{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:22:29Z","timestamp":1793226149258,"version":"4.5.0"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.ejmech.2023.115416","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T11:43:54Z","timestamp":1682682234000},"page":"115416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Perspectives on the current antiviral developments towards RNA-dependent RNA polymerase (RdRp) and methyltransferase (MTase) domains of dengue virus non-structural protein 5 (DENV-NS5)"],"prefix":"10.1016","volume":"256","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-8642","authenticated-orcid":false,"given":"Gopinathan Pillai","family":"Sreekanth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2023.115416_bib1","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro2460","article-title":"Dengue: a continuing global threat","volume":"8","author":"Guzman","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2023.115416_bib2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.hemonc.2013.05.005","article-title":"Dengue fever causing febrile neutropenia in children with acute lymphoblastic leukemia: an unknown entity","volume":"6","author":"Ramzan","year":"2013","journal-title":"Hematol. Oncol. Stem Cell Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3109\/08880018.2011.609581","article-title":"Management of severe refractory thrombocytopenia in dengue hemorrhagic fever with intravenous anti-D immune globulin","volume":"28","author":"Kharya","year":"2011","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.ejmech.2023.115416_bib4","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.4081\/idr.2009.1338","article-title":"Dengue hemorrhagic fever in a peripheral blood stem cell transplant recipient: the first case report","volume":"1","author":"Visuthranukul","year":"2009","journal-title":"Infect. Dis. Rep."},{"key":"10.1016\/j.ejmech.2023.115416_bib5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.4269\/ajtmh.2007.76.737","article-title":"Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-D (Rh(0)-D) immune globulin","volume":"76","author":"de Castro","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ejmech.2023.115416_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/107602960401000111","article-title":"Can hematocrit and platelet determination on admission predict shock in hospitalized children with dengue hemorrhagic fever? A clinical observation from a small outbreak","volume":"10","author":"Wiwanitkit","year":"2004","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.ejmech.2023.115416_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.virusres.2014.03.025","article-title":"Role of ERK1\/2 signaling in dengue virus-induced liver injury","volume":"188","author":"Sreekanth","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.ento.53.103106.093326","article-title":"Dengue virus-mosquito interactions","volume":"53","author":"Halstead","year":"2008","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.ejmech.2023.115416_bib9","first-page":"471","article-title":"Effect of serotypes on clinical manifestations of dengue fever in adults","volume":"42","author":"Tsai","year":"2009","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.ejmech.2023.115416_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.antiviral.2015.04.010","article-title":"The dengue virus NS5 protein as a target for drug discovery","volume":"119","author":"Lim","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004682","article-title":"A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication","volume":"11","author":"Zhao","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2023.115416_bib12","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1128\/JVI.02283-06","article-title":"Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution","volume":"81","author":"Yap","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2023.115416_bib13","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1073\/pnas.90.14.6498","article-title":"A general two-metal-ion mechanism for catalytic RNA","volume":"90","author":"Steitz","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl 13","key":"10.1016\/j.ejmech.2023.115416_bib14","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1186\/1471-2105-12-S13-S24","article-title":"Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus","volume":"12","author":"Lim","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ejmech.2023.115416_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.574067","article-title":"Dengue virus non-structural protein 5 as a versatile, multi-functional effector in host-pathogen interactions","volume":"11","author":"Bhatnagar","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejmech.2023.115416_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.antiviral.2015.04.010","article-title":"The dengue virus NS5 protein as a target for drug discovery","volume":"119","author":"Lim","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005737","article-title":"Potent allosteric dengue virus NS5 polymerase inhibitors: mechanism of action and resistance profiling","volume":"12","author":"Lim","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2023.115416_bib18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","article-title":"Flavivirus genome organization, expression, and replication","volume":"44","author":"Chambers","year":"1990","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2023.115416_bib19","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/emboj\/21.11.2757","article-title":"An RNA cap (nucleoside\u20102\u2032\u2010O\u2010)\u2010methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization","volume":"21","author":"Egloff","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.ejmech.2023.115416_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.antiviral.2013.09.013","article-title":"Ten years of dengue drug discovery: progress and prospects","volume":"100","author":"Lim","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ejmech.2019.05.010","article-title":"Recent update on anti-dengue drug discovery","volume":"176","author":"Dighe","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib22","article-title":"Current trends and limitations in dengue antiviral research","volume":"6","author":"Obi","year":"2021","journal-title":"Trav. Med. Infect. Dis."