{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:45:16Z","timestamp":1793673916172,"version":"4.5.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477012"],"award-info":[{"award-number":["22477012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX0261"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0261"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ejmech.2025.117483","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T11:17:43Z","timestamp":1741173463000},"page":"117483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections"],"prefix":"10.1016","volume":"289","author":[{"given":"Tao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Challa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-7704","authenticated-orcid":false,"given":"Shao-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117483_bib1","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.1002\/anie.201506818","article-title":"Targeting antibiotic resistance","volume":"55","author":"Chellat","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117483_bib2","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1021\/acsinfecdis.3c00156","article-title":"Fitness costs of antibiotic resistance impede the evolution of resistance to other antibiotics","volume":"9","author":"Chowdhury","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117483_bib3","doi-asserted-by":"crossref","first-page":"7400","DOI":"10.1021\/acsomega.7b01368","article-title":"Antibiotic resistance: current perspectives","volume":"2","author":"Petchiappan","year":"2017","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2025.117483_bib4","doi-asserted-by":"crossref","first-page":"10757","DOI":"10.1021\/acsomega.3c00312","article-title":"Antibiotic adjuvants: a versatile approach to combat antibiotic resistance","volume":"8","author":"Dhanda","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2025.117483_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acsinfecdis.1c00367","article-title":"Emerging roles of glycopeptide antibiotics: moving beyond gram-positive bacteria","volume":"8","author":"Acharya","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117483_bib6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1039\/C6MD00585C","article-title":"A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics","volume":"8","author":"Sarkar","year":"2017","journal-title":"MedChemComm"},{"key":"10.1016\/j.ejmech.2025.117483_bib7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1021\/cr030103a","article-title":"Glycopeptide and lipoglycopeptide antibiotics","volume":"105","author":"Kahne","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2025.117483_bib8","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1039\/D1CC06635H","article-title":"Pursuit of next-generation glycopeptides: a journey with vancomycin","volume":"58","author":"Acharya","year":"2022","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2025.117483_bib9","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/CMR.13.4.686","article-title":"Vancomycin-resistant enterococci","volume":"13","author":"Cetinkaya","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ejmech.2025.117483_bib10","doi-asserted-by":"crossref","first-page":"8823","DOI":"10.1002\/anie.202002727","article-title":"Vancomycin resistance is overcome by conjugation of polycationic peptides","volume":"59","author":"Umst\u00e4tter","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117483_bib11","doi-asserted-by":"crossref","first-page":"13946","DOI":"10.1021\/ja207142h","article-title":"A redesigned vancomycin engineered for dual D-Ala-D-Ala and D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria","volume":"133","author":"Xie","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117483_bib12","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1021\/acs.jmedchem.8b01093","article-title":"Battle against vancomycin-resistant bacteria: recent developments in chemical strategies","volume":"62","author":"Dhanda","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117483_bib13","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1021\/acsinfecdis.1c00318","article-title":"vancomycin-polymyxin nonapeptide conjugates that retain anti-Gram-positive activity with enhanced potency against Gram-negative strains","volume":"7","author":"van Groesen","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117483_bib14","doi-asserted-by":"crossref","first-page":"10706","DOI":"10.1002\/anie.201209979","article-title":"Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials","volume":"52","author":"O'Connell","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117483_bib15","doi-asserted-by":"crossref","first-page":"10185","DOI":"10.1021\/acs.jmedchem.1c00449","article-title":"Alkyl-aryl-vancomycins: multimodal glycopeptides with weak dependence on the bacterial metabolic state","volume":"64","author":"Sarkar","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117483_bib16","doi-asserted-by":"crossref","first-page":"28511","DOI":"10.1021\/acsomega.3c02879","article-title":"Synthesis and antibacterial evaluation of novel vancomycin derivatives containing quaternary ammonium moieties","volume":"8","author":"Jiang","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2025.117483_bib17","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/acschembio.0c00091","article-title":"Vancomycin derivative inactivates carbapenem-resistant acinetobacter baumannii and induces autophagy","volume":"15","author":"Sarkar","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117483_bib18","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1021\/acsinfecdis.8b00152","article-title":"N-terminus alkylation of vancomycin: ligand binding affinity, antimicrobial activity, and site-specific nature of quaternary trimethylammonium salt modification","volume":"4","author":"Wu","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117483_bib19","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1128\/AAC.00712-12","article-title":"TD-1792 versus vancomycin for treatment of complicated skin and skin structure infections","volume":"56","author":"Martin","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117483_bib20","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1021\/jm500270w","article-title":"Membrane active vancomycin analogues: a strategy to combat bacterial resistance","volume":"57","author":"Yarlagadda","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117483_bib21","doi-asserted-by":"crossref","first-page":"6678","DOI":"10.1002\/anie.201902210","article-title":"An underestimated moiety for structural modification, alters the antibacterial profile of vancomycin against multidrug-resistant bacteria","volume":"58","author":"Guan","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117483_bib22","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1038\/s41467-018-05821-1","article-title":"Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens","volume":"9","author":"Lin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117483_bib23","doi-asserted-by":"crossref","first-page":"8115","DOI":"10.1039\/D0CC02522D","article-title":"Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA","volume":"56","author":"Peng","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2025.117483_bib24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jconrel.2020.11.045","article-title":"Mannose-modified exosomes for targeted delivery of lysostaphin and vancomycin to eradicate intracellular MRSA","volume":"329","author":"Yang","year":"2020","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejmech.2025.117483_bib25","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1021\/acs.orglett.0c02403","article-title":"Synthesis of vitamin B12-antibiotic conjugates with improved activity against Gram-negative bacteria","volume":"16","author":"Zhao","year":"2020","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2025.117483_bib26","article-title":"Drug repurposing by siderophore conjugation: design, synthesis and biological evaluation of siderophore-methotrexate conjugates as novel antibiotics","volume":"134","author":"Zhao","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117483_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jconrel.2023.03.053","article-title":"Bacteria-mimetic nanomedicine for targeted eradication of intracellular MRSA","volume":"357","author":"Xie","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejmech.2025.117483_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115973","article-title":"Development of membrane-targeting TPP+-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections","volume":"264","author":"Li","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117483_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116381","article-title":"Discovery of novel thymol-TPP antibiotics that eradicate MRSA persisters","volume":"270","author":"Tang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2025.117483_bib30","doi-asserted-by":"crossref","first-page":"8040","DOI":"10.1021\/acs.jmedchem.2c00615","article-title":"Optimization of the natural product calothrixin A to discover novel dual topoisomerase I and II inhibitors with improved anticancer activity","volume":"65","author":"Yang","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117483_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115165","article-title":"Aromatic hydrazides: a potential solution for Acinetobacter baumannii infections","volume":"249","author":"Green","year":"2023","journal-title":"Eur. J. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342500248X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342500248X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:10:19Z","timestamp":1762265419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342500248X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":31,"alternative-id":["S022352342500248X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117483","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117483","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117483"}}