{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:05:11Z","timestamp":1792706711112,"version":"4.5.0"},"reference-count":199,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173651"],"award-info":[{"award-number":["82173651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ejmech.2025.117333","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T11:54:48Z","timestamp":1738065288000},"page":"117333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Natural sideromycins and siderophore-conjugated natural products as inspiration for novel antimicrobial agents"],"prefix":"10.1016","volume":"287","author":[{"given":"Zhi-Ying","family":"Miao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-7841","authenticated-orcid":false,"given":"Wei-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117333_bib1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117333_bib2","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/jama.2016.11764","article-title":"Antimicrobial resistance","volume":"316","author":"Marston","year":"2016","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.ejmech.2025.117333_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41579-020-0348-5","article-title":"Resisting antimicrobial resistance","volume":"18","author":"Nathan","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib4","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global burden of bacterial antimicrobial resistance 1990\u20132021: a systematic analysis with forecasts to 2050","volume":"404","author":"Naghavi","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2025.117333_bib5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ejmech.2018.06.014","article-title":"Cefiderocol (S-649266), a new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: structure activity relationship","volume":"155","author":"Aoki","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib6","series-title":"WHO Bacterial Priority Pathogens List, 2024: Bacterial Pathogens of Public Health Importance to Guide Research, Development and Strategies to Prevent and Control Antimicrobial Resistance","year":"2024"},{"key":"10.1016\/j.ejmech.2025.117333_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau4679","article-title":"The challenge of antimicrobial resistance: what economics can contribute","volume":"364","author":"Roope","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.117333_bib8","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/ja.2017.30","article-title":"The antibiotic resistance crisis, with a focus on the United States","volume":"70","author":"Martens","year":"2017","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ejmech.2025.117333_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/d41573-024-00138-9","article-title":"The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships","volume":"24","author":"Fernow","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2025.117333_bib10","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1021\/acs.jmedchem.8b00540","article-title":"Pseudomonas aeruginosa quorum sensing systems as drug discovery targets: current position and future perspectives","volume":"61","author":"Soukarieh","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/phar.1868","article-title":"Past, present, and future of antibacterial economics: increasing bacterial resistance, limited antibiotic pipeline, and societal implications","volume":"37","author":"Luepke","year":"2017","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ejmech.2025.117333_bib12","series-title":"2023 Antibacterial Agents in Clinical and Preclinical Development: an Overview and Analysis","year":"2024"},{"key":"10.1016\/j.ejmech.2025.117333_bib13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrd4572","article-title":"ESKAPEing the labyrinth of antibacterial discovery","volume":"14","author":"Tommasi","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2025.117333_bib14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/acsinfecdis.5b00097","article-title":"Permeability barrier of gram-negative cell envelopes and approaches to bypass it","volume":"1","author":"Zgurskaya","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117333_bib15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.mib.2013.09.007","article-title":"On the essentiality of lipopolysaccharide to gram-negative bacteria","volume":"16","author":"Zhang","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib16","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1039\/C7NP00006E","article-title":"Bifunctional antimicrobial conjugates and hybrid antimicrobials","volume":"34","author":"Klahn","year":"2017","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111615","article-title":"An overview of recent progress in siderophore-antibiotic conjugates","volume":"182","author":"Kong","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib18","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1039\/D2MD00465H","article-title":"Siderophore conjugates to combat antibiotic-resistant bacteria","volume":"14","author":"Rayner","year":"2023","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib19","first-page":"181","article-title":"Building a trojan horse: siderophore-drug conjugates for the treatment of infectious diseases","volume":"19","author":"Gumienna-Kontecka","year":"2019","journal-title":"Met. Ions Life Sci."},{"key":"10.1016\/j.ejmech.2025.117333_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s40121-020-00286-6","article-title":"Cefiderocol: a novel agent for the management of multidrug-resistant gram-negative organisms","volume":"9","author":"Wu","year":"2020","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.ejmech.2025.117333_bib21","doi-asserted-by":"crossref","first-page":"S538","DOI":"10.1093\/cid\/ciz826","article-title":"Cefiderocol: discovery, chemistry, and in vivo profiles of a novel siderophore cephalosporin","volume":"69","author":"Sato","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117333_bib22","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.6023\/cjoc202006042","article-title":"Research progress of antibiotics conjugated with siderophores","volume":"40","author":"Liu","year":"2020","journal-title":"Chin. