{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:11:38Z","timestamp":1787641898195,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020703","name":"Department of Pharmaceutical Sciences, St. John's University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["2022P5LPHS"],"award-info":[{"award-number":["2022P5LPHS"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003065","name":"Universit\u00e4t Wien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ejmech.2025.117494","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:07:21Z","timestamp":1741694841000},"page":"117494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A new potent and selective peroxisome proliferator-activated receptor alpha partial agonist displays anti-steatotic effects In vitro and behaves as a safe hypolipidemic and hypoglycemic agent in a diabetic mouse model"],"prefix":"10.1016","volume":"289","author":[{"given":"Antonio","family":"Laghezza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Falbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Gilardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Leuci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Piemontese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tortorella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abanish","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Pratap","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Pattnaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesan","family":"Jayaprakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhas","family":"Tambe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Ca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Wackerlig-Damle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Paoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-574X","authenticated-orcid":false,"given":"Fulvio","family":"Loiodice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2181-8026","authenticated-orcid":false,"given":"Antonio","family":"Lavecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117494_bib1","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1136\/bmj.296.6638.1702","article-title":"Blood lipid concentrations and other cardiovascular risk factors: distribution, prevalence, and detection in Britain","volume":"296","author":"Mann","year":"1988","journal-title":"Br. Med. J."},{"key":"10.1016\/j.ejmech.2025.117494_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/650989","article-title":"Lipoprotein(a) in cardiovascular diseases","volume":"2013","author":"Malaguarnera","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2025.117494_bib3","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1021\/jm101360s","article-title":"Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators","volume":"55","author":"Pirat","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib4","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2174\/1389557054553758","article-title":"PPARs as targets for metabolic and cardiovascular diseases","volume":"5","author":"Cheng","year":"2005","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib5","first-page":"317","article-title":"Peroxisome proliferator-activated receptors: targets for the treatment of metabolic illnesses","volume":"1","author":"Moore-Carrasco","year":"2008","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejmech.2025.117494_bib6","doi-asserted-by":"crossref","first-page":"8282","DOI":"10.1021\/acs.jmedchem.8b00835","article-title":"Identification of the first PPARalpha\/gamma dual agonist able to bind to canonical and alternative sites of PPARgamma and to inhibit its Cdk5-mediated phosphorylation","volume":"61","author":"Laghezza","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00018-003-3216-3","article-title":"Peroxisome proliferator-activated receptor alpha target genes","volume":"61","author":"Mandard","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejmech.2025.117494_bib8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/bj20020851","article-title":"Control of human carnitine palmi- toyltransferase II gene transcription by peroxisome proliferator-activated receptor through a partially conserved peroxisome proliferator-responsive element","volume":"369","author":"Barrero","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejmech.2025.117494_bib9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1517\/14656566.2012.658774","article-title":"Fenofibric acid for hyperlipidemia","volume":"13","author":"Saurav","year":"2012","journal-title":"Expet Opin. Pharmacother."},{"key":"10.1016\/j.ejmech.2025.117494_bib10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2165\/00003495-198836030-00004","article-title":"A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia","volume":"36","author":"Todd","year":"1988","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2025.117494_bib11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/17425255.2018.1483337","article-title":"Peroxisome proliferator-activated receptor alpha-mediated drug toxicity in the liver","volume":"14","author":"Hedrington","year":"2018","journal-title":"Expet Opin. Drug Metabol. Toxicol."},{"key":"10.1016\/j.ejmech.2025.117494_bib12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/13543784.2017.1312339","article-title":"PPAR-alpha agonists are still on the rise: an update on clinical and experimental findings","volume":"26","author":"Ferri","year":"2017","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.ejmech.2025.117494_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11883-020-0823-5","article-title":"A new selective PPAR\u03b1 modulator: drug concept and its clinical applications for dyslipidemia and metabolic diseases","volume":"22","author":"Yamashita","year":"2020","journal-title":"Curr. Atheroscler Rep."},{"key":"10.1016\/j.ejmech.2025.117494_bib14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12933-017-0602-y","article-title":"Pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor alpha modulator for management of atherogenic dyslipidaemia","volume":"16","author":"Fruchart","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ejmech.2025.117494_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e05431","article-title":"A PPAR alpha agonist, attenuates neointima formation after vascular injury in mice fed normal chow and a high-fat diet","volume":"6","author":"Horikawa","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.ejmech.2025.117494_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116567","article-title":"A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha\/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties","volume":"275","author":"Laghezza","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep34792","article-title":"Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode","volume":"6","author":"Capelli","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.117494_bib18","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3390\/molecules27030958","article-title":"A new series of aryloxyacetic acids endowed with multi-target activity towards peroxisome proliferator-activated receptors (PPARs), fatty acid amide hydrolase (FAAH), and acetylcholinesterase (AChE)","volume":"27","author":"Leuci","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117494_bib19a","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ejmech.2014.10.083","article-title":"Structural development studies of PPARs ligands based on tyrosine scaffold","volume":"89","author":"De Filippis","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib19b","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202400086","article-title":"Synthesis and in vitro cytotoxicity of benzoxazole-based PPAR\u03b1\/\u03b3 antagonists in colorectal cancer cell lines","volume":"357","author":"Moreno-Rodr\u00edguez","year":"2024","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ejmech.2025.117494_bib20a","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1747-0285.2005.00327.x","article-title":"Use of an induced fit receptor structure in virtual screening","volume":"67","author":"Sherman","year":"2006","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2025.117494_bib20b","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jm050540c","article-title":"Novel procedure for modeling ligand\/receptor induced fit effects","volume":"49","author":"Sherman","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib21","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1038\/ncomms4571","article-title":"An