{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:41:04Z","timestamp":1790700064369,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ejmech.2023.115496","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:27:07Z","timestamp":1684290427000},"page":"115496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Synthesis and anti-inflammatory activity evaluation of NO-releasing furoxan\/1,2,4-triazole hybrid derivatives"],"prefix":"10.1016","volume":"257","author":[{"given":"Sin-Min","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yu","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo-En","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chun","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yen","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Zheng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Pei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Uramaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Jhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-1238","authenticated-orcid":false,"given":"Fung-Fuh","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2023.115496_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/AIA.0b013e318034194e","article-title":"Cytokines, inflammation and pain","volume":"45","author":"Zhang","year":"2007","journal-title":"Int. Anesthesiol. Clin."},{"key":"10.1016\/j.ejmech.2023.115496_bib2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bioorg.2018.09.015","article-title":"1, 2, 4-Triazole-based benzothiazole\/benzoxazole derivatives: design, synthesis, p38\u03b1 MAP kinase inhibition, anti-inflammatory activity and molecular docking studies","volume":"81","author":"Tariq","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/039463200902200301","article-title":"Anti-TNF-\u03b1 inhibitors: a new therapeutic approach for inflammatory immune-mediated diseases: an update upon efficacy and adverse events","volume":"22","author":"Murdaca","year":"2009","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.ejmech.2023.115496_bib4","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/j.ejmech.2010.02.034","article-title":"Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety","volume":"45","author":"de Carvalho","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib5","first-page":"1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.ejmech.2023.115496_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2004.047100","article-title":"Prostaglandins and cancer","volume":"55","author":"Wang","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.ejmech.2023.115496_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.pharmtox.38.1.97","article-title":"Cyclooxygenases 1 and 2","volume":"38","author":"Vane","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejmech.2023.115496_bib8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nm0295-154","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: insight into the mechanism and reversal of NSAID-induced gastrointestinal injury","volume":"1","author":"Lichtenberger","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejmech.2023.115496_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ddr.430250402","article-title":"Mitogen\u2010inducible prostaglandin G\/H synthase: a new target for nonsteroidal antiinflammatory drugs","volume":"25","author":"Xie","year":"1992","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2023.115496_bib10","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.1016\/j.bmc.2011.08.018","article-title":"Searching for new NO-donor aspirin-like molecules: furoxanylacyl derivatives of salicylic acid and related furazans","volume":"19","author":"Lazzarato","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib11","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1021\/jm960803q","article-title":"Synthesis and biological evaluation of the 1, 5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl] benzenesulfonamide (SC-58635, celecoxib)","volume":"40","author":"Penning","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/jm990577v","article-title":"4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2","volume":"43","author":"Talley","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib13a","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1001\/jama.296.13.jrv60011","article-title":"Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2","volume":"296","author":"McGettigan","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.ejmech.2023.115496_bib13b","doi-asserted-by":"crossref","first-page":"143","DOI":"10.14336\/AD.2017.0306","article-title":"A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly","volume":"9","author":"Wongrakpanich","year":"2018","journal-title":"Aging and disease"},{"key":"10.1016\/j.ejmech.2023.115496_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0002-9343(00)00728-2","article-title":"Gastrointestinal toxic side effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2\u2013specific inhibitors","volume":"110","author":"Buttgereit","year":"2001","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejmech.2023.115496_bib15","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.4049\/jimmunol.170.9.4738","article-title":"Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model","volume":"170","author":"Claveau","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejmech.2023.115496_bib16a","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1016\/j.bmc.2007.05.009","article-title":"O2-Acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO\u2013NSAIDs): synthesis, nitric oxide release, and biological evaluation