{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:52:47Z","timestamp":1790358767685,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.ejmech.2023.116067","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:40:34Z","timestamp":1703695234000},"page":"116067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo"],"prefix":"10.1016","volume":"265","author":[{"given":"Hua","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingge","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-0733","authenticated-orcid":false,"given":"Moran","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejmech.2023.116067_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics","volume":"65","author":"Torre","year":"2015","journal-title":"CA A Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.ejmech.2023.116067_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/107327481402100110","article-title":"Advanced EGFR mutation-positive non-small-cell lung cancer: case report, literature review, and treatment recommendations","volume":"21","author":"Kuykendall","year":"2014","journal-title":"Cancer Control"},{"issue":"7","key":"10.1016\/j.ejmech.2023.116067_bib3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/14656566.2017.1316374","article-title":"Emerging treatment using tubulin inhibitors in advanced non-small cell lung cancer","volume":"18","author":"Hardin","year":"2017","journal-title":"Expet Opin. Pharmacother."},{"issue":"39","key":"10.1016\/j.ejmech.2023.116067_bib4","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.2174\/0929867326666191016113631","article-title":"Recent advances in elucidating paclitaxel resistance mechanisms in non-small cell lung cancer and strategies to overcome drug resistance","volume":"27","author":"Cui","year":"2020","journal-title":"Curr. Med. Chem."},{"issue":"24","key":"10.1016\/j.ejmech.2023.116067_bib5","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1073\/pnas.91.24.11358","article-title":"Microtubule dynamics in vitro are regulated by the tubulin isotype composition","volume":"91","author":"Panda","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.ejmech.2023.116067_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1158\/0008-5472.CAN-14-2740","article-title":"TUBB3\/\u03b2III-tubulin acts through the PTEN\/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer","volume":"75","author":"McCarroll","year":"2015","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.ejmech.2023.116067_bib7","article-title":"\u03b2III-tubulin overexpression in cancer: causes, consequences, and potential therapies","volume":"1876","author":"Kanakkanthara","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"6","key":"10.1016\/j.ejmech.2023.116067_bib8","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/anie.201507978","article-title":"Small-molecule PROTACS: new approaches to protein degradation","volume":"55","author":"Toure","year":"2016","journal-title":"Angew Chem. Int. Ed. Engl."},{"issue":"1","key":"10.1016\/j.ejmech.2023.116067_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.chembiol.2017.09.009","article-title":"The advantages of targeted protein degradation over inhibition: an RTK case study","volume":"25","author":"Burslem","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.ejmech.2023.116067_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.872729","article-title":"Overcoming cancer drug resistance utilizing PROTAC technology","volume":"10","author":"Burke","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.ejmech.2023.116067_bib11","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood-2018-07-862953","article-title":"Bruton tyrosine kinase degradation as a therapeutic strategy for cancer","volume":"133","author":"Dobrovolsky","year":"2019","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.ejmech.2023.116067_bib12","first-page":"5","article-title":"Arvinas unveils PROTAC structures","volume":"99","author":"Halford","year":"2021","journal-title":"Chem. Eng."},{"issue":"2","key":"10.1016\/j.ejmech.2023.116067_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bbrc.2009.08.009","article-title":"The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin","volume":"388","author":"Harris","year":"2009","journal-title":"Biochem. Bioph. Res. Co."},{"issue":"5","key":"10.1016\/j.ejmech.2023.116067_bib14","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s10637-011-9734-1","article-title":"Anti-neoplastic agent thymoquinone induces degradation of \u03b1 and \u03b2 tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts","volume":"30","author":"Alhosin","year":"2012","journal-title":"Invest. N. Drugs"},{"issue":"15","key":"10.1016\/j.ejmech.2023.116067_bib15","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.3390\/ijms23158644","article-title":"Isothiocyanates (ITCs) 1-(Isothiocyanatomethyl)-4-phenylbenzene and 1-isothio -cyanato-3,5-bis(trifluoromethyl)benzene\u2014aldehyde dehydrogenase (ALDH) inhibitors, decreases cisplatin tolerance and migratory ability of NSCLC","volume":"23","author":"Kryczka","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ejmech.2023.116067_bib16","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/acs.jmedchem.1c02159","article-title":"Structure-based design and synthesis of N-substituted 3-Amino-\u03b2-Carboline derivatives as potent \u03b1\u03b2-tubulin degradation agents","volume":"65","author":"Li","year":"2022","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2023.116067_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051083","article-title":"Tubulin resists degradation by cereblon-recruiting PROTACs","volume":"9","author":"Gasic","year":"2020","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.ejmech.2023.116067_bib18","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s11899-019-00536-6","article-title":"IMiDs new and old","volume":"14","author":"Yamshon","year":"2019","journal-title":"Curr. Hematol. Malig. Rep."