{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:50:55Z","timestamp":1780325455034,"version":"3.54.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ejmech.2024.116401","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T09:59:33Z","timestamp":1713261573000},"page":"116401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Structure optimizing of flavonoids against both MRSA and VRE"],"prefix":"10.1016","volume":"271","author":[{"given":"Mei-Zhen","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Biao","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Shun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4777-4261","authenticated-orcid":false,"given":"Xiao-Dong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2024.116401_bib1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ejmech.2024.116401_bib2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mib.2020.09.013","article-title":"The challenges of estimating the human global burden of disease of antimicrobial resistant bacteria","volume":"57","author":"Dunachie","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116401_bib4","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Diseases","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2024.116401_bib5","doi-asserted-by":"crossref","first-page":"13517","DOI":"10.1073\/pnas.1408601111","article-title":"Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2024.116401_bib6","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/antibiotics11050606","article-title":"Recent developments in methicillin-resistant Staphylococcus aureus (MRSA) treatment: a review","volume":"11","author":"Nandhini","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2024.116401_bib7","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/s41467-022-29493-0","article-title":"Collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2024.116401_bib8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11908-019-0695-4","article-title":"Treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in children: a reappraisal of vancomycin","volume":"21","author":"Sharma","year":"2019","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.ejmech.2024.116401_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijantimicag.2017.06.008","article-title":"Ampicillin for the treatment of complicated urinary tract infections caused by vancomycin-resistant Enterococcus spp (VRE): a single-center university hospital experience","volume":"51","author":"Shah","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2024.116401_bib10","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/INF.0000000000000342","article-title":"Lactic acidosis as an early side effect of linezolid therapy in pediatric patients","volume":"33","author":"Ozkaya-Parlakay","year":"2014","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ejmech.2024.116401_bib11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/0897190020958233","article-title":"Patient case report daptomycin holiday-A daptomycin dosing strategy for asymptomatic increases in creatine phosphokinase levels","volume":"35","author":"Koh","year":"2022","journal-title":"J. Pharm. Pract."},{"key":"10.1016\/j.ejmech.2024.116401_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ja.2013.49","article-title":"Prospects for new antibiotics: a molecule-centered perspective","volume":"67","author":"Walsh","year":"2014","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ejmech.2024.116401_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201908783","article-title":"Evolving Technologies and strategies for combating antibacterial resistance in the advent of the postantibiotic era","volume":"30","author":"\u015een Karaman","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ejmech.2024.116401_bib14","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1021\/acs.accounts.8b00643","article-title":"Differential drivers of antimicrobial resistance across the World","volume":"52","author":"Vikesland","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2024.116401_bib15","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1039\/D2NP00090C","article-title":"Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018-2022","volume":"40","author":"Woo","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2024.116401_bib16","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.tips.2016.05.001","article-title":"Natural products as a source for novel antibiotics","volume":"37","author":"Moloney","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2024.116401_bib17","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3390\/antibiotics9110830","article-title":"African plant-based natural products with antivirulence activities to the rescue of antibiotics","volume":"9","author":"Mahavy","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2024.116401_bib18","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2174\/1568026622666220221110506","article-title":"The antibacterial activity of natural-derived flavonoids","volume":"22","author":"Tan","year":"2022","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ptr.6208","article-title":"Antibacterial activity of flavonoids and their structure-activity relationship: an update review","volume":"33","author":"Farhadi","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2024.116401_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100749","article-title":"Plant natural flavonoids against multidrug resistant pathogens","volume":"8","author":"Song","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2024.116401_bib21","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1021\/acs.jmedchem.0c00053","article-title":"In vitro and in vivo evaluation of membrane-active flavone amphiphiles: semisynthetic kaempferol-derived antimicrobials against drug-resistant gram-positive bacteria","volume":"63","author":"Lin","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112758","article-title":"Phytochemical and anti-MRSA constituents of