studies","volume":"15","author":"Vel\u00e1zquez","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib16b","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1016\/j.bmc.2005.05.053","article-title":"Synthesis of novel 4-substituted-7-trifluoromethylquinoline derivatives with nitric oxide releasing properties and their evaluation as analgesic and anti-inflammatory agents","volume":"13","author":"Abadi","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib17","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3109\/14756360903357585","article-title":"Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives","volume":"25","author":"Bhandari","year":"2010","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/gast.2000.9304","article-title":"Nitric oxide in mucosal defense: a little goes a long way","volume":"119","author":"Wallace","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejmech.2023.115496_bib19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000007506","article-title":"Role of nitric oxide in pathogenesis of aspirin-induced gastric mucosal damage in rats","volume":"59","author":"Takeuchi","year":"1998","journal-title":"Digestion"},{"key":"10.1016\/j.ejmech.2023.115496_bib20","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/0016-5085(90)90005-L","article-title":"Afferent nerve-mediated protection against deep mucosal damage in the rat stomach","volume":"98","author":"Holzer","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejmech.2023.115496_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0016-5085(99)70448-8","article-title":"Enhanced anti-inflammatory effects of a nitric oxide\u2013releasing derivative of mesalamine in rats","volume":"117","author":"Wallace","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejmech.2023.115496_bib22","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1096\/fasebj.10.7.8635690","article-title":"The cellular and molecular basis of gastric mucosal defense","volume":"10","author":"Wallace","year":"1996","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejmech.2023.115496_bib23","first-page":"371","article-title":"New generation NSAIDS: the benefits without the risks?","volume":"33","author":"Wallace","year":"1997","journal-title":"Drugs Today"},{"key":"10.1016\/j.ejmech.2023.115496_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1389557013407160","article-title":"Nitric oxide-releasing nonsteroidal anti-inflammatory drugs novel gastrointestinal-sparing drugs","volume":"1","author":"Bandarage","year":"2001","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib25","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1021\/jm900587h","article-title":"(Nitrooxyacyloxy) methyl esters of aspirin as novel nitric oxide releasing aspirins","volume":"52","author":"Lazzarato","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib26","doi-asserted-by":"crossref","first-page":"6588","DOI":"10.1021\/jm900561s","article-title":"Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups","volume":"52","author":"Jones","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bmc.2011.11.012","article-title":"Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating\/chalcone hybrids","volume":"20","author":"Abuo-Rahma","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib28","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/j.bmc.2012.01.034","article-title":"Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives","volume":"20","author":"Hern\u00e1ndez","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib29","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.bmcl.2014.03.004","article-title":"Synthesis and cytotoxic activity of nitric oxide-releasing isosteviol derivatives","volume":"24","author":"Wang","year":"2014","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2023.115496_bib30","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.bmcl.2017.04.007","article-title":"Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties","volume":"27","author":"Dutra","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2023.115496_bib31","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.biopha.2017.08.096","article-title":"In vivo antileishmanial activity and histopathological evaluation in Leishmania infantum infected hamsters after treatment with a furoxan derivative","volume":"95","author":"de Almeida","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2023.115496_bib32","series-title":"Monocyclic Furazans and Furoxans","author":"Sheremetev","year":"2001"},{"key":"10.1016\/j.ejmech.2023.115496_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1389557053402864","article-title":"Pharmacological properties of furoxans and benzofuroxans: recent developments","volume":"5","author":"Cerecetto","year":"2005","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib34","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1021\/jm00051a020","article-title":"Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation","volume":"37","author":"Medana","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib35","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1021\/jm0601250","article-title":"Discovery of novel triazole-based opioid receptor antagonists","volume":"49","author":"Zhang","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib36","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1007\/s11164-012-0781-9","article-title":"Synthesis and anti-inflammatory properties of novel 1, 2, 4-triazole derivatives","volume":"39","author":"El-Serwy","year":"2013","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.ejmech.2023.115496_bib37","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ejmech.2007.04.016","article-title":"1, 