{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:26:11Z","timestamp":1791429971612,"version":"4.3.3"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20H300001"],"award-info":[{"award-number":["LY20H300001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ejmech.2023.115913","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T23:20:53Z","timestamp":1699053653000},"page":"115913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Discovery of 4-hydroxyl pyrazole derivatives as potent ferroptosis inhibitors"],"prefix":"10.1016","volume":"263","author":[{"given":"Danzhi","family":"Ying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenteng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fudi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2023.115913_bib1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2023.115913_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2023.115913_bib3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1182\/blood.2019002907","article-title":"Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis","volume":"136","author":"Yu","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.ejmech.2023.115913_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2023.115913_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.yjmcc.2022.10.004","article-title":"Ferroptosis in heart failure","volume":"173","author":"Yang","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejmech.2023.115913_bib6","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1183\/09031936.96.09061293","article-title":"The role of apoptosis in the pathogenesis and treatment of diseases","volume":"9","author":"Solary","year":"1996","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejmech.2023.115913_bib7","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s12276-021-00634-7","article-title":"Necroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators","volume":"53","author":"Seo","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejmech.2023.115913_bib8","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/s41589-019-0408-1","article-title":"The chemical basis of ferroptosis","volume":"15","author":"Conrad","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2023.115913_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chembiol.2020.03.013","article-title":"The chemistry and biology of ferroptosis","volume":"27","author":"Stockwell","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.ejmech.2023.115913_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejmech.2023.115913_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role of ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2023.115913_bib12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/CIRCRESAHA.120.316509","article-title":"Loss of cardiac ferritin H facilitates cardiomyopathy via slc7a11-mediated ferroptosis","volume":"127","author":"Fang","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejmech.2023.115913_bib13","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.drudis.2020.12.020","article-title":"Inhibiting ferroptosis: a novel approach for stroke therapeutics","volume":"26","author":"Jin","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejmech.2023.115913_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.115015","article-title":"Targeting ferroptosis: paving new roads for drug design and discovery","volume":"247","author":"Gu","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"2023","key":"10.1016\/j.ejmech.2023.115913_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11684-023-0992-z","article-title":"Zooming in and out of ferroptosis in human disease","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.ejmech.2023.115913_bib16","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ja411006a","article-title":"Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models","volume":"136","author":"Skouta","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2023.115913_bib17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/acscentsci.7b00028","article-title":"On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death","volume":"3","author":"Zilka","year":"2017","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2023.115913_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejmech.2023.115913_bib19","doi-asserted-by":"crossref","first-page":"19043","DOI":"10.1021\/jacs.1c08254","article-title":"Radical-trapping antioxidant activity of copper and nickel bis(thiosemicarbazone) complexes underlies their potency as inhibitors of ferroptotic cell death","volume":"143","author":"Zilka","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2023.115913_bib20","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/bph.14881","article-title":"Cu(II) (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease","volume":"177","author":"Southon","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2023.115913_bib21","doi-asserted-by":"crossref","first-page":"9022","DOI":"10.1021\/cr500226n","article-title":"Advances in radical-trapping antioxidant chemistry in the 21st century: a kinetics and mechanisms perspective","volume":"114","author":"Ingold","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2023.115913_bib22","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.1021\/acs.jmedchem.0c01914","article-title":"Small-molecule inhibitors of reactive oxygen species production","volume":"64","author":"Sassetti","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115913_bib23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the role of lipoxygenases in the initiation and execution of ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2023.115913_bib24","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1021\/acschembio.7b00730","article-title":"The potency of diarylamine radical-trapping antioxidants as inhibitors of ferroptosis underscores the role of autoxidation in the mechanism of cell death","volume":"12","author":"Shah","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2023.115913_bib25","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1021\/acsmedchemlett.0c00293","article-title":"Antiferroptotic activity of phenothiazine analogues: a novel therapeutic strategy for oxidative stress related disease","volume":"11","author":"Liu","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2023.115913_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112842","article-title":"Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model","volume":"209","author":"Yang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2023.115913_bib27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1021\/acscentsci.6b00199","article-title":"A mitochondrial-targeted nitroxide is a potent inhibitor of ferroptosis","volume":"2","author":"Krainz","year":"2016","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2023.115913_bib28","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1021\/jacs.8b00998","article-title":"The catalytic reaction of nitroxides with peroxyl radicals and its relevance to their cytoprotective properties","volume":"140","author":"Griesser","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2023.115913_bib29","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1586\/14779072.6.10.1311","article-title":"Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity","volume":"6","author":"Jones","year":"2008","journal-title":"Expert Rev. Cardiovasc Ther."},{"key":"10.1016\/j.ejmech.2023.115913_bib30","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2023.115913_bib31","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.4103\/1673-5374.274344","article-title":"Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons","volume":"15","author":"Yao","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejmech.2023.115913_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-24152-2","article-title":"Ferroptosis inhibition by deferiprone, attenuates myelin damage and promotes neuroprotection in demyelinated optic nerve","volume":"12","author":"Rayatpour","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2023.115913_bib33","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1021\/acs.orglett.2c01691","article-title":"Visible-light 2,4-dinitrophenol-mediated photoannulation of \u03b1-azidochalcones into 2,5-diaryloxazoles","volume":"24","author":"Newar","year":"2022","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2023.115913_bib34","doi-asserted-by":"crossref","first-page":"32740","DOI":"10.1039\/C5RA04371A","article-title":"Synthesis of polysubstituted 4-aminopyrazoles and 4-hydroxypyrazoles from vinyl azides and hydrazines","volume":"5","author":"Huang","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2023.115913_bib35","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.chembiol.2019.01.008","article-title":"Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.ejmech.2023.115913_bib36","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3892\/ol.2021.13042","article-title":"Ferroptosis is involved in the anti-tumor effect of lycorine in renal cell carcinoma cells","volume":"22","author":"Du","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejmech.2023.115913_bib37","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1016\/j.bmcl.2015.07.018","article-title":"Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility","volume":"25","author":"Larraufie","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2023.115913_bib38","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41589-021-00751-4","article-title":"A compendium of kinetic modulatory profiles identifies ferroptosis regulators","volume":"17","author":"Conlon","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2023.115913_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/acschemneuro.5b00224","article-title":"Novel 1-Phenyl-3-hydroxy-4-pyridinone derivatives as multifunctional agents for the therapy of alzheimer's disease","volume":"7","author":"Sheng","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejmech.2023.115913_bib40","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/acschembio.2c00914","article-title":"Targeting labile iron-mediated ferroptosis provides a potential therapeutic strategy for rhabdomyolysis-induced acute kidney injury","volume":"18","author":"Zhu","year":"2023","journal-title":"ACS Chem. Biol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423008802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423008802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:54:30Z","timestamp":1759330470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523423008802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":40,"alternative-id":["S0223523423008802"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115913","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of 4-hydroxyl pyrazole derivatives as potent ferroptosis inhibitors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115913"}}