{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:51:28Z","timestamp":1784782288242,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ejmech.2024.117127","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:45:42Z","timestamp":1733445942000},"page":"117127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Synthesis and mechanistic studies of 4-aminoquinoline-Isatin molecular hybrids and Schiff's bases as promising antimicrobial agents"],"prefix":"10.1016","volume":"283","author":[{"given":"Mohd","family":"Shakir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Lakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manika","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haider Thaer","family":"Abdulhameed Almuqdadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Kamthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh C.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleem","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diwan S.","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-8451","authenticated-orcid":false,"given":"Mohammad","family":"Abid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejmech.2024.117127_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/cncr.33918","article-title":"Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system","volume":"128","author":"Gritsch","year":"2022","journal-title":"Cancer"},{"key":"10.1016\/j.ejmech.2024.117127_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-016-1810-x","article-title":"What are the factors driving antimicrobial resistance? Perspectives from a public event in London, England","volume":"16","author":"Castro-S\u00e1nchez","year":"2016","journal-title":"BMC Infect. Dis."},{"issue":"10","key":"10.1016\/j.ejmech.2024.117127_bib3","article-title":"Self-medication with antibiotics: an element increasing resistance","volume":"14","author":"Sachdev","year":"2022","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.ejmech.2024.117127_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.publhealth.29.020907.090904","article-title":"Industrial food animal production, antimicrobial resistance, and human health","volume":"29","author":"Silbergeld","year":"2008","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.ejmech.2024.117127_bib5","series-title":"Tackling Drug-Resistant Infections Globally: Final Report and Recommendations","author":"O'Neill","year":"2016"},{"key":"10.1016\/j.ejmech.2024.117127_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0140-6736(15)00474-2","article-title":"Access to effective antimicrobials: a worldwide challenge","volume":"387","author":"Laxminarayan","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2024.117127_bib7","series-title":"WHO Publishes List of Bacteria for Which New Antibiotics Are Urgently Needed","author":"Organization","year":"2017"},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1541-4337.2006.00004.x","article-title":"Antimicrobial resistance: implications for the food system: an expert report, funded by the IFT Foundation","volume":"5","author":"Doyle","year":"2006","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"2","key":"10.1016\/j.ejmech.2024.117127_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/ijmr.IJMR_331_18","article-title":"Antimicrobial resistance in the environment: the Indian scenario","volume":"149","author":"Taneja","year":"2019","journal-title":"Indian J. Med. Res."},{"issue":"8","key":"10.1016\/j.ejmech.2024.117127_bib11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data","volume":"14","author":"Van Boeckel","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2024.117127_bib12","first-page":"37","article-title":"Quinolines and quinolones as antibacterial, antifungal, anti-virulence, antiviral and anti-parasitic agents","volume":"14","author":"Senerovic","year":"2020","journal-title":"Adv. Microbiol. Infect. Dis. Pub. Health"},{"key":"10.1016\/j.ejmech.2024.117127_bib13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1590\/S0103-50532001000300002","article-title":"The chemistry of isatins: a review from 1975 to 1999","volume":"12","author":"Da Silva","year":"2001","journal-title":"J. Braz. Chem. Soc."},{"issue":"2","key":"10.1016\/j.ejmech.2024.117127_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.52711\/2321-5836.2021.00013","article-title":"A review an Isatin, Isatin derivatives and their pharmacological activity","volume":"13","author":"Beula","year":"2021","journal-title":"Res. J. Pharmacol. Pharmacodyn."