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib23","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1021\/acs.jmedchem.6b01261","article-title":"Discovery of novel pyridone-conjugated monosulfactams as potent and broad-spectrum antibiotics for multidrug-resistant gram-negative infections","volume":"60","author":"Tan","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib24","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/acsinfecdis.2c00556","article-title":"Cytoplasmic delivery of an antibiotic, trimethoprim, with a simple bidentate catechol analog as a siderophore mimetic","volume":"9","author":"Kim","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117333_bib25","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1176667","article-title":"Antibiotics for emerging pathogens","volume":"325","author":"Fischbach","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.117333_bib26","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1038\/s41467-023-40828-3","article-title":"Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117333_bib27","article-title":"Cefiderocol: clinical application and emergence of resistance, Drug Resist","volume":"72","author":"Wang","year":"2024","journal-title":"Update"},{"key":"10.1016\/j.ejmech.2025.117333_bib28","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/antibiotics11060723","article-title":"Cefiderocol: systematic review of mechanisms of resistance, heteroresistance and in vivo emergence of resistance","volume":"11","author":"Karakonstantis","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2025.117333_bib29","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1039\/C7NP00019G","article-title":"Opportunities for natural products in 21st century antibiotic discovery","volume":"34","author":"Wright","year":"2017","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bmcl.2013.12.059","article-title":"New natural products as new leads for antibacterial drug discovery","volume":"24","author":"Brown","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib31","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2025.117333_bib32","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchem.2479","article-title":"Counting on natural products for drug design","volume":"8","author":"Rodrigues","year":"2016","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib33","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00726-013-1468-2","article-title":"Fate of ferrisiderophores after import across bacterial outer membranes: different iron release strategies are observed in the cytoplasm or periplasm depending on the siderophore pathways","volume":"44","author":"Schalk","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.ejmech.2025.117333_bib34","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.molmed.2016.10.005","article-title":"Siderophores in iron metabolism: from mechanism to therapy potential","volume":"22","author":"Wilson","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejmech.2025.117333_bib35","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1073\/pnas.0630018100","article-title":"Enterobactin: an archetype for microbial iron transport","volume":"100","author":"Raymond","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2025.117333_bib36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cmi.2018.03.037","article-title":"Siderophore-antibiotic conjugates: exploiting iron uptake to deliver drugs into bacteria","volume":"24","author":"Schalk","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.ejmech.2025.117333_bib37","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1039\/b906679a","article-title":"Chemistry and biology of siderophores","volume":"27","author":"Hider","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jare.2021.10.010","article-title":"Harnessing microbial iron chelators to develop innovative therapeutic agents","volume":"39","author":"Ribeiro","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejmech.2025.117333_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/acs.jmedchem.2c01212","article-title":"Emerging target-directed approaches for the treatment and diagnosis of microbial infections","volume":"66","author":"Almeida","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib40","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1021\/acs.chemrev.8b00254","article-title":"Hydroxypyridinone journey into metal chelation","volume":"118","author":"Cilibrizzi","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2025.117333_bib41","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.3390\/molecules29163889","article-title":"Location, Location, Location: esablishing design principles for new antibacterials from ferric siderophore transport systems","volume":"29","author":"Luo","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117333_bib42","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.3390\/molecules26113255","article-title":"Deferoxamine B: a natural, excellent and versatile metal chelator","volume":"26","author":"Bellotti","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117333_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1432-1033.1990.tb19094.x","article-title":"Staphyloferrin A: a structurally new siderophore from staphylococci","volume":"191","author":"Konetschny-Rapp","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejmech.2025.117333_bib44","doi-asserted-by":"crossref","first-page":"7841","DOI":"10.1074\/jbc.RA118.002798","article-title":"Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae","volume":"293","author":"Bailey","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202400480","article-title":"Evaluation of the stereochemistry of staphyloferrin A for developing Staphylococcus-specific targeting conjugates","volume":"25","author":"Wang","year":"2024","journal-title":"Chembiochem"},{"key":"10.1016\/j.ejmech.2025.117333_bib46","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00775-006-0088-7","article-title":"Bacterial siderophores: the solution stoichiometry and coordination of the Fe(III) complexes of pyochelin and related compounds","volume":"11","author":"Tseng","year":"2006","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib47","first-page":"2820","article-title":"Pyochelin, a siderophore of Pseudomonas aeruginosa: physicochemical characterization of the iron(III), copper(II) and zinc(II) complexes, Dalton","volume":"41","author":"Brandel","year":"2012","journal-title":"Trans."},{"key":"10.1016\/j.ejmech.2025.117333_bib48","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41579-024-01090-6","article-title":"Bacterial siderophores: diversity, uptake pathways and applications","volume":"23","author":"Schalk","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4155\/fmc.11.191","article-title":"Exploiting bacterial iron acquisition: siderophore conjugates","volume":"4","author":"Ji","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-69152-6","article-title":"The role of FoxA, FiuA, and FpvB in iron acquisition via hydroxamate-type siderophores in Pseudomonas aeruginosa","volume":"14","author":"Will","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib51","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1461-0248.2011.01717.x","article-title":"An evolutionary mechanism for diversity in siderophore-producing bacteria","volume":"15","author":"Lee","year":"2012","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib52","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s10534-009-9218-3","article-title":"Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin \u201cTrojan Horse\u201d antibiotics and synthetic