},{"issue":"16","key":"10.1016\/j.ejmech.2023.116067_bib19","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1039\/D2CS00220E","article-title":"Chemistries of bifunctional PROTAC degraders","volume":"51","author":"Cao","year":"2022","journal-title":"Chem. Soc. Rev."},{"issue":"3","key":"10.1016\/j.ejmech.2023.116067_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bmc.2014.12.027","article-title":"Natural antitubulin agents: importance of 3,4,5-trimethoxyphenyl fragment","volume":"23","author":"Negi","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2023.116067_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41467-018-08027-7","article-title":"Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase","volume":"10","author":"Smith","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.ejmech.2023.116067_bib22","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/acs.jmedchem.6b01816","article-title":"Discovery of a small-molecule degrader of bromodomain and extra-terminal (BET) proteins with picomolar cellular potencies and capable of achieving tumor regression","volume":"61","author":"Zhou","year":"2018","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2023.116067_bib23","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/acs.jmedchem.9b01566","article-title":"Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders","volume":"63","author":"Cheng","year":"2020","journal-title":"J. Med. Chem."},{"issue":"18","key":"10.1016\/j.ejmech.2023.116067_bib24","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.1021\/acs.jmedchem.0c01125","article-title":"Discovery of proteolysis-targeting chimera molecules that selectively degrade the IRAK3 pseudokinase","volume":"63","author":"Degorce","year":"2020","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2023.116067_bib25","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1021\/acs.bioconjchem.6b00353","article-title":"Combretastatin A-4 analogue: a dual-targeting and tubulin inhibitor containing antitumor Pt(IV) moiety with a unique mode of action","volume":"27","author":"Huang","year":"2016","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.ejmech.2023.116067_bib26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bioorg.2018.08.028","article-title":"Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity","volume":"81","author":"Bian","year":"2018","journal-title":"Bioorg. Chem."},{"issue":"98","key":"10.1016\/j.ejmech.2023.116067_bib27","doi-asserted-by":"crossref","first-page":"14848","DOI":"10.1039\/C9CC08509B","article-title":"Plasticity in designing PROTACs for selective and potent degradation of HDAC6","volume":"55","author":"Yang","year":"2019","journal-title":"Chem. Commun. (Camb)"},{"issue":"20","key":"10.1016\/j.ejmech.2023.116067_bib28","doi-asserted-by":"crossref","first-page":"11615","DOI":"10.1021\/acs.jmedchem.0c00793","article-title":"Understanding the metabolism of proteolysis targeting chimeras (PROTACs): the next step toward pharmaceutical applications","volume":"63","author":"Goracci","year":"2020","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2023.116067_bib29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1039\/C0MB00074D","article-title":"Impact of linker length on the activity of PROTACs","volume":"7","author":"Cyrus","year":"2011","journal-title":"Mol. Biosyst."},{"issue":"13","key":"10.1016\/j.ejmech.2023.116067_bib30","doi-asserted-by":"crossref","first-page":"9120","DOI":"10.1021\/acs.jmedchem.1c00270","article-title":"Development of alectinib-based PROTACs as novel potent degraders of anaplastic lymphoma kinase(ALK)","volume":"64","author":"Xie","year":"2021","journal-title":"J. Med. Chem."},{"issue":"23","key":"10.1016\/j.ejmech.2023.116067_bib31","doi-asserted-by":"crossref","first-page":"14562","DOI":"10.1021\/acs.jmedchem.0c01342","article-title":"Discovery of first-in-class potent and selective tropomyosin receptor kinase degraders","volume":"63","author":"Chen","year":"2020","journal-title":"J. Med. Chem."},{"issue":"7597","key":"10.1016\/j.ejmech.2023.116067_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nature16979","article-title":"Structural basis of lenalidomide-induced CK1\u03b1 degradation by the CRL4(CRBN) ubiquitin ligase","volume":"532","author":"Petzold","year":"2016","journal-title":"Nature"},{"issue":"6241","key":"10.1016\/j.ejmech.2023.116067_bib33","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.aab1433","article-title":"Phthalimide conjugation as a strategy for in vivo target protein degradation","volume":"348","author":"Winter","year":"2015","journal-title":"Science"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423010346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523423010346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T14:48:50Z","timestamp":1736866130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523423010346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":33,"alternative-id":["S0223523423010346"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.116067","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2023.116067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116067"}}