},{"issue":"11","key":"10.1016\/j.ejmech.2024.117127_bib15","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3390\/molecules22111958","article-title":"Synthesis, spectroscopic characterization and antimicrobial potential of certain new isatin-indole molecular hybrids","volume":"22","author":"Al-Wabli","year":"2017","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.ejmech.2024.117127_bib16","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/j.bmcl.2006.01.063","article-title":"Structure-guided identification of novel VEGFR-2 kinase inhibitors via solution phase parallel synthesis","volume":"16","author":"Tripathy","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"1","key":"10.1016\/j.ejmech.2024.117127_bib17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/bbrc.2000.3477","article-title":"The endogenous oxindoles 5-hydroxyoxindole and isatin are antiproliferative and proapoptotic","volume":"276","author":"Cane","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5\u20136","key":"10.1016\/j.ejmech.2024.117127_bib18","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jinorgbio.2007.12.033","article-title":"Double-strand DNA cleavage induced by oxindole-Schiff base copper (II) complexes with potential antitumor activity","volume":"102","author":"da Silveira","year":"2008","journal-title":"J. Inorg. Biochem."},{"issue":"20","key":"10.1016\/j.ejmech.2024.117127_bib19","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1016\/j.bmcl.2005.07.046","article-title":"Synthesis and evaluation of anti-HIV activity of isatin \u03b2-thiosemicarbazone derivatives","volume":"15","author":"Bal","year":"2005","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0968-0896(02)00439-X","article-title":"Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines","volume":"11","author":"Raj","year":"2003","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2024.117127_bib21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jinorgbio.2006.09.004","article-title":"Complexes of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl) isatin.: a study of their antimicrobial activity","volume":"101","author":"Rodr\u00edguez-Arg\u00fcelles","year":"2007","journal-title":"J. Inorg. Biochem."},{"issue":"8","key":"10.1016\/j.ejmech.2024.117127_bib22","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.bmcl.2006.01.073","article-title":"Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I","volume":"16","author":"Jiang","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"6","key":"10.1016\/j.ejmech.2024.117127_bib23","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.bmcl.2006.12.108","article-title":"Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles","volume":"17","author":"Maskell","year":"2007","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neuint.2005.02.011","article-title":"Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose-and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells","volume":"47","author":"Igosheva","year":"2005","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.ejmech.2024.117127_bib25","first-page":"49","article-title":"Anticonvulsant activity of Schiff bases of isatin derivatives","volume":"54","author":"Verma","year":"2004","journal-title":"Acta Pharm."},{"issue":"14","key":"10.1016\/j.ejmech.2024.117127_bib26","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1021\/jm100410f","article-title":"Spirotetrahydro \u03b2-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria","volume":"53","author":"Yeung","year":"2010","journal-title":"J. Med. Chem."},{"issue":"5996","key":"10.1016\/j.ejmech.2024.117127_bib27","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.1193225","article-title":"Spiroindolones, a potent compound class for the treatment of malaria","volume":"329","author":"Rottmann","year":"2010","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ejmech.2024.117127_bib28","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/cbdd.12273","article-title":"7\u2010Chloroquinoline\u2013isatin Conjugates: antimalarial, antitubercular, and cytotoxic evaluation","volume":"83","author":"Raj","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2024.117127_bib29","series-title":"Schr\u00f6dinger Release 2017-2: Maestro","first-page":"8","author":"Schr\u00f6dinger","year":"2017"},{"key":"10.1016\/j.ejmech.2024.117127_bib30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"64","author":"Lipinski","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"8","key":"10.1016\/j.ejmech.2024.117127_bib31","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.3390\/microorganisms11081934","article-title":"Microbial biofilms: applications, clinical consequences, and alternative therapies","volume":"11","author":"Ali","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.ejmech.2024.117127_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.131046","article-title":"Experimental spectroscopic and quantum computational analysis of pyridine-2, 6-dicarboxalic acid with molecular docking studies","volume":"1245","author":"Agarwal","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejmech.2024.117127_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134242","article-title":"DFT, molecular docking, molecular dynamics simulation, MMGBSA calculation and hirshfeld surface analysis of 5-sulfosalicylic acid","volume":"1273","author":"Fatima","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"4","key":"10.1016\/j.ejmech.2024.117127_bib34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/adfm.201201385","article-title":"Energy level modulation of HOMO, LUMO, and band\u2010gap in conjugated polymers for organic photovoltaic applications","volume":"23","author":"Kim","year":"2013","journal-title":"Adv. Funct. Mater."