desferridanoxamine-antibiotic conjugates","volume":"22","author":"Wencewicz","year":"2009","journal-title":"Biometals"},{"key":"10.1016\/j.ejmech.2025.117333_bib53","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10534-009-9219-2","article-title":"Siderophores as drug delivery agents: application of the \u201cTrojan Horse\u201d strategy","volume":"22","author":"M\u00f6llmann","year":"2009","journal-title":"Biometals"},{"key":"10.1016\/j.ejmech.2025.117333_bib54","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1111\/j.1462-2920.2011.02556.x","article-title":"New roles for bacterial siderophores in metal transport and tolerance","volume":"13","author":"Schalk","year":"2011","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib55","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.bbamem.2007.07.026","article-title":"Structural biology of bacterial iron uptake","volume":"1778","author":"Krewulak","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2025.117333_bib56","doi-asserted-by":"crossref","first-page":"21990","DOI":"10.1073\/pnas.0910023106","article-title":"Reconstitution of bacterial outer membrane TonB-dependent transporters in planar lipid bilayer membranes","volume":"106","author":"Udho","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2025.117333_bib57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/jobm.201100552","article-title":"Microbial siderophores: a mini review","volume":"53","author":"Saha","year":"2013","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib58","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0923-2508(01)01200-1","article-title":"ABC transporter-mediated uptake of iron, siderophores, heme and vitamin B12","volume":"152","author":"K\u00f6ster","year":"2001","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib59","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1039\/C3MT00359K","article-title":"Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa","volume":"6","author":"Mislin","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.ejmech.2025.117333_bib60","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1021\/acs.accounts.5b00301","article-title":"Coordination chemistry of microbial iron transport","volume":"48","author":"Raymond","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2025.117333_bib61","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1021\/acschembio.8b00543","article-title":"A key role for the periplasmic PfeE esterase in iron acquisition via the siderophore enterobactin in Pseudomonas aeruginosa","volume":"13","author":"Perraud","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/nyas.12024","volume":"1277","author":"Page","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejmech.2025.117333_bib63","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.nano.2016.06.002","article-title":"Antimicrobial molecular nanocarrier\u2013drug conjugates","volume":"12","author":"Skwarecki","year":"2016","journal-title":"Nanomed-Nanotechnol"},{"key":"10.1016\/j.ejmech.2025.117333_bib64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1568026013395524","article-title":"Siderophore-antibiotic conjugates used as Trojan horses against Pseudomonas aeruginosa","volume":"1","author":"Budzikiewicz","year":"2001","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib65","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10534-019-00192-6","article-title":"Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum gram-negative antibiotics","volume":"32","author":"Lin","year":"2019","journal-title":"Biometals"},{"key":"10.1016\/j.ejmech.2025.117333_bib66","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/cmdc.202000806","article-title":"Experimental methods for evaluating the bacterial uptake of Trojan horse antibacterials","volume":"16","author":"Southwell","year":"2021","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2025.117333_bib67","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tips.2014.06.007","article-title":"Siderophore\u2013drug complexes: potential medicinal applications of the \u2018Trojan horse\u2019 strategy","volume":"35","author":"G\u00f3rska","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2025.117333_bib68","first-page":"190","article-title":"Iron Metabolism: a promising target for antibacterial strategies, Recent Pat. Anti-infect","volume":"4","author":"Ballouche","year":"2009","journal-title":"Drug Discovery"},{"key":"10.1016\/j.ejmech.2025.117333_bib69","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3181\/00379727-64-15695","article-title":"Grisein, a new antibiotic produced by a strain of Streptomyces griseus","volume":"64","author":"Reynolds","year":"1947","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ejmech.2025.117333_bib70","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1039\/D0CB00208A","article-title":"Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases","volume":"2","author":"Travin","year":"2021","journal-title":"RSC Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib71","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1136\/bmj.2.4949.1177","article-title":"Recent studies on albomycin, a new antibiotic","volume":"2","author":"Gause","year":"1955","journal-title":"Br. Med. J."},{"key":"10.1016\/j.ejmech.2025.117333_bib72","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/anie.198205271","article-title":"Constitution of the deferriform of the albomycins \u03b41, \u03b42 and \u03b5","volume":"21","author":"Benz","year":"1982","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"10.1016\/j.ejmech.2025.117333_bib73","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/cb300173x","article-title":"Biosynthesis of albomycin \u03b42 provides a template for assembling siderophore and aminoacyl-tRNA synthetase inhibitor conjugates","volume":"7","author":"Zeng","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib74","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1038\/s41467-018-05821-1","article-title":"Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens","volume":"9","author":"Lin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117333_bib75","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1128\/jb.156.1.308-315.1983","article-title":"Intracellular activation of albomycin in Escherichia coli and Salmonella typhimurium","volume":"156","author":"Braun","year":"1983","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ejmech.2025.117333_bib76","doi-asserted-by":"crossref","first-page":"7186","DOI":"10.1128\/jb.177.24.7186-7193.1995","article-title":"Ferrichrome transport in Escherichia coli K-12: altered substrate specificity of mutated periplasmic FhuD and interaction of FhuD with the integral membrane protein FhuB","volume":"177","author":"Rohrbach","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ejmech.2025.117333_bib77","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1110\/ps.9.5.956","article-title":"Crystal structure of the antibiotic albomycin in complex with the outer membrane transporter FhuA","volume":"9","author":"Ferguson","year":"2000","journal-title":"Protein Sci."