{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:47:51Z","timestamp":1793296071634,"version":"4.5.0"},"reference-count":147,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ejmech.2024.116172","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T16:17:05Z","timestamp":1706977025000},"page":"116172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Tackling Influenza A virus by M2 ion channel blockers: Latest progress and limitations"],"prefix":"10.1016","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4047-1416","authenticated-orcid":false,"given":"Gautam","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kakade Aditi","family":"Sakharam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2024.116172_bib1","first-page":"1","article-title":"Aetiological role of common respiratory viruses in acute lower respiratory infections in children under five years: a systematic review and meta\u2013analysis","volume":"5","author":"Shi","year":"2015","journal-title":"J. Glob. Health."},{"key":"10.1016\/j.ejmech.2024.116172_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2020.104338","article-title":"Severity of coronavirus respiratory tract infections in adults admitted to acute care in Toronto, Ontario","volume":"126","author":"Kozak","year":"2020","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib3","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3390\/v7030996","article-title":"Identification of new respiratory viruses in the new millennium","volume":"7","author":"Berry","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2024.116172_bib4","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1080\/21645515.2018.1483810","article-title":"Experience and challenges on influenza and pertussis vaccination in pregnant women","volume":"14","author":"Madhi","year":"2018","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.ejmech.2024.116172_bib5","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.2217\/fmb-2019-0203","article-title":"The challenges of influenza for public health","volume":"14","author":"\u00c1lvarez","year":"2019","journal-title":"Future Microbiol."},{"key":"10.1016\/j.ejmech.2024.116172_bib6","series-title":"Ion-Channel and Neuraminidase toward Inhibitor Design","author":"Mtambo","year":"2021"},{"key":"10.1016\/j.ejmech.2024.116172_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7189\/jogh.09.020421","article-title":"Global mortality associated with seasonal influenza epidemics: new burden estimates and predictors from the GLaMOR Project","volume":"9","author":"Paget","year":"2019","journal-title":"J. Glob. Health."},{"key":"10.1016\/j.ejmech.2024.116172_bib8","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.ajpath.2014.08.030","article-title":"The role of viral, host, and secondary bacterial factors in influenza pathogenesis","volume":"185","author":"Kash","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejmech.2024.116172_bib9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/cid\/ciab625","article-title":"Reducing influenza virus transmission: the potential value of antiviral treatment","volume":"74","author":"Hayden","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/femsre\/fuv039","article-title":"Influenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potential","volume":"40","author":"Richard","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.ejmech.2024.116172_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0136186","article-title":"Clinical characteristics are similar across type A and B influenza virus infections","volume":"10","author":"Mosnier","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2024.116172_bib12","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/cid\/cix1060","article-title":"Seasonal incidence of symptomatic influenza in the United States","volume":"66","author":"Tokars","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13054-019-2491-9","article-title":"Influenza virus-related critical illness: prevention, diagnosis, treatment","volume":"23","author":"Chow","year":"2019","journal-title":"Crit. Care"},{"key":"10.1016\/j.ejmech.2024.116172_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/v8040096","article-title":"Current approaches for diagnosis of influenza virus infections in humans","volume":"8","author":"Vemula","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2024.116172_bib15","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1016\/j.vaccine.2016.08.057","article-title":"Passive immunization for influenza through antibody therapies, a review of the pipeline, challenges and potential applications","volume":"34","author":"Sparrow","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.ejmech.2024.116172_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41541-017-0019-3","article-title":"Antibody therapies for the prevention and treatment of viral infections","volume":"2","author":"Salazar","year":"2017","journal-title":"Npj Vaccines"},{"key":"10.1016\/j.ejmech.2024.116172_bib17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s40262-017-0564-y","article-title":"Pharmacokinetics of MHAA4549A, an anti-influenza A monoclonal antibody, in healthy subjects challenged with influenza A virus in a phase IIa randomized trial","volume":"57","author":"Deng","year":"2018","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejmech.2024.116172_bib18","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1128\/AAC.00607-16","article-title":"Two phase 1, randomized, double-blind, placebo-controlled, single-ascending-dose studies to investigate the safety, tolerability, and pharmacokinetics of an anti-influenza A virus monoclonal antibody, MHAA4549A, in healthy volunteers, antimicrob","volume":"60","author":"Lim","year":"2016","journal-title":"Agents Chemother."},{"key":"10.1016\/j.ejmech.2024.116172_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2019.00109","article-title":"Drugs for influenza treatment: is there significant news?","volume":"6","author":"Principi","year":"2019","journal-title":"Front. Med."