{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T23:33:47Z","timestamp":1786318427696,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023924","name":"Chulalongkorn University Graduate School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ejmech.2025.117303","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T23:59:51Z","timestamp":1737417591000},"page":"117303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Design, synthesis, and antiviral activity of fragmented-lapatinib aminoquinazoline analogs towards SARS-CoV-2 inhibition"],"prefix":"10.1016","volume":"286","author":[{"given":"Ayomide","family":"Adediji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akeanan","family":"Sroithongmoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aphinya","family":"Suroengrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patcharin","family":"Wilasluck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peerapon","family":"Deetanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamonpan","family":"Sanachai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Karnchanapandh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwaporn","family":"Boonyasuppayakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittikhun","family":"Wangkanont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanyada","family":"Rungrotmongkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7236-0625","authenticated-orcid":false,"given":"Tanatorn","family":"Khotavivattana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117303_bib1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"issue":"6558","key":"10.1016\/j.ejmech.2025.117303_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd9149","article-title":"Airborne transmission of respiratory viruses","volume":"373","author":"Wang","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.117303_bib3","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(21)00869-2","article-title":"Ten scientific reasons in support of airborne transmission of SARS-CoV-2","volume":"10285","author":"Greenhalgh","year":"2021","journal-title":"Lancet"},{"issue":"22","key":"10.1016\/j.ejmech.2025.117303_bib4","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1073\/pnas.2006874117","article-title":"The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission","volume":"117","author":"Stadnytskyi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.ejmech.2025.117303_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234765","article-title":"The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): a systematic review and meta-analysis of 148 studies from 9 countries","volume":"15","author":"Grant","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.117303_bib6","series-title":"U.S. Centers For Disease Control And Prevention (CDC)","year":"2021"},{"key":"10.1016\/j.ejmech.2025.117303_bib7","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3390\/v15051171","article-title":"In silico and in vitro evaluation of some amidine derivatives as hit compounds towards development of inhibitors against coronavirus diseases","volume":"15","author":"Hassan","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2025.117303_bib8a","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/acs.jmedchem.1c00598","article-title":"J. Structure-based optimization of ML300-derived, noncovalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CLpro)","volume":"65","author":"Han","year":"2021","journal-title":"Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117303_bib8b","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1021\/acs.jmedchem.1c00509","article-title":"Expedited approach toward the rational design of noncovalent SARS-CoV-2 main protease inhibitors","volume":"65","author":"Kitamura","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117303_bib9","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1021\/acsmedchemlett.0c00521","article-title":"Identification of 14 known drugs as inhibitors of the main protease of SARS-CoV-2","volume":"11","author":"Ghahremanpour","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.117303_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","article-title":"Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117303_bib11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1126\/science.abg5827","article-title":"Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2","volume":"373","author":"Drayman","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.117303_bib12","first-page":"1","article-title":"Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease","author":"Fu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117303_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105419","article-title":"Repurposing of HIV\/HCV protease inhibitors against SARS-CoV-2 3CLpro","volume":"207","author":"Ma","year":"2022","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2025.117303_bib14","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.3390\/ijms21113793","article-title":"Prediction of novel inhibitors of the main protease (Mpro) of SARS-CoV-2 through consensus docking and drug reposition","volume":"21","author":"Gimeno","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.117303_bib15","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.1085658","article-title":"Coronavirus main proteinase (Mpro) structure: basis for design of anti-SARS drugs","volume":"300","author":"Anand","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.117303_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","article-title":"Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117303_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-med-042921-020956","article-title":"COVID-19: challenges of viral variants","volume":"74","author":"Jacobs","year":"2023","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ejmech.2025.117303_bib18","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s13238-021-00883-2","article-title":"Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332","volume":"13","author":"Zhao","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2025.117303_bib19","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","article-title":"An oral SARS-CoV-2 M(pro) inhibitor clinical candidate for the treatment of COVID-19","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.117303_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101972","article-title":"Structural basis for the in vitro eficacy of nirmatrelvir against SARS-CoV-2 variants","volume":"298","author":"Greasley","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.117303_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-022-04856-1","article-title":"Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2","volume":"607","author":"Uraki","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117303_bib22","doi-asserted-by":"crossref","first-page":"7682","DOI":"10.1021\/acs.jmedchem.1c02214","article-title":"Penicillin derivatives inhibit the SARS-CoV-2 main protease by reaction with its nucleophilic cysteine","volume":"65","author":"Malla","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117303_bib23","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1038\/s41467-021-23313-7","article-title":"Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives","volume":"12","author":"Amporndanai","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117303_bib24","doi-asserted-by":"crossref","first-page":"14702","DOI":"10.1021\/acs.jmedchem.1c01214","article-title":"Indole