Zanthoxylum nitidum","volume":"148","author":"Zeng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2024.116401_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116892","article-title":"Curcusinol from the fruit of Carex baccans with antibacterial activity against multidrug-resistant strains","volume":"318","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2024.116401_bib24","article-title":"Antifungal compounds of Chinese prickly ash against drug-resistant Candida albicans","volume":"X 15","author":"Ma","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113119","article-title":"Bioguided isolation, identification and activity evaluation of antifungal compounds from Acorus tatarinowii Schott","volume":"261","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2024.116401_bib26","first-page":"13","article-title":"Antifungal alkaloids from Mahonia fortunei against pathogens of postharvest fruit","author":"Wang","year":"2023","journal-title":"Nat. Prod. Bioprospect."},{"key":"10.1016\/j.ejmech.2024.116401_bib27","doi-asserted-by":"crossref","first-page":"16647","DOI":"10.1021\/acs.jafc.3c05553","article-title":"New and antifungal diterpenoids of sunflower against gray mold","volume":"71","author":"Zhao","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib28","article-title":"Antimicrobial ingredients of Zanthoxylum motuoense and potential in fresh pork meat preservation","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.ejmech.2024.116401_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114542","article-title":"Bioguided isolation, identification and bioactivity evaluation of anti-MRSA constituents from Morus alba Linn","volume":"281","author":"Zhu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2024.116401_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117544","article-title":"A dual mechanism with H2S inhibition and membrane damage of morusin from Morus alba Linn. against MDR-MRSA","volume":"97","author":"Zhu","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib31","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3390\/molecules27041149","article-title":"Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation","volume":"27","author":"Shamsudin","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2024.116401_bib32","doi-asserted-by":"crossref","first-page":"14221","DOI":"10.1021\/acs.jmedchem.2c01437","article-title":"Design and synthesis of phenyl sulfide-based cationic amphiphiles as membrane-targeting antimicrobial agents against gram-positive pathogens","volume":"65","author":"Liang","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/molecules22040608","article-title":"Structure-activity and lipophilicity relationships of selected antibacterial natural flavones and flavanones of Chilean flora","volume":"22","author":"Echeverr\u00eda","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2024.116401_bib34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1021\/acsinfecdis.9b00211","article-title":"Balancing physicochemical properties of phenylthiazole compounds with antibacterial potency by modifying the lipophilic side chain","volume":"6","author":"Mancy","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116401_bib35","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/molecules24081505","article-title":"Lipophilicity as a central component of drug-like properties of chalchones and flavonoid derivatives","volume":"24","author":"Constantinescu","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2024.116401_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106020","article-title":"Synthesis and biological evaluation of antibacterial activity of novel clarithromycin derivatives incorporating 1,2,3-triazole moieties at the 4''- and 11-OH positions","volume":"127","author":"Qin","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-90035-7","article-title":"Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities","volume":"11","author":"Yuan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2024.116401_bib38","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/10286020.2021.1981875","article-title":"P. Biosynthesis and evaluation of a novel highly water-soluble quercetin glycoside derivative","volume":"24","author":"Cao","year":"2021","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.ejmech.2024.116401_bib39","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1016\/j.tet.2017.05.022","article-title":"The total synthesis of (\u00b1)-sanggenol F","volume":"73","author":"Sheng","year":"2017","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2024.116401_bib40","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1016\/j.tet.2013.05.024","article-title":"Total syntheses of norartocarpin and artocarpin","volume":"69","author":"Zhang","year":"2013","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2024.116401_bib41","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1016\/j.tet.2014.04.089","article-title":"Total syntheses of nigrasin I and kuwanon C","volume":"70","author":"Tang","year":"2014","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2024.116401_bib42","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1021\/acs.organomet.9b00629","article-title":"Scope and mechanism of the ruthenium-catalyzed dehydrative C\u2013H coupling of phenols with \u03b1, \u03b2-unsaturated carbonyl compounds: expedient synthesis of chromene and benzoxacyclic derivatives","volume":"38","author":"Mokar","year":"2019","journal-title":"Organometallics"},{"key":"10.1016\/j.ejmech.2024.116401_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.desal.2023.116623","article-title":"Can the mix-charged NF membrane directly obtained by the interfacial polymerization of PIP and TMC?","volume":"558","author":"Zhu","year":"2023","journal-title":"Desalination"},{"key":"10.1016\/j.ejmech.2024.116401_bib44","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1021\/acs.jmedchem.0c02059","article-title":"Design, synthesis, and biological evaluation