{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:31:44Z","timestamp":1787869904802,"version":"build-2784847793"},"reference-count":157,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.ejmech.2024.116359","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T16:50:09Z","timestamp":1711385409000},"page":"116359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Natural polyphenol: Their pathogenesis-targeting therapeutic potential in Alzheimer's disease"],"prefix":"10.1016","volume":"269","author":[{"given":"Chengu","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoxian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingcai","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2024.116359_bib1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-030-32633-3_15","article-title":"Alzheimer's disease therapeutic approaches","volume":"1195","author":"Revi","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejmech.2024.116359_bib2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jconrel.2021.05.044","article-title":"Multifunctional nanorods based on self-assembly of biomimetic apolipoprotein E peptide for the treatment of Alzheimer's disease","volume":"335","author":"Zhang","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejmech.2024.116359_bib3","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/ijms24010778","article-title":"Apoe 4 and Alzheimer's disease pathogenesis-mitochondrial deregulation and targeted therapeutic strategies","volume":"24","author":"Pires","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2024.116359_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2024.116359_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107729","article-title":"Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats","volume":"96","author":"Ali","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejmech.2024.116359_bib6","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.3390\/s20143849","article-title":"Relationship between the presence of the ApoE \u03b54 allele and EEG complexity along the Alzheimer's disease continuum","volume":"20","author":"Guti\u00e9rrez-de Pablo","year":"2020","journal-title":"Sensors"},{"key":"10.1016\/j.ejmech.2024.116359_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-319-28383-8_3","article-title":"Dietary polyphenols as potential remedy for dementia","volume":"12","author":"Desai","year":"2016","journal-title":"Adv. Neurobiol."},{"key":"10.1016\/j.ejmech.2024.116359_bib8","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3390\/membranes11120983","article-title":"Secretases related to amyloid precursor protein processing","volume":"11","author":"Liu","year":"2021","journal-title":"Membranes"},{"key":"10.1016\/j.ejmech.2024.116359_bib9","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/jnc.15212","article-title":"Alzheimer's protection effect of A673T mutation may be driven by lower Abeta oligomer binding affinity","volume":"157","author":"Limegrover","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejmech.2024.116359_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106140","article-title":"Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPP\u03b2 levels in cerebrospinal fluid and 2D\/3D cell culture models","volume":"182","author":"Wittrahm","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejmech.2024.116359_bib11","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1021\/acschemneuro.1c00582","article-title":"Extracellular-signal-regulated kinase inhibition switches APP processing from \u03b2- to \u03b1-secretase under oxidative stress: modulation of ADAM10 by SIRT1\/NF-\u03baB signaling","volume":"12","author":"Thonda","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/19336896.2021.1917289","article-title":"Development of molecular tools for diagnosis of Alzheimer's disease that are based on detection of amyloidogenic proteins","volume":"15","author":"Kulichikhin","year":"2021","journal-title":"Prion"},{"key":"10.1016\/j.ejmech.2024.116359_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/1061186X.2021.1973482","article-title":"Novel strategies for the fight of Alzheimer's disease targeting amyloid-beta protein","volume":"30","author":"Xie","year":"2022","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejmech.2024.116359_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.655015","article-title":"Tau pathology profile across a parietal-hippocampal brain network is associated with spatial reorientation learning and memory performance in the 3xTg-AD mouse","volume":"2","author":"Stimmell","year":"2021","journal-title":"Front. Aging"},{"key":"10.1016\/j.ejmech.2024.116359_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13024-023-00611-w","article-title":"BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of \u03b2-amyloid peptides","volume":"18","author":"Zhou","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejmech.2024.116359_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/jnc.14122","article-title":"The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system","volume":"143","author":"Sosa","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejmech.2024.116359_bib17","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1021\/jacs.3c11511","article-title":"Amyloid-\u03b1 peptide formed through alternative processing of the amyloid precursor protein attenuates Alzheimer's amyloid-\u03b2 toxicity via cross-chaperoning","volume":"146","author":"Kuhn","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2024.116359_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2020.106533","article-title":"The role of surfaces on amyloid formation","volume":"270","author":"Grigolato","year":"2021","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.ejmech.2024.116359_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13024-024-00702-2","article-title":"Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid \u03b2 aggregates in vivo in a mouse model of Alzheimer's disease","volume":"19","author":"Calvo-Rodriguez","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejmech.2024.116359_bib20","article-title":"Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue","volume":"118","author":"Ghosh","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2024.116359_bib21","doi-asserted-by":"crossref","first-page":"17935","DOI":"10.1002\/jcb.29061","article-title":"Computational design and evaluation of beta-sheet breaker peptides for destabilizing Alzheimer's amyloid-beta(42) protofibrils","volume":"120","author":"Shuaib","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ejmech.2024.116359_bib22","first-page":"285","article-title":"REVIEW: curcumin and Alzheimer's disease, CNS neurosci","volume":"16","author":"Hamaguchi","year":"2010","journal-title":"Ther."},{"key":"10.1016\/j.ejmech.2024.116359_bib23","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1021\/acs.jafc.6b01237","article-title":"Effects of sesaminol feeding on brain A\u03b2 accumulation in a senescence-accelerated mouse-prone 8","volume":"64","author":"Katayama","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2024.116359_bib24","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1039\/C9FO00316A","article-title":"Cyanidin-3-O-glucoside inhibits A\u03b240 fibrillogenesis, disintegrates preformed fibrils, and reduces amyloid cytotoxicity","volume":"11","author":"Liu","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.ejmech.2024.116359_bib25","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s12035-013-8608-2","article-title":"(-)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA\/p75NTR signaling in APP\/PS1 transgenic mice","volume":"49","author":"Liu","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejmech.2024.116359_bib26","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/01616412.2016.1244374","article-title":"In vitro antiaggregation and deaggregation potential of Rhizophora mucronata and its bioactive compound (+)- catechin against Alzheimer's beta amyloid peptide (25-35)","volume":"38","author":"Suganthy","year":"2016","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbr.2015.04.028","article-title":"Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble A\u03b2 levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)","volume":"289","author":"Nakajima","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neuroscience.2015.02.054","article-title":"Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells","volume":"294","author":"Zeng","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejmech.2024.116359_bib29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/jnr.21476","article-title":"Multifunction of myricetin on A beta: neuroprotection via a conformational change of A beta and reduction of A beta via the interference of secretases","volume":"86","author":"Shimmyo","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3233\/JAD-130164","article-title":"Ferulic acid inhibits the transition of amyloid-\u03b242 monomers to oligomers but accelerates the transition from oligomers to fibrils","volume":"37","author":"Cui","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejmech.2024.116359_bib31","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2174\/1567205016666190830113420","article-title":"Genistein decreases APP\/tau phosphorylation and ameliorates A\u03b2 overproduction through inhibiting CIP2A","volume":"16","author":"Shentu","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib32","first-page":"1219","article-title":"Reduction of A\u03b2 generation by schisandrin B through restraining beta-secretase 1 transcription and translation","volume":"24","author":"Li","year":"2018","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib33","first-page":"1328","article-title":"Protocatechuic acid attenuates \u03b2-secretase activity and okadaic acid-induced autophagy via the Akt\/GSK-3\u03b2\/MEF2D pathway in PC12 cells","volume":"21","author":"Huang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejmech.2024.116359_bib34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/nu8060333","article-title":"Salvianolic acid B inhibits A\u03b2 generation by modulating BACE1 activity in SH-SY5Y-APPsw cells","volume":"8","author":"Tang","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2024.116359_bib35","doi-asserted-by":"crossref","first-page":"994","DOI":"10.2174\/1389201017666160725120656","article-title":"Potential therapeutic effects of oleuropein aglycone in Alzheimer's disease","volume":"17","author":"Martorell","year":"2016","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.ejmech.2024.116359_bib36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3390\/nu8100637","article-title":"The identification of biochanin A as a potent and selective \u03b2-site app-cleaving enzyme 1 (Bace1) inhibitor","volume":"8","author":"Youn","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2024.116359_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neures.2013.11.004","article-title":"Carnosic acid suppresses the production of amyloid-\u03b2 1-42 and 1-43 by inducing an \u03b1-secretase TACE\/ADAM17 in U373MG human astrocytoma cells","volume":"79","author":"Yoshida","year":"2014","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib38","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bmcl.2014.12.034","article-title":"Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-\u03b2-amyloid (A\u03b2) aggregation and metal chelation properties against Alzheimer's disease","volume":"25","author":"Huang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2024.116359_bib39","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ijbiomac.2021.08.198","article-title":"Caffeic acid for the