8-Naphthyridines VI. Synthesis and anti-inflammatory activity of 5-(alkylamino)-N, N-diethyl [1, 2, 4] triazolo [4, 3-a][1, 8] naphthyridine-6-carboxamides with a new substitution pattern on the triazole ring","volume":"43","author":"Di Braccio","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ejmech.2007.06.026","article-title":"Synthesis, antimicrobial and anti-inflammatory activities of some 1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazoles and 1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazines bearing trichlorophenyl moiety","volume":"43","author":"Karegoudar","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104333","article-title":"New methyl 5-(halomethyl)-1-aryl-1H-1, 2, 4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: design, synthesis, biological evaluation, and docking study","volume":"104","author":"Li","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib40","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.bmcl.2003.12.068","article-title":"Potent imidazole and triazole CB1 receptor antagonists related to SR141716","volume":"14","author":"Dyck","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2023.115496_bib41","doi-asserted-by":"crossref","first-page":"12389","DOI":"10.1021\/jp304212y","article-title":"Mechanisms of organocatalytic amidation and trans-esterification of aromatic esters as a model for the depolymerization of poly (ethylene) terephthalate","volume":"116","author":"Horn","year":"2012","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib42","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/j.tetlet.2018.04.070","article-title":"Recent advances in the synthesis and functionalization of 1, 2, 5-oxadiazole 2-oxides","volume":"59","author":"Makhova","year":"2018","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2023.115496_bib43","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1021\/acs.jmedchem.8b00389","article-title":"Furoxans (oxadiazole-4 N-oxides) with attenuated reactivity are neuroprotective, cross the blood brain barrier, and improve passive avoidance memory","volume":"61","author":"Horton","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib44","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jlac.1991199101207","article-title":"Unsymmetrically substituted furoxans, XIII. Phenylfuroxancarbaldehydes and related compounds","author":"Gasco","year":"1991","journal-title":"Liebigs Ann. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib45","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1021\/acs.orglett.8b01654","article-title":"Synthesis of secondary amides from thiocarbamates","volume":"20","author":"Mampuys","year":"2018","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2023.115496_bib46","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0040-4020(01)80922-4","article-title":"Two reagents for the difficult coupling of the \u03b1, \u03b1-dialkyl amino acid","volume":"47","author":"Fr\u00e9rot","year":"1991","journal-title":"Aib, Tetrahedron"},{"key":"10.1016\/j.ejmech.2023.115496_bib47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/abio.2001.5140","article-title":"A homogeneous fluorometric assay for measuring cell adhesion to immobilized ligand using V-well microtiter plates","volume":"293","author":"Weetall","year":"2001","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2023.115496_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105808","article-title":"Design and synthesis of novel 1, 3, 4-oxadiazole and 1, 2, 4-triazole derivatives as cyclooxygenase-2 inhibitors with anti-inflammatory and antioxidant activity in LPS-stimulated RAW264. 7 macrophages","volume":"124","author":"Hamoud","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib49","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1021\/jm201504s","article-title":"Furoxans (1, 2, 5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents","volume":"55","author":"Schiefer","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib50","first-page":"268","article-title":"An in vitro inhibitory effect on RAW 264.7 cells by anti-inflammatory compounds from Smilax corbularia Kunth","volume":"30","author":"Ruangnoo","year":"2012","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.ejmech.2023.115496_bib51a","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113682","article-title":"Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential","volume":"224","author":"Said","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib51b","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103029","article-title":"Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors","volume":"90","author":"Abdellatif","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0022-1139(01)00375-X","article-title":"Fluorine substituent effects (on bioactivity)","volume":"109","author":"Smart","year":"2001","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib53","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s000110050291","article-title":"Cyclooxygenase selectivity and the risk of gastro-intestinal complications of various non-steroidal anti-inflammatory drugs: a clinical consideration","volume":"47","author":"Kawai","year":"1998","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ejmech.2023.115496_bib54","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ejmech.2014.06.049","article-title":"Novel 1-[4-(Aminosulfonyl) phenyl]-1H-1, 2, 4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies","volume":"83","author":"Abuo-Rahma","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib55a","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.fct.2012.01.041","article-title":"Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246. 