{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:28:10Z","timestamp":1773768490238,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004605","name":"Zhengzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ejmech.2024.116293","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T05:16:07Z","timestamp":1709270167000},"page":"116293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Design, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives"],"prefix":"10.1016","volume":"268","author":[{"given":"Shengcong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangshang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Ampomah-Wireko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauraine","family":"Nininahazwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-756X","authenticated-orcid":false,"given":"En","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2024.116293_bib1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1176667","article-title":"Antibiotics for emerging pathogens","volume":"325","author":"Fischbach","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2024.116293_bib2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.cell.2018.02.018","article-title":"Antibiotic resistance","volume":"172","author":"Yelin","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2024.116293_bib3","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.abg9868","article-title":"Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections","volume":"375","author":"Stracy","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2024.116293_bib4","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1001\/jama.2016.4151","article-title":"Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011","volume":"315","author":"Fleming-Dutra","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.ejmech.2024.116293_bib5","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1016\/S1473-3099(18)30513-9","article-title":"Analysis of the clinical antibacterial and antituberculosis pipeline","volume":"19","author":"Theuretzbacher","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116293_bib6","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41579-020-0340-0","article-title":"Critical analysis of antibacterial agents in clinical development","volume":"18","author":"Theuretzbacher","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116293_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41579-019-0288-0","article-title":"The global preclinical antibacterial pipeline","volume":"18","author":"Theuretzbacher","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116293_bib8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2024.116293_bib9","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1016\/S1473-3099(16)30386-3","article-title":"A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail","volume":"17","author":"Goff","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116293_bib10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1021\/acs.accounts.0c00550","article-title":"De novo design of flavonoid-based mimetics of cationic antimicrobial peptides: discovery, development, and applications","volume":"54","author":"Lin","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2024.116293_bib11","doi-asserted-by":"crossref","first-page":"7793","DOI":"10.1126\/scitranslmed.abo7793","article-title":"The past, present, and future of antibiotics","volume":"14","author":"Cook","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejmech.2024.116293_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau5480","article-title":"Antimicrobial peptides: application informed by evolution","volume":"368","author":"Lazzaro","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2024.116293_bib13","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1039\/D0CS01026J","article-title":"Chemically modified and conjugated antimicrobial peptides against superbugs","volume":"50","author":"Li","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2024.116293_bib14","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1016\/S1473-3099(20)30327-3","article-title":"The value of antimicrobial peptides in the age of resistance","volume":"20","author":"Magana","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116293_bib15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41573-019-0058-8","article-title":"Antimicrobial host defence peptides: functions and clinical potential","volume":"19","author":"Mookherjee","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2024.116293_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101229","article-title":"Design, optimization, and nanotechnology of antimicrobial peptides: from exploration to applications","volume":"39","author":"Tan","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.ejmech.2024.116293_bib17","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1021\/acs.jmedchem.2c00757","article-title":"Small molecular mimetics of antimicrobial peptides as a promising therapy to combat bacterial resistance","volume":"66","author":"Teng","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib18","doi-asserted-by":"crossref","first-page":"9894","DOI":"10.1021\/acs.jmedchem.1c00312","article-title":"Modular design of membrane-active antibiotics: from macromolecular antimicrobials to small scorpionlike peptidomimetics","volume":"64","author":"Wang","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd3591","article-title":"Designing antimicrobial peptides: form follows function","volume":"11","author":"Fjell","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2024.116293_bib20","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1038\/s41467-021-26221-y","article-title":"Addressing MRSA infection and antibacterial resistance with peptoid polymers","volume":"12","author":"Xie","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2024.116293_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2016.00194","article-title":"Antimicrobial peptides: an emerging category of therapeutic agents","volume":"6","author":"Mahlapuu","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116293_bib22","doi-asserted-by":"crossref","first-page":"10750","DOI":"10.1021\/acs.jmedchem.6b01435","article-title":"Antibacterial and antibiofilm activity of cationic small molecules with spatial positioning of hydrophobicity: an in vitro and in vivo