prevention and treatment of Alzheimer's disease: the effect of lipid membranes on the inhibition of aggregation and disruption of A\u03b2 fibrils","volume":"190","author":"Andrade","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2024.116359_bib40","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jbiosc.2009.11.010","article-title":"Catechol derivatives inhibit the fibril formation of amyloid-beta peptides","volume":"109","author":"Huong","year":"2010","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ejmech.2024.116359_bib41","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ijbiomac.2017.05.110","article-title":"Multi-functional activities of citrus flavonoid narirutin in Alzheimer's disease therapeutics: an integrated screening approach and in vitro validation","volume":"103","author":"Chakraborty","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2024.116359_bib42","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ijbiomac.2020.10.202","article-title":"Resistance of nepetin and its analogs on the fibril formation of human islet amyloid polypeptide","volume":"166","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2024.116359_bib43","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1021\/acschemneuro.9b00232","article-title":"Orobol: an isoflavone exhibiting regulatory multifunctionality against four pathological features of Alzheimer's disease","volume":"10","author":"Nam","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib44","doi-asserted-by":"crossref","first-page":"16251","DOI":"10.1074\/jbc.RA119.012330","article-title":"Gallic acid is a dual \u03b1\/\u03b2-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice","volume":"295","author":"Mori","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2024.116359_bib45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jneuroim.2016.08.018","article-title":"Diosmin reduces cerebral A\u03b2 levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice","volume":"299","author":"Sawmiller","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejmech.2024.116359_bib46","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.biopha.2018.08.037","article-title":"Sesamin and sesamolin reduce amyloid-\u03b2 toxicity in a transgenic Caenorhabditis elegans","volume":"107","author":"Keowkase","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2024.116359_bib47","first-page":"905","article-title":"Neuroprotective effect of trans-resveratrol in mild to moderate alzheimer disease: a randomized, double-blind trial, neurol","volume":"10","author":"Gu","year":"2021","journal-title":"Ther"},{"key":"10.1016\/j.ejmech.2024.116359_bib48","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.2174\/1386207323666200901095003","article-title":"G-lymphatic, vascular and immune pathways for A\u03b2 clearance cascade and therapeutic targets for Alzheimer's disease","volume":"24","author":"Chakraborty","year":"2021","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.ejmech.2024.116359_bib49","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.3390\/ijms22147697","article-title":"Redox-active metal ions and amyloid-degrading enzymes in Alzheimer's disease","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2024.116359_bib50","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/path.5777","article-title":"Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases","volume":"255","author":"Sousa","year":"2021","journal-title":"J. Pathol."},{"key":"10.1016\/j.ejmech.2024.116359_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413178","article-title":"Two opposing functions of angiotensin-converting enzyme (ACE) that links hypertension, dementia, and aging","volume":"22","author":"Le","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2024.116359_bib52","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41598-017-00794-5","article-title":"Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer's disease","volume":"7","author":"Kaminari","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2024.116359_bib53","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1124\/jpet.120.000086","article-title":"Distinct uptake kinetics of alzheimer disease amyloid-\u03b2 40 and 42 at the blood-brain barrier endothelium","volume":"376","author":"Sharda","year":"2021","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejmech.2024.116359_bib54","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2174\/1567205018666210906092940","article-title":"Effect of high cholesterol regulation of LRP1 and RAGE on A\u03b2 transport across the blood-brain barrier in Alzheimer's disease","volume":"18","author":"Zhou","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13024-018-0286-0","article-title":"Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-\u03b242 by LRP1-dependent apolipoprotein E isoform-specific mechanism","volume":"13","author":"Ma","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejmech.2024.116359_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9960304","article-title":"Electroacupuncture improves clearance of amyloid-\u03b2 through the glymphatic system in the SAMP8 mouse model of Alzheimer's disease","volume":"2021","author":"Liang","year":"2021","journal-title":"Neural Plast."