},{"key":"10.1016\/j.ejmech.2023.115416_bib23","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrd.2017.33","article-title":"Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond","volume":"16","author":"Boldescu","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2023.115416_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12985-017-0761-1","article-title":"Inhibitors compounds of the flavivirus replication process","volume":"14","author":"Garc\u00eda","year":"2017","journal-title":"Virol. J."},{"key":"10.1016\/j.ejmech.2023.115416_bib25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/0976-500X.142464","article-title":"A novel treatment option for chronic hepatitis C infection","volume":"5","author":"Bhatia","year":"2014","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.ejmech.2023.115416_bib26","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.2174\/09298673113209990178","article-title":"A novel promising therapeutic option against hepatitis C virus: an oral nucleotide NS5B polymerase inhibitor sofosbuvir","volume":"20","author":"Gentile","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coviro.2014.08.004","article-title":"Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus","volume":"9","author":"Deval","year":"2014","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.ejmech.2023.115416_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.antiviral.2017.09.004","article-title":"Cell-line dependent antiviral activity of sofosbuvir against Zika virus","volume":"146","author":"Mumtaz","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007072","article-title":"Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo","volume":"13","author":"De Freitas","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ejmech.2023.115416_bib30","first-page":"1","article-title":"Evaluation of Sofosbuvir (\u03b2-D-2\u2032-deoxy-2\u2032-\u03b1-fluoro-2\u2032-\u03b2-C-methyluridine) as an inhibitor of Dengue virus replication","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2023.115416_bib31","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/cbdd.13091","article-title":"Sofosbuvir as treatment against dengue?","volume":"91","author":"Gan","year":"2018","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2023.115416_bib32","doi-asserted-by":"crossref","first-page":"20435","DOI":"10.1073\/pnas.0907010106","article-title":"An adenosine nucleoside inhibitor of dengue virus","volume":"106","author":"Yin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2023.115416_bib33","first-page":"11","article-title":"The adenosine analogue NITD008 has potent antiviral activity against human and animal caliciviruses","author":"Enosi Tuipulotu","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2023.115416_bib34","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1128\/AAC.00397-10","article-title":"Inhibition of dengue virus by an ester prodrug of an adenosine analog","volume":"54","author":"Chen","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2023.115416_bib35","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1128\/AAC.00397-10","article-title":"Inhibition of dengue virus by an ester prodrug of an adenosine analog","volume":"54","author":"Chen","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2023.115416_bib36","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1021\/acsinfecdis.8b00054","article-title":"Preclinical antiviral testing for dengue virus infection in mouse models and its association with clinical studies","volume":"4","author":"Watanabe","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2023.115416_bib37","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1128\/AAC.48.10.3944-3953.2004","article-title":"A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties","volume":"48","author":"Olsen","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2023.115416_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004695","article-title":"The viral polymerase inhibitor 7-deaza-2'-C-methyladenosine is a potent inhibitor of in vitro Zika virus replication and delays disease progression in a robust mouse infection model","volume":"10","author":"Zmurko","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ejmech.2023.115416_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01960-15","article-title":"Suppression of drug resistance in dengue virus","volume":"6","author":"Mateo","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.ejmech.2023.115416_bib40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/511310","article-title":"A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs","volume":"195","author":"Schul","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ejmech.2023.115416_bib41","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1021\/jm901044z","article-title":"N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase","volume":"52","author":"Yin","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007894","article-title":"Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase","volume":"13","author":"Shimizu","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ejmech.2023.115416_bib43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jphs.2018.06.012","article-title":"Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection","volume":"138","author":"Yao","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2023.115416_bib44","doi-asserted-by":"crossref","first-page":"8541","DOI":"10.1074\/jbc.M115.710731","article-title":"A conserved pocket in the dengue virus polymerase identified through fragment-based screening","volume":"291","author":"Noble","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib45","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1021\/acs.jmedchem.6b00143","article-title":"Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent RNA polymerase from a fragment hit using structure-based drug design","volume":"59","author":"Yokokawa","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0166-3542(82)90027-4","article-title":"Antiviral effects if ribavirin and 6-mercapto-9-tetrahydro-2-furylpurine against dengue viruses in