of membrane-active bakuchiol derivatives as effective broad-spectrum antibacterial agents","volume":"64","author":"Li","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116149","article-title":"Development of cannabidiol derivatives as potent broad-spectrum antibacterial agents with membrane-disruptive mechanism","volume":"266","author":"Fang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib46","doi-asserted-by":"crossref","first-page":"16754","DOI":"10.1021\/acs.jmedchem.2c01604","article-title":"Membrane-active nonivamide derivatives as effective broad-spectrum antimicrobials: rational design, synthesis, and biological evaluation","volume":"65","author":"Cai","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104480","article-title":"Synthesis, biological activity and POM\/DFT\/docking analyses of annulated pyrano[2,3-d]pyrimidine derivatives: identification of antibacterial and antitumor pharmacophore sites","volume":"106","author":"Bhat","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib48","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ppap.200800216","article-title":"Controlled amine functionalization and hydrophilicity of a poly (lactic acid) fabric","volume":"6","author":"Dai","year":"2009","journal-title":"Plasma Process. Polym."},{"key":"10.1016\/j.ejmech.2024.116401_bib49","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1021\/acs.biomac.5b01567","article-title":"Lipopolysaccharide neutralization by cationic-amphiphilic polymers through pseudoaggregate formation","volume":"17","author":"Uppu","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejmech.2024.116401_bib50","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/s41467-021-21748-6","article-title":"Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis","volume":"12","author":"Chakraborty","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2024.116401_bib51","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1039\/D2NP00084A","article-title":"Natural products acting against S. aureus through membrane and cell wall disruption","volume":"40","author":"Kumar","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2024.116401_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4959487","article-title":"The emerging role of probiotics and their derivatives against biofilm-producing MRSA: a scoping review","volume":"2022","author":"Jalalifar","year":"2022","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2024.116401_bib53","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.3390\/ma16217051","article-title":"AC electromagnetic field controls the biofilms on the glass surface by Escherichia coli & Staphylococcus epidermidis inhibition effect","volume":"16","author":"Aoyama","year":"2023","journal-title":"Materials"},{"key":"10.1016\/j.ejmech.2024.116401_bib54","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1021\/acs.jmedchem.2c02135","article-title":"Discovery of quaternized pyridine-thiazole-pleuromutilin derivatives with broad-spectrum antibacterial and potent anti-MRSA activity","volume":"66","author":"Xia","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib55","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1021\/acs.bioconjchem.7b00055","article-title":"Fatty acid comprising lysine conjugates: anti-MRSA agents that display in vivo efficacy by disrupting biofilm with No resistance development","volume":"28","author":"Konai","year":"2017","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib56","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1021\/acs.jmedchem.3c00856","article-title":"Ultrashort all-hydrocarbon stapled \u03b1-helix amphiphile as a potent and stable antimicrobial compound","volume":"66","author":"Shao","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib57","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.bbrc.2019.05.086","article-title":"Antibacterial evaluation and mode of action study of BIMQ, a novel bacterial cell division inhibitor","volume":"514","author":"Sun","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2024.116401_bib58","doi-asserted-by":"crossref","first-page":"16879","DOI":"10.1021\/acs.jmedchem.2c01674","article-title":"Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistant Staphylococcus aureus (MRSA) infections","volume":"65","author":"Yang","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117212","article-title":"Targeting mycobacterial membranes and membrane proteins: progress and limitations","volume":"81","author":"Kumar","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib60","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.ijbiomac.2022.07.171","article-title":"Molecular mechanism of two functional protein structure changes under 2,3-butanedione-induced oxidative stress and apoptosis effects in the hepatocytes","volume":"218","author":"Ni","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2024.116401_bib61","doi-asserted-by":"crossref","first-page":"11692","DOI":"10.1021\/acsnano.3c02365","article-title":"Hybrid biomimetic membrane coated particles-mediated bacterial ferroptosis for acute MRSA pneumonia","volume":"17","author":"Hu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejmech.2024.116401_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115973","article-title":"Development of membrane-targeting TPP+-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections","volume":"264","author":"Li","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47325-y","article-title":"Nano-viscosimetry analysis of the membrane disrupting action of the bee venom peptide melittin","volume":"9","author":"Pandidan","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2024.116401_bib64","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/toxins12020124","article-title":"2-Phenylethyl isothiocyanate exerts antifungal activity against Alternaria alternata by affecting membrane integrity and mycotoxin