{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:59:47Z","timestamp":1784023187363,"version":"3.55.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002665","name":"Research Committee, Aristotle University of Thessaloniki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003447","name":"State Scholarships Foundation","doi-asserted-by":"publisher","award":["MIS-5000432"],"award-info":[{"award-number":["MIS-5000432"]}],"id":[{"id":"10.13039\/501100003447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006470","name":"Aristotle University of Thessaloniki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006470","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012159","name":"Research Centre for the Humanities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012159","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001649","name":"European Geosciences Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001649","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ejmech.2024.116746","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T23:40:08Z","timestamp":1722987608000},"page":"116746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Amine-substituted heterocyclic thioamide Cu(I) and Ag(I) complexes as effective anticancer and antibacterial agents targeting the periplasm of E. coli bacteria"],"prefix":"10.1016","volume":"277","author":[{"given":"Despoina","family":"Varna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Geromichalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Dalezis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios G.","family":"Hatzidimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Psomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Zachariadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Psatha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalis","family":"Aivaliotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rigini","family":"Papi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Trafalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-9225","authenticated-orcid":false,"given":"Panagiotis A.","family":"Angaridis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2024.116746_bib1","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/cr400460s","article-title":"Metallodrugs in medicinal inorganic Chemistry","volume":"114","author":"Mjos","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2024.116746_bib2","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1039\/c2sc20627g","article-title":"Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic Chemistry","volume":"3","author":"Casini","year":"2012","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejmech.2024.116746_bib3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1021\/acscentsci.3c01340","article-title":"Metals in cancer research: beyond platinum metallodrugs","volume":"10","author":"Casini","year":"2024","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2024.116746_bib4","first-page":"488","article-title":"Antibiotic resistance in the patient with cancer: escalating challenges and paths forward","volume":"71","author":"Boucher","year":"2021","journal-title":"CA: A Cancer J. Clin."},{"key":"10.1016\/j.ejmech.2024.116746_bib5","doi-asserted-by":"crossref","first-page":"15470","DOI":"10.1039\/C9RA01804B","article-title":"Silver derivatives of multi-donor heterocyclic thioamides as antimicrobial\/anticancer agents: unusual bioactivity against methicillin resistant S. aureus, S. epidermidis, and E. faecalis and human bone cancer MG63 cell line","volume":"9","author":"Aulakh","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2024.116746_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.procbio.2019.10.022","article-title":"Next generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells","volume":"89","author":"Hurtado","year":"2020","journal-title":"Process Biochem"},{"key":"10.1016\/j.ejmech.2024.116746_bib7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/cr400135x","article-title":"Advances in copper complexes as anticancer agents","volume":"114","author":"Santini","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2024.116746_bib8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1155\/MBD.1994.467","article-title":"Antibacterial silver","volume":"1","author":"Clement","year":"1994","journal-title":"Met.-Based Drugs"},{"key":"10.1016\/j.ejmech.2024.116746_bib9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.22146\/ijc.57343","article-title":"Synthesis, antiproliferative and antimalarial activities of dinuclear silver(I) complexes with triphenylphosphine and thiosemicarbazones ligands","volume":"21","author":"Mohd Khir","year":"2021","journal-title":"Indones. J. Chem."