vitro","volume":"2","author":"Koff","year":"1982","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib47","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/infdis\/jiu319","article-title":"A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection","volume":"210","author":"Fraser","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ejmech.2023.115416_bib48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1128\/AAC.04177-14","article-title":"The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication","volume":"59","author":"Carocci","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2023.115416_bib49","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.antiviral.2016.09.007","article-title":"Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor","volume":"134","author":"Tarantino","year":"2016","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib50","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1021\/acsmedchemlett.9b00619","article-title":"Pyridobenzothiazolones exert potent anti-dengue activity by hampering multiple functions of NS5 polymerase","volume":"11","author":"Cannalire","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2023.115416_bib51","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bbrc.2015.12.042","article-title":"Discovery of conjugated thiazolidinone-thiadiazole scaffold as anti-dengue virus polymerase inhibitors","volume":"469","author":"Manvar","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2023.115416_bib52","doi-asserted-by":"crossref","first-page":"8389","DOI":"10.1021\/jm400828u","article-title":"Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture","volume":"56","author":"Nitsche","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105639","article-title":"Design, synthesis, discovery and SAR of the fused tricyclic derivatives of indoline and imidazolidinone against DENV replication and infection","volume":"120","author":"Qian","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib54","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ejmech.2015.12.046","article-title":"Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase","volume":"109","author":"Benmansour","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib55","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1099\/vir.0.81880-0","article-title":"Antiviral action of nitric oxide on dengue virus type 2 replication","volume":"87","author":"Takhampunya","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ejmech.2023.115416_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104749","article-title":"Antiviral activity of the natural alkaloid anisomycin against dengue and Zika viruses","volume":"176","author":"Quintana","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149486","article-title":"SB203580 modulates p38 MAPK signaling and dengue virus-induced liver injury by reducing MAPKAPK2, HSP27, and ATF2 phosphorylation","volume":"11","author":"Sreekanth","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2023.115416_bib58","doi-asserted-by":"crossref","first-page":"32586","DOI":"10.1074\/jbc.M110.129197","article-title":"Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase","volume":"285","author":"Dong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130062","article-title":"Novel broad spectrum inhibitors targeting the flavivirus methyltransferase","volume":"10","author":"Brecher","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2023.115416_bib60","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1074\/jbc.M110.179184","article-title":"Small molecule inhibitors that selectively block dengue virus methyltransferase","volume":"286","author":"Lim","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012836","article-title":"Crystal structure of the dengue virus methyltransferase bound to a 5'-capped octameric RNA","volume":"5","author":"Yap","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2023.115416_bib62","doi-asserted-by":"crossref","first-page":"35638","DOI":"10.1074\/jbc.M400460200","article-title":"A structural basis for the inhibition of the NS5 dengue virus mRNA 2\u2032-O-methyltransferase domain by ribavirin 5\u2032-triphosphate","volume":"279","author":"Benarroch","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib63","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1021\/ol0165443","article-title":"Fleximers\". Design and synthesis of two novel split nucleosides","volume":"3","author":"Seley","year":"2001","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2023.115416_bib64","first-page":"24","article-title":"Probing the effects of pyrimidine functional group switches on acyclic fleximer analogues for antiviral activity","author":"Yates","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2023.115416_bib65","doi-asserted-by":"crossref","DOI":"10.1177\/2040206618756788","article-title":"Flexibility-Not just for yoga anymore","volume":"26","author":"Seley-Radtke","year":"2018","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.ejmech.2023.115416_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115713","article-title":"Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro","volume":"28","author":"Thames","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib67","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/157340611797928451","article-title":"In silico designing and screening of lead compounds to NS5-methyltransferase of dengue viruses","volume":"7","author":"Sivakumar","year":"2011","journal-title":"Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130062","article-title":"Novel broad spectrum inhibitors targeting the flavivirus methyltransferase","volume":"10","author":"Brecher","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2023.115416_bib69","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ejmech.2016.10.007","article-title":"Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design","volume":"125","author":"Benmansour","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115416_bib70","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12906-019-2629-y","article-title":"Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study","volume":"19","author":"Ellan","year":"2019","journal-title":"BMC complement. med. ther"},{"key":"10.1016\/j.ejmech.2023.115416_bib71","first-page":"355","article-title":"Exploration of Carica papaya bioactive compounds as potential inhibitors of dengue NS2B, NS3 and NS5 