{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:08:26Z","timestamp":1783976906895,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ejmech.2023.115660","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T13:03:55Z","timestamp":1690290235000},"page":"115660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Synthesis and pharmacodynamic evaluation of naphthalene derivatives against influenza A virus in vitro and in vivo"],"prefix":"10.1016","volume":"259","author":[{"given":"Yongzhuang","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2023.115660_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-018-0002-y","volume":"4","author":"Krammer","year":"2018","journal-title":"Influenza, Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ejmech.2023.115660_bib2","doi-asserted-by":"crossref","first-page":"i6258","DOI":"10.1136\/bmj.i6258","volume":"355","author":"Ghebrehewet","year":"2016","journal-title":"Influenza, BMJ"},{"key":"10.1016\/j.ejmech.2023.115660_bib3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jinf.2013.11.013","article-title":"The burden of influenza in England by age and clinical risk group: a statistical analysis to inform vaccine policy","volume":"68","author":"Cromer","year":"2014","journal-title":"J. Infect."},{"issue":"RR08","key":"10.1016\/j.ejmech.2023.115660_bib4","first-page":"1","article-title":"Centers for disease control and prevention (CDC), prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices (ACIP), 2010","volume":"59","author":"Anthony E Fiore 1","year":"2010","journal-title":"MMWR Recomm. Rep. (Morb. Mortal. Wkly. Rep.)"},{"key":"10.1016\/j.ejmech.2023.115660_bib5","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.vaccine.2011.12.098","article-title":"Public health impact of including two lineages of influenza B in a quadrivalent seasonal influenza vaccine","volume":"30","author":"Reed","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.ejmech.2023.115660_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/nyas.12462","article-title":"Continuing challenges in influenza","volume":"1323","author":"Webster","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejmech.2023.115660_bib7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature08157","article-title":"Emergence and pandemic potential of swine-origin H1N1 influenza virus","volume":"459","author":"Neumann","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2023.115660_bib8","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1002\/med.21707","article-title":"Development of anti-influenza agents from natural products","volume":"40","author":"Zhang","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2023.115660_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/rmv.352","article-title":"Functional balance between haemagglutinin and neuraminidase in influenza virus infections","volume":"12","author":"Wagner","year":"2002","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.ejmech.2023.115660_bib10","doi-asserted-by":"crossref","first-page":"826","DOI":"10.7150\/thno.17071","article-title":"Progress of small molecular inhibitors in the development of anti-influenza virus agents","volume":"7","author":"Wu","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2023.115660_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114189","article-title":"Influenza-existing drugs and treatment prospects","volume":"232","author":"Sarker","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.coviro.2014.04.009","article-title":"The epidemiology and spread of drug resistant human influenza viruses","volume":"8","author":"Hurt","year":"2014","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.ejmech.2023.115660_bib13","article-title":"Identification of the I38T PA substitution as a resistance marker for next-generation influenza virus endonuclease inhibitors","volume":"9","author":"Jones","year":"2018","journal-title":"mBio."},{"key":"10.1016\/j.ejmech.2023.115660_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.105124","article-title":"Discovery of M2 channel blockers targeting the drug-resistant double mutants M2-S31N\/L26I and M2-S31N\/V27A from the influenza A viruses","volume":"141","author":"Musharrafieh","year":"2020","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2023.115660_bib15","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1128\/AAC.02335-12","article-title":"Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus","volume":"57","author":"Lejal","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2023.115660_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s41048-018-0047-1","article-title":"Identification of natural products as novel ligands for the human 5-HT2C receptor","volume":"4","author":"Peng","year":"2018","journal-title":"Biophys. Rep."},{"key":"10.1016\/j.ejmech.2023.115660_bib17","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1002\/ejoc.200800255","article-title":"Bioactive nitronaphthalenes from an endophytic Ffungus, Coniothyrium sp., and their chemical Ssynthesis","author":"Krohn","year":"2008","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib18","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/jm801084u","article-title":"Structure\u2212activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts","volume":"52","author":"Ponte-Sucre","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib19","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1021\/jm2008453","article-title":"Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17\u03b2-hydroxysteroid dehydrogenase Type 2 (17\u03b2-HSD2) inhibitors","volume":"54","author":"Wetzel","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib20","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.1021\/jm300351w","article-title":"Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase","volume":"55","author":"Marwaha","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib21","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1021\/jm400938g","article-title":"Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives","volume":"56","author":"Xu","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1021\/np0204904","article-title":"Guieranone A, a naphthyl butenone from the leaves of Guiera senegalensis with antifungal activity","volume":"66","author":"SilvaE","year":"2003","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2023.115660_bib23","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1021\/acs.joc.8b00531","article-title":"Intramolecular aryne-furan cycloadditions for the synthesis of anticancer naphthalimides","volume":"83","author":"Pr\u00e9vost","year":"2018","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib24","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1021\/ol4005883","article-title":"Mbandakamines A and B, unsymmetrically coupled dimeric naphthylisoquinoline alkaloids, from a Congolese Ancistrocladus species","volume":"15","author":"Bringmann","year":"2013","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2023.115660_bib25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11101-020-09668-7","article-title":"Update on naturally occurring novel arylnaphthalenes from plants","volume":"19","author":"Li","year":"2020","journal-title":"Phytochemistry Rev."