{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:28:24Z","timestamp":1793820504710,"version":"4.6.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ejmech.2023.115883","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:52:49Z","timestamp":1697489569000},"page":"115883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities"],"prefix":"10.1016","volume":"262","author":[{"given":"Xiang-Jing","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-He","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Ge","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4395-8879","authenticated-orcid":false,"given":"Sai-Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ru","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2023.115883_bib1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2014.03.053","article-title":"High-resolution microtubule structures reveal the structural transitions in \u03b1\u03b2-tubulin upon GTP hydrolysis","volume":"157","author":"Alushin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2023.115883_bib2","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3253","article-title":"Microtubule-binding agents: a dynamic field of cancer therapeutics","volume":"9","author":"Dumontet","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2023.115883_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106684","article-title":"Tubulin degradation: principles, agents, and applications","volume":"139","author":"Zhang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s41580-021-00399-x","article-title":"Regulation of microtubule dynamics, mechanics and function through the growing tip","volume":"22","author":"Gudimchuk","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2023.115883_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1568026615666150112115805","article-title":"Tubulins - the target for anticancer therapy","volume":"15","author":"Vindya","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.tcb.2018.05.001","article-title":"Microtubule-targeting agents: strategies to hijack the cytoskeleton","volume":"28","author":"Steinmetz","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejmech.2023.115883_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg4168","article-title":"Cevipabulin-tubulin complex reveals a novel agent binding site on \u03b1-tubulin with tubulin degradation effect","volume":"7","author":"Yang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2023.115883_bib8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nrc2803","article-title":"Microtubules and resistance to tubulin-binding agents","volume":"10","author":"Kavallaris","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2023.115883_bib9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10495-022-01750-z","article-title":"Mechanisms of cancer cell death induction by paclitaxel: an updated review","volume":"27","author":"Zhao","year":"2022","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejmech.2023.115883_bib10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ejmech.2018.04.011","article-title":"Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site","volume":"151","author":"Li","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4155\/fmc-2022-0212","article-title":"An update on the recent advances and discovery of novel tubulin colchicine binding inhibitors","volume":"15","author":"Weng","year":"2023","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/biom12121843","article-title":"Recent advances of tubulin inhibitors targeting the colchicine binding site for cancer therapy","volume":"12","author":"Hawash","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejmech.2023.115883_bib13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2174\/1389200221666200226123638","article-title":"Tubulin proteins in cancer resistance: a review","volume":"21","author":"Kamal","year":"2020","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.ejmech.2023.115883_bib14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/acs.jmedchem.2c01411","article-title":"Microtubule-stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as candidate therapeutics for neurodegenerative disease: matched molecular pair analyses and computational studies reveal new structure\u2013activity insights","volume":"66","author":"Alle","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib15","doi-asserted-by":"crossref","first-page":"15805","DOI":"10.1021\/acs.jmedchem.2c01457","article-title":"Induction of ferroptosis in glioblastoma and ovarian cancers by a new pyrrole tubulin assembly inhibitor","volume":"65","author":"Puxeddu","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib16","doi-asserted-by":"crossref","first-page":"16372","DOI":"10.1021\/acs.jmedchem.2c01208","article-title":"Optimization of benzamide derivatives as potent and orally active tubulin inhibitors targeting the colchicine binding site","volume":"65","author":"Lin","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib17","doi-asserted-by":"crossref","first-page":"16774","DOI":"10.1021\/acs.jmedchem.2c01595","article-title":"Discovery of novel N-Heterocyclic-Fused deoxypodophyllotoxin analogues as tubulin polymerization inhibitors targeting the colchicine-binding site for cancer treatment","volume":"65","author":"Leng","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114069","article-title":"Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities","volume":"229","author":"Sun","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114466","article-title":"Discovery of (2-(pyrrolidin-1-yl)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone as a novel potent tubulin depolymerizing and vascular disrupting agent","volume":"238","author":"Tian","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114809","article-title":"Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA)","volume":"244","author":"Prudhomme","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib21","article-title":"Synthesis and biological evaluation of structurally diverse 6-aryl-3-Aroyl-Indole analogues as inhibitors of tubulin polymerization","author":"Ren","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106580","article-title":"Discovery of a novel Coumarin-Dihydroquinoxalone derivative MY-673 as a tubulin polymerization inhibitor capable of inhibiting the ERK pathway with potent anti-gastric cancer activities","volume":"137","author":"Song","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105239","article-title":"Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors","volume":"115","author":"Liang","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105220","article-title":"Design, synthesis and bioevaluation