protease","volume":"33","author":"Farooq","year":"2020","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2023.115416_bib72","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejphar.2017.12.029","article-title":"Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5","volume":"821","author":"Yao","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2023.115416_bib73","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1055\/s-0031-1298355","article-title":"Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase","volume":"78","author":"Coulerie","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2023.115416_bib74","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1055\/s-0033-1350672","article-title":"Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp","volume":"79","author":"Coulerie","year":"2013","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2023.115416_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113541","article-title":"Identification and characterization of new potent inhibitors of dengue virus NS5 proteinase from Andrographis paniculata supercritical extracts on in animal cell culture and in silico approaches","volume":"267","author":"Kaushik","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2023.115416_bib76","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/s41598-018-38450-1","article-title":"Computational screening of medicinal plant phytochemicals to discover potent pan-serotype inhibitors against dengue virus","volume":"9","author":"Tahir ul Qamar","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2023.115416_bib77","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/acs.jnatprod.8b00800","article-title":"Antiviral compounds from Codiaeum peltatum targeted by a multi-informative molecular networks approach","volume":"82","author":"Olivon","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2023.115416_bib78","series-title":"New Inhibitors of the DENV-NS 5 RdRp from Carpolepis Laurifolia as Potential Antiviral Drugs for Dengue Treatment","author":"Coulerie","year":"2014"},{"key":"10.1016\/j.ejmech.2023.115416_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104563","article-title":"Antiviral activity of astragaloside II, astragaloside III and astragaloside IV compounds against dengue virus: computational docking and in vitro studies","volume":"152","author":"Indu","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ejmech.2023.115416_bib80","doi-asserted-by":"crossref","DOI":"10.1177\/2040206618761299","article-title":"Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses","volume":"26","author":"Eyer","year":"2018","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.ejmech.2023.115416_bib81","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cellsig.2018.05.002","article-title":"Role of mitogen-activated protein kinase signaling in the pathogenesis of dengue virus infection","volume":"48","author":"Sreekanth","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejmech.2023.115416_bib82","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.antiviral.2017.02.003","article-title":"JNK1\/2 inhibitor reduces dengue virus-induced liver injury","volume":"141","author":"Sreekanth","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib83","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1002\/ptr.6917","article-title":"A systematic review on phytochemicals for the treatment of dengue","volume":"35","author":"Ali","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib84","article-title":"Ayurvedic and other herbal remedies for dengue: an update","volume":"2","author":"Chavda","year":"2022","journal-title":"Clinical. Comp. Med. Pharma."},{"key":"10.1016\/j.ejmech.2023.115416_bib85","doi-asserted-by":"crossref","first-page":"24048","DOI":"10.1021\/acsomega.2c00625","article-title":"Therapeutic potential of medicinal plants against dengue infection: a mechanistic viewpoint","volume":"7","author":"Altamish","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2023.115416_bib86","first-page":"12","article-title":"Crocetin improves dengue virus-induced liver injury","author":"Sreekanth","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2023.115416_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188121","article-title":"RNAi screen reveals a role of SPHK2 in dengue virus\u2013mediated apoptosis in hepatic cell lines","volume":"12","author":"Morchang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2023.115416_bib88","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.antiviral.2019.03.011","article-title":"Drug repurposing of N-acetyl cysteine as antiviral against dengue virus infection","volume":"166","author":"Sreekanth","year":"2019","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2023.115416_bib89","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2147\/HMER.S263840","article-title":"Repurposing of N-acetylcysteine for the treatment of dengue virus-induced acute liver failure","volume":"12","author":"Tafere","year":"2020","journal-title":"Hepat. Med."},{"key":"10.1016\/j.ejmech.2023.115416_bib90","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3947\/ic.2021.0111","article-title":"Effective antiviral activity of the tyrosine kinase inhibitor sunitinib malate against Zika virus","volume":"53","author":"Lin","year":"2021","journal-title":"Infect. Chemother."},{"key":"10.1016\/j.ejmech.2023.115416_bib91","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11262-019-01710-x","article-title":"Suppression of \u03bc1 subunit of the adaptor protein complex 2 reduces dengue virus release","volume":"56","author":"Tongmuang","year":"2020","journal-title":"Virus Gene."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423003823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423003823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:53:08Z","timestamp":1759330388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523423003823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":91,"alternative-id":["S0223523423003823"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115416","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perspectives on the current antiviral developments towards RNA-dependent RNA polymerase (RdRp) and methyltransferase (MTase) domains of dengue virus non-structural protein 5 (DENV-NS5)","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115416"}}