},{"key":"10.1016\/j.ejmech.2024.116359_bib57","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s42466-021-00102-7","article-title":"Glymphatic system, AQP4, and their implications in Alzheimer's disease","volume":"3","author":"Silva","year":"2021","journal-title":"Neurol. Res. Pract"},{"key":"10.1016\/j.ejmech.2024.116359_bib58","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12974-021-02158-3","article-title":"Crosstalk between astrocytes and microglia results in increased degradation of \u03b1-synuclein and amyloid-\u03b2 aggregates","volume":"18","author":"Rostami","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejmech.2024.116359_bib59","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3390\/nu9101122","article-title":"Resveratrol and amyloid-beta: mechanistic insights","volume":"9","author":"Jia","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2024.116359_bib60","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2202-6-54","article-title":"Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans","volume":"6","author":"Gutierrez-Zepeda","year":"2005","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib61","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3390\/nu12020494","article-title":"5-Caffeoylquinic acid ameliorates cognitive decline and reduces A\u03b2 deposition by modulating A\u03b2 clearance pathways in APP\/PS2 transgenic mice","volume":"12","author":"Ishida","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2024.116359_bib62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/09168451.2017.1399788","article-title":"Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer's disease","volume":"82","author":"Fei","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejmech.2024.116359_bib63","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.nbd.2018.12.007","article-title":"Cinnamic acid activates PPAR\u03b1 to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model","volume":"124","author":"Chandra","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejmech.2024.116359_bib64","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s12031-020-01776-5","article-title":"Tau in the pathophysiology of Parkinson's disease","volume":"71","author":"Pan","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.702788","article-title":"Human tau isoforms and proteolysis for production of toxic tau fragments in neurodegeneration","volume":"15","author":"Boyarko","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.671779","article-title":"Dendritic\/Post-synaptic tau and early pathology of Alzheimer's disease","volume":"14","author":"Yin","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib67","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.conb.2021.03.003","article-title":"A current view on Tau protein phosphorylation in Alzheimer's disease","volume":"69","author":"Wegmann","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ejmech.2024.116359_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105536","article-title":"To target Tau pathologies, we must embrace and reconstruct their complexities","volume":"161","author":"Limorenko","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejmech.2024.116359_bib69","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3233\/ADR-210018","article-title":"Interacting models of amyloid-\u03b2 and tau proteins: an approach to identify drug targets in Alzheimer's disease","volume":"5","author":"Priya","year":"2021","journal-title":"J. Alzheimers Dis. Rep"},{"key":"10.1016\/j.ejmech.2024.116359_bib70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12964-021-00704-3","article-title":"Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation","volume":"19","author":"Sonawane","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ejmech.2024.116359_bib71","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.neuint.2011.02.010","article-title":"Oleuropein and derivatives from olives as Tau aggregation inhibitors","volume":"58","author":"Daccache","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejmech.2024.116359_bib72","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ijbiomac.2021.09.173","article-title":"Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease","volume":"192","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2024.116359_bib73","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1039\/C9FO02133G","article-title":"Xanthohumol inhibits tau protein aggregation and protects cells against tau aggregates","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.ejmech.2024.116359_bib74","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nbd.2011.07.005","article-title":"Morin attenuates tau hyperphosphorylation by inhibiting GSK3\u03b2","volume":"44","author":"Gong","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejmech.2024.116359_bib75","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/00207454.2018.1503183","article-title":"Schisanhenol improves learning and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1\u03b1-Tau signaling pathway","volume":"129","author":"Han","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.697319","article-title":"Oral (-)-Epicatechin inhibits progressive tau pathology in rTg4510 mice independent of direct actions at GSK3\u03b2","volume":"15","author":"Hole","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib77","first-page":"4951","article-title":"Ellagic acid ameliorates learning and memory impairment in APP\/PS1 transgenic mice via inhibition of \u03b2-amyloid production and tau hyperphosphorylation","volume":"16","author":"Zhong","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejmech.2024.116359_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104670","article-title":"An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar 'Ohta ponkan' (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity","volume":"114","author":"Nakajima","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116359_bib79","first-page":"554","article-title":"Effects of curcumin and demethoxycurcumin on amyloid-\u03b2 precursor and tau proteins through the internal ribosome entry sites: a potential therapeutic for Alzheimer's disease, Taiwan","volume":"51","author":"Villaflores","year":"2012","journal-title":"J. Obstet. Gynecol."