production","volume":"12","author":"Zhang","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.ejmech.2024.116401_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111697","article-title":"Covalent immobilization of DJK-5 peptide on porous titanium for enhanced antibacterial effects and restrained inflammatory osteoclastogenesis","volume":"202","author":"Wang","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ejmech.2024.116401_bib66","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","article-title":"A common mechanism of cellular death induced by bactericidal antibiotics","volume":"130","author":"Kohanski","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2024.116401_bib67","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jpha.2020.05.014","article-title":"Antimicrobial activity and mode of action of terpene linalyl anthranilate against carbapenemase-producing Klebsiella pneumoniae","volume":"11","author":"Yang","year":"2021","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.ejmech.2024.116401_bib68","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41420-023-01613-9","article-title":"Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discovery"},{"key":"10.1016\/j.ejmech.2024.116401_bib69","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1128\/AEM.02750-06","article-title":"Assessment and interpretation of bacterial viability by using the LIVE\/DEAD BacLight Kit in combination with flow cytometry","volume":"73","author":"Berney","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116401_bib70","doi-asserted-by":"crossref","first-page":"12105","DOI":"10.1021\/acs.jafc.3c00009","article-title":"TMT-based quantitative proteomics and non-targeted metabolomic analyses reveal the antibacterial mechanism of hexanal against Vibrio parahaemolyticus","volume":"71","author":"Fan","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib71","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.3390\/foods12132625","article-title":"Transcriptome analysis of protocatechualdehyde against Listeria monocytogenes and its effect on chicken quality characteristics","volume":"12","author":"Liao","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.ejmech.2024.116401_bib72","doi-asserted-by":"crossref","first-page":"7596","DOI":"10.3390\/ijms22147596","article-title":"Integration of transcriptome and Metabolome reveals the Genes and metabolites involved in bifidobacterium bifidum biofilm formation","volume":"22","author":"Liu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2024.116401_bib73","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/ijms22010108","article-title":"A label-free cellular proteomics approach to decipher the antifungal action of DiMIQ, a potent indolo[2,3-b]Quinoline agent, against Candida albicans biofilms","volume":"22","author":"Zarnowski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2024.116401_bib74","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s42770-023-01168-y","article-title":"Chitosan nanoparticles encapsulating farnesol evaluated in vivo against Candida albicans","volume":"55","author":"Costa","year":"2023","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116401_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1293633","article-title":"Antibiotic adjuvants: synergistic tool to combat multi-drug resistant pathogens","volume":"13","author":"Kumar","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116401_bib76","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1021\/acs.jmedchem.8b01781","article-title":"Antibiotic adjuvants: make antibiotics great again","volume":"62","author":"Douafer","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116401_bib77","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.2147\/IDR.S431256","article-title":"Potentiation and mechanism of berberine as an antibiotic adjuvant against multidrug-resistant bacteria","volume":"16","author":"Zhou","year":"2023","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.ejmech.2024.116401_bib78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/AAC.02062-19","article-title":"New evidence and insights on dalbavancin and wound healing in a mouse model of skin infection","volume":"64","author":"Simonetti","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2024.116401_bib79","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1080\/17512433.2016.1195683","article-title":"Transitions of care in the management of acute bacterial skin and skin structure infections: a paradigm shift","volume":"9","author":"Verastegui","year":"2016","journal-title":"Expet Rev. Clin. Pharmacol."},{"key":"10.1016\/j.ejmech.2024.116401_bib80","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.diagmicrobio.2008.04.013","article-title":"The burden of vancomycin-resistant enterococcal infections in US hospitals, 2003 to 2004","volume":"62","author":"Reik","year":"2008","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116401_bib81","article-title":"Trends of vancomycin-resistant Enterococcus infections in cancer patients","volume":"14","author":"Rafey","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.ejmech.2024.116401_bib82","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202103442","article-title":"Bacterial outer membrane\u2010coated mesoporous silica nanoparticles for targeted delivery of antibiotic rifampicin against gram\u2010negative bacterial infection in vivo","volume":"31","author":"Wu","year":"2021","journal-title":"Adv. Funct. Mater."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424002812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424002812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T09:33:14Z","timestamp":1717234394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523424002812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":81,"alternative-id":["S0223523424002812"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116401","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure optimizing of flavonoids against both MRSA and VRE","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116401"}}