},{"key":"10.1016\/j.ejmech.2025.117333_bib78","doi-asserted-by":"crossref","first-page":"13966","DOI":"10.1074\/jbc.M109385200","article-title":"X-ray crystallographic structures of the Escherichia coli periplasmic protein FhuD bound to hydroxamate-type siderophores and the antibiotic albomycin","volume":"277","author":"Clarke","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib79","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1128\/JB.00205-06","article-title":"Albomycin uptake via a ferric hydroxamate transport system of Streptococcus pneumoniae R6","volume":"188","author":"Pramanik","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ejmech.2025.117333_bib80","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ijmm.2007.03.002","article-title":"Albomycin is an effective antibiotic, as exemplified with Yersinia enterocolitica and Streptococcus pneumoniae","volume":"297","author":"Pramanik","year":"2007","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115645","article-title":"Synthesis and structural insights into the binding mode of the albomycin \u03b41 core and its analogues in complex with their target aminoacyl-tRNA synthetase","volume":"28","author":"Gadakh","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib82","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0092-8674(00)81700-6","article-title":"Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes","volume":"95","author":"Locher","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2025.117333_bib83","first-page":"1383","article-title":"Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer, Commun","volume":"4","author":"Hu","year":"2021","journal-title":"Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib84","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1021\/acs.jmedchem.9b01131","article-title":"Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase","volume":"62","author":"Cain","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib85","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hlca.19950780105","article-title":"Salmycin A-D, antibiotika aus Streptomyces violaceus, DSM 8286, mit siderophor-aminoglycosid-struktur","volume":"78","author":"V\u00e9rtesy","year":"1995","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.ejmech.2025.117333_bib86","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1021\/jo000050m","article-title":"Total synthesis of the siderophore danoxamine","volume":"65","author":"Roosenberg","year":"2000","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112791","article-title":"Hydroxamate siderophores: natural occurrence, chemical synthesis, iron binding affinity and use as Trojan horses against pathogens","volume":"208","author":"Al Shaer","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib88","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4081\/idr.2019.8208","article-title":"Present and future of siderophore-based therapeutic and diagnostic approaches in infectious diseases","volume":"11","author":"Tonziello","year":"2019","journal-title":"Infect. Dis. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib89","series-title":"Antibacterials","first-page":"151","article-title":"Sideromycins as pathogen-targeted antibiotics","author":"Wencewicz","year":"2017"},{"key":"10.1016\/j.ejmech.2025.117333_bib90","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1039\/b516237h","article-title":"Microcins, gene-encoded antibacterial peptides from enterobacteria","volume":"24","author":"Duquesne","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib91","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1042\/BST20120183","article-title":"Microcins in action: amazing defence strategies of enterobacteria","volume":"40","author":"Rebuffat","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejmech.2025.117333_bib92","doi-asserted-by":"crossref","first-page":"28233","DOI":"10.1074\/jbc.M400228200","article-title":"Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity","volume":"279","author":"Thomas","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib93","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1128\/AAC.00744-09","article-title":"Isolation and characterization of two members of the siderophore-microcin family, microcins M and H47","volume":"54","author":"Vassiliadis","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib94","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1128\/AAC.49.7.3083-3086.2005","article-title":"Cooperative uptake of Microcin E492 by receptors FepA, Fiu, and Cir and inhibition by the siderophore enterochelin and its dimeric and trimeric hydrolysis products","volume":"49","author":"Strahsburger","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib95","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nchembio771","article-title":"How pathogenic bacteria evade mammalian sabotage in the battle for iron","volume":"2","author":"Fischbach","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib96","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1128\/AAC.27.4.666","article-title":"Microcin E492, a low-molecular-weight peptide antibiotic which causes depolarization of the Escherichia coli cytoplasmic membrane","volume":"27","author":"De Lorenzo","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib97","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1128\/JB.00688-06","article-title":"Bactericidal activity of both secreted and nonsecreted microcin E492 requires the mannose permease","volume":"188","author":"Bieler","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ejmech.2025.117333_bib98","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1021\/acschembio.2c00585","article-title":"Comparative metabolomics reveals a bifunctional antibacterial conjugate from combined-culture of Streptomyces hygroscopicus HOK021 and Tsukamurella pulmonis TP-B0596","volume":"17","author":"Asamizu","year":"2022","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib99","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1021\/acs.orglett.2c03788","article-title":"Discovery and biosynthesis of the amodesmycins, aromatic polyketide-siderophore hybrid conjugates","volume":"24","author":"Huang","year":"2022","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib100","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1021\/acscentsci.3c00965","article-title":"A novel natural siderophore antibiotic conjugate reveals a chemical approach to macromolecule coupling","volume":"9","author":"Caradec","year":"2023","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2025.117333_bib101","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/C9NP00011A","article-title":"Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib102","doi-asserted-by":"crossref","first-page":"18033","DOI":"10.3390\/molecules191118033","article-title":"Deciphering