},{"key":"10.1016\/j.ejmech.2024.116359_bib80","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/antiox8040091","article-title":"Juglone in oxidative stress and cell signaling","volume":"8","author":"Ahmad","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejmech.2024.116359_bib81","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000660","article-title":"Quercetin-3-O-Glucuronide alleviates cognitive deficit and toxicity in A\u03b21-42 -induced AD-like mice and SH-SY5Y cells","volume":"65","author":"Xu","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.575645","article-title":"Updating the free radical theory of aging","volume":"8","author":"Ziada","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2024.116359_bib83","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1089\/ars.2020.8134","article-title":"Preventive and therapeutic strategies in Alzheimer's disease: focus on oxidative stress, redox metals, and ferroptosis","volume":"34","author":"Plascencia-Villa","year":"2021","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejmech.2024.116359_bib84","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biochi.2021.08.008","article-title":"A mass spectrometric approach to study the interaction of amyloid \u03b2 peptides with human \u03b1-2-macroglobulin","volume":"191","author":"Protasov","year":"2021","journal-title":"Biochimie"},{"key":"10.1016\/j.ejmech.2024.116359_bib85","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s11011-021-00765-w","article-title":"Role of metals in Alzheimer's disease","volume":"36","author":"Das","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ejmech.2024.116359_bib86","first-page":"163","article-title":"A vicious circle: role of oxidative stress, intraneuronal Abeta and Cu in Alzheimer's disease","volume":"25","author":"Bayer","year":"2006","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.ejmech.2024.116359_bib87","article-title":"Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-\u03b2","volume":"1866","author":"Chai","year":"2021","journal-title":"Biochim. Biophys. Acta. Mol. Cell Biol. Lipids."},{"key":"10.1016\/j.ejmech.2024.116359_bib88","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/ptr.6300","article-title":"Kaempferide prevents cognitive decline via attenuation of oxidative stress and enhancement of brain-derived neurotrophic factor\/tropomyosin receptor kinase B\/cAMP response element-binding signaling pathway","volume":"33","author":"Yan","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib89","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.physbeh.2014.04.046","article-title":"Schisantherin A recovers A\u03b2-induced neurodegeneration with cognitive decline in mice","volume":"132","author":"Li","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejmech.2024.116359_bib90","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1055\/s-0032-1315019","article-title":"Deoxyschisandrin isolated from the fruits of Schisandra chinensis ameliorates A\u03b2\u2081\u208b\u2084\u2082-induced memory impairment in mice","volume":"78","author":"Hu","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2024.116359_bib91","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/ptr.5390","article-title":"Schisandrin C ameliorates learning and memory deficits by A\u03b21-42 -induced oxidative stress and neurotoxicity in mice","volume":"29","author":"Mao","year":"2015","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112696","article-title":"Chrysin loaded lipid-core nanocapsules ameliorates neurobehavioral alterations induced by \u03b2-amyloid1-42 in aged female mice","volume":"390","author":"Giacomeli","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib93","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.brainresbull.2018.07.012","article-title":"The memory-enhancing effects of 7,8,4'-trihydroxyisoflavone, a major metabolite of daidzein, are associated with activation of the cholinergic system and BDNF signaling pathway in mice","volume":"142","author":"Ko","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejmech.2024.116359_bib94","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.brainresbull.2021.02.024","article-title":"Effects of vanillic acid on A\u03b21-40-induced oxidative stress and learning and memory deficit in male rats","volume":"170","author":"Ahmadi","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejmech.2024.116359_bib95","doi-asserted-by":"crossref","first-page":"54","DOI":"10.14715\/cmb\/2019.65.5.9","article-title":"Protective effect of sakuranetin in brain cells of dementia model rats","volume":"65","author":"Li","year":"2019","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.ejmech.2024.116359_bib96","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejphar.2018.02.048","article-title":"6,7,4'-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB\/BDNF signaling pathway in mice","volume":"826","author":"Ko","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116359_bib97","article-title":"The gut microbiota metabolite urolithin B improves cognitive deficits by inhibiting cyt C-mediated apoptosis and promoting the survival of neurons through the PI3K pathway in aging mice","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116359_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104537","article-title":"Danshensu attenuates scopolamine and amyloid-\u03b2-induced cognitive impairments through the activation of PKA-CREB signaling in mice","volume":"131","author":"Bae","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejmech.2024.116359_bib99","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1080\/00207454.2019.1638376","article-title":"Arbutin reduces cognitive deficit and oxidative stress in animal model of Alzheimer's disease","volume":"129","author":"Dastan","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib100","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1007\/s11064-021-03289-y","article-title":"Sex-independent cognition improvement in response to kaempferol in the model