of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors","volume":"115","author":"Liu","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113122","article-title":"Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors","volume":"212","author":"Span\u00f2","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ph13010008","article-title":"Colchicine-binding site inhibitors from chemistry to clinic: a review","volume":"13","author":"McLoughlin","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2023.115883_bib27","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1158\/1535-7163.MCT-19-0536","article-title":"An orally available tubulin inhibitor, VERU-111, suppresses triple-negative breast cancer tumor growth and metastasis and bypasses taxane resistance","volume":"19","author":"Deng","year":"2020","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2023.115883_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.07.064","article-title":"Cinnamamide: an insight into the pharmacological advances and structure-activity relationships","volume":"181","author":"Gaikwad","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.apsb.2016.05.002","article-title":"Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents","volume":"7","author":"Li","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2023.115883_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105420","article-title":"Design, synthesis and biological evaluation of cinnamamide-quinazoline derivatives as potential EGFR inhibitors to reverse T790M mutation","volume":"117","author":"Zhang","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib31","doi-asserted-by":"crossref","first-page":"9942","DOI":"10.1021\/acs.jmedchem.6b01385","article-title":"Development of allosteric hydrazide-containing class I histone deacetylase inhibitors for use in acute myeloid leukemia","volume":"59","author":"McClure","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib32","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1021\/jm901805m","article-title":"Phenylcinnamides as novel antimitotic agents","volume":"53","author":"Leslie","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ejmech.2015.02.018","article-title":"Synthesis, biological evaluation and 3D-QSAR studies of novel 5-phenyl-1H-pyrazol cinnamamide derivatives as novel antitubulin agents","volume":"93","author":"Wang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib34","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/j.bmcl.2014.03.076","article-title":"Synthesis and biological evaluation of cinnamido linked benzophenone hybrids as tubulin polymerization inhibitors and apoptosis inducing agents","volume":"24","author":"Kamal","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2023.115883_bib35","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1016\/j.bmcl.2016.03.049","article-title":"Synthesis and biological evaluation of arylcinnamide linked combretastatin-A4 hybrids as tubulin polymerization inhibitors and apoptosis inducing agents","volume":"26","author":"Kamal","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2023.115883_bib36","first-page":"4740","article-title":"Arylcinnamido-propionone conjugates as tubulin polymerization inhibitors and apoptotic inducers, Arab","volume":"12","author":"Sankara Rao","year":"2019","journal-title":"J. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104191","article-title":"Synthesis and biological evaluation of substituted N-(2-(1H-benzo[d]imidazole-2-yl)phenyl)cinnamides as tubulin polymerization inhibitors","volume":"103","author":"Donthiboina","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib38","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1080\/14756366.2021.1975695","article-title":"Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics","volume":"36","author":"Zhou","year":"2021","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib39","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1016\/j.bmc.2014.04.027","article-title":"Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors","volume":"22","author":"Baytas","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104765","article-title":"Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: synthesis, in silico and cell growth inhibition studies","volume":"110","author":"Sana","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib41","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.1021\/acs.jmedchem.6b00463","article-title":"Blocking blood flow to solid tumors by destabilizing tubulin: an approach to targeting tumor growth","volume":"59","author":"P\u00e9rez-P\u00e9rez","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.10.054","article-title":"Medicinal chemistry of vicinal diaryl scaffold: a mini review","volume":"162","author":"Ramajayam","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114583","article-title":"Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway","volume":"240","author":"Song","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114467","article-title":"Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities","volume":"238","author":"Song","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115883_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115070","article-title":"A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo","volume":"201","author":"Li","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2023.115883_bib46","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00432-021-03604-8","article-title":"A review: hippo signaling pathway promotes tumor invasion and metastasis by regulating target gene expression","volume":"147","author":"Li","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2023.115883_bib47","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","article-title":"The Hippo signalling pathway and its implications in human health and diseases","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejmech.2023.115883_bib48","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2023.2237701","article-title":"Discovery of novel arylamide derivatives containing piperazine moiety as inhibitors of tubulin polymerisation with potent liver cancer inhibitory activity","volume":"38","author":"Shi","year":"2023","journal-title":"J. Enzym. Inhib. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423008504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423008504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:58:52Z","timestamp":1759330732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523423008504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":48,"alternative-id":["S0223523423008504"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115883","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115883"}}