evaluation","volume":"59","author":"Hoque","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib23","doi-asserted-by":"crossref","first-page":"8427","DOI":"10.1039\/C7CC04206J","article-title":"L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria","volume":"53","author":"Ghosh","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2024.116293_bib24","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.1021\/acs.jmedchem.2c01583","article-title":"Development of aromatic-linked diamino acid antimicrobial peptide mimics with low hemolytic toxicity and excellent activity against methicillin-resistant staphylococcus aureus (MRSA)","volume":"66","author":"Kong","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib25","doi-asserted-by":"crossref","first-page":"10185","DOI":"10.1021\/acs.jmedchem.1c00449","article-title":"Alkyl-aryl-vancomycins: multimodal glycopeptides with weak dependence on the bacterial metabolic state","volume":"64","author":"Sarkar","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib26","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1021\/acs.jmedchem.2c02135","article-title":"Discovery of quaternized pyridine-thiazole-pleuromutilin derivatives with broad-spectrum antibacterial and potent anti-MRSA activity","volume":"66","author":"Xia","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115269","article-title":"Novel pyridinium cationic pleuromutilin analogues overcoming bacterial multidrug resistance","volume":"251","author":"Yi","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib28","doi-asserted-by":"crossref","first-page":"E5052","DOI":"10.1073\/pnas.1704125114","article-title":"Peripheral modifications of [\u03a8[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics","volume":"114","author":"Okano","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmech.2024.116293_bib29","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/acschembio.0c00091","article-title":"Vancomycin derivative inactivates carbapenem-resistant Acinetobacter Baumannii and induces autophagy","volume":"15","author":"Sarkar","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2024.116293_bib30","doi-asserted-by":"crossref","first-page":"a025247","DOI":"10.1101\/cshperspect.a025247","article-title":"\u03b2-lactams and \u03b2-lactamase inhibitors: an overview","volume":"6","author":"Bush","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ejmech.2024.116293_bib31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116293_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s40265-019-1055-2","article-title":"Cefiderocol: a siderophore cephalosporin with activity against carbapenem-resistant and multidrug-resistant Gram-negative bacilli","volume":"79","author":"Zhanel","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2024.116293_bib33","series-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2015"},{"key":"10.1016\/j.ejmech.2024.116293_bib34","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1021\/acs.jmedchem.1c00614","article-title":"Novel broad-spectrum antimicrobial peptide derived from anoplin and its activity on bacterial pneumonia in mice","volume":"64","author":"Gou","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib35","doi-asserted-by":"crossref","first-page":"15349","DOI":"10.1021\/acs.jmedchem.1c01352","article-title":"Tandem repeat of a short human chemerin-derived peptide and its nontoxic d-lysine-containing enantiomer display broad-spectrum antimicrobial and antitubercular activities","volume":"64","author":"Verma","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.colsurfb.2019.04.045","article-title":"Polymeric micelles of pluronic F127 reduce hemolytic potential of amphiphilic drugs","volume":"180","author":"Feitosa","year":"2019","journal-title":"Colloids Surf., B"},{"key":"10.1016\/j.ejmech.2024.116293_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tifs.2014.11.004","article-title":"Demonstrating the efficiency of sulphur dioxide replacements in wine: a parameter review","volume":"42","author":"Guerrero","year":"2015","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ejmech.2024.116293_bib38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tube.2017.04.010","article-title":"The role of the time-kill kinetics assay as part of a preclinical modeling framework for assessing the activity of anti-tuberculosis drugs","volume":"105","author":"Bax","year":"2017","journal-title":"Tuberculosis"},{"key":"10.1016\/j.ejmech.2024.116293_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114885","article-title":"Antibacterial efficacy evaluation and mechanism probe of small lysine chalcone peptide mimics","volume":"244","author":"Shen","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111594","article-title":"Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing acetamine phenyl linker","volume":"181","author":"Jin","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105859","article-title":"Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing 4-aminothiophenol linker as promising antibacterial agents","volume":"126","author":"Chai","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib42","article-title":"Green synthesis and antibacterial evaluation of spiro fused tryptanthrin-thiopyrano[2,3-b]indole hybrids targeting drug-resistant S. aureus","volume":"128","author":"Leena","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib43","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2024.116293_bib44","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.ejmech.2018.06.054","article-title":"Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles","volume":"155","author":"Bai","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib45","doi-asserted-by":"crossref","first-page":"14221","DOI":"10.1021\/acs.jmedchem.2c01437","article-title":"Design and synthesis of phenyl sulfide-based cationic amphiphiles as membrane-targeting antimicrobial agents against Gram-positive pathogens","volume":"65","author":"Liang","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114470","article-title":"Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance","volume":"186","author":"Zhong","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116293_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113488","article-title":"Polymyxin B-inspired non-hemolytic tyrocidine a analogues with significantly enhanced activity against gram-negative bacteria: how cationicity impacts cell specificity and antibacterial