{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:36:42Z","timestamp":1792190202755,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22307007"],"award-info":[{"award-number":["22307007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003619"],"award-info":[{"award-number":["82003619"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012556","name":"Sichuan Provincial Youth Science and Technology Foundation","doi-asserted-by":"publisher","award":["2023NSFSC0609"],"award-info":[{"award-number":["2023NSFSC0609"]}],"id":[{"id":"10.13039\/100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012556","name":"Sichuan Provincial Youth Science and Technology Foundation","doi-asserted-by":"publisher","award":["2024NSFSC0995"],"award-info":[{"award-number":["2024NSFSC0995"]}],"id":[{"id":"10.13039\/100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012556","name":"Sichuan Provincial Youth Science and Technology Foundation","doi-asserted-by":"publisher","award":["2023NSFSC1837"],"award-info":[{"award-number":["2023NSFSC1837"]}],"id":[{"id":"10.13039\/100012556","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ejmech.2024.116716","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T23:24:09Z","timestamp":1722036249000},"page":"116716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Development of amphipathic derivatives of thymol and carvacrol as potent broad-spectrum antibacterial agents"],"prefix":"10.1016","volume":"276","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-5343","authenticated-orcid":false,"given":"Hongbo","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanwei","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2024.116716_bib2","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1016\/j.bmc.2019.07.023","article-title":"Natural product derived promising anti-MRSA drug leads: a review","volume":"27","author":"Gatadi","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib3","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1021\/acs.chemrev.0c00922","article-title":"Ethnobotany and the role of plant natural products in antibiotic drug discovery","volume":"121","author":"Porras","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2024.116716_bib4","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2024.116716_bib5","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1080\/10408398.2019.1675585","article-title":"The antibacterial properties of phenolic isomers, carvacrol and thymol","volume":"60","author":"Kachur","year":"2020","journal-title":"Crit. Rev. Food Sci."},{"key":"10.1016\/j.ejmech.2024.116716_bib6","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1021\/jf980154m","article-title":"Characterization of the action of selected essential oil components on gram-negative bacteria","volume":"46","author":"Helander","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02421","article-title":"Antimicrobial potential of carvacrol against uropathogenic Escherichia coli via membrane disruption, depolarization, and reactive oxygen species generation","volume":"8","author":"Khan","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116716_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/07388551.2011.594423","article-title":"Antimicrobial peptides: key components of the innate immune system","volume":"32","author":"Pasupuleti","year":"2012","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.ejmech.2024.116716_bib9","doi-asserted-by":"crossref","first-page":"E216","DOI":"10.1016\/S1473-3099(20)30327-3","article-title":"The value of antimicrobial peptides in the age of resistance","volume":"20","author":"Magana","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116716_bib10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2174\/092986711794088399","article-title":"Use of antimicrobial peptides against microbial biofilms: advantages and limits","volume":"18","author":"Batoni","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd3591","article-title":"Designing antimicrobial peptides: form follows function","volume":"11","author":"Fjell","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2024.116716_bib12","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1021\/acs.jmedchem.2c01793","article-title":"Discovery of amphiphilic xanthohumol derivatives as membrane-targeting antimicrobials against methicillin-resistant Staphylococcus aureus","volume":"66","author":"Cheng","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116274","article-title":"Novel membrane-targeting isoxanthohumol-amine conjugates for combating methicillin-resistant Staphylococcus aureus (MRSA) infections","volume":"268","author":"Yang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114593","article-title":"Design, synthesis, and biological evaluation of membrane-active honokiol derivatives as potent antibacterial agents","volume":"240","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib15","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.bmcl.2017.06.022","article-title":"Design, synthesis and antibacterial evaluation of honokiol derivatives","volume":"28","author":"Wu","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2024.116716_bib16","doi-asserted-by":"crossref","first-page":"16879","DOI":"10.1021\/acs.jmedchem.2c01674","article-title":"Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistant Staphylococcus aureus (MRSA) infections","volume":"65","author":"Yang","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116149","article-title":"Development of cannabidiol derivatives as potent broad-spectrum antibacterial agents with membrane-disruptive mechanism","volume":"266","author":"Fang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib18","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1021\/acs.jmedchem.0c02059","article-title":"Design, synthesis, and