{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:34:04Z","timestamp":1783398844322,"version":"3.54.6"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-030"],"award-info":[{"award-number":["2021-I2M-1-030"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences and Peking Union Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ejmech.2024.116509","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T16:15:12Z","timestamp":1715876112000},"page":"116509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism"],"prefix":"10.1016","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3637-7796","authenticated-orcid":false,"given":"Yonghua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laixing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2024.116509_bib1","unstructured":"International Agency for Research on Cancer. https:\/\/www.iarc.who.int\/news-events\/latest-global-cancer-data-cancer-burden-rises-to-19-3-million-new-cases-and-10-0-million-cancer-deaths-in-2020\/(Accessed December 2020)."},{"key":"10.1016\/j.ejmech.2024.116509_bib2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3322\/caac.21731","article-title":"Cancer treatment and survivorship statistics","volume":"72","author":"Miller","year":"2022","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.ejmech.2024.116509_bib3","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.2174\/1568026617666170104145640","article-title":"Microtubule Targeting Agents as Cancer Chemotherapeutics: an overview of molecular hybrids as stabilizing and destabilizing agents","volume":"17","author":"Tangutur","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nrc2803","article-title":"Microtubules and resistance to tubulin-binding agents","volume":"10","author":"Kavallaris","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2024.116509_bib5","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/med.21568","article-title":"Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy","volume":"39","author":"Arnst","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2024.116509_bib6","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/annonc\/mdq708","article-title":"Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer","volume":"22","author":"Zweifel","year":"2011","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ejmech.2024.116509_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40661-017-0058-5","article-title":"Clinical trial experience with CA4p anticancer therapy: focus on efficacy, cardiovascular adverse events, and hypertension management","volume":"5","author":"Grisham","year":"2018","journal-title":"Gynecol. Oncol. Res. Pract."},{"key":"10.1016\/j.ejmech.2024.116509_bib8","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1158\/1078-0432.CCR-11-0937","article-title":"Clinical, pharmacodynamic, and pharmacokinetic evaluation of BNC105P: a phase I trial of a novel vascular disrupting agent and inhibitor of cancer cell proliferation","volume":"17","author":"Rischin","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2024.116509_bib9","doi-asserted-by":"crossref","first-page":"12049","DOI":"10.1021\/acs.jmedchem.1c00715","article-title":"Design, synthesis, and biological evaluation of stable colchicine-binding site tubulin inhibitors 6-Aryl-2-benzoyl-pyridines as potential anticancer agents","volume":"64","author":"Chen","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib10","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1021\/acs.jmedchem.9b00706","article-title":"Structure-guided design, synthesis, and biological evaluation of (2-(1H-Indol-3-yl)-1H-imidazole-4-yl)(3,4,5-trimethoxyphenyl) methanone (ABI-231) analogues targeting the colchicine binding site in tubulin","volume":"62","author":"Wang","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115437","article-title":"Discovery of novel 6-p-tolyl-3-(3,4,5-trimethoxybenzyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivative as a potent tubulin inhibitor with promising in vivo antitumor activity","volume":"256","author":"Ji","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib12","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3390\/molecules21111468","article-title":"Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption\/angiogenesis","volume":"21","author":"Banerjee","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2024.116509_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113999","article-title":"Current status of carbazole hybrids as anticancer agents","volume":"229","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib14","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1080\/14756366.2019.1640692","article-title":"Carbazole scaffolds in cancer therapy: a review from 2012 to 2018","volume":"34","author":"Issa","year":"2019","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejps.2016.09.039","article-title":"Multifaceted properties of 1,4-dimethylcarbazoles: focus on trimethoxybenzamide and trimethoxyphenylurea derivatives as novel human topoisomerase II inhibitors","volume":"96","author":"Iacopetta","year":"2017","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2024.116509_bib16","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.1021\/jm4018042","article-title":"Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6","volume":"57","author":"Hou","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115213","article-title":"Optimization of carbazole carboxamide ROR\u03b3t agonists: challenges in improving the metabolic stability and maintaining the agonistic activity","volume":"251","author":"Sun","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib18","doi-asserted-by":"crossref","first-page":"6273","DOI":"10.1021\/jm060546h","article-title":"Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors","volume":"49","author":"Hu","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib19","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.bmcl.2006.12.034","article-title":"Novel pyridinyl and pyrimidinyl carbazole sulfonamides as antiproliferative agents","volume":"17","author":"Hu","year":"2007","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2024.116509_bib20","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1158\/1078-0432.CCR-08-0550","article-title":"N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide as a novel tubulin ligand against human cancer","volume":"14","author":"Wang","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2024.116509_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bmcl.2016.11.068","article-title":"Novel carbazole sulfonamide derivatives of antitumor agent: synthesis, antiproliferative activity and aqueous solubility","volume":"27","author":"Sun","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2024.116509_bib22","first-page":"60","article-title":"Novel carbazole sulfonamide microtubule-destabilizing agents exert potent antitumor activity against esophageal squamous cell carcinoma, Canc","author":"Niu","year":"2018","journal-title":"Lett. 420"},{"key":"10.1016\/j.ejmech.2024.116509_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112181","article-title":"Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents","volume":"191","author":"Liu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116509_bib24","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.drudis.2021.09.020","article-title":"Advances in understanding the role of P-gp in doxorubicin resistance: molecular pathways, therapeutic strategies, and prospects","volume":"27","author":"Mirzaei","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejmech.2024.116509_bib25","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1158\/1535-7163.MCT-09-0366","article-title":"Microtubule inhibitors: differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance","volume":"8","author":"Perez","year":"2009","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2024.116509_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/j.1460-2075.1985.tb02316.x","article-title":"Structural differences between brain beta 1- and beta 2-tubulins: implications for microtubule assembly and colchicine binding","volume":"4","author":"Little","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.ejmech.2024.116509_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174802","article-title":"IMB5476, a novel microtubule inhibitor, induces mitotic catastrophe and overcomes multidrug resistance in tumors","volume":"919","author":"Zheng","year":"2022","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424003891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424003891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T21:05:25Z","timestamp":1717880725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523424003891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":27,"alternative-id":["S0223523424003891"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116509","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116509"}}