of sporadic Alzheimer's disease","volume":"46","author":"Babaei","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib101","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22319","article-title":"Protective effect of daidzein against streptozotocin-induced Alzheimer's disease via improving cognitive dysfunction and oxidative stress in rat model","volume":"33","author":"Wei","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejmech.2024.116359_bib102","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.biopha.2017.10.142","article-title":"Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats","volume":"97","author":"Huang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2024.116359_bib103","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.lfs.2011.09.023","article-title":"Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells","volume":"89","author":"Jim\u00e9nez-Aliaga","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2024.116359_bib104","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000711","article-title":"Pterostilbene alleviates A\u03b21-42 -induced cognitive dysfunction via inhibition of oxidative stress by activating Nrf2 signaling pathway","volume":"65","author":"Xu","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib105","first-page":"243","article-title":"Carvacrol and thymol attenuate cytotoxicity induced by amyloid \u03b225-35 via activating protein kinase C and inhibiting oxidative stress in PC12 cells, Iran","volume":"24","author":"Azizi","year":"2020","journal-title":"Biomed. J."},{"key":"10.1016\/j.ejmech.2024.116359_bib106","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3233\/JAD-190098","article-title":"Tyrosol reduces amyloid-\u03b2 oligomer neurotoxicity and alleviates synaptic, oxidative, and cognitive disturbances in Alzheimer's disease model mice","volume":"70","author":"Taniguchi","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejmech.2024.116359_bib107","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1655","article-title":"Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up-regulating SIRT1","volume":"10","author":"Xu","year":"2020","journal-title":"Brain Behav"},{"key":"10.1016\/j.ejmech.2024.116359_bib108","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2018.03.028","article-title":"Rosmarinic acid attenuates \u03b2-amyloid-induced oxidative stress via Akt\/GSK-3\u03b2\/Fyn-mediated Nrf2 activation in PC12 cells","volume":"120","author":"Rong","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2024.116359_bib109","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/10715762.2012.742518","article-title":"Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3\u03b2\/Nrf2 signaling pathway","volume":"47","author":"Zou","year":"2013","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib110","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1196\/annals.1397.051","article-title":"Protective effects of piceatannol against beta-amyloid-induced neuronal cell death","volume":"1095","author":"Kim","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejmech.2024.116359_bib111","first-page":"760","article-title":"Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells","volume":"20","author":"Koskela","year":"2014","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ejmech.2024.116359_bib112","first-page":"2666","article-title":"Protective effect of ethyl vanillin against A\u03b2-induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis","volume":"17","author":"Zhong","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejmech.2024.116359_bib113","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3390\/antiox9060551","article-title":"Esculetin as a bifunctional antioxidant prevents and counteracts the oxidative stress and neuronal death induced by amyloid protein in SH-SY5Y cells","volume":"9","author":"Pruccoli","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejmech.2024.116359_bib114","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.fct.2011.03.005","article-title":"[6]-Gingerol attenuates \u03b2-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system","volume":"49","author":"Lee","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejmech.2024.116359_bib115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejmech.2024.116359_bib116","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s11011-021-00696-6","article-title":"Modulating neuroinflammation in neurodegeneration-related dementia: can microglial toll-like receptors pull the plug?","volume":"36","author":"Tiwari","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ejmech.2024.116359_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101335","article-title":"Reactive astrocytes: the nexus of pathological and clinical hallmarks of Alzheimer's disease","volume":"68","author":"Price","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ejmech.2024.116359_bib118","first-page":"194","article-title":"Distinct microglial profiles associated with amyloid and tau pathology in Alzheimer disease","volume":"17","author":"Lempri\u00e8re","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejmech.2024.116359_bib119","doi-asserted-by":"crossref","first-page":"12717","DOI":"10.1021\/acs.jafc.1c04687","article-title":"Sesamol attenuates amyloid peptide accumulation and cognitive deficits in APP\/PS1 mice: the mediating role of the gut-brain Axis","volume":"69","author":"Liu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2024.116359_bib120","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.4103\/1673-5374.219049","article-title":"Calycosin improves cognitive function in a transgenic mouse model of Alzheimer's disease by activating the protein kinase C pathway","volume":"12","author":"Song","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib121","article-title":"5-Heptadecylresorcinol, a