},{"key":"10.1016\/j.ejmech.2024.116172_bib20","first-page":"240","article-title":"Influenza antivirals currently in late-phase clinical trial, Influenza Other Respi","volume":"11","author":"Koszalka","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2024.116172_bib21","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00705-018-3708-y","article-title":"The emerging influenza virus threat: status and new prospects for its therapy and control","volume":"163","author":"Kumar","year":"2018","journal-title":"Arch. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib22","first-page":"1","article-title":"Common aspects of animal influenza 1 Influenza A virus","author":"Suarez","year":"2016","journal-title":"Anim. Influ."},{"key":"10.1016\/j.ejmech.2024.116172_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7774\/cevr.2018.7.1.1","article-title":"Challenges of influenza A viruses in humans and animals and current animal vaccines as an effective control measure","volume":"7","author":"Yoo","year":"2018","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.ejmech.2024.116172_bib24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.virol.2015.03.009","article-title":"Transmission of influenza A viruses","volume":"479\u2013480","author":"Neumann","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.ejmech.2024.116172_bib25","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/B978-0-12-809633-8.21505-7","article-title":"Influenza B, C and D viruses (orthomyxoviridae)","author":"Wolff","year":"2021","journal-title":"Encycl. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib26","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1002\/jmv.26990","article-title":"A brief review of influenza virus infection","volume":"93","author":"Javanian","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib27","series-title":"Anim. Influ.","first-page":"1","article-title":"Influenza A virus","author":"Suarez","year":"2016"},{"key":"10.1016\/j.ejmech.2024.116172_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2217\/fmb.15.120","article-title":"Knowns and unknowns of influenza B viruses","volume":"11","author":"Koutsakos","year":"2016","journal-title":"Future Microbiol."},{"key":"10.1016\/j.ejmech.2024.116172_bib29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s13238-015-0193-x","article-title":"Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus","volume":"7","author":"Wang","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2024.116172_bib30","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1128\/JVI.03122-15","article-title":"Pathogenesis of influenza D virus in cattle","volume":"90","author":"Ferguson","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2011.00269","article-title":"Native morphology of influenza virions","volume":"2","author":"Noda","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116172_bib32","first-page":"1","article-title":"Quercetin as a natural therapeutic candidate for the treatment of influenza virus","volume":"11","author":"Mehrbod","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejmech.2024.116172_bib33","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1128\/JVI.00592-15","article-title":"Structural analysis of the roles of influenza A virus membrane-associated proteins in assembly and morphology","volume":"89","author":"Chlanda","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.virol.2019.08.020","article-title":"Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2 . 3 . 4 . 4) in experimentally infected mallards and chickens","volume":"537","author":"Leyson","year":"2019","journal-title":"Virology"},{"key":"10.1016\/j.ejmech.2024.116172_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s40588-016-0041-7","article-title":"Filamentous influenza viruses","author":"Badham","year":"2016","journal-title":"Curr. Clin. Microbiol. Reports"},{"key":"10.1016\/j.ejmech.2024.116172_bib36","first-page":"1755","volume":"97","author":"Dadonaite","year":"2018","journal-title":"Europe PMC Funders Group Filamentous Influenza Viruses"},{"key":"10.1016\/j.ejmech.2024.116172_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.medmic.2023.100083","article-title":"Influenza A virus and its antiviral drug treatment options","volume":"16","author":"Singh","year":"2023","journal-title":"Med. Microecol."},{"key":"10.1016\/j.ejmech.2024.116172_bib38","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.tim.2018.05.013","article-title":"Influenza virus","volume":"26","author":"Hutchinson","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2024.116172_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1752-0509-7-97","article-title":"A comprehensive map of the influenza A virus replication cycle","volume":"7","author":"Matsuoka","year":"2013","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ejmech.2024.116172_bib40","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.1128\/JVI.00180-16","article-title":"Molecular characterizations of surface proteins hemagglutinin and neuraminidase from recent H5Nx avian influenza viruses","volume":"90","author":"Yang","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib41","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrmicro3346","article-title":"The sweet spot: defining virus\u2013sialic acid interactions","volume":"12","author":"Stencel-Baerenwald","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116172_bib42","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1007\/s00018-014-1615-2","article-title":"Antiviral strategies against influenza virus: towards new therapeutic approaches","volume":"71","author":"Loregian","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejmech.2024.116172_bib43","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3390\/v5010352","article-title":"Influenza