alternate binding site for PPAR\u03b3 ligands","volume":"5","author":"Hughes","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117494_bib22","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.str.2007.07.014","article-title":"Partial agonists activate PPARgamma using a helix 12 independent mechanism","volume":"15","author":"Bruning","year":"2007","journal-title":"Structure"},{"key":"10.1016\/j.ejmech.2025.117494_bib23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.biochi.2005.02.002","article-title":"The conserved residue Phe273(282) of PPAR alpha(gamma), beyond the ligand-binding site, functions in binding affinity through solvation effect","volume":"87","author":"Yue","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.ejmech.2025.117494_bib24","doi-asserted-by":"crossref","first-page":"15655","DOI":"10.1073\/pnas.232137699","article-title":"Infection of a human hepatoma cell line by hepatitis B virus","volume":"99","author":"Gripon","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2025.117494_bib25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.taap.2014.02.001","article-title":"PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells","volume":"276","author":"Rogue","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.117494_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114240","article-title":"A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity","volume":"235","author":"Sblano","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib27","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.toxrep.2014.02.003","article-title":"Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL\/6 mice","volume":"1","author":"Zarzecki","year":"2014","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.ejmech.2025.117494_bib28","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/jdi.12845","article-title":"Effects of a novel selective peroxisome proliferator-activated receptor-\u0251 modulator, pemafibrate, on hepatic and peripheral glucose uptake in patients with hypertriglyceridemia and insulin resistance","volume":"9","author":"Matsuba","year":"2018","journal-title":"J Diabetes Investig."},{"key":"10.1016\/j.ejmech.2025.117494_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11883-020-0823-5","article-title":"A new selective PPAR\u03b1 modulator: drug concept and its clinical applications for dyslipidemia and metabolic diseases","volume":"22","author":"Yamashita","year":"2020","journal-title":"Curr. Atheroscler Rep."},{"key":"10.1016\/j.ejmech.2025.117494_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1124\/mol.104.005553","article-title":"Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms","volume":"67","author":"Erbe","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.117494_bib31","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.2337\/diab.45.10.1379","article-title":"Protein tyrosine phosphatase 1B interacts with the activated insulin receptor","volume":"45","author":"Seely","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.ejmech.2025.117494_bib32","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3109\/10409238.2013.819830","article-title":"PTP1B: a simple enzyme for a complex world","volume":"48","author":"Feldhammer","year":"2013","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.117494_bib33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2174\/1389557515666150203144339","article-title":"Small molecules as potent protein tyrosine phosphatase 1B (PTP1B) inhibitor documented in patients from 2009 to 2013","volume":"15","author":"Wang","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib34","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1021\/acs.jctc.1c00302","article-title":"OPLS4: improving force field accuracy on challenging regimes of chemical space","volume":"17","author":"Lu","year":"2021","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.ejmech.2025.117494_bib35","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/(SICI)1097-461X(1996)60:7<1271::AID-QUA8>3.0.CO;2-W","article-title":"Calculation of intramolecular force fields from second-derivative tensors","volume":"60","author":"Seminario","year":"1996","journal-title":"Int. J. Quant. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib36","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1021\/acs.jcim.5b00674","article-title":"MCPB.py: a Python based metal center parameter builder","volume":"56","author":"Li","year":"2016","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2025.117494_bib37","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1021\/acs.jcim.4c00540","article-title":"A toolkit to derive automated force fields from quantum mechanical information","volume":"64","author":"Falbo","year":"2024","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2025.117494_bib38","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1021\/ct300826t","article-title":"Systematic parametrization of polarizable force fields from quantum chemistry data","volume":"9","author":"Wang","year":"2013","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.ejmech.2025.117494_bib39","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","article-title":"Development and testing of a general AMBER force field","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib40","series-title":"Amber 2022","author":"Case","year":"2022"},{"key":"10.1016\/j.ejmech.2025.117494_bib41","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1021\/acs.jctc.2c00654","article-title":"Integration of quantum chemistry, statistical mechanics, and artificial intelligence for computational spectroscopy: the UV\u2013Vis spectrum of TEMPO radical in different solvents","volume":"18","author":"Falbo","year":"2022","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.ejmech.2025.117494_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cplett.2021.138893","article-title":"On the analysis of X-ray absorption spectra for polyoxometallates","volume":"780","author":"Falbo","year":"2021","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.ejmech.2025.117494_bib43","doi-asserted-by":"crossref","first-page":"9722","DOI":"10.1021\/acs.chemrev.0c01195","article-title":"Unsupervised learning methods for molecular simulation data","volume":"121","author":"Glielmo","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2025.117494_bib44","first-page":"1","article-title":"Top 10 algorithms in data mining","volume":"vol. 14","author":"Wu","year":"2007"},{"key":"10.1016\/j.ejmech.2025.117494_bib45","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0003-2697(89)90616-7","article-title":"Variation in enzymatic transient gene expression assays","volume":"182","author":"Hollon","year":"1989","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2025.117494_bib46","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/hep.21536","article-title":"Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor","volume":"45","author":"Cerec","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2025.117494_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103211","article-title":"Design and evaluation of non-carboxylate 5- arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B","volume":"92","author":"Ottan\u00e0","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.117494_bib48","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/molecules26020330","article-title":"In search for multi-target ligands as potential agents for diabetes mellitus and its complications - a structure-activity relationship study on inhibitors of aldose reductase and protein tyrosine phosphatase 1B","volume":"26","author":"Ottan\u00e0","year":"2021","journal-title":"Molecules"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425002594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425002594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:13:38Z","timestamp":1762265618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425002594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":50,"alternative-id":["S0223523425002594"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117494","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new potent and selective peroxisome proliferator-activated receptor alpha partial agonist displays anti-steatotic effects In vitro and behaves as a safe hypolipidemic and hypoglycemic agent in a diabetic mouse model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117494","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"117494"}}