7 macrophages and the \u03bb-carrageenan-induced paw edema model","volume":"50","author":"Huang","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejmech.2023.115496_bib55b","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.canlet.2019.11.003","article-title":"Centromere protein U (CENPU) enhances angiogenesis in triple-negative breast cancer by inhibiting ubiquitin\u2013proteasomal degradation of COX-2","volume":"482","author":"Pan","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2023.115496_bib56","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1016\/j.bmcl.2010.07.054","article-title":"The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life","volume":"20","author":"Wang","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2023.115496_bib57","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/bioinformatics\/btaa018","article-title":"A web server for automatic structure matching and RMSD calculations among identical and similar compounds in protein-ligand docking","volume":"36","author":"Vel\u00e1zquez-Libera","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejmech.2023.115496_bib58","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jmgm.2018.05.010","article-title":"Identification of COX-2 inhibitors via structure-based virtual screening and molecular dynamics simulation","volume":"83","author":"Razzaghi-Asl","year":"2018","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.ejmech.2023.115496_bib59","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.bmcl.2017.04.020","article-title":"Novel pyrazoles and pyrazolo [1, 2-a] pyridazines as selective COX-2 inhibitors; Ultrasound-assisted synthesis, biological evaluation, and DFT calculations","volume":"27","author":"Ghareb","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2023.115496_bib60","series-title":"Madame Curie Bioscience Database [Internet]","article-title":"Prediction of drug-like properties","author":"Schneider","year":"2013"},{"key":"10.1016\/j.ejmech.2023.115496_bib61","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ejmech.2017.12.065","article-title":"Novel click modifiable thioquinazolinones as anti-inflammatory agents: design, synthesis, biological evaluation and docking study","volume":"144","author":"Moussa","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114485","article-title":"Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: crossing or circumventing the blood-brain barrier (BBB) to manage neurological disorders","author":"Correia","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2023.115496_bib63","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuint.2015.07.003","article-title":"Bioavailability of dietary polyphenols: factors contributing to their clinical application in CNS diseases","volume":"89","author":"Pandareesh","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejmech.2023.115496_bib64","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1021\/jm500734a","article-title":"Importance of purity evaluation and the potential of quantitative 1H NMR as a purity assay: miniperspective","volume":"57","author":"Pauli","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib65","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1021\/acs.jmedchem.8b00389","article-title":"Furoxans (oxadiazole-4 N-oxides) with attenuated reactivity are neuroprotective, cross the blood brain barrier, and improve passive avoidance memory","volume":"61","author":"Horton","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib66","series-title":"A New Reagent for Activating Carboxyl Groups; Preparation and Reactions of N, N-Bis [2-Oxo-3-Ox-Azolidinyl] Phosphorodiamidic Chloride, Synthesis","first-page":"547","author":"Diago-Meseguer","year":"1980"},{"key":"10.1016\/j.ejmech.2023.115496_bib67a","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molstruc.2016.05.064","article-title":"Microwave assisted regioselective synthesis and 2D-NMR studies of novel azoles and azoloazines utilizing fluorine-containing building Blocks","volume":"1121","author":"Al-Bogami","year":"2016","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejmech.2023.115496_bib67b","article-title":"Enhanced energy transfer in A \u03c0\u2010conjugated covalent organic framework facilitates excited\u2010state nickel catalysis","volume":"135","author":"Fan","year":"2023","journal-title":"Angew. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib68","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ejmech.2011.12.008","article-title":"A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions","volume":"48","author":"Huang","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115496_bib69","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.bmcl.2014.02.074","article-title":"Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2, 5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors","volume":"24","author":"Kim","year":"2014","journal-title":"Bioorg. Med. Chem. Lett"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423004622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423004622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T14:52:15Z","timestamp":1730991135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523423004622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":74,"alternative-id":["S0223523423004622"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115496","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and anti-inflammatory activity evaluation of NO-releasing furoxan\/1,2,4-triazole hybrid derivatives","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115496"}}