A virus entry inhibitors targeting the hemagglutinin","volume":"5","author":"Yang","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2024.116172_bib44","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.chom.2018.04.015","article-title":"A sialylated voltage-dependent Ca2+ channel binds hemagglutinin and mediates influenza A virus entry into mammalian cells","volume":"23","author":"Fujioka","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ejmech.2024.116172_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmolb.2021.777095","article-title":"pH-dependent mechanisms of influenza infection mediated by hemagglutinin","volume":"8","author":"Caffrey","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejmech.2024.116172_bib46","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/acs.jmedchem.6b01852","article-title":"Expeditious lead optimization of isoxazole-containing influenza A virus M2-S31N inhibitors using the suzuki-miyaura cross-coupling reaction","volume":"60","author":"Li","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116172_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104780","article-title":"Put a cork in it: plugging the M2 viral ion channel to sink influenza","volume":"178","author":"Jalily","year":"2020","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ejmech.2024.116172_bib48","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1128\/JVI.02346-12","article-title":"T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro","volume":"87","author":"Baranovich","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.virusres.2017.01.013","article-title":"Structural insights into RNA synthesis by the influenza virus transcription-replication machine","volume":"234","author":"Pflug","year":"2017","journal-title":"Virus Res."},{"key":"10.1016\/j.ejmech.2024.116172_bib50","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1099\/jgv.0.000770","article-title":"Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations","volume":"98","author":"Zhang","year":"2017","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib51","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-virology-110615-042345","article-title":"Moving on out: transport and packaging of influenza viral RNA into virions","volume":"3","author":"Lakdawala","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib52","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.chom.2010.05.008","article-title":"Cellular networks involved in the influenza virus life cycle","volume":"7","author":"Watanabe","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ejmech.2024.116172_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.00858-17","article-title":"Mutations in the influenza A virus M1 protein enhance virus budding to complement lethal mutations in the M2 cytoplasmic tail","volume":"92","author":"Liu","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.01581","article-title":"Influenza A virus cell entry, replication, virion assembly and movement","volume":"9","author":"Dou","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2024.116172_bib55","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/rmv.1879","article-title":"A new role of neuraminidase (NA) in the influenza virus life cycle: implication for developing NA inhibitors with novel mechanism of action","volume":"26","author":"Yang","year":"2016","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib56","first-page":"13","article-title":"Structure of influenza viruses , connected with influenza life cycle","volume":"1","author":"Krejcova","year":"2015","journal-title":"J. Met. Nanotechnologies."},{"key":"10.1016\/j.ejmech.2024.116172_bib57","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ja.2017.115","article-title":"Current landscape and future prospects of antiviral drugs derived from microbial products","volume":"71","author":"Takizawa","year":"2018","journal-title":"J. Antibiot. (Tokyo)."},{"key":"10.1016\/j.ejmech.2024.116172_bib58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/13543776.2020.1831471","article-title":"Searching for effective antiviral small molecules against influenza A virus: a patent review","volume":"31","author":"Ginex","year":"2021","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2024.116172_bib59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1741-7015-10-104","article-title":"New treatments for influenza","volume":"10","author":"Barik","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.ejmech.2024.116172_bib60","doi-asserted-by":"crossref","DOI":"10.1021\/acsinfecdis.0c00552","article-title":"Inhibition of influenza virus polymerase by interfering with its protein-protein interactions","volume":"7","author":"Massari","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib61","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/QCO.0000000000000532","article-title":"Influenza virus polymerase inhibitors in clinical development","volume":"32","author":"Hayden","year":"2019","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib62","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00705-011-1087-8","article-title":"Inhibition of influenza A virus replication by RNA interference targeted against the PB1 subunit of the RNA polymerase gene","volume":"156","author":"Li","year":"2011","journal-title":"Arch. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002830","article-title":"Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease","volume":"8","author":"DuBois","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2024.116172_bib64","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.virol.2015.01.014","article-title":"Initiation and regulation of paramyxovirus transcription and replication","volume":"479\u2013480","author":"Noton","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.ejmech.2024.116172_bib65","article-title":"Novel hemagglutinin-based influenza virus inhibitors","volume":"5","author":"Shen","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib66","series-title":"Influenza Neuraminidase : A Druggable Target for Natural Products","first-page":"29","author":"Rollinger","year":"2012"},{"key":"10.1016\/j.ejmech.2024.116172_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/v13040624","article-title":"Antivirals targeting the surface glycoproteins of influenza virus: mechanisms of action and resistance","volume":"13","author":"Bai","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2024.116172_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10071722","article-title":"How influenza virus uses host cell pathways during uncoating","volume":"10","author":"Moreira","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ejmech.2024.116172_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cmi.13038","article-title":"Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle","volume":"21","author":"Zhu","year":"2019","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.ejmech.2024.116172_bib70","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virusres.2017.05.021","article-title":"Mutations in matrix protein 1 and nucleoprotein caused human-specific defects in nuclear exportation and viral assembly of an avian influenza H7N1 virus","volume":"238","author":"Ninpan","year":"2017","journal-title":"Virus Res."},{"key":"10.1016\/j.ejmech.2024.116172_bib71","first-page":"1","article-title":"Current and future antivirals medications to treat influenza: mechanisms of action","volume":"3","author":"Ramirez","year":"2019","journal-title":"J. Respir. Infect."},{"key":"10.1016\/j.ejmech.2024.116172_bib72","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.3390\/v7062771","article-title":"Viral membrane channels: role and function in the virus life cycle","volume":"7","author":"Sze","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2024.116172_bib73","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1080\/15548627.2019.1580089","article-title":"Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2024.116172_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.01972-17","article-title":"Ubiquitination of the cytoplasmic domain of influenza A virus M2 protein is crucial for production of infectious virus particles","volume":"92","author":"Su","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib75","series-title":"Influenza and Antiviral Resistance : an Overview","first-page":"1201","author":"Lampejo","year":"2020"},{"key":"10.1016\/j.ejmech.2024.116172_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.onehlt.2015.03.001","article-title":"One health, multiple challenges: the inter-species transmission of influenza A virus","volume":"1","author":"Short","year":"2015","journal-title":"One Heal"},{"key":"10.1016\/j.ejmech.2024.116172_bib77","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1177\/1060028019826565","article-title":"Baloxavir marboxil: the first cap-dependent endonuclease inhibitor for the treatment of influenza","volume":"53","author":"Yang","year":"2019","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.ejmech.2024.116172_bib78","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMoa1716197","article-title":"Baloxavir marboxil for uncomplicated influenza in adults and adolescents","volume":"379","author":"Hayden","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejmech.2024.116172_bib79","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.coviro.2019.01.006","article-title":"Baloxavir marboxil: the new influenza drug on the market","volume":"35","author":"O'Hanlon","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib80","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/infdis\/jiy547","article-title":"Phase 2b study of pimodivir (JNJ-63623872) as monotherapy or in combination with oseltamivir for treatment of acute uncomplicated seasonal influenza A: TOPAZ trial","volume":"219","author":"Finberg","year":"2019","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2021.105035","article-title":"Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir","volume":"188","author":"Patel","year":"2021","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ejmech.2024.116172_bib82","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/infdis\/jiaa376","article-title":"A phase 2 study of pimodivir (JNJ-63623872) in combination with oseltamivir in elderly and nonelderly adults hospitalized with influenza A infection: OPAL study","volume":"226","author":"O'Neil","year":"2022","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib83","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.arbres.2016.07.004","article-title":"Anti-influenza treatment: drugs currently used and under development","volume":"53","author":"Amarelle","year":"2017","journal-title":"Arch. Bronconeumol."},{"key":"10.1016\/j.ejmech.2024.116172_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107512","article-title":"Favipiravir, an anti-influenza drug against life-threatening RNA virus infections","volume":"209","author":"Shiraki","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2024.116172_bib85","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1073\/pnas.1811345115","article-title":"The mechanism of resistance to favipiravir in influenza","volume":"115","author":"Goldhill","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejmech.2024.116172_bib86","series-title":"Infect. Dis. (Auckl).","first-page":"1318","article-title":"Antiviral agents against respiratory viruses","author":"Ison","year":"2017"},{"key":"10.1016\/j.ejmech.2024.116172_bib87","series-title":"Peramivir : an Intravenous Neuraminidase Inhibitor","first-page":"1","author":"Mclaughlin","year":"2015"},{"key":"10.1016\/j.ejmech.2024.116172_bib88","series-title":"Laninamivir Octanoate : a New Long-Acting Neuraminidase Inhibitor for the Treatment of