},{"key":"10.1016\/j.ejmech.2023.115660_bib26","first-page":"2033","article-title":"FeCl3-Catalyzed intramolecular hydroarylation of Alkynes","author":"Dal Zotto","year":"2008","journal-title":"Synlett"},{"key":"10.1016\/j.ejmech.2023.115660_bib27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/ejoc.201201270","article-title":"Synthesis of vinyl sulfides and vinylamines through catalytic intramolecular hydroarylation in the presence of FeCl3 and AgOTf","author":"Eom","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib28","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1021\/jo000255v","article-title":"Ru(II)- and Pt(II)-Catalyzed cycloisomerization of \u03c9-aryl-1-alkynes. Generation of carbocationic species from alkynes and transition metal halides and its interception by an aromatic ring","volume":"65","author":"Chatani","year":"2000","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ejmech.2023.115660_bib29","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1021\/ol035622e","article-title":"Mercuric triflate\u2212(TMU)3-catalyzed cyclization of \u03c9-arylalkyne leading to dihydronaphthalenes","volume":"5","author":"Nishizawa","year":"2003","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2023.115660_bib30","doi-asserted-by":"crossref","first-page":"12455","DOI":"10.1039\/C8CC05484C","article-title":"Metal-free cycloisomerizations of o-alkynylbiaryls","volume":"54","author":"Zhang","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2023.115660_bib31","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1039\/D1QO01831K","article-title":"Metal-free intramolecular hydroarylation of alkynes","volume":"9","author":"Zhang","year":"2022","journal-title":"Org. Chem. Front."},{"key":"10.1016\/j.ejmech.2023.115660_bib32","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.tetlet.2010.10.094","article-title":"Triflic acid-catalyzed cascade cyclization of arenyl enynes via acetylene-cation cyclization and Friedel\u2013Crafts type reaction","volume":"52","author":"Jin","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2023.115660_bib33","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1021\/ol0620850","article-title":"Site-specific preparation of 2-carboalkoxy-4-substituted naphthalenes and 9-alkylphenanthrenes and evidence for an allene intermediate in the novel base-catalyzed cyclization of 2-alkynylbiphenyls","volume":"8","author":"WangD","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2023.115660_bib34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tim.2019.03.001","article-title":"Influenza neuraminidase: underrated role in receptor binding","volume":"27","author":"Wen","year":"2019","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2023.115660_bib35","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s13238-010-0054-6","article-title":"Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines","volume":"1","author":"Jiang","year":"2010","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2023.115660_bib36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41590-019-0317-1","article-title":"Fighting influenza through hemagglutinin diversity","volume":"20","author":"Krammer","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejmech.2023.115660_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200821119","article-title":"Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface","volume":"119","author":"Zhu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2023.115660_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tips.2011.09.001","article-title":"Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy","volume":"33","author":"Vlahos","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2023.115660_bib39","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1080\/15548627.2019.1580089","article-title":"Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2023.115660_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41590-017-0013-y","article-title":"Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway","volume":"19","author":"Holze","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejmech.2023.115660_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/nu11092101","article-title":"Selenium, selenoproteins and viral infection","volume":"11","author":"Guillin","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2023.115660_bib42","article-title":"B-cell lymphoma-2 family proteins-activated proteases as potential therapeutic targets for influenza A virus and severe acute respiratory syndrome coronavirus-2: killing two birds with one stone?","author":"Soni","year":"2022","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.ejmech.2023.115660_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118036","article-title":"Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN\/PI3K\/AKT in grass carp hepatocytes","volume":"290","author":"Miao","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ejmech.2023.115660_bib44","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/21505594.2019.1605803","article-title":"The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections","volume":"10","author":"Mehrbod","year":"2019","journal-title":"Virulence"},{"key":"10.1016\/j.ejmech.2023.115660_bib45","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.immuni.2020.07.009","article-title":"Single-cell sequencing of peripheral mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients","volume":"53","author":"Zhu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.ejmech.2023.115660_bib46","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/15548627.2020.1725375","article-title":"Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy","volume":"17","author":"Wang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2023.115660_bib47","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.coi.2014.12.012","article-title":"Viral RNA detection by RIG-I-like receptors","volume":"32","author":"Yoneyama","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejmech.2023.115660_bib48","article-title":"Antiviral activity of 3D, a butene lactone derivative against influenza A virus in vitro and in vivo","volume":"13","author":"Wang","year":"2021","journal-title":"Viruses"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423006268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423006268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:58:34Z","timestamp":1759330714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523423006268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":48,"alternative-id":["S0223523423006268"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115660","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and pharmacodynamic evaluation of naphthalene derivatives against influenza A virus in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115660"}}