10101310","article-title":"Bacterial antibiotic resistance: the most critical pathogens","volume":"10","author":"Mancuso","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.ejmech.2023.115224_bib6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","year":"2022","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejmech.2023.115224_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America","volume":"48","author":"Boucher","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2023.115224_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201901872","article-title":"Considerations and caveats in combating ESKAPE pathogens against nosocomial infections","volume":"7","author":"Ma","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2023.115224_bib9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3389\/fmicb.2019.00539","article-title":"Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: a review","volume":"10","author":"Mulani","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2023.115224_bib10","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/antibiotics10040398","article-title":"Bacterial targets of antibiotics in methicillin-resistant Staphylococcus aureus","volume":"10","author":"Lade","year":"2021","journal-title":"Antibiot"},{"key":"10.1016\/j.ejmech.2023.115224_bib11","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.3390\/molecules25102302","article-title":"Synergistic effects of thiosemicarbazides with clinical drugs against S. aureus","volume":"25","author":"Chudzik-Rz\u0105d","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2023.115224_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/jac\/dkx370","article-title":"Long-lasting successful dissemination of resistance to oxazolidinones in MDR Staphylococcus epidermidis clinical isolates in a tertiary care hospital in France","volume":"73","author":"Dortet","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2023.115224_bib13","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s10096-020-03893-w","article-title":"Emergence of linezolid-resistant Staphylococcus epidermidis in the tertiary children's hospital in Cracow, Poland","volume":"39","author":"Kosecka-Strojek","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejmech.2023.115224_bib15","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"P.T."},{"key":"10.1016\/j.ejmech.2023.115224_bib16","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/s41564-018-0230-7","article-title":"Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis","volume":"3","author":"Lee","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2023.115224_bib17","article-title":"Enterococci: between emerging pathogens and potential probiotics","volume":"2019","author":"Bra\u00efek","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2023.115224_bib18","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/anie.201906755","article-title":"Mechanochemistry for synthesis","volume":"59","author":"Fri\u0161\u010di\u0107","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2023.115224_bib19","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.3390\/molecules26133828","article-title":"Design, sustainable synthesis and biological evaluation of a novel dual \u03b12A\/5-HT7 receptor antagonist with antidepressant-like properties","volume":"26","author":"Canale","year":"2021","journal-title":"Molecules"},{"year":"2021","series-title":"Reading Guide for Brothmicrodilution","key":"10.1016\/j.ejmech.2023.115224_bib20"},{"key":"10.1016\/j.ejmech.2023.115224_bib21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/mmi.13634","article-title":"Staphylococcus aureus biofilm: a complex developmental organism","volume":"104","author":"Moormeier","year":"2017","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ejmech.2023.115224_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41579-018-0019-y","article-title":"Implant infections: adhesion, biofilm formation and immune evasion","volume":"16","author":"Arciola","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"year":"2020","series-title":"Molecular Discovery; Program","author":"Metasite","key":"10.1016\/j.ejmech.2023.115224_bib23"},{"key":"10.1016\/j.ejmech.2023.115224_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4172\/2157-7609.1000126","article-title":"Comparative in vitro intrinsic clearance of Imipramine in multiplespecies liver microsomes: human, rat, mouse and dog","volume":"3","author":"Singh","year":"2012","journal-title":"J. Drug Metabol. Toxicol."},{"key":"10.1016\/j.ejmech.2023.115224_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112765","article-title":"A dual-acting 5-HT6 receptor inverse agonist\/MAO-B inhibitor displays glioprotective and pro-cognitive properties","volume":"208","author":"Canale","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115224_bib26","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1128\/AAC.35.11.2282","article-title":"Daptomycin disrupts membrane potential in growing Staphylococcus aureus","volume":"35","author":"Alborn","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2023.115224_bib27","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.bbamem.2006.02.009","article-title":"Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: comparison with cationic antimicrobial peptides and lipopeptides","volume":"1758","author":"Straus","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2023.115224_bib28","doi-asserted-by":"crossref","first-page":"e00910","DOI":"10.1128\/AAC.00910-20","article-title":"Use of a fluorescence-based assay to measure Escherichia coli membrane potential changes in high throughput","volume":"64","author":"Hudson","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"year":"2022","series-title":"The European Committee on Antimicrobial Susceptibility Testing. Breakpoint Tables for Interpretation of MICs and Zone Diameters","key":"10.1016\/j.ejmech.2023.115224_bib29"},{"year":"1999","series-title":"Standard Institute (CLSI) Methods for Determining Bactericidal Activity of Antimicrobial Agents","key":"10.1016\/j.ejmech.2023.115224_bib30"},{"year":"2022","series-title":"Standard Institute (CLSI) Performance Standards for Antimicrobial Susceptibility Testing","key":"10.1016\/j.ejmech.2023.115224_bib31"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423001903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423001903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:50:55Z","timestamp":1759330255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523423001903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":29,"alternative-id":["S0223523423001903"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115224","relation":{},"ISSN":["0223-5234"],"issn-type":[{"type":"print","value":"0223-5234"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of novel arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive bacteria","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115224"}}