the role of phytoalexins in plant-microorganism interactions and human health","volume":"19","author":"Jeandet","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117333_bib103","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.mib.2018.08.004","article-title":"Opportunities for plant natural products in infection control","volume":"45","author":"Salam","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib104","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3390\/molecules21070877","article-title":"New perspectives on the use of phytochemicals as an emergent strategy to control bacterial infections including biofilms","volume":"21","author":"Borges","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117333_bib105","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1128\/AAC.46.10.3133-3141.2002","article-title":"Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials","volume":"46","author":"Tegos","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib106","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1021\/ja109665t","article-title":"Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria","volume":"133","author":"Miller","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117333_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115454","article-title":"3-Hydroxy-pyridin-4(1H)-ones as siderophores mediated delivery of isobavachalcone enhances antibacterial activity against pathogenic Pseudomonas aeruginosa","volume":"257","author":"Huang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116339","article-title":"Cajaninstilbene acid derivatives conjugated with siderophores of 3-hydroxypyridin-4(1H)-ones as novel antibacterial agents against gram-negative bacteria based on the Trojan horse strategy","volume":"269","author":"Huang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib109","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1039\/B816679J","article-title":"Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents","volume":"39","author":"Chaturvedi","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2025.117333_bib110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1021\/ar020227u","article-title":"Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides","volume":"37","author":"Posner","year":"2004","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2025.117333_bib111","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10111","article-title":"Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117333_bib112","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1021\/jm030571c","article-title":"A medicinal chemistry perspective on artemisinin and related endoperoxides","volume":"47","author":"O'Neill","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105483","article-title":"Pharmacological review of isobavachalcone, a naturally occurring chalcone","volume":"165","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejmech.2025.117333_bib114","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/membranes12030269","article-title":"Antibacterial Activity of isobavachalcone (IBC) is associated with membrane disruption","volume":"12","author":"de Assis","year":"2022","journal-title":"Membranes"},{"key":"10.1016\/j.ejmech.2025.117333_bib115","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100749","article-title":"Plant natural flavonoids against multidrug resistant pathogens","volume":"8","author":"Song","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2025.117333_bib116","doi-asserted-by":"crossref","first-page":"14470","DOI":"10.1021\/acs.jmedchem.0c01480","article-title":"Hydroxypyridinone-based iron chelators with broad-ranging biological activities","volume":"63","author":"Jiang","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib117","first-page":"6371","article-title":"Design of iron chelators with therapeutic application, Dalton","volume":"41","author":"Zhou","year":"2012","journal-title":"Trans."},{"key":"10.1016\/j.ejmech.2025.117333_bib118","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1128\/AAC.01525-09","article-title":"In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli","volume":"54","author":"Page","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib119","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1021\/ml200012f","article-title":"Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols","volume":"2","author":"Flanagan","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib120","doi-asserted-by":"crossref","first-page":"6334","DOI":"10.1128\/AAC.01345-12","article-title":"Clinically relevant gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam","volume":"56","author":"McPherson","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib121","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/acsmedchemlett.5b00026","article-title":"SAR and structural analysis of siderophore-conjugated monocarbam inhibitors of Pseudomonas aeruginosa PBP3","volume":"6","author":"Murphy-Benenato","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib122","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1021\/jm501506f","article-title":"Discovery of efficacious Pseudomonas aeruginosa-targeted siderophore-conjugated monocarbams by application of a semi-mechanistic pharmacokinetic\/pharmacodynamic model","volume":"58","author":"Murphy-Benenato","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib123","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1021\/jm400560z","article-title":"Pyridone-conjugated monobactam antibiotics with gram-negative activity","volume":"56","author":"Brown","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib124","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1021\/acs.jmedchem.2c02044","article-title":"Design and synthesis of 3-hydroxy-pyridin-4(1H)-ones-ciprofloxacin conjugates as dual antibacterial and antibiofilm agents against Pseudomonas aeruginosa","volume":"66","author":"Wang","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib125","doi-asserted-by":"crossref","first-page":"15823","DOI":"10.1021\/acs.jmedchem.3c01328","article-title":"3-Hydroxypyridin-4(1H)-one derivatives as pqs quorum sensing inhibitors attenuate virulence and reduce antibiotic resistance in Pseudomonas aeruginosa","volume":"66","author":"Miao","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib126","doi-asserted-by":"crossref","first-page":"16835","DOI":"10.1021\/acs.jmedchem.4c01760","article-title":"Hybrids of 3-hydroxypyridin-4(1H)-ones and long-chain 4-aminoquinolines as potent biofilm inhibitors of Pseudomonas aeruginosa potentiate tobramycin and polymyxin B activity","volume":"67","author":"Miao","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib127","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.foodchem.2010.01.062","article-title":"Cajanuslactone, a new coumarin with anti-bacterial