},{"issue":"109","key":"10.1016\/j.ejmech.2024.117127_bib35","doi-asserted-by":"crossref","first-page":"63655","DOI":"10.1039\/C4RA09768H","article-title":"Synthesis, antimalarial activity, heme binding and docking studies of 4-aminoquinoline\u2013pyrimidine based molecular hybrids","volume":"4","author":"Kumar","year":"2014","journal-title":"RSC Adv."},{"issue":"8","key":"10.1016\/j.ejmech.2024.117127_bib36","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3390\/antibiotics11081126","article-title":"Design, synthesis and Mechanistic studies of novel isatin-Pyrazole Hydrazone conjugates as selective and potent Bacterial MetAP inhibitors","volume":"11","author":"Irfan","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2024.117127_bib37","series-title":"Synthesis, Characterization and Biological Evaluation of Multi Substituted Quinoline-Thiazolidinone Mannich Bases","author":"Madhu","year":"2012"},{"key":"10.1016\/j.ejmech.2024.117127_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejmech.2018.11.021","article-title":"N-Substituted aminoquinoline-pyrimidine hybrids: synthesis, in vitro antimalarial activity evaluation and docking studies","volume":"162","author":"Maurya","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"29","key":"10.1016\/j.ejmech.2024.117127_bib39","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1002\/slct.202101364","article-title":"Assessment of dihydro [1, 3] oxazine\u2010fused isoflavone and 4\u2010thionoisoflavone hybrids as antibacterials","volume":"6","author":"Lathwal","year":"2021","journal-title":"ChemistrySelect"},{"issue":"42","key":"10.1016\/j.ejmech.2024.117127_bib40","doi-asserted-by":"crossref","first-page":"27798","DOI":"10.1021\/acsomega.1c03379","article-title":"Development of oxadiazole-sulfonamide-based compounds as potential antibacterial agents","volume":"6","author":"Ali","year":"2021","journal-title":"ACS Omega"},{"issue":"23","key":"10.1016\/j.ejmech.2024.117127_bib41","doi-asserted-by":"crossref","first-page":"13724","DOI":"10.1080\/07391102.2023.2179541","article-title":"Synthesis, spectral characterization of pyrazole derived Schiff base analogs: molecular dynamic simulation, antibacterial and DNA binding studies","volume":"41","author":"Sultana","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"1","key":"10.1016\/j.ejmech.2024.117127_bib42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/07391102.2023.2194004","article-title":"Synergistic antimicrobial activity, MD simulation studies and crystal structure of natural alcohol motif containing novel substituted cinnamates","volume":"42","author":"Irfan","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"4","key":"10.1016\/j.ejmech.2024.117127_bib43","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2166\/wh.2021.085","article-title":"Lentic and effluent water of Delhi-NCR: a reservoir of multidrug-resistant bacteria harbouring bla CTX-M, bla TEM and bla SHV type ESBL genes","volume":"19","author":"Ali","year":"2021","journal-title":"J. Water Health"},{"issue":"45","key":"10.1016\/j.ejmech.2024.117127_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202302360","article-title":"Synthesis of 1, 2, 4\u2010Oxadiazole\u2010sulfonamide conjugates and their synergistic effect with ampicillin as antimicrobial agents","volume":"8","author":"Habib","year":"2023","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.ejmech.2024.117127_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jorganchem.2023.122994","article-title":"Pd-catalyzed synthesis, characterization, and biological evaluations of pyrazole derivatives: DFT, molecular modelling and antioxidant studies","volume":"1005","author":"Mehandi","year":"2024","journal-title":"J. Organomet. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib46","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1021\/acsfoodscitech.1c00005","article-title":"Valorization of agro-industrial waste from peanuts for sustainable natural dye production: focus on adsorption mechanisms, ultraviolet protection, and antimicrobial properties of dyed wool fabric","volume":"1","author":"Rather","year":"2021","journal-title":"ACS Food Sci. Technol."},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0168-1605(02)00022-3","article-title":"Estimating the precision of serial dilutions and viable bacterial counts","volume":"76","author":"Hedges","year":"2002","journal-title":"Int. J. Food Microbiol."},{"issue":"8","key":"10.1016\/j.ejmech.2024.117127_bib48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00284-022-02911-8","article-title":"Development of synergy-based combination of methanolic extract of Andrographis paniculata and Berberis aristata against E. coli and S. aureus","volume":"79","author":"Abass","year":"2022","journal-title":"Curr. Microbiol."