Influenza","first-page":"851","author":"Profile","year":"2011"},{"key":"10.1016\/j.ejmech.2024.116172_bib89","first-page":"1","article-title":"Influenza viruses - antiviral therapy and resistance","volume":"5","author":"Duwe","year":"2017","journal-title":"GMS Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib90","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1099\/jgv.0.001325","article-title":"Mutated influenza A virus exhibiting reduced susceptibility to baloxavir marboxil from an experimentally infected horse","volume":"100","author":"Nemoto","year":"2019","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib91","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1038\/s41598-018-27890-4","article-title":"Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil","volume":"8","author":"Omoto","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2024.116172_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/v13071196","article-title":"Comprehensive profiling of mutations to influenza virus PB2 that confer resistance to the cap-binding inhibitor pimodivir","volume":"13","author":"Soh","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2024.116172_bib93","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3390\/molecules27051645","article-title":"Impact of the R292K mutation on influenza A (H7N9) virus resistance towards peramivir: a molecular dynamics perspective","volume":"27","author":"Mtambo","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2024.116172_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.00301-20","article-title":"Laninamivir-interferon lambda 1 combination treatment promotes resistance by influenza A virus more rapidly than laninamivir alone","volume":"64","author":"Adams","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2024.116172_bib95","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1021\/bi901799k","article-title":"Functional studies and modeling of pore-lining residue mutants of the influenza A virus M2 ion channel","volume":"49","author":"Balannik","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2024.116172_bib96","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1128\/JVI.00576-15","article-title":"Proton Channel activity of influenza A virus matrix protein 2 contributes to autophagy arrest","volume":"90","author":"Ren","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib97","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.bbamem.2017.10.026","article-title":"Functional studies reveal the similarities and differences between AM2 and BM2 proton channels from influenza viruses","volume":"1860","author":"Ma","year":"2018","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.ejmech.2024.116172_bib98","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1016\/j.str.2015.09.011","article-title":"Dynamic short hydrogen bonds in histidine tetrad of full-length M2 proton channel reveal tetrameric structural heterogeneity and functional mechanism","volume":"23","author":"Miao","year":"2015","journal-title":"Structure"},{"key":"10.1016\/j.ejmech.2024.116172_bib99","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bbamem.2010.04.015","article-title":"Influenza M2 proton channels","volume":"1808","author":"Pielak","year":"2011","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.ejmech.2024.116172_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-40217-1","article-title":"The transmembrane conformation of the influenza B virus M2 protein in lipid bilayers","volume":"9","author":"Mandala","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2024.116172_bib101","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1128\/JVI.03253-14","article-title":"Influenza virus M2 protein ion channel activity helps to maintain pandemic 2009 H1N1 virus hemagglutinin fusion competence during transport to the cell surface","volume":"89","author":"Alvarado-Facundo","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib102","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/pro.2158","article-title":"Structural basis for proton conduction and inhibition by the influenza M2 protein","volume":"21","author":"Hong","year":"2012","journal-title":"Protein Sci."},{"key":"10.1016\/j.ejmech.2024.116172_bib103","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.1191750","article-title":"Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer","volume":"330","author":"Sharma","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2024.116172_bib104","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.bpj.2013.02.054","article-title":"PH-dependent conformation, dynamics, and aromatic interaction of the gating tryptophan residue of the influenza M2 proton channel from solid-state NMR","volume":"104","author":"Williams","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejmech.2024.116172_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms18122649","article-title":"Influenza A virus M2 protein: roles from ingress to egress","volume":"18","author":"Manzoor","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2024.116172_bib106","doi-asserted-by":"crossref","first-page":"12946","DOI":"10.1073\/pnas.1715127114","article-title":"Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR","volume":"114","author":"Elkins","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejmech.2024.116172_bib107","doi-asserted-by":"crossref","first-page":"12644","DOI":"10.1021\/jp5102225","article-title":"Proton release from the histidine-tetrad in the M2 channel of the influenza A virus","volume":"118","author":"Dong","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejmech.2024.116172_bib108","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nsmb.1779","article-title":"Structures of influenza A proteins and insights into antiviral drug targets","volume":"17","author":"Das","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ejmech.2024.116172_bib109","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1073\/pnas.1705624114","article-title":"XFEL