activity from pigeon pea [Cajanus cajan (L.) Millsp.] leaves","volume":"121","author":"Kong","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib128","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejmech.2015.06.008","article-title":"Novel cajaninstilbene acid derivatives as antibacterial agents","volume":"100","author":"Geng","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib129","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.cclet.2019.04.043","article-title":"A facile synthesis of cajaninstilbene acid and its derivatives","volume":"30","author":"Chen","year":"2019","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113691","article-title":"Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms","volume":"224","author":"Yu","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.112026","article-title":"Biological evaluation and chemoproteomics reveal potential antibacterial targets of a cajaninstilbene-acid analogue","volume":"188","author":"Lu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib132","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2958.2003.03288.x","article-title":"Siderophore-mediated cell signalling in Pseudomonas aeruginosa: divergent pathways regulate virulence factor production and siderophore receptor synthesis","volume":"47","author":"Beare","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib133","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11030-022-10417-5","article-title":"Antibacterial natural products from microbial and fungal sources: a decade of advances","volume":"27","author":"Mohan","year":"2023","journal-title":"Mol. Divers."},{"key":"10.1016\/j.ejmech.2025.117333_bib134","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ja.2012.27","article-title":"Thoughts and facts about antibiotics: where we are now and where we are heading","volume":"65","author":"B\u00e9rdy","year":"2012","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ejmech.2025.117333_bib135","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1128\/JB.00275-16","article-title":"Multifaceted interfaces of bacterial competition","volume":"198","author":"Stubbendieck","year":"2016","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ejmech.2025.117333_bib136","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10295-013-1325-z","article-title":"Importance of microbial natural products and the need to revitalize their discovery","volume":"41","author":"Demain","year":"2014","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2025.117333_bib137","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.tim.2017.06.003","article-title":"Natural-product antibiotics: cues for modulating bacterial biofilm formation","volume":"25","author":"Townsley","year":"2017","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib138","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mib.2019.10.012","article-title":"Natural products discovery and potential for new antibiotics","volume":"51","author":"Genilloud","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib139","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3390\/antibiotics10070842","article-title":"Bacterial natural product drug discovery for new antibiotics: strategies for tackling the problem of antibiotic resistance by efficient bioprospecting","volume":"10","author":"Schneider","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2025.117333_bib140","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","article-title":"A new antibiotic kills pathogens without detectable resistance","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117333_bib141","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molcel.2018.03.001","article-title":"Odilorhabdins, antibacterial aagents that cause miscoding by binding at a new ribosomal site","volume":"70","author":"Pantel","year":"2018","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ejmech.2025.117333_bib142","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-019-1791-1","article-title":"A new antibiotic selectively kills gram-negative pathogens","volume":"576","author":"Imai","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117333_bib143","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.3390\/molecules24183314","article-title":"Siderophore-antibiotic conjugate design: new drugs for bad bugs?","volume":"24","author":"Negash","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117333_bib144","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1016\/S0040-4039(00)85439-8","article-title":"Structure of lactivicin, an antibiotic having a new nucleus and similar biological activities to \u03b2-lactam antibiotics","volume":"27","author":"Harada","year":"1986","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/325179a0","article-title":"Binding of a non-\u03b2-lactam antibiotic to penicillin-binding proteins","volume":"325","author":"Nozaki","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117333_bib146","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nchembio.2007.21","article-title":"Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins","volume":"3","author":"Macheboeuf","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib147","doi-asserted-by":"crossref","first-page":"84","DOI":"10.7164\/antibiotics.42.84","article-title":"Lactivicin, a naturally occurring non-\u03b2-lactam antibiotic having \u03b2-lactam-like action: biological activities and mode of action","volume":"42","author":"Nozaki","year":"1989","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ejmech.2025.117333_bib148","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1021\/jm100437u","article-title":"Structural basis for the interaction of lactivicins with serine \u03b2-lactamases","volume":"53","author":"Brown","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib149","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1248\/cpb.38.116","article-title":"Synthesis and antibacterial activity of lactivicin derivatives","volume":"38","author":"Tamura","year":"1990","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2025.117333_bib150","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1021\/jm500219c","article-title":"Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria","volume":"57","author":"Starr","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib151","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/AAC.00629-13","article-title":"Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa","volume":"57","author":"Tomaras","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib152","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00423-24","article-title":"A metabolomics perspective on clorobiocin biosynthesis: discovery of bromobiocin and novel derivatives through LC-MSE-based molecular networking","volume":"12","author":"Janzing","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.ejmech.2025.117333_bib153","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1074-5521(03)00051-6","article-title":"Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs","volume":"10","author":"Eust\u00e1quio","year":"2003","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib154","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1128\/AAC.22.4.662","article-title":"Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth","volume":"22","author":"Hooper","year":"1982","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib155","first-page":"41","article-title":"The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin, Proteins Struct","volume":"28","author":"Tsai","year":"1997","journal-title":"Funct. Genet."