biomarker for whole grain rye consumption, ameliorates cognitive impairments and neuroinflammation in APP\/PS1 transgenic mice","volume":"64","author":"Liu","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib122","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/WNR.0000000000001583","article-title":"Pinoresinol diglucoside attenuates neuroinflammation, apoptosis and oxidative stress in a mice model with Alzheimer's disease","volume":"32","author":"Lei","year":"2021","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejmech.2024.116359_bib123","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00210-018-1588-z","article-title":"The modulatory role of phloretin in A\u03b225-35 induced sporadic Alzheimer's disease in rat model","volume":"392","author":"Ghumatkar","year":"2019","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116359_bib124","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopha.2016.06.021","article-title":"Pelargonidin improves memory deficit in amyloid \u03b225-35 rat model of Alzheimer's disease by inhibition of glial activation, cholinesterase, and oxidative stress","volume":"83","author":"Sohanaki","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2024.116359_bib125","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12974-019-1450-3","article-title":"Urolithin A attenuates memory impairment and neuroinflammation in APP\/PS1 mice","volume":"16","author":"Gong","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejmech.2024.116359_bib126","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s12035-014-9042-9","article-title":"Naringenin suppresses neuroinflammatory responses through inducing suppressor of cytokine signaling 3 expression","volume":"53","author":"Wu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejmech.2024.116359_bib127","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuropharm.2017.01.025","article-title":"Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB","volume":"117","author":"Kim","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejmech.2024.116359_bib128","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1179\/1743132810Y.0000000029","article-title":"The protective effects of coumestrol against amyloid-\u03b2 peptide- and lipopolysaccharide-induced toxicity on mice astrocytes","volume":"33","author":"Liu","year":"2011","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115697","article-title":"Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K\/Akt, Wnt\/\u03b2-catenin, AMPK\/mTOR signaling pathways","volume":"429","author":"Salem","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116359_bib130","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1096\/fj.201601071R","article-title":"Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-\u03baB","volume":"31","author":"Liu","year":"2017","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejmech.2024.116359_bib131","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1021\/acs.jafc.8b03731","article-title":"Eriodictyol attenuates LPS-induced neuroinflammation, amyloidogenesis, and cognitive impairments via the inhibition of NF-\u03baB in male C57BL\/6J mice and BV2 microglial cells","volume":"66","author":"He","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2024.116359_bib132","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3390\/brainsci10120923","article-title":"Sinapic acid alleviates oxidative stress and neuro-inflammatory changes in sporadic model of Alzheimer's disease in rats","volume":"10","author":"Verma","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.ejmech.2024.116359_bib133","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1002\/ptr.6686","article-title":"Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: the role of JAK2\/STAT3 and Nrf2\/HO-1 signalling pathway modulation","volume":"34","author":"Hindam","year":"2020","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib134","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fnagi.2020.00119","article-title":"Neuroimmunomodulatory and neuroprotective effects of the flavonoid apigenin in in vitro models of neuroinflammation associated with Alzheimer's disease","volume":"12","author":"Dourado","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib135","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.638772","article-title":"Isoliquiritigenin confers neuroprotection and alleviates amyloid-\u03b242-induced neuroinflammation in microglia by regulating the Nrf2\/NF-\u03baB signaling","volume":"15","author":"Fu","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172500","article-title":"Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: an outlined review","volume":"858","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116359_bib137","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1021\/jf501314g","article-title":"p-Coumaric acid and ursolic acid from Corni fructus attenuated \u03b2-amyloid(25-35)-induced toxicity through regulation of the NF-\u03baB signaling pathway in PC12 cells","volume":"62","author":"Yoon","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2024.116359_bib138","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1007\/s11064-021-03406-x","article-title":"Sinensetin attenuates amyloid beta25-35-induced oxidative stress, inflammation, and apoptosis in SH-SY5Y cells through the TLR4\/NF-\u03baB signaling pathway","volume":"46","author":"Zhi","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib139","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.2174\/1871527313666140806124322","article-title":"Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models: the control of neuroinflammation","volume":"13","author":"Paterniti","year":"2014","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"10.1016\/j.ejmech.2024.116359_bib140","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/470393","article-title":"Pinocembrin