},{"issue":"8","key":"10.1016\/j.ejmech.2024.116746_bib10","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1021\/acs.jmedchem.3c01036","article-title":"Paraptotic cell death as an unprecedented mode of action observed for new bipyridine-silver(I) compounds bearing phosphane coligands","volume":"67","author":"Teixeira","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10616-017-0070-y","article-title":"Apoptosis-inducing ability of silver(I) cyanide-phosphines useful for anti-cancer studies","volume":"69","author":"Human-Engelbrecht","year":"2017","journal-title":"Cytotechnology"},{"key":"10.1016\/j.ejmech.2024.116746_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/molecules21020087","article-title":"Antibacterial activity and cytotoxicity of silver(I) complexes of pyridine and (benz)imidazole derivatives. X-ray crystal structure of [Ag(2,6-di(CH2OH)py)2]NO3","volume":"21","author":"Kalinowska-Lis","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2024.116746_bib13","first-page":"15026","article-title":"Cytotoxicity and biodistribution studies of luminescent N-heterocyclic Au(I) and Ag(I) carbenes","volume":"45","author":"Visbal","year":"2016","journal-title":"Searching for new biological targets, Dalton Trans"},{"key":"10.1016\/j.ejmech.2024.116746_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2019.126905","article-title":"From coins to cancer therapy: gold, silver and copper complexes targeting human topoisomerases","volume":"30","author":"Ceramella","year":"2020","journal-title":"Biorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2024.116746_bib15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2147\/DDDT.S119488","article-title":"Metal complexes in cancer therapy - an update from drug design perspective","volume":"11","author":"Ndagi","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejmech.2024.116746_bib16","doi-asserted-by":"crossref","first-page":"9080","DOI":"10.1039\/D4RA00545G","article-title":"Antibacterial, antibiofilm, and antioxidant activities of two novel metal\u2013organic frameworks (MOFs) based on 4,6-diamino-2-pyrimidinethiol with Zn and Co metal ions as coordination polymers","volume":"14","author":"Hamaraw","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2024.116746_bib17","article-title":"Biocompatible silver(I) complexes with heterocyclic thioamide ligands for selective killing of cancer cells and high antimicrobial activity - a combined in vitro and in silico study","volume":"28","author":"Varna","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2024.116746_bib18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/cryst11060688","article-title":"Synthesis, structural studies, and anticancer properties of [CuBr(PPh3)2(4,6-Dimethyl-2- thiopyrimidine-\u03bas]","volume":"11","author":"Babgi","year":"2021","journal-title":"Crystals"},{"key":"10.1016\/j.ejmech.2024.116746_bib19","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1021\/acs.chemrev.7b00042","article-title":"Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications","volume":"117","author":"Zielonka","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2024.116746_bib20","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1021\/mp500038g","article-title":"Mitochondrial delivery of doxorubicin via triphenylphosphine modification for overcoming drug resistance in MDA-MB-435\/DOX cells","volume":"11","author":"Han","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejmech.2024.116746_bib21","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.ejmech.2017.10.067","article-title":"New metalo-therapeutics of NSAIDs against human breast cancer cells","volume":"143","author":"Banti","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib22","doi-asserted-by":"crossref","first-page":"16973","DOI":"10.1039\/C8RA00954F","article-title":"Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest","volume":"8","author":"Mahendiran","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2024.116746_bib23","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1021\/acs.jmedchem.2c02126","article-title":"New apoptosis inducers containing anti-inflammatory drugs and pnictogen derivatives: a new strategy in the development of mitochondrial targeting chemotherapeutics","volume":"66","author":"Banti","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2019.110750","article-title":"Bi- and trinuclear copper(I) compounds of 2,2,5,5-tetramethyl-imidazolidine-4-thione and 1,2-bis(diphenylphosphano)ethane: synthesis, crystal structures, in vitro and in silico study of antibacterial activity and interaction with DNA and albumins","volume":"198","author":"Anastasiadou","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2024.116746_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111167","article-title":"Silver complexes with heterocyclic thioamide and tertiary arylphosphane ligands: synthesis, crystal structures, in vitro and in silico antibacterial and cytotoxic activity, and interaction with DNA","volume":"210","author":"Anastasiadou","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2024.116746_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.poly.2014.12.012","article-title":"Structural diversity in dinuclear copper(I) halide complexes of 2,4-dithiouracil: synthesis, crystal structures, induction of DNA damage and oxidative stress mediated by ROS","volume":"88","author":"Varna","year":"2015","journal-title":"Polyhedron"},{"key":"10.1016\/j.ejmech.2024.116746_bib27","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1002\/ejic.201800076","article-title":"Binuclear copper(I) compounds with N-heterocyclic thiolate and diphosphane ligands: effects of thiolate ligands on solid-state molecular structures and luminescence properties","volume":"25","author":"Stylidou","year":"2018","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.poly.2018.05.020","article-title":"Heterocyclic thioamide\/phosphine mixed-ligand silver(I) complexes: synthesis, molecular structures, DNA-binding properties and antibacterial activity","volume":"151","author":"Varna","year":"2018","journal-title":"Polyhedron"},{"key":"10.1016\/j.ejmech.2024.116746_bib29","doi-asserted-by":"crossref","first-page":"9412","DOI":"10.1039\/D2DT00793B","article-title":"Silver(i) complexes bearing heterocyclic thioamide ligands