structures of the influenza M2 proton channel: room temperature water networks and insights into proton conduction","volume":"114","author":"Thomaston","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2024.116172_bib110","doi-asserted-by":"crossref","first-page":"E6955","DOI":"10.1073\/pnas.1615471113","article-title":"Acid activation mechanism of the influenza A M2 proton channel","volume":"113","author":"Liang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2024.116172_bib111","doi-asserted-by":"crossref","first-page":"14260","DOI":"10.1073\/pnas.1518493112","article-title":"High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction","volume":"112","author":"Thomaston","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejmech.2024.116172_bib112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0214448","article-title":"Model of influenza virus acidification","volume":"14","author":"Akole","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2024.116172_bib113","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s13238-010-0025-y","article-title":"Flu channel drug resistance: a tale of two sites","volume":"1","author":"Pielak","year":"2010","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2024.116172_bib114","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nature08722","article-title":"Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers","volume":"463","author":"Cady","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2024.116172_bib115","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.tibs.2010.03.006","article-title":"Where does amantadine bind to the influenza virus M2 proton channel?","volume":"35","author":"Kozakov","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejmech.2024.116172_bib116","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1021\/jp506807y","article-title":"Hydrogen-bonded water molecules in the m2 channel of the influenza a virus guide the binding preferences of ammonium-based inhibitors","volume":"119","author":"Gianti","year":"2015","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejmech.2024.116172_bib117","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s13238-018-0536-5","article-title":"Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors","volume":"10","author":"Guo","year":"2019","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2024.116172_bib118","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.2174\/0929867324666170920165926","article-title":"Influenza virus: small molecule therapeutics and mechanisms of antiviral resistance","volume":"25","author":"Han","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116172_bib119","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/17460441.2019.1560261","article-title":"Novel antiviral drug discovery strategies to tackle drug-resistant mutants of influenza virus strains","volume":"14","author":"Shin","year":"2019","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.ejmech.2024.116172_bib120","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1021\/jp508545d","article-title":"Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N)","volume":"119","author":"Gleed","year":"2015","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejmech.2024.116172_bib121","doi-asserted-by":"crossref","first-page":"11481","DOI":"10.1021\/jacs.9b02196","article-title":"X-Ray crystal structure of the influenza A M2 proton channelchannel S31N mutant in two conformational states: an open and shut case","volume":"141","author":"Thomaston","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2024.116172_bib122","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/pro.2937","article-title":"Crystal structure of the drug-resistant S31N influenza M2 proton channel","volume":"25","author":"Thomaston","year":"2016","journal-title":"Protein Sci."},{"key":"10.1016\/j.ejmech.2024.116172_bib123","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1021\/acs.biochem.9b00971","article-title":"X-Ray crystal structures of the influenza M2 proton channel drug-resistant V27A mutant bound to a spiro-adamantyl amine inhibitor reveal the mechanism of adamantane resistance","volume":"59","author":"Thomaston","year":"2020","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2024.116172_bib124","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bbrc.2010.09.008","article-title":"Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel","volume":"401","author":"Pielak","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2024.116172_bib125","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1021\/ml100297w","article-title":"Exploring the requirements for the hydrophobic scaffold and polar amine in inhibitors of M2 from influenza A virus","volume":"2","author":"Wang","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2024.116172_bib126","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1039\/C4MD00515E","article-title":"Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus","volume":"6","author":"Zhao","year":"2015","journal-title":"Medchemcomm"},{"key":"10.1016\/j.ejmech.2024.116172_bib127","first-page":"265","article-title":"Construction and synthesis of tricyclic matrinic derivatives against influenza A virus by privileged structure strategy","volume":"74","author":"Jiang","year":"2019","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejmech.2024.116172_bib128","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1007\/s10989-019-09983-4","article-title":"Adamantane derivatives containing thiazole moiety: synthesis, antiviral and antibacterial