mechanism","volume":"221","author":"Zhu","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib48","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/acsinfecdis.9b00078","article-title":"Synthesis and bioactivities of new membrane-active agents with aromatic linker: high selectivity and broad-spectrum antibacterial activity","volume":"5","author":"Chu","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116293_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100749","article-title":"Plant natural flavonoids against multidrug resistant pathogens","volume":"8","author":"Song","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2024.116293_bib50","doi-asserted-by":"crossref","first-page":"14377","DOI":"10.1021\/acsnano.9b07836","article-title":"Molecular nanomachines disrupt bacterial cell wall, increasing sensitivity of extensively drug-resistant klebsiella pneumoniae to meropenem","volume":"13","author":"Galbadage","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejmech.2024.116293_bib51","doi-asserted-by":"crossref","first-page":"20257","DOI":"10.1021\/jacs.0c10771","article-title":"Molecular sizes and antibacterial performance relationships of flexible ionic liquid derivatives","volume":"142","author":"Zheng","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2024.116293_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112141","article-title":"Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane","volume":"190","author":"Fan","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115773","article-title":"Identification of unique indolylcyanoethylenyl sulfonylanilines as novel structural scaffolds of potential antibacterial agents","volume":"260","author":"Zhou","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib54","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1021\/acschembio.9b00141","article-title":"Morphological deconvolution of beta-lactam polyspecificity in E. coli","volume":"14","author":"Godinez","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2024.116293_bib55","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1039\/D0SC04337K","article-title":"Enterobactin- and salmochelin-\u03b2-lactam conjugates induce cell morphologies consistent with inhibition of penicillin-binding proteins in uropathogenic Escherichia coli CFT073","volume":"12","author":"Sargun","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejmech.2024.116293_bib56","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1021\/acsinfecdis.1c00005","article-title":"Conjugation to enterobactin and salmochelin S4 enhances the antimicrobial activity and selectivity of \u03b2-lactam antibiotics against nontyphoidal salmonella","volume":"7","author":"Sargun","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116293_bib57","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/AAC.35.11.2312","article-title":"Comparison of cefepime, cefpirome, and cefaclidine binding affinities for penicillin-binding proteins in Escherichia-coli k-12 and Pseudomonas aeruginosa SC8329","volume":"35","author":"Pucci","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2024.116293_bib58","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1126\/science.1136611","article-title":"Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis","volume":"315","author":"Lovering","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2024.116293_bib59","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1021\/acsabm.9b00124","article-title":"Mechanistic insight into the antibacterial activity of chitosan exfoliated MoS2 nanosheets: membrane damage, metabolic inactivation, and oxidative stress","volume":"2","author":"Roy","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.ejmech.2024.116293_bib60","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","article-title":"A common mechanism of cellular death induced by bactericidal antibiotics","volume":"130","author":"Kohanski","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2024.116293_bib61","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.tim.2016.12.008","article-title":"The role of reactive oxygen species in antibiotic-mediated killing of bacteria","volume":"25","author":"Van Acker","year":"2017","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2024.116293_bib62","article-title":"Efficient killing of multidrug-resistant internalized bacteria by aiegens in vivo","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2024.116293_bib63","article-title":"Metformin restores tetracyclines susceptibility against multidrug resistant bacteria","volume":"7","author":"Liu","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2024.116293_bib64","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2024.116293_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115088","article-title":"Benzenesulfonyl thiazoloimines as unique multitargeting antibacterial agents towards Enterococcus faecalis","volume":"248","author":"Zhou","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116293_bib66","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1021\/acsinfecdis.9b00334","article-title":"Hydrophobicity-modulated small antibacterial molecule eradicates biofilm with potent efficacy against skin infections","volume":"6","author":"Konai","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116293_bib67","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0014-827X(00)00058-6","article-title":"A rapid procedure to prepare cefotaxime","volume":"55","author":"Rodriguez","year":"2000","journal-title":"Farmaco"},{"key":"10.1016\/j.ejmech.2024.116293_bib68","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.7164\/antibiotics.41.1374","article-title":"Synthesis and structure-activity relationships in the cefpirome series. I. 7-[2-(2-Aminothiazol-4-yl)-2-(Z)-oxyiminoacetamido]-3-[(substituted-1-pyridinio)methyl]ceph-3-em-4-carboxylates","volume":"41","author":"Lattrell","year":"1988","journal-title":"J. Antibiot."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424001739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424001739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:10:42Z","timestamp":1759331442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523424001739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":68,"alternative-id":["S0223523424001739"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116293","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116293","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116293"}}