},{"key":"10.1016\/j.ejmech.2025.117333_bib156","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/j.1460-2075.1996.tb00483.x","article-title":"The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography","volume":"15","author":"Lewis","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.ejmech.2025.117333_bib157","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/1568026033452500","article-title":"The ATP-binding site of type II topoisomerases as a target for antibacterial drugs","volume":"3","author":"Maxwell","year":"2003","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib158","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1365-2958.1993.tb01728.x","article-title":"The interaction between coumarin drugs and DNA gyrase","volume":"9","author":"Maxwell","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib159","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.chembiol.2010.12.016","article-title":"An artificial pathway to 3,4-dihydroxybenzoic acid allows generation of new aminocoumarin antibiotic recognized by catechol transporters of E. coli","volume":"18","author":"Alt","year":"2011","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117333_bib160","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1016\/S0040-4039(00)95117-7","article-title":"Isolation and spectroscopic structure elucidation of sorangicin A, a new type of macrolide-polyether antibiotic from gliding bacteria","volume":"26","author":"Jansen","year":"1985","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib161","doi-asserted-by":"crossref","first-page":"30423","DOI":"10.1073\/pnas.2013706117","article-title":"The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase","volume":"117","author":"Lilic","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2025.117333_bib162","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/sj.emboj.7600499","article-title":"Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase","volume":"24","author":"Campbell","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.ejmech.2025.117333_bib163","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/acsinfecdis.2c00523","article-title":"Synthesis and characterization of DOTAM-based sideromycins for bacterial imaging and antimicrobial therapy","volume":"9","author":"Peukert","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117333_bib164","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1039\/D2SC06850H","article-title":"Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli","volume":"14","author":"Peukert","year":"2023","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejmech.2025.117333_bib165","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01732-17","article-title":"Orientia tsutsugamushi is highly susceptible to the RNA polymerase switch region inhibitor corallopyronin A in vitro and in vivo","volume":"62","author":"Kock","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib166","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2008.09.033","article-title":"The RNA polymerase \u201cSwitch Region\u201d is a target for inhibitors","volume":"135","author":"Mukhopadhyay","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2025.117333_bib167","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1021\/acs.jnatprod.5b00175","article-title":"Insights into structure-activity relationships of bacterial RNA polymerase inhibiting corallopyronin derivatives","volume":"78","author":"Sch\u00e4berle","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2025.117333_bib168","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3390\/pharmaceutics12111105","article-title":"Solubility and stability enhanced oral formulations for the anti-infective corallopyronin A","volume":"12","author":"Krome","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejmech.2025.117333_bib169","doi-asserted-by":"crossref","DOI":"10.3389\/fitd.2022.983107","article-title":"Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes","volume":"3","author":"Ehrens","year":"2022","journal-title":"Front. Trop. Dis."},{"key":"10.1016\/j.ejmech.2025.117333_bib170","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/jlac.198519850418","article-title":"Corallopyronin A, B und C - drei neue Antibiotika aus Corallococcus coralloides Cc c127 (Myxobacterales)","volume":"4","author":"Jansen","year":"1985","journal-title":"Liebigs Ann. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib171","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1039\/D2NP00012A","article-title":"Corallopyronin A: antimicrobial discovery to preclinical development","volume":"39","author":"Krome","year":"2022","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib172","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev.micro.61.080706.093501","article-title":"Lantibiotics: peptides of diverse structure and function","volume":"61","author":"Willey","year":"2007","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117333_bib173","doi-asserted-by":"crossref","first-page":"14360","DOI":"10.1002\/anie.201701586","article-title":"Chemical and biological aspects of nutritional immunity-perspectives for new anti-infectives that target iron uptake systems","volume":"56","author":"Bilitewski","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117333_bib174","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1042\/BST20120190","article-title":"Antimicrobial mechanism of lantibiotics","volume":"40","author":"Islam","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejmech.2025.117333_bib175","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1128\/AAC.50.4.1449-1457.2006","article-title":"Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies","volume":"50","author":"Bonelli","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib176","first-page":"53","article-title":"Gallidermin: a new lanthionine\u2010containing polypeptide antibiotic","volume":"177","author":"Kellner","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejmech.2025.117333_bib177","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1039\/c0ob00846j","article-title":"Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates","volume":"9","author":"Yoganathan","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib178","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1021\/acs.jnatprod.7b01054","article-title":"Antibacterial