{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:03:55Z","timestamp":1793333035815,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009019","name":"Shenzhen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ejmech.2025.117489","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:13:20Z","timestamp":1741346000000},"page":"117489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Mitochondrial DNA-targeted triphenylamine-thiophene (TPATP)-derived ligands boost type-I\/II photodynamic therapy for triple-negative breast cancer"],"prefix":"10.1016","volume":"289","author":[{"given":"Xiao-Dong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Si","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ling","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-3884","authenticated-orcid":false,"given":"Ming-Hao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117489_bib1","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1056\/NEJMra1001389","article-title":"Triple-negative breast cancer","volume":"363","author":"Foulkes","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejmech.2025.117489_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2017.07.002","article-title":"Immunotherapy for triple-negative breast cancer: existing challenges and exciting prospects","volume":"32","author":"Jia","year":"2017","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.ejmech.2025.117489_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2147\/CMAR.S146658","article-title":"Neoadjuvant treatments in triple-negative breast cancer patients: where we are now and where we are going","volume":"10","author":"Omarini","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.ejmech.2025.117489_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/PPO.0b013e3181d24ff7","article-title":"Triple-negative breast cancer: role of specific chemotherapy agents","volume":"16","author":"Isakoff","year":"2010","journal-title":"Cancer J."},{"key":"10.1016\/j.ejmech.2025.117489_bib5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2025.117489_bib6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrc1894","article-title":"Photodynamic therapy and anti-tumour immunity","volume":"6","author":"Castano","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2025.117489_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202206659","article-title":"An activity-based photosensitizer to reverse hypoxia and oxidative resistance for tumor photodynamic eradication","volume":"34","author":"Shi","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejmech.2025.117489_bib8","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.tig.2018.05.009","article-title":"Mitochondrial DNA transcription and its regulation: an evolutionary perspective","volume":"34","author":"Barshad","year":"2018","journal-title":"Trends Genet."},{"key":"10.1016\/j.ejmech.2025.117489_bib9","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.2174\/0929867325666180228165527","article-title":"Potential roles for G-quadruplexes in mitochondria","volume":"26","author":"Falabella","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117489_bib10","doi-asserted-by":"crossref","first-page":"20779","DOI":"10.1021\/jacs.1c08860","article-title":"Monitoring and modulating mtDNA G-quadruplex dynamics reveal its close relationship to cell glycolysis","volume":"143","author":"Chen","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117489_bib11","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.1093\/nar\/gkad535","article-title":"Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells","volume":"51","author":"Doimo","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2025.117489_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tig.2022.10.006","article-title":"Mitochondria and G-quadruplex evolution: an intertwined relationship","volume":"39","author":"Sahayasheela","year":"2023","journal-title":"Trends Genet."},{"key":"10.1016\/j.ejmech.2025.117489_bib13","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1021\/acs.jmedchem.3c02240","article-title":"Mitochondria-selective dicationic small-molecule ligand targeting G-quadruplex structures for human colorectal cancer therapy","volume":"67","author":"Zheng","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117489_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116361","article-title":"Discovery of a triphenylamine-based ligand that targets mitochondrial DNA G-quadruplexes and activates the cGAS-STING immunomodulatory pathway","volume":"269","author":"Wang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117489_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116046","article-title":"Discovery of a far-red carbazole-benzoindolium fluorescent ligand that selectively targets mitochondrial DNA and suppresses breast cancer growth","volume":"264","author":"Wang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117489_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132230","article-title":"Discovery of a mitochondrial G-quadruplex targeted fluorescent ligand via a slight variation on the near-infrared heptamethine cyanine scaffold","volume":"269","author":"Nie","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2025.117489_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136350","article-title":"A highly emissive near infrared thiophene-benzoindolium ligand binding to mitochondrial G-quadruplexes triggers triple-negative breast cancer cell death","volume":"418","author":"Wang","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.ejmech.2025.117489_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140556","article-title":"Diphenylaminothiophen-derived fluorescent ligands targeting mitochondrial DNA G-quadruplexes potentially for triple-negative breast cancer therapy","volume":"302","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2025.117489_bib19","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1021\/acs.jmedchem.4c02121","article-title":"PET imaging of solid tumors with a G-quadruplex-targeting 18F-labeled peptide probe","volume":"68","author":"Guo","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117489_bib20","article-title":"Zwitterionic AIEgens: rational molecular design for NIR-II fluorescence imaging-guided synergistic phototherapy","volume":"31","author":"Zhu","year":"2021","journal-title":"Adv. Funct. Mater."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425002545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425002545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:07:31Z","timestamp":1762265251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425002545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":20,"alternative-id":["S0223523425002545"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117489","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial DNA-targeted triphenylamine-thiophene (TPATP)-derived ligands boost type-I\/II photodynamic therapy for triple-negative breast cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117489","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117489"}}