biological evaluation of membrane-active bakuchiol derivatives as effective broad-spectrum antibacterial agents","volume":"64","author":"Li","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116293","article-title":"Design, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives","volume":"268","author":"Chen","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116215","article-title":"Effective ciprofloxacin cationic antibacterial agent against persister bacteria with low hemolytic toxicity","volume":"267","author":"Gao","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116449","article-title":"Novel natural osthole-inspired amphiphiles as membrane targeting antibacterials against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"271","author":"Yang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib22","article-title":"Development of membrane-targeting fluorescent 2-Phenyl-1H-phenanthro [9,10-d] imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant Staphylococcus aureus","author":"Xu","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib23","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1039\/C9CC00857H","article-title":"Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance","volume":"55","author":"Chu","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2024.116716_bib24","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.1021\/acs.jmedchem.2c01583","article-title":"Development of aromatic-linked diamino acid antimicrobial peptide mimics with low hemolytic toxicity and excellent activity against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"66","author":"Kong","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib25","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1021\/acs.jnatprod.3c00466","article-title":"Total synthesis of Kuwanons A and B and discovery of their antibacterial mechanism","volume":"86","author":"Dong","year":"2023","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2024.116716_bib26","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1021\/acs.jnatprod.2c00658","article-title":"Total syntheses and antibacterial evaluations of neocyclomorusin and related flavones","volume":"85","author":"Dong","year":"2022","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2024.116716_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106764","article-title":"Total syntheses and antibacterial evaluations of cudraflavones A-C and related flavones","volume":"140","author":"Dong","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2024.116716_bib28","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1021\/acs.jnatprod.4c00008","article-title":"Total synthesis and antibacterial evaluation of lupinifolin and its natural analogues","volume":"87","author":"Dong","year":"2024","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2024.116716_bib29","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s10600-013-0585-1","article-title":"Synthesis of N-aryloxyalkylanabasine derivatives","volume":"49","author":"Slyn'ko","year":"2013","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.ejmech.2024.116716_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1517\/17460441.2012.648612","article-title":"Going further than Lipinski's rule in drug design","volume":"7","author":"Walters","year":"2012","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.ejmech.2024.116716_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chom.2019.06.002","article-title":"Surviving as a community: antibiotic tolerance and persistence in bacterial biofilms","volume":"26","author":"Yan","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ejmech.2024.116716_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.955286","article-title":"Treatment of Pseudomonas aeruginosa infectiousbiofilms: challenges and strategies","volume":"13","author":"Yin","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116716_bib33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13020-021-00481-8","article-title":"Quinic acid: a potential antibiofilm agent against clinical resistant Pseudomonas aeruginosa","volume":"16","author":"Lu","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.ejmech.2024.116716_bib34","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.diagmicrobio.2007.05.013","article-title":"In vitro antibacterial activities of tigecycline and comparative agents by time-kill kinetic studies in fresh Mueller-Hinton broth","volume":"59","author":"Petersen","year":"2007","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.116716_bib35","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2217\/nnm-2023-0335","article-title":"Nanoparticles integrated with mild photothermal therapy and oxaliplatin for tumor cHemotherapy and immunotherapy","volume":"19","author":"Yi","year":"2024","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejmech.2024.116716_bib36","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/0471141755.ph0706s19","article-title":"Determination of the stability of drugs in plasma","volume":"19","author":"Hartman","year":"2002","journal-title":"Curr. Protoc. Pharmacol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342400597X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342400597X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T16:50:06Z","timestamp":1730739006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342400597X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":35,"alternative-id":["S022352342400597X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116716","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of amphipathic derivatives of thymol and carvacrol as potent broad-spectrum antibacterial agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116716","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116716"}}