},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib49","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/microorganisms10030597","article-title":"Insights into the antibacterial activity of prolactin-inducible protein against the standard and environmental MDR bacterial strains","volume":"10","author":"Yousuf","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.ejmech.2024.117127_bib50","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00175505","article-title":"Endotherms, ectotherms, and mitochondrial genome-size variation","volume":"37","author":"Rand","year":"1993","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.ejmech.2024.117127_bib51","series-title":"Gaussian 16","author":"Frisch","year":"2016"},{"key":"10.1016\/j.ejmech.2024.117127_bib52","series-title":"GaussView, Version 6.0. 16","author":"Dennington","year":"2016"},{"issue":"2","key":"10.1016\/j.ejmech.2024.117127_bib53","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/prot.10613","article-title":"A hierarchical approach to all\u2010atom protein loop prediction","volume":"55","author":"Jacobson","year":"2004","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"10.1016\/j.ejmech.2024.117127_bib54","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Madhavi Sastry","year":"2013","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"7","key":"10.1016\/j.ejmech.2024.117127_bib55","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening","volume":"47","author":"Halgren","year":"2004","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib56","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1021\/acs.jctc.8b01026","article-title":"OPLS3e: Extending force field coverage for drug-like small molecules","volume":"15","author":"Roos","year":"2019","journal-title":"J. Chem. Theor. Comput."},{"issue":"7","key":"10.1016\/j.ejmech.2024.117127_bib57","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy","volume":"47","author":"Friesner","year":"2004","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.ejmech.2024.117127_bib58","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein\u2212 ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2024.117127_bib59","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fmed.2019.00074","article-title":"Treatment of infections due to MDR Gram-negative bacteria","volume":"6","author":"Bassetti","year":"2019","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.ejmech.2024.117127_bib60","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cbpa.2003.12.007","article-title":"From large networks to small molecules","volume":"8","author":"Sharom","year":"2004","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejmech.2024.117127_bib61","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.ejmech.2024.117127_bib62","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrc1691","article-title":"The concept of synthetic lethality in the context of anticancer therapy","volume":"5","author":"Kaelin","year":"2005","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.ejmech.2024.117127_bib63","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrd1609","article-title":"Multicomponent therapeutics for networked systems","volume":"4","author":"Keith","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.ejmech.2024.117127_bib64","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/JB.06112-11","article-title":"Lag phase is a distinct growth phase that prepares bacteria for exponential growth and involves transient metal accumulation","volume":"194","author":"Rolfe","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ejmech.2024.117127_bib65","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/B978-1-4377-0795-3.00088-0","article-title":"Intra-abdominal infections","author":"Sykes","year":"2014","journal-title":"Canine Feline Infect. Dis."},{"issue":"4","key":"10.1016\/j.ejmech.2024.117127_bib66","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jhin.2015.01.008","article-title":"Multidrug-resistant Gram-negative bacteria: a product of globalization","volume":"89","author":"Hawkey","year":"2015","journal-title":"J. Hosp. Infect."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424010092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523424010092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T18:59:09Z","timestamp":1741287549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523424010092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":66,"alternative-id":["S0223523424010092"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.117127","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and mechanistic studies of 4-aminoquinoline-Isatin molecular hybrids and Schiff's bases as promising antimicrobial agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2024.117127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117127"}}