activity","volume":"26","author":"Stankova","year":"2020","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.ejmech.2024.116172_bib129","doi-asserted-by":"crossref","first-page":"12834","DOI":"10.1021\/ja204969m","article-title":"Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2","volume":"133","author":"Wang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2024.116172_bib130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.antiviral.2017.01.006","article-title":"An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses","volume":"140","author":"Hu","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ejmech.2024.116172_bib131","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1021\/acs.jmedchem.6b01758","article-title":"Slow but steady wins the race: dissimilarities among new dual inhibitors of the wild-type and the V27A mutant M2 channels of influenza A virus","volume":"60","author":"Barniol-Xicota","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116172_bib132","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejmech.2016.05.008","article-title":"Novel spirothiazamenthane inhibitors of the influenza A M2 proton channel","volume":"120","author":"Arns","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116172_bib133","doi-asserted-by":"crossref","first-page":"13844","DOI":"10.1021\/ja2050666","article-title":"Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel","volume":"133","author":"Wang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2024.116172_bib134","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.antiviral.2018.03.002","article-title":"Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers","volume":"153","author":"Musharrafieh","year":"2018","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ejmech.2024.116172_bib135","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ejmech.2015.12.013","article-title":"Imidazole-based pinanamine derivatives: discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus","volume":"108","author":"Dong","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116172_bib136","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1021\/acsinfecdis.6b00130","article-title":"Discovery of potent antivirals against amantadine-resistant influenza A viruses by targeting the M2-S31N proton channel","volume":"2","author":"Li","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116172_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104106","article-title":"Design and synthesis of pinane oxime derivatives as novel anti-influenza agents","volume":"102","author":"Dong","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2024.116172_bib138","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1021\/acs.jmedchem.5b01910","article-title":"Discovery of highly potent inhibitors targeting the predominant drug-resistant S31N mutant of the influenza A virus M2 proton channel","volume":"59","author":"Li","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116172_bib139","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1021\/acschembio.0c00553","article-title":"Chemical probes for blocking of influenza A M2 wild-type and S31N channels","volume":"15","author":"Tzitzoglaki","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2024.116172_bib140","article-title":"Amantadine variant \u2013 aryl conjugates that inhibit multiple M2 mutant \u2013 amantadine resistant influenza a viruses","volume":"6","author":"Tzitzoglaki","year":"2022","journal-title":"Eur. J. Med. Chem. Reports."},{"key":"10.1016\/j.ejmech.2024.116172_bib141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.poly.2020.114590","article-title":"Amantadine copper(II) chloride conjugate with possible implementation in influenza virus inhibition","volume":"185","author":"Banti","year":"2020","journal-title":"Polyhedron"},{"key":"10.1016\/j.ejmech.2024.116172_bib142","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.antiviral.2017.10.009","article-title":"Divalent copper complexes as influenza A M2 inhibitors","volume":"147","author":"Gordon","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ejmech.2024.116172_bib143","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01441-18","article-title":"Salinomycin inhibits influenza virus infection by disrupting endosomal acidification and viral matrix protein 2 function","volume":"92","author":"Jang","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2024.116172_bib144","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1016\/j.bmcl.2017.08.062","article-title":"Anti-influenza activity of diazaadamantanes combined with monoterpene moieties","volume":"27","author":"Suslov","year":"2017","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2024.116172_bib145","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1124\/mol.116.105346","article-title":"Pharmacological characterization of the spectrum of antiviral activity and genetic barrier to drug resistance of M2-S31N channel blockers","volume":"90","author":"Ma","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116172_bib146","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/cmdc.201500318","article-title":"Isocyanides as influenza A virus subtype H5N1 wild-type M2 channel inhibitors","volume":"10","author":"Wu","year":"2015","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2024.116172_bib147","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1039\/C8MD00474A","article-title":"Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus","volume":"10","author":"Yu","year":"2019","journal-title":"Medchemcomm"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424000527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424000527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T19:18:25Z","timestamp":1735067905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523424000527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":147,"alternative-id":["S0223523424000527"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116172","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tackling Influenza A virus by M2 ion channel blockers: Latest progress and limitations","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116172"}}