muraymycins from mutant strains of Streptomyces sp. NRRL 30471","volume":"81","author":"Cui","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2025.117333_bib179","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/molecules25010022","article-title":"Muraymycin nucleoside antibiotics: structure-activity relationship for variations in the nucleoside unit","volume":"25","author":"Heib","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117333_bib180","doi-asserted-by":"crossref","first-page":"10260","DOI":"10.1021\/ja017748h","article-title":"Structures of the muraymycins, novel peptidoglycan biosynthesis inhibitors","volume":"124","author":"McDonald","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117333_bib181","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.3390\/molecules23123085","article-title":"Aminoribosylated analogues of muraymycin nucleoside antibiotics","volume":"23","author":"Wiegmann","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117333_bib182","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1248\/cpb.c17-00684","article-title":"Synthesis and medicinal chemistry of muraymycins, nucleoside antibiotics","volume":"66","author":"Katsuyama","year":"2018","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2025.117333_bib183","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1002\/chem.201404775","article-title":"Lead structures for new antibacterials: stereocontrolled synthesis of a bioactive muraymycin analogue","volume":"20","author":"Spork","year":"2014","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2025.117333_bib184","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202202408","article-title":"Synthesis of an antimicrobial enterobactin-muraymycin conjugate for improved activity against gram-negative bacteria","volume":"29","author":"Rohrbacher","year":"2023","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2025.117333_bib185","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3762\/bjoc.12.77","article-title":"Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents","volume":"12","author":"Wiegmann","year":"2016","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib186","series-title":"Sanofi. Antibacterial Compounds Produced by the Microorganism Strain Corallococcus Coralloides ST201330 (DSM 24989)","author":"Stump","year":"2020"},{"key":"10.1016\/j.ejmech.2025.117333_bib187","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202210747","article-title":"Structure elucidation, total synthesis, antibacterial in vivo efficacy and biosynthesis proposal of myxobacterial corramycin","volume":"61","author":"Couturier","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117333_bib188","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1039\/D3NP00062A","article-title":"Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023","volume":"41","author":"Wang","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2025.117333_bib189","doi-asserted-by":"crossref","first-page":"8981","DOI":"10.1021\/jacs.3c13208","article-title":"The peptide antibiotic corramycin adopts a \u03b2-hairpin-like structure and is inactivated by the kinase ComG","volume":"146","author":"Adam","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117333_bib190","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1021\/acs.orglett.4c00774","article-title":"Chemical ligation-mediated total synthesis of corramycin","volume":"26","author":"Siebert","year":"2024","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib191","doi-asserted-by":"crossref","first-page":"16869","DOI":"10.1021\/acs.jmedchem.3c01564","article-title":"Optimization of the antibacterial spectrum and the developability profile of the novel-class natural product corramycin","volume":"66","author":"Renard","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib192","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01660-16","article-title":"The mechanism of killing by the proline-rich peptide Bac7(1\u201335) against clinical strains of Pseudomonas aeruginosa differs from that against other gram-negative bacteria","volume":"61","author":"Runti","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117333_bib193","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1021\/acsinfecdis.5b00044","article-title":"Helping chemists discover new antibiotics","volume":"1","author":"Blaskovich","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117333_bib194","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1016\/j.bmcl.2015.02.034","article-title":"Evaluation of (acyloxy)alkyl ester linkers for antibiotic release from siderophore-antibiotic conjugates","volume":"25","author":"Zheng","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.117333_bib195","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1021\/acs.jmedchem.8b00218","article-title":"A synthetic dual drug sideromycin induces gram-negative bacteria to commit suicide with a gram-positive antibiotic","volume":"61","author":"Liu","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117333_bib196","doi-asserted-by":"crossref","first-page":"14546","DOI":"10.1039\/D1SC04283A","article-title":"Galbofloxacin: a xenometal-antibiotic with potent in vitro and in vivo efficacy against S. aureus","volume":"12","author":"Pandey","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejmech.2025.117333_bib197","doi-asserted-by":"crossref","first-page":"21310","DOI":"10.1021\/jacs.0c06987","article-title":"Platform to discover protease-activated antibiotics and application to siderophore-antibiotic conjugates","volume":"142","author":"Boyce","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117333_bib198","article-title":"Drug repurposing by siderophore conjugation: synthesis and biological evaluation of siderophore-methotrexate conjugates as antibiotics","volume":"61","author":"Zhao","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117333_bib199","doi-asserted-by":"crossref","first-page":"12756","DOI":"10.1021\/jacs.2c03324","article-title":"Heavy-metal Trojan horse: enterobactin-directed delivery of platinum(IV) prodrugs to Escherichia coli","volume":"144","author":"Guo","year":"2022","journal-title":"J. Am. Chem. Soc."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425000984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425000984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:59:12Z","timestamp":1759298352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425000984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":199,"alternative-id":["S0223523425000984"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117333","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural sideromycins and siderophore-conjugated natural products as inspiration for novel antimicrobial agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117333"}}