protects human brain microvascular endothelial cells against fibrillar amyloid-\u03b2(1-40) injury by suppressing the MAPK\/NF-\u03baB inflammatory pathways","volume":"2014","author":"Liu","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2024.116359_bib141","first-page":"5581","article-title":"Scutellarein suppresses A\u03b2-induced memory impairment via inhibition of the NF-\u03baB pathway in vivo and in vitro","volume":"17","author":"Huang","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejmech.2024.116359_bib142","doi-asserted-by":"crossref","first-page":"e1592","DOI":"10.1212\/WNL.0000000000009249","article-title":"In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease","volume":"94","author":"Terada","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.ejmech.2024.116359_bib143","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/med.21715","article-title":"Mitochondria as a promising target for developing novel agents for treating Alzheimer's disease","volume":"41","author":"Shevtsova","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2024.116359_bib144","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1091230","article-title":"ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease","volume":"304","author":"Lustbader","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2024.116359_bib145","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13024-021-00448-1","article-title":"Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease","volume":"16","author":"Terada","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejmech.2024.116359_bib146","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13041-021-00803-9","article-title":"APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer's disease and age-matched non-demented brains","volume":"14","author":"Ojo","year":"2021","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejmech.2024.116359_bib147","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10571-014-0098-x","article-title":"Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease","volume":"34","author":"Wang","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejmech.2024.116359_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113248","article-title":"Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing","volume":"328","author":"Grewal","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejmech.2024.116359_bib149","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12974-020-01976-1","article-title":"Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in A\u03b2-exposed U251 cells and APP\/PS1 mice","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejmech.2024.116359_bib150","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pbb.2014.11.002","article-title":"Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction","volume":"127","author":"Sachdeva","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejmech.2024.116359_bib151","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s12031-021-01936-1","article-title":"Paeonol ameliorates cognitive deficits in streptozotocin murine model of sporadic Alzheimer's disease via attenuation of oxidative stress, inflammation, and mitochondrial dysfunction","volume":"72","author":"Tayanloo-Beik","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib152","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s12640-019-0008-6","article-title":"Eugenol attenuates scopolamine-induced hippocampal cholinergic, glutamatergic, and mitochondrial toxicity in experimental rats","volume":"35","author":"Garabadu","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejmech.2024.116359_bib153","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000507818","article-title":"Schisandrin restores the amyloid \u03b2-induced impairments on mitochondrial function, energy metabolism, biogenesis, and dynamics in rat primary hippocampal neurons","volume":"106","author":"Piao","year":"2021","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejmech.2024.116359_bib154","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/antiox10071003","article-title":"Hesperetin nanocrystals improve mitochondrial function in a cell model of early alzheimer disease","volume":"10","author":"Babylon","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejmech.2024.116359_bib155","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.3390\/nu11102356","article-title":"Equol pretreatment protection of SH-SY5Y cells against A\u03b2 (25-35)-induced cytotoxicity and cell-cycle reentry via sustaining estrogen receptor alpha expression","volume":"11","author":"Tsai","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2024.116359_bib156","first-page":"1","article-title":"Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer's disease","author":"Visioli","year":"2020","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.ejmech.2024.116359_bib157","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10571-013-0006-9","article-title":"Protective effect of paeoniflorin on A\u03b225-35-induced SH-SY5Y cell injury by preventing mitochondrial dysfunction","volume":"34","author":"Wang","year":"2014","journal-title":"Cell. Mol. Neurobiol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424002393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424002393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:14:51Z","timestamp":1712967291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523424002393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":157,"alternative-id":["S0223523424002393"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116359","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural polyphenol: Their pathogenesis-targeting therapeutic potential in Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116359"}}