with NH2 and CF3 substituents: effect of ligand group substitution on antibacterial and anticancer properties","volume":"51","author":"Varna","year":"2022","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2024.116746_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2023.112472","article-title":"N-heterocyclic-carbene vs diphosphine auxiliary ligands in thioamidato Cu(I) and Ag(I) complexes towards the development of potent and dual-activity antibacterial and apoptosis-inducing anticancer agents","volume":"252","author":"Varna","year":"2024","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2024.116746_bib31","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/acs.inorgchem.9b00117","article-title":"Modification of biodistribution and brain uptake of copper bis(thiosemicarbazonato) complexes by the incorporation of amine and polyamine functional groups","volume":"58","author":"Paterson","year":"2019","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib32","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1021\/ja00191a039","article-title":"Crystal structure of the covalent complex formed by a peptidyl .alpha.,.alpha.-difluoro-.beta.-keto amide with porcine pancreatic elastase at 1.78 .ANG. resolution","volume":"111","author":"Takahashi","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2024.116746_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nsb0194-55","article-title":"Analogous inhibitors of elastase do not always bind analogously","volume":"1","author":"Mattos","year":"1994","journal-title":"Struct. Biol."},{"key":"10.1016\/j.ejmech.2024.116746_bib34","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1039\/a709098f","article-title":"Silver(I) nitrate adducts with bidentate 2-, 3- and 4-pyridyl phosphines. Solution 31P and [31P\u2013109Ag] NMR studies of 1\u22362 complexes and crystal structure of dimeric [{Ag(d2pype)(\u03bc-d2pype)}2][NO3]2\u00b72CH2Cl2 [d2pype = 1,2-bis(di-2-pyridylphosphino)ethane]","author":"Berners-Price","year":"1998","journal-title":"J. Chem. Soc. Dalton Trans."},{"key":"10.1016\/j.ejmech.2024.116746_bib35","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1039\/C4NJ02203C","article-title":"The structural and electronic impact on the photophysical and biological properties of a series of CuI and AgI complexes with triphenylphosphine and pyrimidine-type thiones","volume":"39","author":"Papanikolaou","year":"2015","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib36","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.msec.2019.01.107","article-title":"Homoleptic and heteroleptic silver(I) complexes bearing diphosphane and thioamide ligands: synthesis, structures, DNA interactions and antibacterial activity studies","volume":"99","author":"Varna","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ejmech.2024.116746_bib37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0040-4039(94)02206-Q","article-title":"Bidentate phosphines of heteroarenes: 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene","volume":"36","author":"Hillebrand","year":"1995","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2024.116746_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.213884","article-title":"Heterocyclic-2-thione derivatives of group 10\u201312 metals: coordination versatility, activation of C=S (thione) bonds and biochemical potential","volume":"441","author":"Lobana","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2024.116746_bib39","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1021\/cr020010d","article-title":"Biochemical modulation of cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance","volume":"103","author":"Fuertes","year":"2003","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2024.116746_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126656","article-title":"Efficient inactivation of bacteria in ballast water by adding potassium peroxymonosulfate alone: role of halide ions","volume":"253","author":"Xu","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejmech.2024.116746_bib41","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.talanta.2015.11.069","article-title":"Thioamides as radical scavenging compounds: methods for screening antioxidant activity and detection","volume":"149","author":"Chernov\u2019yants","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.ejmech.2024.116746_bib42","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1039\/C4NJ02203C","article-title":"The structural and electronic impact on the photophysical and biological properties of a series of Cu(I) and Ag(I) complexes with triphenylphosphine and pyrimidine-type thiones","volume":"39","author":"Papanikolaou","year":"2015","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib43","doi-asserted-by":"crossref","first-page":"23677","DOI":"10.1002\/ange.202008584","article-title":"Activating antibacterial effect of 4,6-diamino-2-pyrimidinethiol-modified gold nanoparticles by reducing their sizes","volume":"132","author":"Xie","year":"2020","journal-title":"Angew. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib44","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1128\/AEM.02001-07","article-title":"Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli","volume":"74","author":"Jung","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116746_bib45","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1016\/S0021-9258(17)41044-1","article-title":"Periplasmic space in Salmonella typhimurium and Escherichia coli","volume":"252","author":"Stock","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2004935","article-title":"The gram-negative bacterial periplasm: size matters","volume":"16","author":"Miller","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejmech.2024.116746_bib47","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1039\/C6CC07463D","article-title":"Tracking silver delivery to bacteria using turn-on fluorescence","volume":"53","author":"Pinto","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2024.116746_bib48","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1039\/D3JA00378G","article-title":"Performance of single-cell ICP-MS for quantitative biodistribution studies of silver interactions with bacteria","volume":"39","author":"Gimenez-Ingalaturre","year":"2024","journal-title":"J. Anal. At. Spectrom."},{"key":"10.1016\/j.ejmech.2024.116746_bib49","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1039\/C5AN02358K","article-title":"A fluorescent nanoprobe for single bacterium tracking: functionalization of silver nanoparticles with tryptophan to probe the nanoparticle accumulation with single cell resolution","volume":"141","author":"Doj\u010dilovi\u0107","year":"2016","journal-title":"Analyst"},{"key":"10.1016\/j.ejmech.2024.116746_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","article-title":"Drug-DNA interactions and their study by UV-visible, fluorescence spectrosco-pies and cyclic voltammetry","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J. Photochem. Photobiol., A"},{"key":"10.1016\/j.ejmech.2024.116746_bib51","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006"},{"key":"10.1016\/j.ejmech.2024.116746_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111390","article-title":"The first copper(I) complex of anthrahydrazone with potential ROS scavenging activity showed significant in vitro anticancer activity by inducing apoptosis and autophagy","volume":"218","author":"Liu","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2024.116746_bib53","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejmech.2014.03.028","article-title":"A novel silver iodide metalo-drug: experimental and computational modelling assessment of its interaction with intracellular DNA, lipoxygenase and glutathione","volume":"77","author":"Banti","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.116746_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2021.120316","article-title":"Ag(I) symmetrical N,N\u2032-diarylformamidine dithiocarbamate PPh3 complexes: synthesis, structural characterization, quantum chemical calculations and in vitro biological studies","volume":"520","author":"Oladipo","year":"2021","journal-title":"Inorg. Chim. Acta."},{"key":"10.1016\/j.ejmech.2024.116746_bib55","first-page":"215","article-title":"AcrB and related multidrug efflux pumps of Escherichia coli","volume":"3","author":"Nikaido","year":"2001","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2024.116746_bib56","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1369-5274(00)00242-3","article-title":"Multidrug resistance in Gram-negative bacteria","volume":"4","author":"Poole","year":"2001","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ejmech.2024.116746_bib57","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1574-6976.2011.00290.x","article-title":"Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria","volume":"36","author":"Nikaido","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.ejmech.2024.116746_bib58","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nature10641","article-title":"Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket","volume":"480","author":"Nakashima","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2024.116746_bib59","first-page":"225","article-title":"Inhibition of efflux pumps as a novel approach to combat drug resistance in bacteria","volume":"3","author":"Lomovskaya","year":"2001","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2024.116746_bib60","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.3402\/ljm.v6i0.5870","article-title":"Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa","volume":"6","author":"Askoura","year":"2011","journal-title":"Libyan J. Med."},{"key":"10.1016\/j.ejmech.2024.116746_bib61","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1016\/j.bmcl.2003.07.024","article-title":"MexAB-OprM- specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: discovery and early strategies for lead optimization","volume":"13","author":"Nakayama","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2024.116746_bib62","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1016\/j.bmc.2007.07.039","article-title":"MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13\u20139001, a potential preclinical candidate","volume":"15","author":"Yoshida","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424006275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424006275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T12:13:32Z","timestamp":1738412012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523424006275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":62,"alternative-id":["S0223523424006275"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116746","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amine-substituted heterocyclic thioamide Cu(I) and Ag(I) complexes as effective anticancer and antibacterial agents targeting the periplasm of E. coli bacteria","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116746"}}