chloropyridinyl ester-derived SARS-CoV-2 3 CLpro inhibitors: enzyme inhibition, antiviral eficacy, structure-activity relationship, and X-ray structural studies","volume":"64","author":"Ghosh","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117303_bib25","doi-asserted-by":"crossref","first-page":"7818","DOI":"10.1021\/acs.jmedchem.2c00224","article-title":"Structure-guided design of potent spirocyclic inhibitors of severe acute respiratory syndrome coronavirus-2 3C-like protease","volume":"65","author":"Dampalla","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117303_bib26","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1038\/s41467-021-23751-3","article-title":"Identification of pyrogallol as a warhead in design of covalent I nhibitors for the SARS-CoV-2 3CL protease","volume":"12","author":"Su","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117303_bib27","doi-asserted-by":"crossref","first-page":"16922","DOI":"10.1021\/acs.jmedchem.1c00409","article-title":"Perspectives on SARS-CoV-2 main protease inhibitors","volume":"64","author":"Gao","year":"2021","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.ejmech.2025.117303_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0269563","article-title":"Identification of repurposing therapeutics toward SARS-CoV-2 main protease by virtual screening","volume":"17","author":"Sanachai","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.117303_bib29a","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.virol.2021.11.008","article-title":"Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro","volume":"566","author":"Raymonda","year":"2020","journal-title":"Virology"},{"key":"10.1016\/j.ejmech.2025.117303_bib29b","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1126\/science.abg5827","article-title":"Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2","volume":"373","author":"Drayman","year":"2021","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.ejmech.2025.117303_bib30","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1021\/acs.jcim.3c00663","article-title":"Identification of promising sulfonamide chalcones as inhibitors of SARS-CoV-2 3CLpro through structure-based virtual screening and experimental approaches","volume":"63","author":"Pojtanadithee","year":"2023","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.ejmech.2025.117303_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.ejmech.2025.117303_bib32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead-and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today Technol."},{"issue":"1","key":"10.1016\/j.ejmech.2025.117303_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/092986709787002817","article-title":"Topological polar surface area: a useful descriptor in 2D-QSAR","volume":"16","author":"Prasanna","year":"2009","journal-title":"Curr. Med. Chem."},{"issue":"1\u20133","key":"10.1016\/j.ejmech.2025.117303_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2025.117303_bib35","doi-asserted-by":"crossref","first-page":"W522","DOI":"10.1093\/nar\/gkm276","article-title":"PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations","volume":"35","author":"Dolinsky","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.ejmech.2025.117303_bib36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/prot.340080302","article-title":"Automated docking of substrates to proteins by simulated annealing","volume":"8","author":"Goodsell","year":"1990","journal-title":"Proteins: Struct., Funct., Bioinf."},{"issue":"1","key":"10.1016\/j.ejmech.2025.117303_bib37","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1021\/ci049885e","article-title":"LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters","volume":"45","author":"Wolber","year":"2005","journal-title":"J. Chem. Inf. Model."},{"issue":"20","key":"10.1016\/j.ejmech.2025.117303_bib38","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1021\/acs.jcim.3c01153","volume":"63","author":"Case","year":"2023","journal-title":"J. Chem. Inf. Model."},{"issue":"9","key":"10.1016\/j.ejmech.2025.117303_bib39","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","article-title":"Development and testing of a general amber force field","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"8","key":"10.1016\/j.ejmech.2025.117303_bib40","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theor. Comput."},{"issue":"12","key":"10.1016\/j.ejmech.2025.117303_bib41","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle mesh Ewald: an N\u22c5 log (N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ejmech.2025.117303_bib42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/b99427","article-title":"Thermostat algorithms for molecular dynamics simulations. Advanced computer simulation: approaches for soft matter sciences I","author":"H\u00fcnenberger","year":"2005","journal-title":"Adv. Polym. Sci."},{"issue":"7","key":"10.1016\/j.ejmech.2025.117303_bib43","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.ejmech.2025.117303_bib44","unstructured":"Suroengrit, A., Cao, V., Wilasluck, P., Deetanya, P., Wangkanont, K., Hengphasatporn, K., Harada, R., Chamni, S., Leelahavanichkul, A., Shigeta, Y., Rungrotmongkol, T., Hannongbua, S., Chavasiri, W., Wacharapluesadee, S., Boonyasuppayakorn, S. Manuscript under Review in Phytomedicine."},{"key":"10.1016\/j.ejmech.2025.117303_bib45","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.3390\/molecules27092841","article-title":"Semi-synthesis of N-aryl amide analogs of piperine from Piper nigrum and evaluation of their antitrypanosomal, antimalarial, and anti-SARS-CoV-2 main protease activities","volume":"27","author":"Wansri","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.ejmech.2025.117303_bib46","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jmb.2006.11.073","article-title":"Production of authentic SARS-CoV M-pro with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction","volume":"366","author":"Xue","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.117303_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0006-2952(73)90196-2","article-title":"\"Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction","volume":"22","author":"Yung-Chi","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.117303_bib48","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1016\/j.csbj.2021.05.053","article-title":"Interaction of 8-anilinonaphthalene-1-sulfonate with SARS-CoV-2 main protease and its application as a fluorescent probe for inhibitor identification","volume":"19","author":"Deetanya","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425000686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425000686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T07:44:32Z","timestamp":1740469472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425000686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":50,"alternative-id":["S0223523425000686"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117303","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and antiviral activity of fragmented-lapatinib aminoquinazoline analogs towards SARS-CoV-2 inhibition","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117303"}}